Role of oxidative stress in neurodegenerative disorders: a review of reactive oxygen species and prevention by antioxidants

Brain Communications, Journal Year: 2023, Volume and Issue: 6(1)

Published: Dec. 28, 2023

Abstract Neurological disorders include a variety of conditions, including Alzheimer’s disease, motor neuron disease and Parkinson’s affecting longevity quality life, their pathogenesis is associated with oxidative stress. Several the chronic neurodegenerative pathologies CNS share some common features, such as stress, inflammation, synapse dysfunctions, protein misfolding defective autophagia. Neuroinflammation can involve activation mast cells, contributing to in addition other sources reactive oxygen species. Antioxidants powerfully neutralize species free radicals, decreasing damage. Antioxidant genes, like manganese superoxide dismutase enzyme, undergo epigenetic changes that reduce expression, thus increasing stress tissue. Alternatively, DNA be altered by radical The landscape these genes change antioxidant function may result disease. This imbalance production increases cause cell damage neurons often observed an age-related event. Increased expression mice protective against exogenous supplementation antioxidants. Manganese requires for its enzymic function. therapy considered diseases, new mimetic dismutase, avasopasem manganese, described suggested putative treatment causes aim this narrative review explore evidence role inhibiting Can neuronal environment causing neuroinflammation neurodegeneration, reduced or reversed?

Language: Английский

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Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 15(1), P. 1 - 30

Published: Dec. 14, 2023

Aging is a dynamic, time-dependent process that characterized by gradual accumulation of cell damage. Continual functional decline in the intrinsic ability living organisms to accurately regulate homeostasis leads increased susceptibility and vulnerability diseases. Many efforts have been put forth understand prevent effects aging. Thus, major cellular molecular hallmarks aging identified, their relationships age-related diseases malfunctions explored. Here, we use data from CAS Content Collection analyze publication landscape recent aging-related research. We review advances knowledge delineate trends research advancements on factors attributes across time geography. also current concepts related molecular, cellular, organismic level, age-associated diseases, with attention brain health, as well biochemical processes associated Major outlined, correlations features are hope this will be helpful for apprehending field mechanisms progression, an effort further solve remaining challenges fulfill its potential.

Language: Английский

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Recent progress of nanomaterials for colorimetric and fluorescence sensing of reactive oxygen species in biological and environmental samples

Trends in Environmental Analytical Chemistry, Journal Year: 2023, Volume and Issue: 37, P. e00196 - e00196

Published: Jan. 6, 2023

Language: Английский

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Oxidative stress modulating nanomaterials and their biochemical roles in nanomedicine

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 9(10), P. 1630 - 1682

Published: Jan. 1, 2024

Many pathological conditions are predominantly associated with oxidative stress, arising from reactive oxygen species (ROS); therefore, the modulation of redox activities has been a key strategy to restore normal tissue functions. Current approaches involve establishing favorable cellular environment through administration therapeutic drugs and redox-active nanomaterials (RANs). In particular, RANs not only provide stable reliable means delivery but also possess capacity finely tune various interconnected components, including radicals, enzymes, proteins, transcription factors, metabolites. Here, we discuss roles that engineered play in spectrum conditions, such as cancer, neurodegenerative diseases, infections, inflammation. We visualize dual functions both generator scavenger ROS, emphasizing their profound impact on diverse The focus this review is solely inorganic (inorganic RANs). Additionally, deliberate challenges current RANs-based propose potential research directions for future clinical translation.

Language: Английский

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Influence of Physicochemical Properties of Iron Oxide Nanoparticles on Their Antibacterial Activity

ACS Omega, Journal Year: 2024, Volume and Issue: 9(31), P. 33303 - 33334

Published: July 25, 2024

The increasing occurrence of infectious diseases caused by antimicrobial resistance organisms urged the necessity to develop more potent, selective, and safe agents. unique magnetic tunable properties iron oxide nanoparticles (IONPs) make them a promising candidate for different theragnostic applications, including Though IONPs act as nonspecific agent, their activities are directly or indirectly linked with synthesis methods, synthesizing precursors, size, shapes, concentration, surface modifications. Alteration these parameters could accelerate decelerate production reactive oxygen species (ROS). An increase in ROS role disrupts bacterial cell walls, membranes, alters major biomolecules (e.g., lipids, proteins, nucleic acids), affects metabolic processes Krebs cycle, fatty acid synthesis, ATP glycolysis, mitophagy). In this review, we will investigate antibacterial activity bare surface-modified influence physiochemical on activity. Additionally, report potential mechanism IONPs' action driving

Language: Английский

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Immunomodulatory Effects of SGLT2 Inhibitors—Targeting Inflammation and Oxidative Stress in Aging

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(17), P. 6671 - 6671

Published: Aug. 29, 2023

Given that the increase in aging population has grown into one of largest public health issues, inflammation and oxidative stress, which are closely associated with process, became a focus recent research. Sodium-glucose co-transporter 2 (SGLT2) inhibitors, group drugs initially developed as oral antidiabetics, have shown many beneficial effects over time, including improvement renal function cardioprotective effects. It been SGLT2 drug class, an immunomodulatory antioxidative effect, affecting endothelial well metabolic parameters. Therefore, it is not surprising various studies investigated potential mechanisms action inhibitors age-related diseases. The proposed by can achieve their anti-inflammatory include influence on AMPK/SIRT1/PGC-1α signaling, cytokines, NLRP3 inflammasome. effect related to mitochondria signaling pathways transforming growth factor β nuclear erythroid 2-related 2/antioxidant response element. Also, parameters, such uric acid reduction, stimulation ketogenesis, reduction body weight, lipolysis, epicardial fat tissue. Finally, display anti-atherosclerotic modulate inflammatory reactions, potentially resulting function. This narrative review offers complete comprehensive overview possible pathophysiologic involved process development disease. However, order use inhibitor anti-aging therapy, further basic clinical research needed elucidate complex they processes.

Language: Английский

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Recent Advances in Cellular Signaling Interplay between Redox Metabolism and Autophagy Modulation in Cancer: An Overview of Molecular Mechanisms and Therapeutic Interventions

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 428 - 428

Published: Feb. 9, 2023

Autophagy is a fundamental homeostatic process in which certain cellular components are ingested by double-membrane autophagosomes and then degraded to create energy or maintain homeostasis survival. It typically observed nutrient-deprived cells as survival mechanism. However, it has also been identified crucial maintaining disease progression. Normal metabolism produces reactive oxygen (ROS) nitrogen species at low levels. increased production causes oxidative stress, can lead diabetes, cardiovascular diseases, neurological disorders, cancer. was recently shown that redox equilibrium via autophagy critical for responses stress. little understood about the molecular cancer processes connect control of autophagy. In cells, oncogenic mutations, carcinogens, metabolic reprogramming cause ROS generation Recent studies have suggested activates pathways promote development metastasis. Moreover, relationship between programming involved malignant phenotype. Currently, while signaling events governing how affects cascades well understood, very known related this review, we focus on current knowledge modulation role further stress progression regulation. Therefore, review focuses understanding oxidation/reduction fine-tune help understand govern cancer, either leading cell death strategies

Language: Английский

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Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(3), P. 408 - 446

Published: Jan. 12, 2024

Aging is typified by a gradual loss of physiological fitness and accumulation cellular damage, leading to deteriorated functions enhanced vulnerability diseases. Antiaging research has long history throughout civilization, with many efforts put forth understand prevent the effects aging. Multiple strategies aiming promote healthy aging extend lifespan have been developed including lifestyle adjustments, medical treatments, social programs. A multitude antiaging medicines remedies also explored. Here, we use data from CAS Content Collection analyze publication landscape recent related treatments. We review advances delineate trends in headway knowledge practice across time, geography, development pipelines. further assess state-of-the-art approaches explore their correlations age-related The drugs outlined Well-recognized novel, currently evaluated agents summarized. Finally, clinical applications products objective this summarize current on preventive treatment field aging, outline challenges evaluate growth opportunities, order solve problems that remain.

Language: Английский

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Spaceflight-induced contractile and mitochondrial dysfunction in an automated heart-on-a-chip platform

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(40)

Published: Sept. 23, 2024

With current plans for manned missions to Mars and beyond, the need better understand, prevent, counteract harmful effects of long-duration spaceflight on body is becoming increasingly important. In this study, an automated heart-on-a-chip platform was flown International Space Station a 1-mo mission during which contractile cardiac function monitored in real-time. Upon return Earth, engineered human heart tissues (EHTs) were further analyzed with ultrastructural imaging RNA sequencing investigate impact prolonged microgravity cardiomyocyte health. Spaceflight EHTs exhibited significantly reduced twitch forces, increased incidences arrhythmias, signs sarcomere disruption mitochondrial damage. Transcriptomic analyses showed up-regulation genes pathways associated metabolic disorders, failure, oxidative stress, inflammation, while related contractility calcium signaling significant down-regulation. Finally, silico modeling revealed potential link between stress dysfunction that corresponded results. This represents vitro model faithfully reproduce adverse three-dimensional (3D)-engineered tissue.

Language: Английский

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Study on the Mechanism of Lipid Peroxidation Induced by Carbonate Radicals

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1125 - 1125

Published: March 2, 2024

Based on the reported research, hydroxyl radicals can be rapidly transformed into carbonate in carbonate–bicarbonate buffering system vivo. Many of processes considered to initiated by may caused radicals, which indicates that lipid peroxidation also radicals. To date, theoretical research reactions hydrogen abstraction from and radical addition polyunsaturated fatty acids (PUFAs) has not been carried out systematically. This paper employs (3Z,6Z)-nona-3,6-diene (NDE) as a model for (PUFAs). Density functional theory (DFT) with CAM-B3LYP method at 6-311+g(d,p) level was used calculate differences reactivity abstracting different positions NDE their double bonds under solvent conditions dielectric constant 4.0 (CPCM model). Grimme’s empirical dispersion correction taken account through D3 scheme. The energy barrier, reaction rate constants, internal energy, enthalpy Gibbs free changes these were calculated With zero-point vibrational (ZPVE) corrections. results indicated initiate primarily diallyl carbon atoms. atoms exhibits highest rate, approximately 43-fold greater than second-ranked allyl process lowest enthalpy, changes, indicating it is most spontaneous process.

Language: Английский

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