Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Feb. 22, 2024
Abstract
The
COVID-19
pandemic
has
given
rise
to
post-acute
cognitive
symptoms,
often
described
as
‘brain
fog’.
To
comprehensively
grasp
the
extent
of
these
issues,
we
conducted
a
study
integrating
traditional
neuropsychological
assessments
with
experimental
tasks
targeting
attention
control,
working
memory,
and
long-term
three
domains
most
commonly
associated
We
enrolled
33
post-COVID
patients,
all
self-reporting
difficulties,
matched
control
group
(N
=
27)
for
psychological
assessments.
Our
findings
revealed
significant
deficits
in
patients
across
both
measurements
tasks,
evidencing
reduced
performance
involving
interference
resolution
selective
sustained
attention.
Mild
executive
function
naming
impairments
also
emerged
from
assessment.
Notably,
61%
reported
prospective
memory
failures
daily
life,
aligning
our
recruitment
focus.
Furthermore,
patient
showed
alterations
psycho-affective
domain,
indicating
complex
interplay
between
factors,
which
could
point
non-cognitive
determinant
subjectively
experienced
changes
following
COVID-19.
In
summary,
offers
valuable
insights
into
challenges
faced
by
individuals
recovering
COVID-19,
stressing
importance
comprehensive
evaluations
supporting
individuals.
Journal of Global Health,
Journal Year:
2022,
Volume and Issue:
12
Published: May 21, 2022
Abstract
Background
Long
COVID
is
defined
as
symptoms
and
signs
related
to
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
that
are
present
at
least
four
weeks
following
infection.
These
poorly
characterised
but
may
be
associated
with
significant
morbidity.
We
sought
synthesise
the
evidence
on
their
incidence
guide
future
research,
policy
practice.
Methods
searched
Medline
Embase
for
longitudinal
cohort
studies
from
January
2020
July
2021
investigated
adults
long
after
Risk
of
bias
was
assessed
using
Joanna
Briggs
Institute
checklist
studies.
Random-effects
meta-analyses
were
performed
subgroup
analysis
by
follow-up
time
(4-12
vs
more
than
12
weeks).
Results
19
included,
13
which
included
patients
hospitalised
COVID-19.
The
total
sample
size
10
643
ranged
30
340
days.
high
in
one
study,
moderate
two
low
remaining
16
most
common
seen
any
point
fatigue
(37%;
95%
confidence
interval
(CI)
=
23-55),
dyspnoea
(21%;
CI
14-30),
olfactory
dysfunction
(17%;
9-29),
myalgia
(12%;
5-25),
cough
(11%;
6-20)
gustatory
(10%;
7-17).
High
heterogeneity
all
presence
some
funnel
plot
asymmetry
indicate
reporting
bias.
No
effect
found
symptom
or
sign
analysis.
Conclusions
have
summarised
COVID.
meta-analysis
means
pooled
estimates
should
interpreted
caution.
This
attributable
including
different
health
care
settings
countries.
Human Brain Mapping,
Journal Year:
2022,
Volume and Issue:
44(4), P. 1629 - 1646
Published: Dec. 2, 2022
Neuropsychological
deficits
and
brain
damage
following
SARS-CoV-2
infection
are
not
well
understood.
Then,
116
patients,
with
either
severe,
moderate,
or
mild
disease
in
the
acute
phase
underwent
neuropsychological
olfactory
tests,
as
completed
psychiatric
respiratory
questionnaires
at
223
±
42
days
postinfection.
Additionally,
a
subgroup
of
50
patients
functional
magnetic
resonance
imaging.
Patients
severe
group
displayed
poorer
verbal
episodic
memory
performances,
moderate
had
reduced
mental
flexibility.
Neuroimaging
revealed
patterns
hypofunctional
hyperfunctional
connectivities
while
only
hyperconnectivity
were
observed
for
moderate.
The
default
mode,
somatosensory,
dorsal
attention,
subcortical,
cerebellar
networks
implicated.
Partial
least
squares
correlations
analysis
confirmed
specific
association
between
memory,
executive
functions
performances
connectivity.
severity
is
predictor
performance
6-9
months
infection.
causes
long-term
dysfunctions,
related
to
large-scale
connectivity
alterations.
Journal of Neurology,
Journal Year:
2022,
Volume and Issue:
270(3), P. 1215 - 1223
Published: Nov. 23, 2022
Abstract
Background
A
fraction
of
patients
with
asymptomatic
to
mild/moderate
acute
COVID-19
disease
report
cognitive
deficits
as
part
the
post-COVID-19
syndrome.
This
study
aimed
assess
neuropsychological
profile
these
patients.
Methods
Assessment
at
baseline
(three
months
or
more
following
COVID-19)
a
monocentric
prospective
cohort
Multidomain
tests
were
performed,
and
questionnaires
on
depression,
anxiety,
fatigue,
sleep,
general
health
status
administered.
Results
Of
58
screened,
six
excluded
due
possible
alternative
causes
impairment
(major
neurodegenerative
disease).
remaining
52
individuals,
only
one
had
below-threshold
screening
result
Mini-Mental
State
Examination,
13
scored
below
cut-off
Montreal
Cognitive
Assessment.
Extended
testing
revealed
neurocognitive
disorder
(NCD)
in
31
(59.6%)
participants
minor
NCD
majority
cases
(
n
=
26).
In
NCD,
domains
learning/memory
executive
functions
impaired
60.7%,
complex
attention
51.6%,
language
35.5%,
perceptual-motor
function
29.0%.
profiles
associated
daytime
sleepiness
but
not
sleep
quality,
total
status,
fatigue.
Conclusion
Neurocognitive
can
be
confirmed
around
60%
individuals
self-reported
syndrome
mild
course.
Notably,
cannot
reliably
detect
this
dysfunction.
Standard
psychiatric
assessments
showed
no
association
profiles.
Longitudinal
studies
are
needed
further
evaluate
course
clarify
pathophysiology.
Journal of Neurology,
Journal Year:
2023,
Volume and Issue:
270(5), P. 2392 - 2408
Published: March 20, 2023
Patients
with
post-coronavirus
disease
2019
(COVID-19)
conditions
typically
experience
cognitive
problems.
Some
studies
have
linked
COVID-19
severity
long-term
damage,
while
others
did
not
observe
such
associations.
This
discrepancy
can
be
attributed
to
methodological
and
sample
variations.
We
aimed
clarify
the
relationship
between
outcomes
determine
whether
initial
symptomatology
predict
Cognitive
evaluations
were
performed
on
109
healthy
controls
319
post-COVID
individuals
categorized
into
three
groups
according
WHO
clinical
progression
scale:
severe-critical
(n
=
77),
moderate-hospitalized
73),
outpatients
169).
Principal
component
analysis
was
used
identify
factors
associated
symptoms
in
acute-phase
domains.
Analyses
of
variance
regression
linear
models
study
intergroup
differences
The
group
significantly
worse
than
control
general
cognition
(Montreal
Assessment),
executive
function
(Digit
symbol,
Trail
Making
Test
B,
phonetic
fluency),
social
(Reading
Mind
Eyes
test).
Five
components
emerged
from
principal
analysis:
"Neurologic/Pain/Dermatologic"
"Digestive/Headache",
"Respiratory/Fever/Fatigue/Psychiatric"
"Smell/
Taste"
predictors
Montreal
Assessment
scores;
predicted
attention
working
memory;
verbal
memory,
"Respiratory/Fever/Fatigue/Psychiatric,"
"Neurologic/Pain/Dermatologic,"
"Digestive/Headache"
function.
severe
exhibited
persistent
deficits
Several
sequelae,
indicating
role
systemic
inflammation
neuroinflammation
COVID-19."
Study
Registration:
www.ClinicalTrials.gov
,
identifier
NCT05307549
NCT05307575.
Trends in Cognitive Sciences,
Journal Year:
2023,
Volume and Issue:
27(11), P. 1053 - 1067
Published: Aug. 30, 2023
COVID-19
is
associated
with
a
range
of
neurological,
cognitive,
and
mental
health
symptoms
both
acutely
chronically
that
can
persist
for
many
months
after
infection
in
people
long-COVID
syndrome.
Investigations
cognitive
function
neuroimaging
have
begun
to
elucidate
the
nature
some
these
symptoms.
They
reveal
that,
although
deficits
may
be
related
brain
imaging
abnormalities
people,
also
occur
absence
objective
or
changes.
Furthermore,
impairment
detected
even
asymptomatic
individuals.
We
consider
evidence
regarding
symptoms,
deficits,
neuroimaging,
as
well
their
possible
underlying
mechanisms.
Brain Behavior & Immunity - Health,
Journal Year:
2023,
Volume and Issue:
27, P. 100587 - 100587
Published: Jan. 5, 2023
Subjective
and
objective
cognitive
dysfunction
are
reported
after
COVID-19
but
with
limited
data
on
their
congruence
associations
the
severity
of
acute
disease.
The
aim
this
cohort
study
is
to
describe
prevalence
subjective
at
three
six
months
symptoms
psychological
disease-related
factors.We
assessed
a
184
patients
COVID-19:
82
admitted
Intensive
Care
Unit
(ICU),
53
regular
hospital
wards,
49
isolated
home.
A
non-COVID
control
group
individuals
was
included.
Demographic
clinical
were
collected.
symptoms,
impairment,
depressive
post-traumatic
stress
disorder
(PTSD)
assessed.At
months,
impairment
by
32.3%
ICU-treated,
37.3%
ward-treated,
33.3%
home-isolated
observed
in
36.1%
34.7%
8.9%
patients.
associated
PTSD
female
sex,
not
assessment
or
metrics.One-third
patients,
regardless
disease
severity,
high
levels
which
results
from
screening
demographic
factors.
Our
stresses
importance
thorough
reporting
long-term
for
underlying
mental
health
related
factors
such
as
depression.
BMC Geriatrics,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: Jan. 23, 2023
Abstract
Background
Older
adults
experience
persistent
symptoms
post-COVID-19,
termed
as
Long
COVID,
affecting
their
physical
and
mental
health.
This
study
aimed
to
evaluate
the
effects
of
level
activity,
functional
decline
on
older
adults’
health-related
quality
life
post-COVID-19.
Methods
cross-sectional
was
conducted
121
with
60
90
years
old
post-coronavirus
infection.
The
standardized
metrics
used
in
were
Fatigue
Severity
Scale,
Physical
Activity
Elderly,
SF12,
Post-COVID-19
status
scale,
COVID-19
Yorkshire
rehabilitation
screening
scale.
severity
coronavirus
infection
evaluated
by
changes
chest
CT
scan
images
O
2
saturation
at
hospital
admission.
Data
analyzed
using
linear
regression
analyses.
Results
results
analysis
revealed
six
factors
be
predictors
health
6
months
post-COVID-19
(F
=
9.046,
P
<
0.001;
explained
variance
63%),
which
significant
fatigue,
worsened
pain,
difficulties
activities
daily
living
cognitive-communication
problems.
Among
these
factors,
greater
fatigue
pain
intensity
strongest
predictors.
Mental
associated
days
hospitalization
problems
2.866,
35%).
Conclusions
Considering
negative
impact
low
life,
early
accurate
evaluation
management
are
required
for
recovered
