Approach to mathematical modeling of the process of carcinogenesis DOI
Марина Анатоліївна Бондаренко, Olga Zaytseva, A.S. Solodovnikov

et al.

Published: Dec. 30, 2024

Background. The steady increase in the incidence and mortality rates of malignant neoplasms necessitates integration advanced high-tech research methods into oncology, one which is mathematical modeling initiation, promotion, progression tumors. complexity carcinogenesis associated with need to consider a significant number factors influencing this process, as well its specificity, multi-level nature, multi-stage progression, varying scales. A detailed study molecular mechanisms underlying process essential for developing new approaches describing cell malignancy. Purpose – conduct comparative analysis existing models malignancy development oncological diseases, predicting dynamics biological systemsʼ behavior various types cells during their interaction. This intended optimize processes cancer detection treatment. Materials Methods. involves an scientific data on biology medicine, particularly through review available domestic international literature. Results. examined specific features pathogenesis diseases that must be considered process. It was demonstrated has unique characteristics, importance selecting appropriate tools accordance objectives highlighted. deterministic model interaction between tumor immune body analyzed, limitations were identified. Evidence supporting necessity employing probabilistic approach describe presented. Conclusions. correct choice method tumors represents powerful modern studying etiology diseases. application oncology improves understanding hidden clinical patterns, enhances disease diagnosis, enables better forecasting ultimately optimizing treatment strategies patients.

Language: Английский

Targeting autophagy to enhance chemotherapy and immunotherapy in oral cancer DOI Creative Commons
Xiaoli Zeng, Yue Chen, Jing Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Oral cancer is a highly malignant disease characterized by recurrence, metastasis, and poor prognosis. Autophagy, catabolic process induced under stress conditions, has been shown to play dual role in oral development therapy. Recent studies have identified that autophagy activation epithelial cells suppresses cell survival inhibiting key pathways such as the mammalian target of rapamycin (mTOR) mitogen-activated protein kinase (MAPK), while activating adenosine monophosphate-activated (AMPK) pathway. Inducing promotes degradation eukaryotic initiation factor 4E, thus reducing metastasis enhancing efficacy chemotherapy, radiotherapy, immunotherapy. Furthermore, induction can modulate tumor immune microenvironment enhance antitumor immunity. This review comprehensively summarizes relationship between cancer, focusing on its mechanisms therapeutic potential when combined with conventional treatments. While promising, precise clinical applications inducers therapy remain be elucidated, offering new directions for future research improve treatment outcomes reduce recurrence.

Language: Английский

Citations

1
Oxidative Stress-Induced Gastrointestinal Diseases: Biology and Nanomedicines—A Review DOI Creative Commons
Maryam Rezvani

BioChem, Journal Year: 2024, Volume and Issue: 4(3), P. 189 - 216

Published: July 29, 2024

Gastrointestinal diseases have been among the main concerns of medical and scientific societies for a long time. Several studies emphasized critical role oxidative stress in pathogenesis most common gastrointestinal diseases. To provide comprehensive overview caused by stress, their biological aspects, molecular mechanisms specific pathways, results recent published articles from online databases were studied considering both upper lower parts digestive tract. The revealed that although each part system manifests itself way, all these arise imbalance between generation reactive intermediates (especially oxygen species) antioxidant defense system. Annual incidence mortality statistics worldwide emphasize urgent need to find an effective non-invasive treatment method overcome life-threatening problems. Therefore, next step, variety nanomedicurfines developed treat effect investigated precisely. Furthermore, important nanomedicines responsive endogenous exogenous stimuli evaluated detail. This review could pave way open new horizon effectively treating

Language: Английский

Citations

5
Beyond Genetics: Exploring Lifestyle, Microbiome, and Social Determinants in Oral Cancer Development DOI Open Access
Anil G. Menon, Vimi Sunil Mutalik, Yongqiang Chen

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1094 - 1094

Published: March 25, 2025

Oral cancer refers to cancers originating in the oral cavity and oropharyngeal regions. It is 16th most prevalent sixth leading cause of cancer-related deaths. However, mechanisms its progression are still being understood, interventions provide early diagnosis need be improved. More studies have recently been conducted on cancer, many reviews summarized findings this field, focusing individual factors. few review articles evaluated combinational impacts different factors cancer. This aimed an overview effects three extracellular factors, including lifestyle habits, microbiome, socioeconomic progression. differentially affected by habits; high-sugar diets, processed foods, alcohol, smoking, possibly sleep disorders benefit progression, whereas eating natural such as fruits, vegetables, fish, garlic, drinking tea or coffee, physical exercise can combat it. The microbiome could suppress promote Low status impact development. Furthermore, crosstalk among these affects has limitations not all cancer-affecting important publications. focus should placed multiple treatment. study update researchers landscape help formulate approaches prevention

Language: Английский

Citations

0
Matrix Dynamics and Microbiome Crosstalk: Matrix Metalloproteinases as Key Players in Disease and Therapy DOI Open Access
Paraskevi Ioannou,

Elias Katsoulieris,

Nikolaos A. Afratis

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3621 - 3621

Published: April 11, 2025

Matrix metalloproteinases (MMPs) are key enzymes involved in extracellular matrix (ECM) remodeling, regulating a wide range of cellular and immune processes both homeostatic pathological conditions. Host–microbiota interactions play critical role maintaining ECM balance; however, during dysbiosis, this regulation is disrupted, leading to compromised barrier integrity, pathogen translocation into circulation, the development systemic diseases cancer. This review highlights bidirectional relationship between MMP expression/activity microbiota emphasizing tissue-specific alterations activity that contribute disease progression. In addition, it integrates interdisciplinary evidence illustrate MMP-dependent mechanisms underlying various pathologies associated with oral gut microbiome including long-range effects through gut–skin gut–brain axes. Thus, introduces emerging field MatrixBiome, which explores complex ECM, microbiota, host tissues. Finally, also outlines therapeutic strategies modulate levels, either indirectly microbiome-targeted approaches (e.g., prebiotics, probiotics, postbiotics) or directly using inhibitors, offering promising avenues for future clinical interventions.

Language: Английский

Citations

0
A bibliometric analysis of programmed cell death in oral cancer literature: research patterns and emerging trends (2000–2024) DOI Creative Commons

Wenli Gu

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 22, 2025

Language: Английский

Citations

0
Impact of oral flora in tongue coating and saliva on oral cancer risk and the regulatory role of Interleukin-8 DOI
Xuemin Wang,

Xiaona Song,

Jiping Gao

et al.

Cytokine, Journal Year: 2024, Volume and Issue: 185, P. 156821 - 156821

Published: Dec. 3, 2024

Language: Английский

Citations

1
New Insights into Aspirin’s Anticancer Activity: The Predominant Role of Its Iron-Chelating Antioxidant Metabolites DOI Creative Commons
George J. Kontoghiorghes

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 29 - 29

Published: Dec. 29, 2024

Epidemiological studies have suggested that following long-term, low-dose daily aspirin (LTLDA) administration for more than 5 years at 75–100 mg/day, 20–30% of patients (50–80 old) had a lower risk developing colorectal cancer (CRC) and about the same proportion in iron deficiency anemia (IDA). In cases IDA, an increase excretion is suspected, which caused by chelating metabolites (ACMs): salicylic acid, salicyluric 2,5-dihydroxybenzoic 2,3-dihydroxybenzoic acid. The ACMs constitute 70% administered dose much longer half-lives blood tissues. mechanisms reduction LTLDA users likely due to ACM’s targeting involved free radical damage, iron-containing toxins, proteins, associated metabolic pathways such as ferroptosis. from non-absorbed (about 30%) may also mitigate toxicity heme nitroso-heme other toxins food, are responsible cause cancer. mode action antioxidant pro-drug ACMs, with continuous presence users, increases prospect prophylaxis diseases. It anticancer effects depend primarily on iron-chelating activity ACMs. role diseases incomplete without considering its rapid biotransformation half-life

Language: Английский

Citations

0
Approach to mathematical modeling of the process of carcinogenesis DOI
Марина Анатоліївна Бондаренко, Olga Zaytseva, A.S. Solodovnikov

et al.

Published: Dec. 30, 2024

Background. The steady increase in the incidence and mortality rates of malignant neoplasms necessitates integration advanced high-tech research methods into oncology, one which is mathematical modeling initiation, promotion, progression tumors. complexity carcinogenesis associated with need to consider a significant number factors influencing this process, as well its specificity, multi-level nature, multi-stage progression, varying scales. A detailed study molecular mechanisms underlying process essential for developing new approaches describing cell malignancy. Purpose – conduct comparative analysis existing models malignancy development oncological diseases, predicting dynamics biological systemsʼ behavior various types cells during their interaction. This intended optimize processes cancer detection treatment. Materials Methods. involves an scientific data on biology medicine, particularly through review available domestic international literature. Results. examined specific features pathogenesis diseases that must be considered process. It was demonstrated has unique characteristics, importance selecting appropriate tools accordance objectives highlighted. deterministic model interaction between tumor immune body analyzed, limitations were identified. Evidence supporting necessity employing probabilistic approach describe presented. Conclusions. correct choice method tumors represents powerful modern studying etiology diseases. application oncology improves understanding hidden clinical patterns, enhances disease diagnosis, enables better forecasting ultimately optimizing treatment strategies patients.

Language: Английский

Citations

0