Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis

Brain Behavior and Immunity, Journal Year: 2021, Volume and Issue: 101, P. 93 - 135

Published: Dec. 29, 2021

Language: Английский

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Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis

Brain Communications, Journal Year: 2021, Volume and Issue: 4(1)

Published: Dec. 15, 2021

The nature and extent of persistent neuropsychiatric symptoms after COVID-19 are not established. To help inform mental health service planning in the pandemic recovery phase, we systematically determined prevalence survivors COVID-19. For this pre-registered systematic review meta-analysis (PROSPERO ID CRD42021239750), searched MEDLINE, EMBASE, CINAHL PsycINFO to 20 February 2021, plus our own curated database. We included peer-reviewed studies reporting at post-acute or later time-points infection control groups where available. each study, a minimum two authors extracted summary data. symptom, calculated pooled using generalized linear mixed models. Heterogeneity was measured with I2. Subgroup analyses were conducted for hospitalization, severity duration follow-up. From 2844 unique titles, 51 (n = 18 917 patients). mean follow-up 77 days (range 14-182 days). Study quality most commonly moderate. prevalent symptom sleep disturbance [pooled 27.4% (95% confidence interval 21.4-34.4%)], followed by fatigue [24.4% (17.5-32.9%)], objective cognitive impairment [20.2% (10.3-35.7%)], anxiety [19.1% (13.3-26.8%)] post-traumatic stress [15.7% (9.9-24.1%)]. Only reported groups, both higher frequencies versus controls. Between-study heterogeneity high (I2 79.6-98.6%). There little no evidence differential based on hospitalization status, duration. Neuropsychiatric common from literature longer-term consequences is still maturing but indicates particularly insomnia, fatigue, disorders first 6 months infection.

Language: Английский

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COVID-19 associated cognitive impairment: A systematic review

Cortex, Journal Year: 2022, Volume and Issue: 152, P. 77 - 97

Published: April 18, 2022

Language: Английский

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Neuropsychological deficits in patients with cognitive complaints after COVID‐19

Brain and Behavior, Journal Year: 2022, Volume and Issue: 12(3)

Published: Feb. 8, 2022

While much of the scientific focus thus far has been on cognitive sequelae in patients with severe COVID-19, subjective complaints are being reported across spectrum disease severity, recent studies beginning to corroborate patients' perceived deficits. In response this, aims this study were (1) explore frequency impaired performance domains post-COVID and (2) uncover whether impairment existed within a single domain or multiple.Sixty-three assessed comprehensive protocol consisting various neuropsychological tests mood measures. Cognitive test was transformed into T scores classified based recommended guidelines. After performing principal component analysis define factors, distributions analyzed.Results revealed pervasive impact attention abilities, both as singularly affected (19% single-domain impairment) well coupled decreased executive functions, learning, long-term memory. These salient attentional associated deficits largely unrelated clinical factors such hospitalization, duration, biomarkers, affective measures.These findings stress importance evaluation intervention address varying courses, not just those who hospitalized experienced symptoms. Future should investigate what extent these abilities recuperated over time employ neuroimaging techniques underlying mechanisms neural damage.

Language: Английский

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Rapid vigilance and episodic memory decrements in COVID-19 survivors

Brain Communications, Journal Year: 2021, Volume and Issue: 4(1)

Published: Dec. 15, 2021

Abstract Recent studies indicate that COVID-19 infection can lead to serious neurological consequences in a small percentage of individuals. However, the months following acute illness, many more suffer from fatigue, low motivation, disturbed mood, poor sleep and cognitive symptoms, colloquially referred as ‘brain fog’. But what about individuals who had asymptomatic moderate reported no concerns after recovering COVID-19? Here, we examined wide range functions critical for daily life (including sustained attention, memory, motor control, planning, semantic reasoning, mental rotation spatial–visual attention) people previously suffered but were not significantly different control group on self-reported forgetfulness, abnormality, depression, anxiety personality profile. Reassuringly, survivors performed well most abilities tested, including working executive function, planning rotation. they displayed worse episodic memory (up 6 post-infection) greater decline vigilance with time task (for up 9 months). Overall, results show specific chronic changes are evident objective testing even amongst those do report symptom burden. Importantly, sample tested here, these normal 6–9 months, demonstrating evidence recovery over time.

Language: Английский

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‘I can’t cope with multiple inputs’: a qualitative study of the lived experience of ‘brain fog’ after COVID-19

BMJ Open, Journal Year: 2022, Volume and Issue: 12(2), P. e056366 - e056366

Published: Feb. 1, 2022

To explore the lived experience of 'brain fog'-the wide variety neurocognitive symptoms that can follow COVID-19.A UK-wide longitudinal qualitative study comprising online focus groups with email follow-up.50 participants were recruited from a previous long COVID-19 (n=23) and support for people persistent following (n=27). In remotely held groups, invited to describe their comment on others' accounts. Individuals followed up by 4-6 months later. Data audiotaped, transcribed, anonymised coded in NVIVO. They analysed an interdisciplinary team expertise general practice, clinical neuroscience, sociology chronic illness service delivery, checked brain fog.Of 50 participants, 42 female 32 white British. Most had never been hospitalised COVID-19. Qualitative analysis revealed themes: mixed views appropriateness term fog'; rich descriptions (especially executive function, attention, memory language), accounts how fluctuated-and progressed over time; profound psychosocial impact condition relationships, personal professional identity; self-perceptions guilt, shame stigma; strategies used self-management; challenges accessing navigating healthcare system; participants' search physical mechanisms explain symptoms.These findings complement research into epidemiology after Services such patients should include: ongoing therapeutic relationship clinician who engages its personal, social occupational context as well specialist services include provision symptoms, are accessible, easily navigable, comprehensive interdisciplinary.

Language: Английский

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One‐year cognitive follow‐up of COVID‐19 hospitalized patients

European Journal of Neurology, Journal Year: 2022, Volume and Issue: 29(7), P. 2006 - 2014

Published: March 14, 2022

Cognitive dysfunction has been observed following recovery from COVID-19. To the best of our knowledge, however, no study assessed progression cognitive impairment after 1 year. The aim was to assess functioning at year hospital discharge, and eventual associations with specific clinical variables.Seventy-six patients (aged 22-74 years) who had hospitalized for COVID-19 were recruited. Patients received neuropsychological assessments 5 (n = 76) 12 months 53) discharge.Over half (63.2%) deficits in least one test months. Compared assessment months, verbal memory, attention processing speed improved significantly (all p < 0.05), whereas visuospatial memory did not > 0.500). most affected domains (28.3%) long-term (18.1%) (15.1%) memory. Lower PaO2 /FiO2 ratios acute phase associated worse (p 0.029) learning 0.041) Worse hyposmia 0.020) dysgeusia 0.037).Our expands results previous studies showing that can still be severe should receive periodic follow-up evaluations, as recovered could have social occupational implications.

Language: Английский

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Cognitive Impairment in Non-critical, Mild-to-Moderate COVID-19 Survivors

Frontiers in Psychology, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 17, 2022

Previous studies of post-acute COVID-19 syndrome have focused on critical cases with severe disease. However, most are mild to moderate in disease severity.

Language: Английский

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Long COVID is associated with severe cognitive slowing: a multicentre cross-sectional study

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 68, P. 102434 - 102434

Published: Jan. 25, 2024

Summary

Background

COVID-19 survivors may experience a wide range of chronic cognitive symptoms for months or years as part post-COVID-19 conditions (PCC). To date, there is no definitive objective marker PCC. We hypothesised that key common deficit in people with PCC might be generalised slowing.

Methods

examine slowing, patients completed two short web-based tasks, Simple Reaction Time (SRT) and Number Vigilance Test (NVT). 270 diagnosed at different clinics UK Germany were compared to control groups: individuals who contracted before but did not after recovery (No-PCC group) uninfected (No-COVID group). All the study between May 18, 2021 July 4, 2023 Jena University Hospital, Jena, Long COVID clinic, Oxford, UK.

Findings

identified pronounced slowing PCC, which distinguished them from age-matched healthy previously had symptomatic manifest Cognitive was evident even on 30-s task measuring simple reaction time (SRT), responding stimuli ∼3 standard deviations slower than controls. 53.5% PCC's response speed 2 mean, indicating high prevalence This finding replicated across clinic samples Comorbidities such fatigue, depression, anxiety, sleep disturbance, post-traumatic stress disorder account extent Furthermore, SRT highly correlated poor performance NVT measure sustained attention.

Interpretation

Together, these results robustly demonstrate distinguishes an important factor contributing some impairments reported

Funding

Wellcome Trust (206330/Z/17/Z), NIHR Oxford Health Biomedical Research Centre, Thüringer Aufbaubank (2021 FGI 0060), German Forschungsgemeinschaft (DFG, FI 1424/2-1) Horizon 2020 Framework Programme European Union (ITN SmartAge, H2020-MSCA-ITN-2019-859890).

Language: Английский

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Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study

BMJ Open, Journal Year: 2021, Volume and Issue: 11(10), P. e055164 - e055164

Published: Oct. 1, 2021

Objectives To report findings on brain MRI and neurocognitive function, as well persisting fatigue at long-term follow-up after COVID-19 hospitalisation in patients identified high risk for affection of the central nervous system. Design Ambidirectional observational cohort study. Setting All 734 from a regional population Sweden with laboratory-confirmed diagnosis admitted to hospital during period 1 March 31 May 2020. Participants A subgroup (n=185) symptoms still interfering daily life telephone 4 months discharge were invited medical neuropsychological evaluation. Thirty-five those who assessed test battery clinical visit, presented picture concerning COVID-19-related pathology, further investigated by MRI. Main outcome measures Findings MRI, results reported fatigue. Results Twenty-five (71%) had abnormalities MRI; multiple white matter lesions most common finding. Sixteen (46%) demonstrated impaired which 10 (29%) severe impairment. Twenty-six (74%) clinically significant Patients lower Visuospatial Index (p=0.031) compared group normal findings. Conclusions In this selected undergo evaluation, majority abnormal and/or results. Abnormal not restricted disease.

Language: Английский

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