Infection, Journal Year: 2022, Volume and Issue: 50(5), P. 1067 - 1109
Published: June 24, 2022
Language: Английский
Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(3), P. 133 - 146
Published: Jan. 13, 2023
Language: Английский
Citations
2725
Circulation, Journal Year: 2024, Volume and Issue: 149(8)
Published: Jan. 24, 2024
BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, obesity) factors (cholesterol, blood pressure, glucose control, metabolic syndrome) that contribute health. AHA Disease Stroke Statistical Update presents latest data on a range major clinical circulatory disease conditions (including brain health, complications pregnancy, kidney congenital rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary cardiomyopathy, failure, valvular venous thromboembolism, peripheral artery disease) associated outcomes quality care, procedures, economic costs). METHODS: AHA, through its Epidemiology Prevention Statistics Committee, continuously monitors evaluates sources stroke United States globally provide current information available annual review published literature year before writing. 2024 is product full year’s worth effort 2023 by dedicated volunteer clinicians scientists, committed government professionals, staff members. strives further understand help heal problems inflicted structural racism, public crisis can significantly damage mental perpetuate disparities access education, income, housing, several other vital healthy lives. This edition includes additional global data, as well monitoring benefits population, an enhanced focus equity across key domains. RESULTS: Each chapters focuses different topic statistics. CONCLUSIONS: represents critical resource for lay public, policymakers, media clinicians, care administrators, researchers, advocates, others seeking best these conditions.
Language: Английский
Citations
882
Nature Medicine, Journal Year: 2022, Volume and Issue: 28(10), P. 2027 - 2037
Published: Oct. 1, 2022
Language: Английский
Citations
309
Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)
Published: March 22, 2022
Abstract Background Fatigue, exertion intolerance and post-exertional malaise are among the most frequent symptoms of Post-COVID Syndrome (PCS), with a subset patients fulfilling criteria for Myalgic Encephalomyelitis/Chronic Fatigue (ME/CFS). As SARS-CoV-2 infects endothelial cells, causing endotheliitis damaging endothelium, we investigated dysfunction (ED) biomarkers in PCS. Methods We studied function 30 PCS persistent fatigue as well 15 age- sex matched seronegative healthy controls (HCs). 14 fulfilled diagnostic ME/CFS. The other were considered to have Peripheral was assessed by reactive hyperaemia index (RHI) using peripheral arterial tonometry (PAT) HCs. In larger cohort HCs, including post-COVID reconvalescents (PCHCs), Endothelin-1 (ET-1), Angiopoietin-2 (Ang-2), Endocan (ESM-1), IL-8, Angiotensin-Converting Enzyme (ACE) ACE2 analysed biomarkers. Results Five ME/CFS five 16 showed ED defined diminished RHI (< 1.67), but none HCs exhibited this finding. A paradoxical positive correlation age, blood pressure BMI found not patients. ET-1 concentration significantly elevated both compared PCHCs. serum Ang-2 lower PCHCs Conclusion display evidence shown altered Different associations clinical parameters varying biomarker profiles may suggest distinct pathomechanisms patient subgroups.
Language: Английский
Citations
206
BMJ, Journal Year: 2022, Volume and Issue: unknown, P. e071050 - e071050
Published: Oct. 13, 2022
Abstract Objectives To describe symptoms and symptom clusters of post-covid syndrome six to 12 months after acute infection, risk factors, examine the association with general health working capacity. Design Population based, cross sectional study Setting Adults aged 18-65 years confirmed SARS-CoV-2 infection between October 2020 March 2021 notified authorities in four geographically defined regions southern Germany. Participants 50 457 patients were invited participate study, whom 053 (24%) responded 11 710 (58.8% (n=6881) female; mean age 44.1 years; 3.6% (412/11 602) previously admitted covid-19; follow-up time 8.5 months) could be included analyses. Main outcome measures Symptom frequencies (six versus before infection), severity clustering, associations recovery Results The fatigue (37.2% (4213/11 312), 95% confidence interval 36.4% 38.1%) neurocognitive impairment (31.3% (3561/11 361), 30.5% 32.2%) contributed most reduced capacity, but chest symptoms, anxiety/depression, headache/dizziness, pain syndromes also prevalent relevant for some differences according sex age. Considering new at least moderate daily life ≤80% recovered or overall estimate was 28.5% (3289/11 536, 27.7% 29.3%) among participants 6.5% (3289/50 457) infected adult population (assuming that all non-responders had completely recovered). true value is likely these estimates. Conclusions Despite limitation a low response rate possible selection recall biases, this suggests considerable burden self-reported post-acute sequelae, notably impairment, even young middle adults mild substantial impact on Trial registration German registry clinical studies DRKS 00027012.
Language: Английский
Citations
205
CNS Drugs, Journal Year: 2022, Volume and Issue: 36(7), P. 681 - 702
Published: June 21, 2022
Language: Английский
Citations
159
EClinicalMedicine, Journal Year: 2022, Volume and Issue: 53, P. 101651 - 101651
Published: Sept. 17, 2022
Language: Английский
Citations
137
Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 28(2), P. 564 - 578
Published: Oct. 24, 2022
Language: Английский
Citations
137
Cardiovascular Research, Journal Year: 2022, Volume and Issue: 119(2), P. 336 - 356
Published: July 25, 2022
Abstract Long COVID has become a world-wide, non-communicable epidemic, caused by long-lasting multiorgan symptoms that endure for weeks or months after SARS-CoV-2 infection already subsided. This scientific document aims to provide insight into the possible causes and therapeutic options available cardiovascular manifestations of long COVID. In addition chronic fatigue, which is common symptom COVID, patients may present with chest pain, ECG abnormalities, postural orthostatic tachycardia, newly developed supraventricular ventricular arrhythmias. Imaging heart vessels provided evidence chronic, post-infectious perimyocarditis consequent left right failure, arterial wall inflammation, microthrombosis in certain patient populations. Better understanding underlying cellular molecular mechanisms will aid development effective treatment strategies its manifestations. A number have been proposed, including those involving direct effects on myocardium, microthrombotic damage endothelium, persistent inflammation. Unfortunately, existing circulating biomarkers, coagulation, inflammatory markers, are not highly predictive either presence outcome when measured 3 infection. Further studies needed understand mechanisms, identify specific guide future preventive treatments address sequelae.
Language: Английский
Citations
126
Journal of Psychiatric Research, Journal Year: 2022, Volume and Issue: 156, P. 349 - 360
Published: Oct. 20, 2022
Language: Английский
Citations
109