Phytomedicine, Journal Year: 2023, Volume and Issue: 116, P. 154902 - 154902
Published: May 24, 2023
Language: Английский
Frontiers in Genetics, Journal Year: 2022, Volume and Issue: 13
Published: March 8, 2022
Melanoma is an aggressive malignant skin tumour with increasing global incidence. However, current treatments have limitations owing to the acquired drug resistance. Ferroptosis a recently discovered form of programmed cell death characterised by iron accumulation and lipid peroxidation plays critical role in growth inhibition. Recently, ferroptosis inducers been regarded as promising therapeutic strategy overcome apoptosis resistance cells. In this study, we reported that nobiletin, natural product isolated from citrus peel, exhibited antitumour activity inducing melanoma Subsequently, further explored potential mechanism nobiletin-induced ferroptosis, found expression level glycogen synthase kinase 3β (GSK3β) tissue patients was significantly reduced compared normal tissue. Additionally, nobiletin increased GSK3β Moreover, Kelch-like Ech-associated protein-1 (Keap1) increased, while nuclear factor erythroid 2-related 2 (Nrf2), haem oxygenase-1 (HO-1) decreased nobiletin-treated cells, suggesting antioxidant defence system downregulated. Furthermore, knockdown upregulated Keap1/Nrf2/HO-1 signalling pathway, opposite observed cells overexpressing GSK3β. addition, molecular docking assay results indicated showed strong binding affinities for GSK3β, Keap1, Nrf2, HO-1. Taken together, our demonstrated could induce regulating GSK3β-mediated pathway human Hence, stands candidate treatment development prospects.
Language: Английский
Citations
39
ACS Omega, Journal Year: 2023, Volume and Issue: 8(10), P. 8960 - 8976
Published: Feb. 28, 2023
Since the first report on pharmacological activity of curcumin in 1949, enormous amounts research have reported diverse activities for this natural polyphenol found dietary spice turmeric. However, has not yet been used human application as an approved drug. The clinical translation hampered due to its low solubility and bioavailability. improvement bioavailability can be achieved by formulation using drug delivery systems. Hydrogels with their biocompatibility toxicity effects shown a substantial impact successful hydrophobic drugs trials. This review focuses hydrogel-based systems describes applications anti-cancer well wound healing agents.
Language: Английский
Citations
28
Environmental Research, Journal Year: 2023, Volume and Issue: 233, P. 116432 - 116432
Published: June 16, 2023
Language: Английский
Citations
24
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 1, 2024
Lung cancer (LC) produces some of the most malignant tumors in world, with high morbidity and mortality. Tumor immune microenvironment (TIME), a component tumor (TME), are critical development, escape, drug resistance. The TIME is composed various cells, cytokines, etc, which important biological characteristics determinants progression outcomes. In this paper, we reviewed recently published literature discussed potential uses natural products regulating TIME. We observed that total 37 compounds have been reported to exert anti-cancer effects by targeting different classes products, terpenoids frequently mentioned compounds. TAMs one investigated cells about therapies TIME, 9 acting through it. 17 exhibit properties LC modulating PD-1 PD-L1 protein activity. These extensively evaluated animal cellular models, but their clinical trials patients lacking. Based on current review, revealed mechanisms can be treated intervention, resulting new perspective therapeutic drugs.
Language: Английский
Citations
8
Phytomedicine, Journal Year: 2020, Volume and Issue: 69, P. 153184 - 153184
Published: Feb. 10, 2020
Language: Английский
Citations
60
Biomedicines, Journal Year: 2020, Volume and Issue: 8(9), P. 347 - 347
Published: Sept. 12, 2020
Nanotechnology is the science of nanoscale, which scale nanometers or one billionth a meter. encompasses broad range technologies, materials, and manufacturing processes that are used to design and/or enhance many products, including medicinal products. This technology has achieved considerable progress in oncology field recent years. Most chemotherapeutic agents not specific cancer cells they intended treat, can harm healthy cells, leading numerous adverse effects. Due this non-specific targeting, it feasible administer high doses may cells. Moreover, low cause acquire resistance, thus making them hard kill. A solution could potentially drug targeting delivery lies understanding complexity nanotechnology. Engineering pharmaceutical natural products into nano-products diagnosis treatment cancer. Novel nano-formulations such as liposomes, polymeric micelles, dendrimers, quantum dots, nano-suspensions, gold nanoparticles have been shown drugs. Improved targets rather than thereby preventing undesirable side effects decreasing resistance. also revolutionized by using nanotechnology-based imaging contrast specifically target therefore tumor detection. In addition drugs, nanotechnology be deliver nutraceuticals like phytochemicals multiple properties, antioxidant activity, protect from oxidative damage reduce risk There advancements implications for use both nutraceutical prevention, diagnosis, treatment.
Language: Английский
Citations
50
Biomolecules, Journal Year: 2021, Volume and Issue: 11(9), P. 1275 - 1275
Published: Aug. 25, 2021
Cardiac glycosides are natural sterols and constitute a group of secondary metabolites isolated from plants animals. These cardiotonic agents well recognized accepted in the treatment various cardiac diseases as they can increase rate contractions by acting on cellular sodium potassium ATPase pump. However, growing number recent efforts were focused exploring antitumor antiviral potential these compounds. Several reports suggest their properties hence, today (CG) represent most diversified naturally derived compounds strongly recommended for cancers. Mutated or dysregulated transcription factors have also gained prominence therapeutic targets that be selectively targeted. Thus, we explored advances CGs mediated cancer scope considered signaling pathways, molecular aberration, (TFs), oncogenic genes to highlight management.
Language: Английский
Citations
49
Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(23), P. 6309 - 6329
Published: Jan. 28, 2022
As a leading cause of death, second only to heart disease, cancer has always been one the burning topics in medical research. When targeting multiple signal pathways tumorigenesis chemoprevention, using natural or synthetic anti-cancer drugs is vital strategy reduce damage. However, toxic effects, multidrug resistance (MDR) as well stem cells (CSCs) all prominently limited clinical application conventional anticancer drugs. With low side strong biological activity, unique mechanism, and wide range targets, products derived from plants are considered significant sources for new drug development. Nobiletin most attractive compounds, flavonoid primarily isolated peel citrus fruits. Numerous studies vitro vivo have suggested that nobiletin its derivatives possess eminent potential become effective chemoprevention agents through various cellular molecular levels. This article aims comprehensively review efficacy specific mechanisms nobiletin, enhancing our understanding properties providing latest research findings. At end this review, we also give some discussion future perspectives regarding challenges opportunities efficient exploitation.
Language: Английский
Citations
36
Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12
Published: March 10, 2022
Prostate cancer is a major health issue in western countries and the second leading cause of death American men. depends on androgen receptor (AR), transcriptional factor critical for prostate growth progression. Castration by surgery or medical treatment reduces levels, resulting prostatic atrophy regression. Thus, metastatic cancers are initially managed with deprivation therapy. Unfortunately, rapidly relapse after castration therapy progress to disease stage called castration-resistant (CRPC). Currently, clinical CRPCs focused suppressing AR activity antagonists like Enzalutamide reducing production Abiraterone. In practice, these treatments fail yield curative benefit CRPC patients part due gene mutations splicing variations, reactivation. It conceivable that eliminating protein cells promising solution provide potential outcome. Multiple strategies have emerged, several potent agents reduce levels were reported eliminate xenograft tumor preclinical models via distinct mechanisms, including proteasome-mediated degradation, heat-shock inhibition, suppression, blockage nuclear localization, N-terminal suppression. A few small chemical compounds undergoing trials combined existing antagonists. elimination enhanced mRNA degradation realistic avoiding reactivation during cancers.
Language: Английский
Citations
31
Clinical and Experimental Pharmacology and Physiology, Journal Year: 2022, Volume and Issue: 50(1), P. 3 - 18
Published: Sept. 16, 2022
The incidence of cancer has been growing worldwide. Better survival rates following the administration novel drugs and new combination therapies may concomitantly cause concern regarding long-term adverse effects therapy, for example, second primary malignancies. Moreover, overcoming tumour resistance to anticancer agents long considered as a critical challenge in research. Some low toxic adjuvants such herb-derived molecules be interest chemoprevention malignancies therapy. Apigenin is plant-derived molecule with attractive properties chemoprevention, instance, promising anti-tumour effects, which make it desirable adjuvant reduce genomic instability risks among normal tissues. improve efficiency modalities. This paper aims review various apigenin both tissues In addition, we explain how have ability protect usual cells against genotoxic repercussions radiotherapy chemotherapy. Furthermore, inhibitory on tumours will discussed.
Language: Английский
Citations
31