A new perspective for evaluating the efficacy of tACS and tDCS in improving executive functions: A combined tES and fNIRS study DOI Creative Commons
Hongliang Lü, Yajuan Zhang,

Huake Qiu

et al.

Human Brain Mapping, Journal Year: 2023, Volume and Issue: 45(1)

Published: Dec. 11, 2023

Abstract Background Executive function enhancement is considered necessary for improving the quality of life patients with neurological or psychiatric disorders, such as attention‐deficit/hyperactivity disorder, obsessive‐compulsive disorder and Alzheimer's disease. Transcranial electrical stimulation (tES) has been shown to have some beneficial effects on executive functioning, but quantification these improvements remains controversial. We aimed explore potential functioning induced by use transcranial alternating current (tACS)/transcranial direct (tDCS) right inferior frontal gyrus (IFG) accompanying brain variations in resting state. Methods recruited 229 healthy adults participate Experiments 1 (105 participants) 2 (124 participants). The participants each experiment were randomly divided into tACS, tDCS, sham groups. completed cognitive tasks assess behavior related three core components functions. Functional near‐infrared spectroscopy (fNIRS) was used monitor hemodynamic changes crucial cortical regions Results Inhibition flexibility (excluding working memory) significantly increased after tACS/tDCS, there no significant behavioral differences between tACS tDCS fNIRS revealed that decreases functional connectivity (increased neural efficiency) relevant cortices. Conclusions Enhancement observed tES, tACS/tDCS may need be precisely evaluated via imaging indicators at rest. better benefits than during phase. These findings might provide new insights selecting intervention methods future studies evaluating clinical efficacy tES.

Language: Английский

Exposure to gamma tACS in Alzheimer’s disease: A randomized, double-blind, sham-controlled, crossover, pilot study DOI Creative Commons
Alberto Benussi, Valentina Cantoni, Maria Sofia Cotelli

et al.

Brain stimulation, Journal Year: 2021, Volume and Issue: 14(3), P. 531 - 540

Published: March 21, 2021

To assess whether exposure to non-invasive brain stimulation with transcranial alternating current at γ frequency (γ-tACS) applied over Pz (an area overlying the medial parietal cortex and precuneus) can improve memory modulate cholinergic transmission in mild cognitive impairment due Alzheimer's disease (MCI-AD).In this randomized, double-blind, sham controlled, crossover pilot study, participants were assigned a single 60 min treatment γ-tACS or tACS. Each subject underwent clinical evaluation including assessment of episodic pre- post-γ-tACS stimulation. Indirect measures evaluated using magnetic (TMS) tACS evaluated.Twenty MCI-AD completed study. No tACS-related side effects observed, intervention was well tolerated all participants. We observed significant improvement Rey auditory verbal learning (RAVL) test total recall (5.7 [95% CI, 4.0 7.4], p < 0.001) long delayed scores (1.3 0.4 2.1], = 0.007) after but not Face-name associations improved during (4.3 2.8 5.8], Short latency afferent inhibition, an indirect measure TMS, increased only (0.31 0.24 0.38], tACS.exposure showed performances, along restoration intracortical connectivity neurotransmission, compared

Language: Английский

Citations

108
A neurocognitive account of attentional control theory: how does trait anxiety affect the brain’s attentional networks? DOI Creative Commons
Michael W. Eysenck, Jason S. Moser,

Nazanin Derakshan

et al.

Cognition & Emotion, Journal Year: 2022, Volume and Issue: 37(2), P. 220 - 237

Published: Dec. 30, 2022

Attentional control theory (ACT) was proposed to account for trait anxiety's effects on cognitive performance. According ACT, impaired processing efficiency in high anxiety is mediated through inefficient executive processes that are needed effective attentional control. Here we review the central assumptions and predictions of ACT within context more recent empirical evidence from neuroimaging studies. We then attempt provide an a framework relevant their associated neural mechanisms networks, particularly fronto-parietal, cingular-opercula, default mode networks. Future research directions, including whether neuroscience-informed model can platform novel neurocognitive intervention anxiety, also discussed.

Language: Английский

Citations

61
Neurobiological After-Effects of Low Intensity Transcranial Electric Stimulation of the Human Nervous System: From Basic Mechanisms to Metaplasticity DOI Creative Commons
Sohaib Ali Korai, Federico Ranieri, Vincenzo Di Lazzaro

et al.

Frontiers in Neurology, Journal Year: 2021, Volume and Issue: 12

Published: Feb. 15, 2021

Non-invasive low-intensity transcranial electrical stimulation (tES) of the brain is an evolving field that has brought remarkable attention in past few decades for its ability to directly modulate specific functions. Neurobiological after-effects tES seems be related changes neuronal and synaptic excitability plasticity, however mechanisms are still far from being elucidated. We aim review recent results vitro vivo studies highlight molecular cellular direct (tDCS) alternating (tACS) current stimulation. Changes membrane potential neural synchronization explain ongoing short-lasting effects tES, while induced existing proteins new protein synthesis required long-lasting plastic (LTP/LTD). Glial cells, supporting elements, now considered constitutive part synapse might contribute plasticity. This brings into focus neurobiological tDCS tACS studies, both animals humans, highlighting possible pathways development targeted therapeutic applications.

Language: Английский

Citations

57
Noninvasive Brain Stimulation: Multiple Effects on Cognition DOI Creative Commons
Gesa Hartwigsen, Juha Silvanto

The Neuroscientist, Journal Year: 2022, Volume and Issue: 29(5), P. 639 - 653

Published: July 29, 2022

Noninvasive brain stimulation (NIBS) techniques are widely used tools for the study and rehabilitation of cognitive functions. Different NIBS approaches aim to enhance or impair different processes. The methodological focus achieving this has been on protocols that considered either inhibitory facilitatory. However, despite more than three decades use, their application is based incomplete overly simplistic conceptualizations mechanisms action. Such misconception limits usefulness these in basic science clinical domains. In review, we challenge view by arguing themselves neither nor Instead, suggest all induced effects reflect complex interactions internal external factors. Given considerations, present a novel model which conceptualize as an interaction between activity characteristics stimulus. This interactive can explain various phenomena literature have unexpected paradoxical. We argue no longer seem paradoxical when from viewpoint state dependency.

Language: Английский

Citations

41
Multiple functions of the angular gyrus at high temporal resolution DOI
Mohamed L. Seghier

Brain Structure and Function, Journal Year: 2022, Volume and Issue: 228(1), P. 7 - 46

Published: June 8, 2022

Language: Английский

Citations

39
A meta-analysis showing improved cognitive performance in healthy young adults with transcranial alternating current stimulation DOI Creative Commons
Tae Lee Lee,

Hanall Lee,

Nyeonju Kang

et al.

npj Science of Learning, Journal Year: 2023, Volume and Issue: 8(1)

Published: Jan. 3, 2023

Abstract Transcranial alternating current stimulation (tACS) is a non-invasive brain used for improving cognitive functions via delivering weak electrical with certain frequency. This systematic review and meta-analysis investigated the effects of tACS protocols on in healthy young adults. We identified 56 qualified studies that compared between sham control groups, as indicated by performances cognition-related reaction time. Moderator variable analyses specified effect size according to (a) timing tACS, (b) frequency band simulation, (c) targeted region, domain, respectively. Random-effects model revealed small positive performances. The moderator found significant online-tACS theta band, gamma offline-tACS band. Moreover, were improved online- either prefrontal posterior parietal cortical regions, further both enhanced executive function. Online-tACS cortex was effective performances, improvements appeared function perceptual-motor These findings suggested specific may effectively improve

Language: Английский

Citations

29
Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part II: Biophysics, Dosimetry, and Safety Recommendations DOI Creative Commons
Antonino M. Cassarà, Taylor Newton, Katie Zhuang

et al.

Bioelectromagnetics, Journal Year: 2025, Volume and Issue: 46(1)

Published: Jan. 1, 2025

ABSTRACT Temporal interference stimulation (TIS) is a new form of transcranial electrical (tES) that has been proposed as method for targeted, noninvasive deep brain structures. While TIS holds promise variety clinical and nonclinical applications, little data yet available regarding its effects in humans mechanisms action. To inform the design safe conduct experiments involving TIS, researchers require quantitative guidance exposure limits other safety considerations. this end, we undertook two‐part effort to determine frequency‐dependent thresholds applied currents below which unlikely pose risk terms heating or unwanted stimulation. In Part II effort, described here, draw on previously compiled list (see I) adverse (AEs) reported direct/alternating current (tDCS/ACS), (DBS), biophysics‐informed metrics assessing safety. Using an silico approach, multiphysics simulations various tACS, DBS, scenarios anatomically detailed head model. By matching identified metrics, infer parameters produce conditions equivalent those known be tACS DBS. Based results our existing knowledge tES DBS safety, propose voltages are humans. Safety‐related from ongoing future human studies required verify refine here.

Language: Английский

Citations

1
Electroencephalogram-Based Approaches for Driver Drowsiness Detection and Management: A Review DOI Creative Commons
Gang Li, Wan‐Young Chung

Sensors, Journal Year: 2022, Volume and Issue: 22(3), P. 1100 - 1100

Published: Jan. 31, 2022

Drowsiness is not only a core challenge to safe driving in traditional conditions but also serious obstacle for the wide acceptance of added services self-driving cars (because drowsiness is, fact, one most representative early-stage symptoms carsickness). In view importance detecting drivers’ drowsiness, this paper reviews algorithms electroencephalogram (EEG)-based detection (DDD). To facilitate review, EEG-based DDD approaches are organized into tree structure taxonomy, having two main categories, namely “detection (open-loop)” and “management (closed-loop)”, both aimed at designing better systems that ensure early detection, reliability practical utility. achieve goal, we addressed seven questions, answers which helped developing an system superior existing ones. A basic assumption review article although driver carsickness-induced caused by different factors, brain network regulates same.

Language: Английский

Citations

27
The hidden brain-state dynamics of tACS aftereffects DOI
Florian H. Kasten, Christoph S. Herrmann

NeuroImage, Journal Year: 2022, Volume and Issue: 264, P. 119713 - 119713

Published: Oct. 26, 2022

Language: Английский

Citations

23
Efficacy of Transcranial Alternating Current Stimulation in the Enhancement of Working Memory Performance in Healthy Adults: A Systematic Meta-Analysis DOI Creative Commons
Nicole R. Nissim,

Darrian C. McAfee,

Shanna Edwards

et al.

Neuromodulation Technology at the Neural Interface, Journal Year: 2023, Volume and Issue: 26(4), P. 728 - 737

Published: Feb. 8, 2023

BackgroundTranscranial alternating current stimulation (tACS)—a noninvasive brain technique that modulates cortical oscillations in the brain—has shown capacity to enhance working memory (WM) abilities healthy individuals. The efficacy of tACS improvement WM performance individuals is not yet fully understood.Objective/HypothesisThis meta-analysis aimed systematically evaluate enhancement and assess moderators response stimulation. We hypothesized active would significantly compared with sham. further it do so a task-dependent manner differing parameters affect tACS.Materials MethodsTen studies met inclusion criteria provided 32 effects overall analysis. Random-effect models assessed mean change scores on tasks from baseline poststimulation. included involved varied parameters, between-subject within-subject study designs, online vs offline tACS.ResultsWe observed significant, heterogeneous, moderate effect size for over sham (Cohen's d = 0.5). Cognitive load, task domain, session number, region showed significant relationship between enhanced behavior sham.ConclusionsOur findings indicate enhances Future randomized controlled trials are needed explore key including personalized standardized electroencephalography frequencies maintenance effects, whether tACS-induced translate populations impairments.

Language: Английский

Citations

16