A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(15), P. 8293 - 8293

Published: July 27, 2022

Microfluidics is defined as emerging science and technology based on precisely manipulating fluids through miniaturized devices with micro-scale channels chambers. Such microfluidic systems can be used for numerous applications, including reactions, separations, or detection of various compounds. Therefore, due to their potential microreactors, a particular research focus was noted in exploring microchannel configurations on-chip chemical syntheses materials tailored properties. Given the significant number studies field, this paper aims review recently developed geometry particularities, starting from brief presentation nanoparticle synthesis mixing within microchannels, further moving more detailed discussion different chip use nanomaterial fabrication.

Language: Английский

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Recent Advances of Organ-on-a-Chip in Cancer Modeling Research

Biosensors, Journal Year: 2022, Volume and Issue: 12(11), P. 1045 - 1045

Published: Nov. 18, 2022

Although many studies have focused on oncology and therapeutics in cancer, cancer remains one of the leading causes death worldwide. Due to unclear molecular mechanism complex vivo microenvironment tumors, it is challenging reveal nature develop effective therapeutics. Therefore, development new methods explore role heterogeneous TME individual patients’ drug response urgently needed critical for therapeutic management cancer. The organ-on-chip (OoC) platform, which integrates technology 3D cell culture, tissue engineering, microfluidics, emerging as a method simulate structures tumor functional characteristics. It overcomes failure traditional 2D/3D culture models preclinical animal completely replicate human tumors. As brand-new technology, OoC great significance realization personalized treatment drugs. This review discusses recent advances biology studies. focuses design principles devices associated applications modeling. challenges future this field are also summarized review. displays broad technique has reference value development.

Language: Английский

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Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: April 25, 2023

The inefficiency of existing animal models to precisely predict human pharmacological effects is the root reason for drug development failure. Microphysiological system/organ-on-a-chip technology (organ-on-a-chip platform) a microfluidic device cultured with living cells under specific organ shear stress which can faithfully replicate organ-body level pathophysiology. This emerging organ-on-chip platform be remarkable alternative broad range purposes in testing and precision medicine. Here, we review parameters employed using on chip as plot mimic diseases, genetic disorders, toxicity different organs, biomarker identification, discoveries. Additionally, address current challenges that should overcome accepted by regulatory agencies pharmaceutical industries. Moreover, highlight future direction enhancing accelerating discoveries personalized

Language: Английский

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Review on Bortezomib Resistance in Multiple Myeloma and Potential Role of Emerging Technologies

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(1), P. 111 - 111

Published: Jan. 12, 2023

Multiple myeloma is a hematological cancer type. For its treatment, Bortezomib has been widely used. However, drug resistance to this effective chemotherapeutic developed for various reasons. 2D cell cultures and animal models have failed understand the MM disease resistance. It therefore essential utilize new technologies reveal complete molecular profile of disease. In review, we in-depth examined possible mechanisms that cause specifically addressed Moreover, also included use nanoparticles, 3D culture methods, microfluidics, organ-on-chip devices in multiple myeloma. We discussed whether emerging technology offers necessary tools prevent Despite ongoing research activities on MM, related studies cannot provide summary MM. Nanoparticle culturing frequently used number microfluidic application insufficient. By combining siRNA/miRNA with devices, genetic could be revealed. Microfluidic chips should clinically personal therapy point-of-care applications. At least microneedles, it ensured patients can go through treatment process more painlessly. This way, switched curable type list, targeted fewer side effects.

Language: Английский

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Current Status and Emerging Trends in Colorectal Cancer Screening and Diagnostics

Biosensors, Journal Year: 2023, Volume and Issue: 13(10), P. 926 - 926

Published: Oct. 13, 2023

Colorectal cancer (CRC) is a prevalent and potentially fatal disease categorized based on its high incidences mortality rates, which raised the need for effective diagnostic strategies early detection management of CRC. While there are several conventional diagnostics available, they have certain limitations that hinder their effectiveness. Significant research efforts currently being dedicated to elucidating novel methodologies aim at comprehending intricate molecular mechanism underlies Recently, microfluidic emerged as pivotal solution, offering non-invasive approaches real-time monitoring progression treatment response. Microfluidic devices enable integration multiple sample preparation steps into single platform, speeds up processing improves sensitivity. Such advancements in technologies hold immense promise revolutionizing field CRC diagnosis enabling efficient strategies. This article elucidates latest developments technology diagnostics. In addition diagnostics, artificial intelligence (AI) holds great further enhancing capabilities. Advancements systems AI-driven can revolutionize colorectal accurate, efficient, personalized improve patient outcomes transform management.

Language: Английский

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Tailoring drug delivery systems by microfluidics for tumor therapy

Materials Today, Journal Year: 2024, Volume and Issue: 73, P. 151 - 178

Published: Jan. 30, 2024

Language: Английский

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Tumor-associated macrophage-derived exosomal miR21-5p promotes tumor angiogenesis by regulating YAP1/HIF-1α axis in head and neck squamous cell carcinoma

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: April 11, 2024

Abstract Extracellular vesicles (EVs) have recently received increasing attention as essential mediators of communication between tumor cells and their microenvironments. Tumor-associated macrophages (TAMs) play a proangiogenic role in various tumors, especially head neck squamous cell carcinoma (HNSCC), angiogenesis is closely related to growth metastasis. This research focused on exploring the mechanisms by which EVs derived from TAMs modulate HNSCC. Our results indicated that infiltration correlated positively with microvascular density Then we collected identified TAMs. In microfluidic chip, significantly enhanced angiogenic potential pHUVECs successfully induced formation perfusable blood vessels. qPCR immunofluorescence analyses revealed transferred miR-21-5p endothelial (ECs). And targeting could effectively inhibit TAM-EVs angiogenesis. Western blot tube assays showed downregulated LATS1 VHL levels but upregulated YAP1 HIF-1α levels, inhibitors both reduce HUVECs. The vivo experiments further proved carried promoted process via YAP1/HIF-1α axis Conclusively, TAM-derived ECs target mRNA , inhibited phosphorylation subsequently YAP1-mediated transcription reduced VHL-mediated ubiquitination, contributing These findings present novel regulatory mechanism angiogenesis, miR-21-5p/YAP1/HIF-1α might be therapeutic for

Language: Английский

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Advancement of organ-on-chip towards next generation medical technology

Biosensors and Bioelectronics X, Journal Year: 2024, Volume and Issue: 18, P. 100480 - 100480

Published: April 25, 2024

Organ-on-a-Chip, or OOC, is a widely discussed topic in science due to its many unique advantages the biomedical field. Nevertheless, there still much learn about OOC's various aspects of conception and significance for advancement medical technology future. A platform organs-on-a-chip must go through fabrication process. Various manufacturing processes were also used depending on required disease modelling drug screening. Organs chip included Brain-On-Chip, Kidney-On-Chip, Liver-On-Chip, Heart-On-Chip. In order provide new beginnings with thorough understanding we have studied most recent developments organ-on-a-chip expertise critically assessed relevant features this research.

Language: Английский

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Multi-Template Molecularly Imprinted Polymeric Electrochemical Biosensors

Chemosensors, Journal Year: 2025, Volume and Issue: 13(1), P. 11 - 11

Published: Jan. 8, 2025

Dual- or multi-template molecularly imprinted polymers have been an attractive research field for many years as they allow simultaneous detection of more than one target with high selectivity and sensitivity by creating template-specific recognition sites multiple targets on the same functional monomer. Dual/multi-template molecular imprinting techniques applied to identify, extract, detect targets, from heavy metal ions viruses, different methods, such high-performance liquid chromatography (HPLC), chromatography–mass spectrometry (LC-MS), piezoelectric, optical, electrochemical methods. This article focuses sensors based dual/multi-template detecting a wide range Furthermore, this work highlights use these point-of-care applications, their commercialization integration microfluidic systems.

Language: Английский

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Advancing microfluidic design with machine learning: a Bayesian optimization approach

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The proposed Bayesian optimization-based approach enhances micromixer performance by optimizing geometric parameters, significantly reducing required number of simulations, and accelerating the design process compared to conventional methods.

Language: Английский

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