Natural remedies proposed for the management of diabetic retinopathy (DR): diabetic complications DOI Creative Commons
Emad Gamil Khidr,

Nourhan Ibrahim Morad,

Shymaa Hatem

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Abstract Diabetic retinopathy (DR) represents a significant and serious complication associated with diabetes mellitus (DM), often resulting in considerable visual impairment or even blindness. The intricate pathological processes underlying DR complicate the effectiveness of current treatment modalities. Studies have highlighted potential natural products via several beneficial effects including anti-inflammatory, antioxidant, anti-neovascular, anti-apoptotic properties. Flavonoids, saponins, saccharides, alkaloids exhibited various vivo vitro studies. However, clinical utilization these compounds is hindered by issues such as inadequate specificity, low bioavailability, toxicity. Therefore, there pressing need for rigorous studies to confirm efficacy preventing mitigating progression DR.

Language: Английский

Astragalin from Thesium chinense: A Novel Anti-Aging and Antioxidant Agent Targeting IGFR/CD38/Sirtuins DOI Creative Commons
Ruifeng Wang,

Anping Ding,

Jiaye Wang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 859 - 859

Published: July 18, 2024

Astragalin (AG), a typical flavonoid found in Thesium chinense Turcz (T. chinense), is abundant various edible plants and possesses high nutritional value, as well antioxidant antibacterial effects. In this study, we initially predicted the mechanism of action AG with two anti-aging antioxidant-related protein targets (CD38 IGFR) by molecular docking dynamics simulation techniques. Subsequently, examined effects Caenorhabditis elegans (C. elegans), zebrafish, verified related mechanisms. C. elegans, synergistically extended lifespan up-regulating expression daf-16 through inhibiting daf-2/IGFR also activating AMPK MAPK pathways to up-regulate sir-2.1, sir-2.4, skn-1. oxidatively damaged zebrafish embryos, demonstrated synergistic effect augmenting resistance embryos oxidative stress levels SIRT1 SIRT6 within system via suppression CD38 enzymatic activity then IGFR SIRT6. These findings highlight properties indicate its potential application supplementary ingredient aquaculture for enhancing fish health growth.

Language: Английский

Citations

5
Natural remedies proposed for the management of diabetic retinopathy (DR): diabetic complications DOI Creative Commons
Emad Gamil Khidr,

Nourhan Ibrahim Morad,

Shymaa Hatem

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Abstract Diabetic retinopathy (DR) represents a significant and serious complication associated with diabetes mellitus (DM), often resulting in considerable visual impairment or even blindness. The intricate pathological processes underlying DR complicate the effectiveness of current treatment modalities. Studies have highlighted potential natural products via several beneficial effects including anti-inflammatory, antioxidant, anti-neovascular, anti-apoptotic properties. Flavonoids, saponins, saccharides, alkaloids exhibited various vivo vitro studies. However, clinical utilization these compounds is hindered by issues such as inadequate specificity, low bioavailability, toxicity. Therefore, there pressing need for rigorous studies to confirm efficacy preventing mitigating progression DR.

Language: Английский

Citations

0