Selenium in Bodily Homeostasis: Hypothalamus, Hormones, and Highways of Communication

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 15445 - 15445

Published: Dec. 6, 2022

The ability of the body to maintain homeostasis requires constant communication between brain and peripheral tissues. Different organs produce signals, often in form hormones, which are detected by hypothalamus. In response, hypothalamus alters its regulation bodily processes, is achieved through own pathways hormonal communication. generation transmission molecules involved these bi-directional axes can be affected redox balance. essential trace element selenium known influence numerous physiological including energy homeostasis, various functions. Selenium must obtained diet used synthesize selenoproteins, a family proteins with mainly antioxidant Alterations status have been correlated homeostatic disturbances humans studies animal models selenoprotein dysfunction indicate strong on relationship metabolism complicated, however, as has shown participate multiple levels This review discusses role that for maintaining homeostasis.

Language: Английский

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Stress regulatory hormones and cancer: the contribution of epinephrine and cancer therapeutic value of beta blockers

Endocrine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Language: Английский

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Arginine vasopressin and copeptin: comparative review and perspective in veterinary medicine

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: March 14, 2025

Although arginine vasopressin (AVP) deficiency, AVP resistance, and primary polydipsia are important causes of polyuria (PUPD), measurement has never been implemented as a routine diagnostic test for patient care in either human or veterinary medicine, due to significant challenges with the methodologic reliability laboratory assays measuring AVP. Responses modified water deprivation and/or desmopressin acetate trial have used indirect markers deficiency resistance. However, interpretations these tests can be especially challenging cases partial Over past decade, plasma copeptin (CoP), glycopeptide comprising C-terminal part preprohormone, mostly replaced humans. When combined CoP-based stimulation tests, such hypertonic saline CoP offers excellent accuracy diagnosis differentiation central diabetes insipidus (DI), nephrogenic DI, In dogs, recently measured saliva serum using canine enzyme-linked immunosorbent assays. This review will provide an update on physiologic regulation production secretion, limitations its well summary indications performance medicine date. is purpose encourage validation implementation medicine.

Language: Английский

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Evolution of the arginine-vasopressin system: from chordates to primates

Gazzetta Medica Italiana Archivio per le Scienze Mediche, Journal Year: 2025, Volume and Issue: 184(1-2)

Published: March 1, 2025

Language: Английский

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How Does the Camel Survive in the Desert Without Drinking?

Masterclass in neuroendocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 389 - 423

Published: Jan. 1, 2025

Language: Английский

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2-cyanopyridine derivatives enable N-terminal cysteine bioconjugation and peptide bond cleavage of glutathione under aqueous and mild conditions

RSC Advances, Journal Year: 2024, Volume and Issue: 14(10), P. 6542 - 6547

Published: Jan. 1, 2024

Inspired by the chemical reactivity of apalutamide, an efficient method for N-terminal cysteine bioconjugation with 2-cyanopyridine derivatives has been developed.

Language: Английский

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Role of Vasoactive Hormone-Induced Signal Transduction in Cardiac Hypertrophy and Heart Failure

Cells, Journal Year: 2024, Volume and Issue: 13(10), P. 856 - 856

Published: May 17, 2024

Heart failure is the common concluding pathway for a majority of cardiovascular diseases and associated with cardiac dysfunction. Since heart invariably preceded by adaptive or maladaptive hypertrophy, several biochemical mechanisms have been proposed to explain development hypertrophy progression failure. One these includes activation different neuroendocrine systems elevating circulating levels vasoactive hormones such as catecholamines, angiotensin II, vasopressin, serotonin endothelins. All are released in circulation stimulate signal transduction acting on their respective receptors cell membrane promote protein synthesis cardiomyocytes induce hypertrophy. The elevated hemodynamic overload, increase ventricular wall tension, occurrence remodeling. In addition, there occurs an proinflammatory cytokines collagen induction myocardial fibrosis transition prolonged exposure hypertrophied has reported result oxidation catecholamines via monoamine oxidase well NADPH II endothelins oxidative stress. stress produces subcellular defects, Ca2+-handling abnormalities, mitochondrial Ca2+-overload dysfunction activating proteases depressing gene expression, addition destabilizing extracellular matrix upon some metalloproteinases. These observations support view that various hormones, producing overload receptor-mediated mechanisms, Furthermore, due plays critical role

Language: Английский

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The Interaction of Vasopressin with Hormones of the Hypothalamo–Pituitary–Adrenal Axis: The Significance for Therapeutic Strategies in Cardiovascular and Metabolic Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7394 - 7394

Published: July 5, 2024

A large body of evidence indicates that vasopressin (AVP) and steroid hormones are frequently secreted together closely cooperate in the regulation blood pressure, metabolism, water-electrolyte balance, behavior, thereby securing survival comfort life. Vasopressin cooperates with hypothalamo-pituitary-adrenal axis (HPA) at several levels through release corticotropin-releasing hormone (CRH), adrenocorticotropic (ACTH), multiple hormones, as well interactions steroids target organs. These facilitated by positive negative feedback between specific components HPA. Altogether, AVP HPA a coordinated functional AVP-HPA system. It has been shown cooperation may be affected cellular stress combined hypoxia, metabolic, cardiovascular, respiratory disorders; neurogenic stress; inflammation. Growing central peripheral reprogrammed cardiovascular metabolic diseases these rearrangements exert either beneficial or harmful effects. The present review highlights mechanisms systemic analyses consequences inappropriate various system for pathogenesis diseases.

Language: Английский

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The hypothalamic paraventricular nucleus as a central hub for the estrogenic modulation of neuroendocrine function and behavior

Frontiers in Neuroendocrinology, Journal Year: 2022, Volume and Issue: 65, P. 100974 - 100974

Published: Jan. 5, 2022

Language: Английский

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Interaction of Vasopressin with Hormones of the Hypothalamo-Pituitary-Adrenal Axis: Significance for Therapeutic Strategies in Cardiovascular and Metabolic Diseases

Published: June 7, 2024

Abstract A multiple number of studies provide evidence that vasopressin (AVP) and steroid hormones are frequently secreted together closely cooperate in the regulation blood pressure, metabolism, water-electrolyte balance, behavior, securing thereby survival comfort life. Vasopressin interacts with hypothalamo-pituitary-adrenal axis (HPA) at several levels through release corticotropin-releasing hormone (CRH), adrenocorticotropic ACTH, hormones, as well interactions steroids target organs. The facilitated by positive negative feedbacks occurring between specific components HPA engagement other regulatory molecules. Altogether AVP a coordinated functional AVP-HPA system. It has been shown cooperation may be affected cellular stress combined hypoxia, metabolic, cardiovascular respiratory disorders, neurogenic inflammation. Growing indicates central peripheral reprogrammed diseases rearrangements play either beneficial or harmful effects. present review highlights mechanisms systemic analyses consequences inappropriate various system for energy balance metabolic diseases.

Language: Английский

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