Polymer Composites,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
Abstract
Many
papers
have
investigated
the
conductivity
of
nanocomposites
containing
a
perfect
interphase.
Herein,
an
imperfect
interphase
is
considered,
and
conduction
transference
from
graphene
to
medium
in
polymer
system
denoted
as
Y
expressed
by
efficient
dimensions
nanosheets.
Also,
real
inverse
aspect
ratio,
filler
portion,
percolation
threshold,
proportion
percolated
nets
are
suggested
.
Besides,
appropriate
model
for
nanocomposite
established,
assuming
mentioned
issues
contact
region
among
neighboring
The
novel
examined
various
tested
data.
In
addition,
characters
main
terms
explained.
calculations
developed
display
good
arrangement
with
data,
while
original
underestimates
conductivity.
Strong
large
interfacial/interphase
regions,
big
slim
nanosheets,
dense
harvest
high
nanocomposites.
Additionally,
great
extent
small
ratio
increase
efficiency
which
results
highest
obtained
thinnest
nanosheets
thickest
interphase,
enhancing
Highlights
Conduction
thicknesses
graphene.
A
simple
proposed
nanocomposite's
transference.
agreements
data
samples.
strong
interface/interphase
produces
transfer.
amount
transferring
increases
Small Science,
Journal Year:
2024,
Volume and Issue:
4(3)
Published: Jan. 22, 2024
Despite
significant
advancements
in
medical
technology,
cancer
remains
the
world's
second‐leading
cause
of
death,
largely
attributed
to
late‐stage
diagnoses.
While
traditional
detection
methodologies
offer
foundational
insights,
they
often
lack
specificity,
affordability,
and
sensitivity
for
early‐stage
identification.
In
this
context,
development
biosensors
offers
a
distinct
possibility
precise
rapid
identification
biomarkers.
Carbon
nanomaterials,
including
graphene,
carbon
nitride,
quantum
dots,
other
carbon‐based
nanostructures,
are
highly
promising
detection.
Their
simplicity,
high
sensitivity,
cost‐effectiveness
contribute
their
potential
field.
This
review
aims
elucidate
emerging
carbon‐nanomaterial‐based
early
diagnosis.
The
relevance
various
biosensor
mechanisms
performance
physicochemical
properties
nanomaterials
is
discussed
depth,
focusing
on
demonstrating
broad
creating
biosensors.
Diverse
techniques,
such
as
electrochemical,
fluorescence,
surface
plasmon
resonance,
electrochemiluminescence,
quartz
crystal
microbalance,
emphasized
At
last,
summary
existing
challenges
future
outlook
field
elaborated.
Cancer Biology & Therapy,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: March 13, 2025
Early
and
precise
diagnosis
of
cancer
is
pivotal
for
effective
therapeutic
intervention.
Traditional
diagnostic
methods,
despite
their
reliability,
often
face
limitations
such
as
invasiveness,
high
costs,
labor-intensive
procedures,
extended
processing
times,
reduced
sensitivity
early-stage
detection.
Electrochemical
biosensing
a
revolutionary
method
that
provides
rapid,
cost-effective,
highly
sensitive
detection
biomarkers.
This
review
discusses
the
use
electrochemical
in
biosensors
to
provide
real-time
insights
into
disease-specific
molecular
interactions,
focusing
on
target
recognition
signal
generation
mechanisms.
Furthermore,
superior
efficacy
compared
conventional
techniques
explored,
particularly
ability
detect
biomarkers
with
enhanced
specificity
sensitivity.
Advancements
electrode
materials
nanostructured
designs,
integrating
nanotechnology,
microfluidics,
artificial
intelligence,
have
potential
overcome
biological
interferences
scale
clinical
use.
Research
innovation
oncology
diagnostics
hold
personalized
medicine,
challenges
commercial
viability
real-world
application.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(18), P. 6719 - 6719
Published: Sept. 20, 2023
Graphene
is
an
emerging
nanomaterial
increasingly
being
used
in
electrochemical
biosensing
applications
owing
to
its
high
surface
area,
excellent
conductivity,
ease
of
functionalization,
and
superior
electrocatalytic
properties
compared
other
carbon-based
electrodes
nanomaterials,
enabling
faster
electron
transfer
kinetics
higher
sensitivity.
biosensors
may
have
the
potential
enable
rapid,
sensitive,
low-cost
detection
cancer
biomarkers.
This
paper
reviews
early-stage
research
proof-of-concept
studies
on
development
graphene
for
future
diagnostic
applications.
Various
synthesis
methods
are
outlined
along
with
common
functionalization
approaches
using
polymers,
biomolecules,
synthetic
chemistry
facilitate
immobilization
recognition
elements
improve
performance.
Major
sensor
configurations
including
field-effect
transistors,
modified
nanocomposites,
3D
networks
highlighted
their
principles
operation,
advantages,
capabilities.
Strategies
biorecognition
like
antibodies,
aptamers,
peptides,
DNA/RNA
probes
onto
platforms
impart
target
specificity
summarized.
The
use
labels,
hybrid
nanocomposites
graphene,
chemical
modification
signal
enhancement
also
discussed.
Examples
provided
illustrate
sensitive
a
broad
range
biomarkers
proteins,
circulating
tumor
cells,
DNA
mutations,
non-coding
RNAs
miRNA,
metabolites,
glycoproteins.
Current
challenges
opportunities
elucidated
guide
ongoing
efforts
towards
transitioning
from
promising
lab
tools
into
mainstream
clinical
practice.
Continued
addressing
issues
reproducibility,
stability,
selectivity,
integration,
validation,
regulatory
approval
could
wider
adoption.
Overall,
present
powerful
versatile
diagnosis
at
point
care.
Biosensors,
Journal Year:
2023,
Volume and Issue:
13(8), P. 823 - 823
Published: Aug. 15, 2023
Hydrogel-based
wearable
electrochemical
biosensors
(HWEBs)
are
emerging
biomedical
devices
that
have
recently
received
immense
interest.
The
exceptional
properties
of
HWEBs
include
excellent
biocompatibility
with
hydrophilic
nature,
high
porosity,
tailorable
permeability,
the
capability
reliable
and
accurate
detection
disease
biomarkers,
suitable
device–human
interface,
facile
adjustability,
stimuli
responsive
to
nanofiller
materials.
Although
biomimetic
three-dimensional
hydrogels
can
immobilize
bioreceptors,
such
as
enzymes
aptamers,
without
any
loss
in
their
activities.
However,
most
suffer
from
low
mechanical
strength
electrical
conductivity.
Many
studies
been
performed
on
electroactive
nanofillers,
including
biomacromolecules,
carbon-based
materials,
inorganic
organic
nanomaterials,
tackle
these
issues.
Non-conductive
even
conductive
may
be
modified
by
well
redox
species.
All
modifications
led
design
development
efficient
nanocomposites
biosensors.
In
this
review,
both
conductive-based
non-conductive-based
derived
natural
synthetic
polymers
systematically
reviewed.
main
synthesis
methods
characterization
techniques
addressed.
behavior
discussed
detail.
Finally,
prospects
potential
applications
biosensing,
healthcare
monitoring,
clinical
diagnostics
highlighted.
