Bulletin of Problems Biology and Medicine, Journal Year: 2024, Volume and Issue: 1(4), P. 275 - 275
Published: Jan. 1, 2024
Language: Английский
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 7, 2025
This study aims to evaluate whether laparoscopic surgery enhances health-related quality of life (HRQoL) in endometriosis patients, utilizing the Endometriosis Health Profile-30 (EHP-30) questionnaire. The also explores correlations between disease severity, preoperative scores, and subsequent changes following surgical intervention. is a prospective observational study. Seventy women undergoing for at Fujian Maternity Child Hospital were prospectively recruited. Each participant was assessed using EHP-30 questionnaire both 4 weeks prior 3 months post-surgery obtain postoperative subscale scores. Wilcoxon signed-rank test applied determine statistical significance these Spearman's rank correlation coefficient employed explore relationships serum CA125 levels, intraoperative revised American Society Reproductive Medicine (rASRM) Statistically significant further examined multivariate linear regression analysis adjust potential confounders. Laparoscopic resulted reduction scores (P ≤ 0.002), indicating marked improvement HRQoL among patients. Spearman revealed positive levels = 0.005) rASRM with pain 0.035) sexual intercourse 0.046). Additionally, analyses demonstrated that (ΔPain), control powerlessness (ΔControl Powerlessness), work (ΔWork Life) significantly interrelated < 0.01). Emotional well-being (ΔEmotional Well-being), exhibited mutual influences Furthermore, social support (ΔSocial Support), self-image (ΔSelf-image), treatment perception (ΔTreatment) positively correlated 0.01), as (ΔSexual Intercourse) concern about infertility (ΔConcern on Infertility) improves by alleviating influencing daily functioning emotional well-being. These findings highlight critical role an effective intervention enhancing
Language: Английский
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1
Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: 168, P. 104425 - 104425
Published: Jan. 9, 2025
Language: Английский
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Ciência Cuidado e Saúde, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 28, 2025
Objetivo: avaliar o conteúdo de um roteiro produzido para guiar desenvolvimento tecnologia educativa audiovisual sobre endometriose. Método: pesquisa desenvolvimento, incluindo etapas delineamento do conteúdo, produção roteiro, avaliação com especialistas e revisão roteiro. Para a utilizou-se instrumento questões relacionadas objetivo, estrutura apresentação relevância, encaminhado via on-line selecionados segundo critérios expertise temática. análise das respostas, foi considerado Índice Concordância entre as assertivas instrumento. Resultados: subsidiado por da literatura. O 12 tópicos-questões partir modelo duas colunas. os 22 0,94. As sugestões incluir, alterar, reforçar revisar foram consideradas, atualizado. A versão final material disponibilizada no formato impresso. Conclusão: produzido, avaliado atualizado, servindo guia 1Manuscrito extraído dissertação, título “Tecnologia Educacional Audiovisual Mulheres Sobre Endometriose”, apresentada ao Programa Pós-graduação em Enfermagem Saúde Pública Escola Superior Ciências Universidade Estado Amazonas (UEA), ano 2021.
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Russian Journal of Human Reproduction, Journal Year: 2025, Volume and Issue: 31(2), P. 62 - 62
Published: April 29, 2025
The article focuses on the of methods for objectifying pain syndrome in patients with endometriosis. Endometriosis-related pain, including dysmenorrhea, dyspareunia, and chronic pelvic is a clinically significant symptom disease that leads to seek medical help significantly reduces their quality life. discusses pathophysiological mechanisms related inflammation, abnormal innervation endometrial foci, peripheral, central cross-sensitization. Special attention paid modern diagnosing caused by endometriosis, use modified scales (PainDetect), analysis biomarkers (neurotransmitters, sex hormones, immune markers metabolites) patient’ biosamples assessment histological features endometriotic lesions. Modern neuroimaging techniques such as MRI tractography, neurography resting-state functional are also described. These allow evaluation presence neuropathic components syndromes associated describes animal models endometriosis highlights potential non-invasive tests assessing humans. It emphasizes need developing actively applying objectification key aspect early diagnosis timely treatment prevent progression.
Language: Английский
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Medicina, Journal Year: 2024, Volume and Issue: 60(11), P. 1866 - 1866
Published: Nov. 14, 2024
According to the World Health Organization (WHO), endometriosis affects roughly 10% (190 million) of reproductive-age women and girls in world (2023). The diagnostic challenge lies limited value clinical tools, making it crucial address complexities patients with suggestive symptoms inconclusive or imaging findings. Saliva micro ribonucleic acid (miRNA) signature, nanotechnologies, artificial intelligence (AI) have opened up new perspectives on diagnosis. aim this article is review innovations at intersection technology AI when diagnosing endometriosis. Aberrant epigenetic regulation, such as DNA methylation endometriotic cells (ECs), associated pathogenesis development By leveraging nano-sized sensors, biomarkers specific can be detected high sensitivity specificity. A chemotherapeutic agent an LDL-like nano-emulsion targets rapidly dividing developed sensor demonstrated effective carbohydrate antigen 19-9 detection within normal physiological range. Researchers magnetic iron oxide nanoparticles composed oxide. As novel methods continue emerge forefront research, becomes imperative explore impact nanotechnology innovative solutions.
Language: Английский
Citations
1
Women, Journal Year: 2024, Volume and Issue: 4(4), P. 453 - 468
Published: Nov. 18, 2024
The world of science is increasingly looking for answers to the question how specific dietary components affect risk chronic diseases and assessing their potential alleviate severity individual diseases. This research concerns both assessment benefits using those nutritional models. Endometriosis, due its inflammatory nature, also a topic interest among scientists, who seek support course through proper nutrition. In endometriosis, great focused on patterns such as an anti-inflammatory diet, gluten-free low-FODMAP or Mediterranean diet. An diet primarily focuses fresh vegetables, fruits, seeds, nuts, whole grain products, healthy sources protein fats, including mono- polyunsaturated fatty acids, eliminating highly processed meat trans refined sugars. It believed that this type may contribute reducing endometriosis symptoms help reduce inflammation. aim review identify main trends in field diets supporting treatment last 5 years.
Language: Английский
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1
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(1), P. 149 - 149
Published: Dec. 30, 2024
Background/Objectives: Chronic inflammation plays a critical role in pelvic pain among endometriosis patients. This study examines the association between inflammatory markers—specifically neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR)—and endometriosis. Methods: We conducted retrospective analysis of patients, assessing NLR PLR levels those with without pain. Diagnostic utility was evaluated using ROC curves, logistic regression determined associations these markers, presence, severity. Results: Patients had significantly higher median both (p < 0.05). demonstrated moderate diagnostic accuracy an AUC 0.63, sensitivity 59%, specificity 71% at cut-off 1.85. PLR, 139.77, showed 0.60, 82% 40%, indicating better for excluding Logistic revealed that > 1.85 associated (OR = 3.06, 95% CI: 1.45–6.49, p 0.003), as 139.77 2.84, 1.18–6.82, 0.02). Advanced rASRM stages (III IV) also correlated elevated values. Conclusions: Elevated are advanced endometriosis, suggesting ratios potential markers disease Further studies should explore combining other biomarkers to improve
Language: Английский
Citations
1
Cuadernos de Educación y Desarrollo, Journal Year: 2024, Volume and Issue: 16(8), P. e5064 - e5064
Published: Aug. 6, 2024
A endometriose é uma condição ginecológica crônica caracterizada pela presença de tecido endometrial fora da cavidade uterina, afetando milhões mulheres em idade reprodutiva globalmente. Este estudo revisa a eficácia das terapias farmacológicas e intervenções cirúrgicas modernas no tratamento endometriose, analisando seu impacto na qualidade vida pacientes, bem como os custos acessibilidade desses tratamentos. metodologia envolveu Revisão Integrativa Literatura, utilizando operadores booleanos para buscar dados bases PubMed, LILACS Scopus. Os resultados indicam que as hormonais, agonistas do GnRH contraceptivos orais combinados, são eficazes redução dos sintomas, mas estão associadas efeitos colaterais significativos alta taxa recorrência. As cirúrgicas, especialmente laparoscopia, mostram benefícios remoção lesões endometrióticas melhora taxas fertilidade, embora recorrência pós-cirúrgica continue sendo um desafio. O desenvolvimento biológicas o uso fitoterápicos emergem promissoras alternativas terapêuticas, necessitando mais pesquisas validar sua segurança.
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Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1473 - 1473
Published: Nov. 13, 2024
Clitoria ternatea L. (CT) is a perennial herbaceous plant with deep blue flowers native to tropical Asia. This work explores the endometrial pain (EP) regulation of CT flower through multifaceted approach. Phytochemical screening unveiled presence alkaloids, steroids, flavonoids, glycosides, and tannins in methanolic extract (ME). In vitro membrane stabilizing experiment, ME demonstrated 91.47% suppression heat-induced hemolysis. Upon carrageenan-induced paw edema assay conducted on male Swiss albino mice at doses 200 mg/kg 400 mg/kg, 65.28% 81.89% inhibition rates, respectively, were reported. For same doses, upon acetic acid-induced-writhing assay, 75.6% 76.78% observed. network pharmacology analyses, protein–protein interaction was constructed for 92 overlapping gene targets EP, followed by GO KEGG pathway enrichment analyses. Network pharmacology-based investigation identified anti-EP activity be mostly regulated proteins SRC homology, ESR1, PI3KR1. Physicochemical, pharmacokinetic, toxicity property predictions compounds stable ligand–target interactions molecular dynamics simulation highest interacting complex further validated these findings. affirmed role against suggesting probable mechanism involved.
Language: Английский
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International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12242 - 12242
Published: Nov. 14, 2024
Endometriosis is an oestrogen-dependent inflammatory disease affecting menstruating women, with varying levels of severity. Oestrogen dysregulation responsible for chronic inflammation, angiogenesis, endometrial lesion development, progression, and infertility during menarche in afflicted women. The mediators associated this painful have been established, research also indicating the relationship between dysbiosis manifestation. present several comorbidities, including cancer, cardiovascular disease, autoimmunity. lack specific sensitive non-invasive diagnostic procedures, coupled poor response to current therapeutic approaches, means that treatment needs remain unmet. Surgical procedures are performed remove endometriosis ectopic lesions, which recurrence rate up 50%, certain patients exhibiting no alleviation symptoms. This review aims outline aetiology endometriosis, detailing novel approaches potential namely advanced medical products (ATMPs), stem cell therapy clustered regularly interspaced short palindromic repeats (CRISPR) gene editing. timely provides insights into important recent modalities may be applied diagnosis biomarkers, microfluidic platforms, organoid systems. Undoubtedly, reliable, reproducible, sensitive, models humans urgently needed investigate detail debilitating disease.
Language: Английский
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