Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(2), P. 411 - 426
Published: Feb. 21, 2024
Language: Английский
Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 651 - 651
Published: March 6, 2023
Aging is a complex biological process accompanied by progressive decline in the physical function of organism and an increased risk age-related chronic diseases such as cardiovascular diseases, cancer, neurodegenerative diseases. Studies have established that there exist nine hallmarks aging process, including (i) telomere shortening, (ii) genomic instability, (iii) epigenetic modifications, (iv) mitochondrial dysfunction, (v) loss proteostasis, (vi) dysregulated nutrient sensing, (vii) stem cell exhaustion, (viii) cellular senescence, (ix) altered communication. All these alterations been linked to sustained systemic inflammation, mechanisms contribute timing not clearly determined yet. Nevertheless, dysfunction one most important contributing process. Mitochondria primary endogenous source reactive oxygen species (ROS). During ATP production elevated ROS together with antioxidant defense. Elevated levels can cause oxidative stress severe damage cell, organelle membranes, DNA, lipids, proteins. This contributes phenotype. In this review, we summarize recent advances emphasis on production.
Language: Английский
Citations
204
ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(9), P. 4028 - 4054
Published: Aug. 31, 2022
Research on the role of reactive oxygen species (ROS) in aging process has advanced significantly over last two decades. In light recent findings, ROS takes part cells along with contributing to various physiological signaling pathways. Antioxidants being cells' natural defense mechanism against ROS-mediated alteration, play an imperative maintain intracellular homeostasis. Although complete understanding regulated is yet be fully comprehended, current insights into sources cellular and their correlation age-related diseases are portrayed this review. addition, results effect antioxidants homeostasis as well advances clinical trials also discussed detail. The future perspective ROS-antioxidant dynamics antiaging research marshaled provide directions for fields.
Language: Английский
Citations
92
Redox Biology, Journal Year: 2022, Volume and Issue: 59, P. 102595 - 102595
Published: Dec. 30, 2022
As a dietary intervention, methionine restriction (MR) has been reported to increase longevity and improve metabolism disorders. However, the effects of MR on alleviating neurodegenerative diseases such as Alzheimer's disease (AD) are largely unexplored. Here we sought investigate neuroprotective low intake in mild cognitive impairment (MCI) patients APP/PS1 AD model mice, uncover underlying mechanisms. In cohort composed 45 individuals diagnosed with MCI 61 healthy controls without impairment, was found be positively associated increased risk MCI, where no sex differences were observed. We further conducted 16-week intervention (0.17% methionine, w/w) mice. Although reduced Aβ accumulation brain both male female improved function only assessed by Morris water maze test. Consistently, restored synapse ultrastructure alleviated mitochondrial dysfunction enhancing biogenesis Importantly, effectively balanced redox status activated cystathionine-β-synthase (CBS)/H2S pathway Together, our study indicated that lower is function, which CBS/H2S plays an essential role. could promising nutritional for preventing development.
Language: Английский
Citations
38
Nature Aging, Journal Year: 2023, Volume and Issue: 3(5), P. 567 - 584
Published: May 4, 2023
Telomere shortening is a hallmark of aging and counteracted by telomerase. As in humans, the zebrafish gut one organs with fastest rate telomere decline, triggering early tissue dysfunction during normal prematurely aged telomerase mutants. However, whether telomere-dependent an individual organ, gut, causes systemic unknown. Here we show that tissue-specific expression can prevent rescues premature tert-/-. Induction senescence low cell proliferation, while restoring integrity, inflammation age-dependent microbiota dysbiosis. Averting beneficial impacts, rescuing distant such as reproductive hematopoietic systems. Conclusively, gut-specific extends lifespan tert-/- 40%, ameliorating natural aging. Our work demonstrates rescue leading to elongation sufficient systemically counteract zebrafish.
Language: Английский
Citations
24
Animal nutrition, Journal Year: 2022, Volume and Issue: 12, P. 116 - 127
Published: Oct. 1, 2022
Probiotics can improve animal growth performance and intestinal health. Bacillus species, Lactobacillus Bifidobacterium yeast etc. are the common types of probiotics. However, understanding effects probiotics on immune status gut microbiota weaning piglets how exert their impact still limited. This study aimed to investigate amyloliquefaciens 40 (BA40) performance, piglets. A total 12 litters newborn were randomly divided into 3 groups. Piglets in control group orally dosed with phosphate buffered saline; BA40 gavaged resuspension a product, respectively. The results showed that treatment significantly decreased (P < 0.05) diarrhea incidence (from d 5 40), diamine oxidase, D-lactate, interleukin (IL)-1β interferon-γ concentrations compared group. Meanwhile dramatically increased antioxidant capacity, IL-10 secretory immunoglobulin-A contrast For microbial composition, modulated by improving abundance Bacteroides, Phascolarctobacterium (producing short-chain fatty acids) Desulfovibrio reducing proliferation pathogens (Streptococcus, Tyzzerella, Vellionella paraeggerthella). Meanwhile, metabolic function prediction explained carbohydrate metabolism amino acid enriched correlation analysis, demonstrated BA40-enriched provide insights strategies for elevating health weaned Altogether, exerted stronger ability decreasing improved activity, barrier than other treatments. Our provided experimental theoretical basis application pig production.
Language: Английский
Citations
31
Cancer Discovery, Journal Year: 2022, Volume and Issue: 12(10), P. 2258 - 2279
Published: Aug. 23, 2022
Abstract In population studies, dietary patterns clearly influence the development, progression, and therapeutic response of cancers. Nonetheless, interventional trials have had relatively little impact on prevention treatment malignant disease. Standardization nutritional interventions combined with high-level mode-of-action studies holds promise identifying specific entities pathways endowed antineoplastic properties. Here, we critically review effects caloric restriction more macro- micronutrients in preclinical models as well clinical studies. We place special emphasis prospect using defined nutrition-relevant molecules to enhance efficacy established anticancer treatments. Significance: The avoidance intrinsically hypercaloric toxic diets contributes cure cancer. addition, diet-induced such ketone bodies micronutrients, including vitamins, drug-like that are demonstrable models, mostly context immunotherapies. Multiple underway determine utility molecules.
Language: Английский
Citations
29
Redox Biology, Journal Year: 2022, Volume and Issue: 57, P. 102464 - 102464
Published: Sept. 8, 2022
Methionine is an essential amino acid, involved in the promotion of growth, immunity, and regulation energy metabolism. Over decades, research has long focused on beneficial effects methionine supplementation, while data positive restriction (MR) were first published 1993. MR a low-methionine dietary intervention that been reported to ameliorate aging aging-related health concomitants diseases, such as obesity, type 2 diabetes, cognitive disorders. In addition, seems be approach prolong lifespan which validated extensively various animal models, Caenorhabditis elegans, Drosophila, yeast, murine models. appears associated with reduction oxidative stress via so far mainly undiscovered mechanisms, these changes redox status appear one underlying mechanisms for extension effects. present review, association metabolism pathways homeostasis described. lifespan, age-related implications, comorbidities, diseases are discussed.
Language: Английский
Citations
29
Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(28), P. 10419 - 10437
Published: June 16, 2023
The human gut microbiota plays numerous roles in regulating host growth, the immune system, and metabolism. Age-related changes environment lead to chronic inflammation, metabolic dysfunction, illness, which turn affect aging increase risk of neurodegenerative disorders. Local immunity is also affected by environment. Polyamines are crucial for cell development, proliferation, tissue regeneration. They regulate enzyme activity, bind stabilize DNA RNA, have antioxidative properties, necessary control translation. All living organisms contain natural polyamine spermidine, has anti-inflammatory antioxidant properties. It can protein expression, prolong life, improve mitochondrial activity respiration. Spermidine levels experience an age-related decrease, development diseases correlated with decreased endogenous spermidine concentrations. As more than just a consequence, this review explores connection between metabolism identifies advantageous bacteria anti-aging metabolites they produce. Further research being conducted on probiotics prebiotics that support uptake ingestion from food extracts or stimulate production polyamines microbiota. This provides successful strategy levels.
Language: Английский
Citations
18
Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1281 - 1281
Published: July 30, 2024
Cellular senescence has been increasingly recognized as a hallmark of cancer, reflecting its association with aging and inflammation, role response to deregulated proliferation oncogenic stress, induction by cancer therapies. While therapy-induced (TIS) linked resistance, recurrence, metastasis, normal tissue toxicity, TIS also the potential enhance therapy stimulate anti-tumor immunity. In this review, we examine Jekyll Hyde nature senescent cells (SnCs), focusing on how their persistence while expressing senescence-associated secretory phenotype (SASP) modulates tumor microenvironment through autocrine paracrine mechanisms. Through SASP, SnCs can mediate both resistance To fulfill unmet immunotherapy, consider may influence inflammation serve an antigen source potentiate immune response. This new perspective suggests treatment approaches based checkpoint blockade. Finally, describe strategies for mitigating detrimental effects senescence, such modulating SASP or targeting SnC persistence, which overall benefits treatment.
Language: Английский
Citations
7
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 4, 2024
The intricate interplay of one-carbon metabolism (OCM) with various cellular processes has garnered substantial attention due to its fundamental implications in several biological processes. OCM serves as a pivotal hub for methyl group donation vital biochemical reactions, influencing DNA methylation, protein synthesis, and redox balance. In the context aging, dysregulation can contribute epigenetic modifications aberrant states, accentuating senescence age-associated pathologies. Furthermore, OCM’s involvement cancer progression is evident through capacity provide essential units crucial nucleotide synthesis thereby fueling uncontrolled cell proliferation tumor development. neurodegenerative disorders like Alzheimer’s Parkinson’s, perturbations pathways are implicated neurotransmitter mitochondrial dysfunction, contributing disease pathophysiology. This review underscores profound impact diverse contexts, reinforcing need comprehensive understanding molecular complexities pave way targeted therapeutic interventions across inflammation, aging disorders.
Language: Английский
Citations
5