Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action

Phytomedicine, Journal Year: 2021, Volume and Issue: 90, P. 153626 - 153626

Published: July 9, 2021

Antibiotic-resistant bacteria pose a global health threat. Traditional antibiotics can lose their effectiveness, and the development of novel effective antimicrobials has become priority in recent years. In this area, plants represent an invaluable source antimicrobial compounds with vast therapeutic potential.To review full possible spectrum plant agents (plant compounds, extracts essential oils) discovered from 2016 to 2021 potential decrease bacterial resistance. Their activities against bacteria, special emphasis on multidrug resistant mechanisms action, combinations traditional antibiotics, roles current medicine future perspectives are discussed.Studies focusing activity origin mechanism action were identified summarized, including contributions January until 2021. Articles extracted Medline database using PubMed search engine relevant keywords operators.The yielded 11,689 articles 149 countries, which 101 included review. Reports 41 phytochemicals belonging 20 families included. oils 39 species 17 also Polyphenols terpenes most active studied, either alone or as part oils. Plasma membrane disruption was common action. Number position phenolic hydroxyl groups, double bonds, delocalized electrons conjugation sugars case flavonoids seemed be crucial for capacity. Combinations beta-lactam inhibition efflux pumps synergistic mechanism.In years, terpenes, flavones, flavonols some alkaloids phenylpropanoids, isolated extracts, have shown promising activity, being mechanism. However, utilization appropriate need boosted by means new omics technologies network pharmacology find among them combination antibiotics.

Language: Английский

---

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Advanced Science, Journal Year: 2022, Volume and Issue: 9(27)

Published: July 25, 2022

Due to the abuse of antibiotics and emergence multidrug resistant microorganisms, medical devices, related biomaterials are at high risk microbial infection during use, placing a heavy burden on patients healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, antibacterial by making use coordination between phenolic ligands metal ions. Further, MPNs received widespread attention antimicrobial infections due their facile synthesis process, biocompatibility, brought about polyphenols In this review, different categories based (nanoparticles, coatings, capsules, hydrogels) fabrication strategies summarized, research advances applications biomedical fields (e.g., skin repair, bone regeneration, etc.) highlighted.

Language: Английский

---

Marine Actinomycetes, New Sources of Biotechnological Products

Marine Drugs, Journal Year: 2021, Volume and Issue: 19(7), P. 365 - 365

Published: June 25, 2021

The Actinomycetales order is one of great genetic and functional diversity, including diversity in the production secondary metabolites which have uses medical, environmental rehabilitation, industrial applications. Secondary produced by actinomycete species are an abundant source antibiotics, antitumor agents, anthelmintics, antifungals. These actinomycete-derived medicines circulation as current treatments, but actinomycetes also being explored potential sources new compounds to combat multidrug resistance pathogenic bacteria. Actinomycetes a solve concerns another area recent investigation, particularly their utility bioremediation pesticides, toxic metals, radioactive wastes, biofouling. Other applications include biofuels, detergents, food preservatives/additives. Exploring other unique properties will allow for deeper understanding this interesting taxonomic group. Combined with engineering, microbial experimental evolution, enhancement techniques, it reasonable assume that use marine continue increase. Novel products begin be developed diverse applied research purposes, zymology enology. This paper outlines knowledge usage research, focusing on isolates providing direction future research.

Language: Английский

---

New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use

Molecules, Journal Year: 2022, Volume and Issue: 27(5), P. 1643 - 1643

Published: March 2, 2022

This review describes the recent Food and Drug Administration (FDA)-approved drugs (in year 2021) containing at least one halogen atom (covalently bound). The structures proposed throughout this work are grouped according to their therapeutical use. Their synthesis is presented as well. number of halogenated molecules that reaching market regularly preserved, 14 50 approved by FDA in last contain halogens. underlines emergent role halogens and, particular, fluorine chlorine preparation for treatment several diseases such viral infections, types cancer, cardiovascular disease, multiple sclerosis, migraine inflammatory vasculitis.

Language: Английский

---

An update on the potential mechanism of gallic acid as an antibacterial and anticancer agent

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(10), P. 5856 - 5872

Published: Aug. 31, 2023

Drug resistance to antibacterial and anticancer drugs is one of the most important global problems in treatment field that constantly expanding hinders recovery survival patients. Therefore, it necessary identify compounds have properties or increase effectiveness existing drugs. One these approaches using natural few side effects are effective. Gallic acid (GA) has been identified as plant polyphenols health-promoting various aspects such bacterial viral infections, cancer, inflammatory, neuropsychological, gastrointestinal, metabolic disease. Various studies shown GA inhibits growth by altering membrane structure, metabolism, biofilm formation. Also, cancer cell targeting different signaling pathways apoptosis, increasing reactive oxygen species (ROS) production, cycle, inhibiting oncogenes matrix metalloproteinases (MMPs) expression. Due powerful function against bacteria cells. In this review, we describe latest findings sources chemical GA, its pharmacological bioavailability, activities derivatives alone, combination with other form nanoformulation. This review can be a comprehensive perspective for scientists use medicinal containing future research expand clinical applications.

Language: Английский

---

A Mechanistic Overview on Green Assisted Formulation of Nanocomposites and Their Multifunctional Role in Biomedical Applications

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e41654 - e41654

Published: Jan. 8, 2025

The importance of nanocomposites constantly attains attention because their unique properties all across the fields especially in medical perspectives. study green-synthesized has grown to be extremely fascinating field research. Nanocomposites are more promising than mono-metallic nanoparticles they exhibit synergistic effects. This review encapsulates current development formulation plant-mediated by using several plant species and impact secondary metabolites on biocompatible functioning. Phyto-synthesis produces diverse nanomaterials with biocompatibility, environment-friendliness, vivo actions, characterized varying sizes, shapes, biochemical nature. process is advantageous conventional physical chemical procedures. New studies have been conducted determine biomedical efficacy against various diseases. Unfortunately, there inadequate investigation into green-assisted nanocomposites. Incorporating phytosynthesized therapeutic interventions not only enhances healing processes but also augments host's immune defenses infections. highlights phytosynthesis applications, including antibacterial, antidiabetic, antiviral, antioxidant, antifungal, anti-cancer, other as well toxicity. explores mechanistic action achieve designated tasks. Biogenic for multimodal imaging potential exchange methods materials Well-designed utilized innovative theranostic agents subsequent objective efficiently diagnosing treating a variety human disorders.

Language: Английский

---

A review on the biomedical efficacy of transition metal triazole compounds

Journal of Coordination Chemistry, Journal Year: 2022, Volume and Issue: 75(3-4), P. 293 - 334

Published: Feb. 16, 2022

From the apocalyptic era of antibiotic resistance, scientific community around world is engaged in designing and developing metal-based compounds to inhibit control continuously rising microbial infections. Metal based triazole-derived are being explored for antimicrobial actions potentially applicable provide effective nontoxic drug candidates having preferred improved pharmacological activity. Updating existing literature supporting such details, this review combines chemistry, synthetic aspects formation triazole Schiff bases, mechanism bioactivity metal complexes accompanied by assessment biological efficacy including antibacterial, antifungal, enzyme inhibition antioxidant This covers bioactive symmetrical assymmetrical mono bis-Schiff bases synthesized from condensation involving amine group 3-amino-1,2,4-triazole 3,5-diamino-1,2,4-triazole with carbonyl several aromatic aldehydes ketones along their transition which were characterized physical, spectral chemical properties. In most studies highlighting biomedical imine functionalized compounds, showed outstanding results comparison free ligands.

Language: Английский

---

Antimicrobial activities and mechanisms of extract and components of herbs in East Asia

RSC Advances, Journal Year: 2022, Volume and Issue: 12(45), P. 29197 - 29213

Published: Jan. 1, 2022

This article reviews antimicrobial activities and mechanisms of components from herbs in East Asia which may be developed as novel products.

Language: Английский

---

Antimicrobial efficacy of alternative root canal disinfection strategies: An evaluation on multiple working models

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117833 - 117833

Published: Jan. 18, 2025

Language: Английский

---

Valorization of Winemaking By-Products as a Novel Source of Antibacterial Properties: New Strategies to Fight Antibiotic Resistance

Molecules, Journal Year: 2021, Volume and Issue: 26(8), P. 2331 - 2331

Published: April 16, 2021

The emergence of antibiotic-resistance in bacteria has limited the ability to treat bacterial infections, besides increasing their morbidity and mortality at global scale. need for alternative solutions deal with this problem is urgent brought about a renewed interest natural products as sources potential antimicrobials. wine industry responsible production vast amounts waste by-products, associated environmental problems. These residues are rich bioactive secondary metabolites, especially phenolic compounds. Some phenolics bacteriostatic/bactericidal against several pathogenic may have synergistic action towards antibiotics, mitigating or reverting resistance these drugs. Complex mixtures, such those present winemaking (pomace, skins, stalks, leaves, seeds), even more effective antimicrobials could be used combined therapy, thereby contributing management antibiotic crisis. This review focuses on potentialities extracts, constituents chemotherapeutic antibacterial agents.

Language: Английский

---