Postpartum Psychosis

Current Psychiatry Reports, Journal Year: 2023, Volume and Issue: 25(2), P. 65 - 72

Published: Jan. 13, 2023

Language: Английский

---

Risk Factors for Postpartum Depression Based on Genetic and Epigenetic Interactions

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 60(7), P. 3979 - 4003

Published: April 1, 2023

Language: Английский

---

Diagnosis of peripartum depression disorder: A state-of-the-art approach from the COST Action Riseup-PPD

Comprehensive Psychiatry, Journal Year: 2024, Volume and Issue: 130, P. 152456 - 152456

Published: Jan. 29, 2024

Peripartum depression (PPD) is a major disorder (MDD) episode with onset during pregnancy or within four weeks after childbirth, as defined in DSM-5. However, research suggests that PPD may be distinct diagnosis. The goal of this study was to summarize the similarities and differences between MDD by synthesizing current on diagnosis concerning different clinical features give directions for improving practice. To lay groundwork narrative review, several databases were searched using general search phrases its components When compared MDD, peripartum exhibits characteristics. manifests variety symptoms, i.e., more anxiety, psychomotor obsessive thoughts, impaired concentration, fatigue loss energy, but less sad mood suicidal ideation, MDD. Although prevalence rates are comparable, there greater cross-cultural variances PPD. Additionally, has some risk factors mechanisms such ovarian tissue expression, premenstrual syndrome, unintended pregnancy, obstetric complications. There need in-depth comparing entire postpartum year. diagnostic criteria should modified, particularly (i) addition specific symptoms (i.e., anxiety), (ii) specifier extending first year following (iii) change either "pregnancy onset" "postpartum onset". Diagnostic further discussed.

Language: Английский

---

Psychiatric Risk Factors for Postpartum Depression: A Systematic Review

Behavioral Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 173 - 173

Published: Feb. 7, 2025

The perinatal period, due to the many physical, psychological, and social changes in future mothers, may represent a critical phase with an increased risk for mental health. Postpartum depression (PPD) is one of main syndromes that affect around 17 percent women after pregnancy first months motherhood. This systematic review, following PRISMA guidelines, aimed identify pre-partum psychiatric factors influence occurrence diagnosis PPD focus on antenatal clinical history depression, bipolar disorders, obsessive-compulsive disorder, psychosis. From search scientific databases (Web Science, Pubmed, Psychinfo, Scopus), 37 articles were included evaluation. studies showed depressive episodes during higher PPD. Also, major especially if associated other (such as poor demographic or conditions) increases analysis emerged paucity considering should be overcome. represents multisystemic syndrome involving all aspects mother's life well affecting children's development; this reason, exploring role health onset, progression, prognosis relevant, from point view, find best way promote psychological well-being period.

Language: Английский

---

Risk for midlife psychosis in women: critical gaps and opportunities in exploring perimenopause and ovarian hormones as mechanisms of risk

Psychological Medicine, Journal Year: 2022, Volume and Issue: 52(9), P. 1612 - 1620

Published: May 18, 2022

Women show a heightened risk for psychosis in midlife that is not observed men. The menopausal transition (i.e. perimenopause) and accompanying changes ovarian hormones are theorized to account this increase risk. This narrative review aims empirically examine these theories by reviewing studies of perimenopausal women potential hormone mechanisms effects. Clinical pre-clinical examining the effects age, stage, across adulthood on were identified. Synthesis body work revealed peak ages overlap with age range key stages (especially transition), although directly assessing stage lacking. Studies have almost exclusively focused earlier developmental events (e.g. pregnancy, menstrual cycle) increases psychotic symptoms female rats during periods lower estradiol levels. Estrogen treatment also tends enhance neuroleptics females species at various reproductive phases. Initial data promising suggesting role However, critical gaps our knowledge base remain, as there tendency rely indirect proxy measures status hormones. Opportunities future research discussed goal increasing area women's health.

Language: Английский

---

Postpartum psychosis: A proposed treatment algorithm

Journal of Psychopharmacology, Journal Year: 2023, Volume and Issue: 37(10), P. 960 - 970

Published: July 29, 2023

Postpartum psychosis (PPP) is a psychiatric emergency that generally warrants acute inpatient care. PPP marked by the sudden onset of affective and psychotic symptoms with rapid deterioration in mental state. Evidence suggests discrete disorder on bipolar spectrum distinct treatment profile prognosis.

Language: Английский

---

Zuranolone – synthetic neurosteroid in treatment of mental disorders: narrative review

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 5, 2023

With each passing year, the number of people suffering from mental disorders grows at a disturbing speed. Neuroactive steroids are new promising group drugs with potential for use in many diseases like postpartum depression, postnatal psychosis, major insomnia, bipolar disorder, and Parkinson’s tremor, due to their ability modulate activity GABA A receptor. Neurosteroids progesterone metabolites that synthesized cholesterol or steroid hormones various brain regions. They regulate neuronal development, regeneration, neurotransmission. implicated mood disorders, anxiety schizophrenia, PTSD, impulsive aggression. have been studied prevent treat neurodegenerative such as Alzheimer’s disease HIV-associated dementia. can promote neurogenesis, survival, myelination, memory function. also affect growth sensitivity hormone-dependent tumors gliomas. Zuranolone, newly registered neurosteroid drug has shown huge flexibility both clinical ambulatory treatment thanks its pharmacokinetic traits, especially possibility oral administration, unlike predecessor Brexanolone. Zuranolone is synthetic positive allosteric modulator GABAA receptor be taken orally. The review aims summarize current knowledge on zuranolone novel which this was meant originally. It covers studies indexed PubMed, Scopus, Web Science databases published since 2017. Keywords used search, well inclusion exclusion criteria, given methodology section. explains evidence role neurosteroids, allopregnanolone, pathophysiology depression. discusses mechanisms action, changes levels during pregnancy postpartum, trials brexanolone zuranolone, two analogs provides an overview biosynthesis metabolism neurosteroids central peripheral nervous system. Furthermore, it different sources pathways production factors influence synthesis regulation, stress, hormones, drugs, genetic variations. explores relevance other psychiatric post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder. Finally, highlights associations between symptom severity effects modulation mood, cognition, neuroplasticity.

Language: Английский

---

The lived experience of postpartum depression and psychosis in women: a bottom‐up review co‐written by experts by experience and academics

World Psychiatry, Journal Year: 2025, Volume and Issue: 24(1), P. 32 - 45

Published: Jan. 15, 2025

This is the first bottom‐up review of lived experience postpartum depression and psychosis in women. The study has been co‐designed, co‐conducted co‐written by experts academics, drawing on first‐person accounts within outside medical field. material initially identified was shared with all participants a cloud‐based system, discussed across research team, enriched phenomenological insights. subjective world characterized sudden onset (“being hit ton bricks”), unbearable loneliness sadness that are often suffered silence, inability to feel positive emotions, grieving over loss self, feelings being bad mothers (haunted suffocating burden guilt due that), concentrate, lack control thoughts (“feeling like tightrope walker without emotions”), insecurity (up needing be nurtured mothered themselves), death (“contemplating as glimmer hope escape living nightmare”). In addition these themes, difficulty articulating brain centrifuge”); perceptual abnormalities unusual beliefs disrupting sense personal unity (with, few cases, harming themselves or their baby, so women may they “sinking depths hell”); losing trust (“ploughing through fog safety”), stripping down relationships. Much isolation, disorientation experienced conditions relates sociocultural family environments, especially gulf between how web norms expectations surrounding motherhood. most stigma related knowledge what are. Stigma core drivers impacting health care terms seeking professional help, accessing mental services, receiving pharmacological psychological treatments. narratives described this paper should inform clinical practice, public education. brings voice unspoken unheard, fosters relational connections which different mothering experiences expressed understood. vital challenging negative attitudes towards psychosis, providing supportive experiencing such pervasive psychiatric disorders at critical, fragile time lives.

Language: Английский

---

Canadian Network for Mood and Anxiety Treatments 2024 Clinical Practice Guideline for the Management of Perinatal Mood, Anxiety, and Related Disorders: Guide de pratique 2024 du Canadian Network for Mood and Anxiety Treatments pour le traitement des troubles de l'humeur, des troubles anxieux et des troubles connexes périnatals

The Canadian Journal of Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Background The Canadian Network for Mood and Anxiety Treatments (CANMAT) publishes clinical practice guidelines mood anxiety disorders. This CANMAT guideline aims to provide comprehensive guidance the pregnancy postpartum (perinatal) management of mood, related Methods convened a core editorial group interdisciplinary academic clinicians persons with lived experience (PWLE), 3 advisory panels PWLE perinatal health mental clinicians. We searched systematic reviews prevention treatment interventions depressive, bipolar, anxiety, obsessive–compulsive post-traumatic stress disorders (January 2013–October 2023). prioritized evidence from randomized controlled trials (RCTs), except safety medications where large high-quality observational studies were due absence RCT data. Targeted searches individual conducted when limited or absent. Recommendations organized by lines based on CANMAT-defined levels quality, supplemented consensus balance efficacy, safety, tolerability feasibility considerations. Results covers 10 sections in question-and-answer format that maps onto patient care journey: case identification; organization delivery care; non-pharmacological (lifestyle, psychosocial, psychological), pharmacological, neuromodulation complementary alternative medicine interventions; high-risk situations; father co-parent. Equity, diversity inclusion considerations are provided. Conclusions guideline's detailed evidence-based recommendations key information promote effective safe healthcare. It is hoped will serve as valuable tool Canada around world help optimize outcomes area health.

Language: Английский

---

Maternal neuroplasticity and mental health during the transition to motherhood

Nature Mental Health, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

---