A new perspective for evaluating the efficacy of tACS and tDCS in improving executive functions: A combined tES and fNIRS study DOI Creative Commons
Hongliang Lü, Yajuan Zhang,

Huake Qiu

et al.

Human Brain Mapping, Journal Year: 2023, Volume and Issue: 45(1)

Published: Dec. 11, 2023

Abstract Background Executive function enhancement is considered necessary for improving the quality of life patients with neurological or psychiatric disorders, such as attention‐deficit/hyperactivity disorder, obsessive‐compulsive disorder and Alzheimer's disease. Transcranial electrical stimulation (tES) has been shown to have some beneficial effects on executive functioning, but quantification these improvements remains controversial. We aimed explore potential functioning induced by use transcranial alternating current (tACS)/transcranial direct (tDCS) right inferior frontal gyrus (IFG) accompanying brain variations in resting state. Methods recruited 229 healthy adults participate Experiments 1 (105 participants) 2 (124 participants). The participants each experiment were randomly divided into tACS, tDCS, sham groups. completed cognitive tasks assess behavior related three core components functions. Functional near‐infrared spectroscopy (fNIRS) was used monitor hemodynamic changes crucial cortical regions Results Inhibition flexibility (excluding working memory) significantly increased after tACS/tDCS, there no significant behavioral differences between tACS tDCS fNIRS revealed that decreases functional connectivity (increased neural efficiency) relevant cortices. Conclusions Enhancement observed tES, tACS/tDCS may need be precisely evaluated via imaging indicators at rest. better benefits than during phase. These findings might provide new insights selecting intervention methods future studies evaluating clinical efficacy tES.

Language: Английский

Transcranial alternating current stimulation combined with sound stimulation improves cognitive function in patients with Alzheimer’s disease: Study protocol for a randomized controlled trial DOI Creative Commons
Yang Liu, Shuzhen Liu,

Can Tang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 9, 2023

Background The number of patients with Alzheimer’s disease (AD) worldwide is increasing yearly, but the existing treatment methods have poor efficacy. Transcranial alternating current stimulation (tACS) a new for AD, offline effect tACS insufficient. To prolong effect, we designed to combine sound maintain long-term post-effect. Materials and explore safety effectiveness combined its impact on cognition AD patients. This trial will recruit 87 mild moderate AD. All were randomly divided into three groups. change in Disease Assessment Scale-Cognitive (ADAS-Cog) scores from day before end 3 months after was used as main evaluation index. We also changes brain structural network, functional metabolic network each group treatment. Discussion hope conclude that safe tolerable under standardized regimens. Compared alone or alone, combination had significant cognitive improvement. screen out better plan previously unexplored, non-invasive joint intervention improve patients’ status. study may identify potential mechanism treating Clinical Trial Registration Clinicaltrials.gov , NCT05251649. Registered February 22, 2022.

Language: Английский

Citations

15
The effects of transcranial alternating current stimulation on memory performance in healthy adults: A systematic review DOI
Samantha J. Booth, Jason R. Taylor, Laura Brown

et al.

Cortex, Journal Year: 2021, Volume and Issue: 147, P. 112 - 139

Published: Dec. 24, 2021

Language: Английский

Citations

28
Effects of online parietal transcranial electric stimulation on associative memory: a direct comparison between tDCS, theta tACS, and theta-oscillatory tDCS DOI Creative Commons
Marko Živanović, Jovana Bjekić, Uroš Konstantinović

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Aug. 18, 2022

Abstract Associative memory (AM) is the ability to remember and retrieve multiple items bound together. Previous studies aiming modulate AM by various transcranial electric stimulation (tES) techniques were inconclusive, although overall suggestive that tES could be a tool for enhancement. However, evidence from direct comparison between different lacking. Here, in sham-controlled cross-over experiment, we comparatively assessed effects of three types tES—anodal tDCS, theta-band alternating current (tACS), theta-oscillatory tDCS (otDCS), delivered over left posterior parietal cortex, during short-term digit-color task with cued-recall. The tested 40 healthy young participants while both oscillatory at previously determined individual theta frequency (4–8 Hz). All active stimulations facilitated performance, no differences detected them on comparison. unlike which appeared stem mainly facilitation low-memory demand trials, theta-modulated tACS otDCS primarily promoted high trials. Comparable yet differential tACS, attributed their presumed modes action.

Language: Английский

Citations

21
Potential role for peripheral nerve stimulation on learning and long-term memory: A comparison of alternating and direct current stimulations DOI Creative Commons
Alison M. Luckey,

S. Lauren McLeod,

Anusha Mohan

et al.

Brain stimulation, Journal Year: 2022, Volume and Issue: 15(3), P. 536 - 545

Published: March 20, 2022

Language: Английский

Citations

19
Targeting the neural bases of novel word acquisition using theta-band transcranial alternating current stimulation DOI
Anna Zhuravleva,

Ekaterina Stupina,

Svetlana Malyutina

et al.

Language Cognition and Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: Feb. 2, 2025

Language: Английский

Citations

0
Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part I: Principles of Electrical Neuromodulation and Adverse Effects DOI Creative Commons
Antonino M. Cassarà, Taylor Newton, Katie Zhuang

et al.

Bioelectromagnetics, Journal Year: 2025, Volume and Issue: 46(2)

Published: Feb. 1, 2025

ABSTRACT Temporal interference stimulation (TIS) is a new form of transcranial electrical (tES) that has been proposed as method for targeted, non‐invasive deep brain structures. While TIS holds promise variety clinical and non‐clinical applications, little data yet available regarding its effects in humans mechanisms action. In order to inform the design safe conduct experiments involving TIS, researchers require quantitative guidance exposure limits other safety considerations. To this end, we undertook two‐part effort determine frequency‐dependent thresholds applied currents below which unlikely pose risk terms heating or unwanted stimulation. Part I effort, described here, comprises summary current knowledge pertaining related techniques. Specifically, provide: i) broad overview electrophysiological impacts neurostimulation, ii) review (bio‐)physical principles underlying action alternating/direct (tACS/tDCS), (DBS), iii) comprehensive survey adverse (AEs) associated with each technique reported scientific literature regulatory databases. II, perform an silico study field metrics tDCS/tACS DBS under normal (safe) operating conditions infer result equivalent levels exposure.

Language: Английский

Citations

0
Neurofilaments – Small proteins of physiological significance and predictive power for future neurodegeneration and cognitive decline across the life span DOI
Julia Elmers, Lorenza S. Colzato, Katja Akgün

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 90, P. 102037 - 102037

Published: Aug. 22, 2023

Language: Английский

Citations

10
No Frequency-Specific Effect of Transcranial Random Noise Stimulation on Resting EEG DOI Creative Commons

Shih-Chiang Ke,

Yu‐Hui Lo, Philip Tseng

et al.

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(3)

Published: March 19, 2024

Background: Transcranial random noise stimulation (tRNS) is a form of noninvasive transcranial electrical that applies alternating current in various randomized frequencies to the cortex, thereby improving cognitive functioning multiple domains. However, precise mechanism tRNS, as well its impact on human electroencephalography (EEG), remains unclear. This partly because most studies have used tRNS conjunction with task, making it difficult tease apart whether observed changes EEG are result or their interaction. Methods: Forty-nine healthy individuals participated this study and were randomly assigned active (n = 24) sham 25) groups. was delivered for 20 minutes over Fp1/Fp2 Oz. Resting-state data collected before after either stimulation. Results: Cluster-based permutation tests using FieldTrip revealed no frequency-specific effect resting-state across four frequency bands (theta, alpha, beta, gamma). Conclusions: These observations suggest itself does not target alter specific frequencies. Rather, likely interacts task/activity at hand produce an observable difference post-tRNS EEG. Positive tRNS-EEG findings from previous also resulted interactive activity-dependent nature tRNS.

Language: Английский

Citations

3
Enhancement of hybrid BCI system performance based on motor imagery and SSVEP by transcranial alternating current stimulation DOI Creative Commons
Zhaohui Li, Ruoqing Zhang, Wenjing Li

et al.

IEEE Transactions on Neural Systems and Rehabilitation Engineering, Journal Year: 2024, Volume and Issue: 32, P. 3222 - 3230

Published: Jan. 1, 2024

The hybrid brain-computer interface (BCI) is verified to reduce disadvantages of conventional BCI systems. Transcranial electrical stimulation (tES) can also improve the performance and applicability BCI. However, enhancement in attained solely from perspective users or angle system design limited. In this study, a combining MI SSVEP was proposed. Furthermore, transcranial alternating current (tACS) utilized enhance proposed system. presented depiction grabbing ball with both hands, left-hand right-hand flickering at frequencies 34 Hz 35 Hz. Subjects watched imagined either left hand right perform task. signals were processed separately using filter bank common spatial patterns (FBCSP) canonical correlation analysis (FBCCA) algorithms, respectively. A fusion method fuse features extracted SSVEP. Twenty healthy subjects took part online experiment underwent tACS sequentially. accuracy post-tACS reached 90.25% ± 11.40%, which significantly different pre-tACS. surpassed These results indicated superior would

Language: Английский

Citations

3
Comparative Efficacy of Neuromodulatory Strategies for Drug-Resistant Epilepsy: A Systematic Review and Meta-Analysis DOI Creative Commons
Jianwei Shi,

Dafeng Lu,

Penghu Wei

et al.

World Neurosurgery, Journal Year: 2024, Volume and Issue: 193, P. 373 - 396

Published: Oct. 16, 2024

The study aims to evaluate the efficacy of neuromodulatory strategies for people who have drug-resistant epilepsy (DRE). We searched electronic repositories, including PubMed, Web Science, Embase, and Cochrane Library, randomized controlled trials, their ensuing open-label extension studies, prospective studies focusing on surgical or neuromodulation interventions with DRE. used seizure frequency reduction as primary outcome. A single-arm meta-analysis synthesized data across all assess treatment effectiveness at multiple time points. network evaluated diverse therapies in trials. Grading Recommendations, Assessment, Development, Evaluations was applied overall quality evidence. Twenty-eight representing 2936 individuals underwent 10 treatments were included. Based cumulative ranking meta-analysis, top 3 options deep brain stimulation (DBS) 27% probability, responsive neurostimulation (RNS) 22.91%, transcranial direct current 24.31%. In short-to-medium term, control is more effective RNS than invasive vagus nerve (inVNS), which turn slightly DBS, though differences are minimal. However, long inVNS appears be less both DBS RNS. Trigeminal stimulation, magnetic alternating did not demonstrate significant reduction. Regarding long-term efficacy, outperformed inVNS. While transcutaneous auricular VNS showed promise treating DRE, further needed confirm efficacy.

Language: Английский

Citations

3