The Effects of Appropriate Perioperative Exercise on Perioperative Neurocognitive Disorders: a Narrative Review DOI Creative Commons
Hao Feng, Zheng Zhang,

Wenyuan Lyu

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(7), P. 4663 - 4676

Published: Dec. 19, 2023

Abstract Perioperative neurocognitive disorders (PNDs) are now considered the most common neurological complication in older adult patients undergoing surgical procedures. A significant increase exists incidence of post-operative disability and mortality with PNDs. However, no specific treatment is still available for Recent studies have shown that exercise may improve cognitive dysfunction-related disorders, including Neuroinflammation a key mechanism underlying exercise-induced neuroprotection PNDs; others include regulation gut microbiota mitochondrial synaptic function. Maintaining optimal skeletal muscle mass through preoperative important to prevent occurrence This review summarizes current clinical preclinical evidence proposes potential molecular mechanisms by which perioperative improves PNDs, providing new direction exploring exercise-mediated neuroprotective effects on In addition, it intends provide strategies prevention

Language: Английский

Early postoperative cognitive decline—are there any preventive strategies for surgical patients in the emergency setting? DOI Open Access

Ana-Maria Cotae,

Liliana Mirea, Cristian Cobilinschi

et al.

Signa Vitae, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Postoperative neurocognitive impairments following surgery are a growing concern, especially in the elderly population, since it is associated with significantly increased risk of morbi-mortality postoperative period. Among them, delirium or early cognitive decline further prolonged dysfunction and may quicken long-term impairment (POCD). The current knowledge regarding preventive strategies for not focused anymore only on pharmacological behavioral management period, but also supports preoperative training programs. Since evaluation proactive interventions to optimize surgical patient outcomes rather impossible emergency setting, what appropriate that can be implemented day-to-day practice? In this review, we try highlight most recent experimental clinical strategies, outline relevant recommendations clinicial practicioners based available data.

Language: Английский

Citations

2
The effect of dexmedetomidine on emergence delirium of postanesthesia events in pediatric department: A systematic review and meta-analysis of randomized controlled trials DOI Creative Commons

Sunyu Tang,

Jikai Liu,

Zheng Ding

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(36), P. e39337 - e39337

Published: Sept. 6, 2024

Background: Emergence delirium (ED) is a common occurrence in pediatric postanesthesia events, leading to negative outcomes. Dexmedetomidine (DEX), as an anesthesia adjuvant, has shown promise preventing ED adult surgeries, and it been increasingly used surgical settings. However, its effectiveness other such MRI examinations ambulatory surgery centers, remains unclear. This meta-analysis aims assess the safety efficacy of DEX various events beyond surgery. Methods: Prospective randomized controlled trials were searched Pubmed, Web Science, EBSCO until October 13, 2023. Comparisons made between sedatives or analgesics different (including operations, examination MRI, day surgery, invasive action). Subgroup analyses conducted based on drug delivery methods, medication timing, dosages, use analgesics, event types, recovery time. Results: A total 33 involving 3395 patients included. significantly reduced incidence (odds ratios [OR] = 0.23, 95% confidence interval [CI]: 0.19–0.27, I 2 37%, P < .00001). Intranasal was most effective (OR 0.18, CI: 0.10–0.32, .00001, 0%). also showed benefits mask insertion 0.30, 0.14–0.26, .001, Conclusion: demonstrates superior compared analgesics. Its recommended settings for managing ED.

Language: Английский

Citations

2
Dexmedetomidine prevents hemorrhagic brain injury by reducing damage induced by ferroptosis in mice DOI Creative Commons

Man-Jia Liu,

Xiaochun Zhao,

Hesong Gong

et al.

Neuroscience Letters, Journal Year: 2022, Volume and Issue: 788, P. 136842 - 136842

Published: Aug. 19, 2022

Intracerebral hemorrhage (ICH) is a devastating condition with significant morbidity and mortality for which few effective treatments are clinically available. After ICH, iron overload within the perihaematomal region can induce lethal reactive oxygen species (ROS) production lipid peroxidation, contribute to secondary brain injury. An iron-dependent form of non-apoptotic cell death known as ferroptosis was recently identified. Ferroptosis plays an important role in ICH pathology. It characterized by accumulation iron-induced ROS, leads intracellular oxidative stress. Dexmedetomidine (DEX), α2-adrenergic agonist, widely used anesthesia, pain control, intensive care unit sedation. DEX has numerous beneficial activities, including anti-inflammatory, anti-oxidative, anti-cell activities. Here, we established mouse model using collagenase VII evaluated effect preventing ICH-induced Our study showed that administering reduced damage induced after regulating metabolism, amino acid metabolism peroxidation processes.

Language: Английский

Citations

11
Dexmedetomidine Improves Anxiety-like Behaviors in Sleep-Deprived Mice by Inhibiting the p38/MSK1/NFκB Pathway and Reducing Inflammation and Oxidative Stress DOI Creative Commons

Jiangjing Li,

Heming Zhang, Bin Deng

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(7), P. 1058 - 1058

Published: July 11, 2023

(1) Background: Sleep deprivation (SD) triggers a range of neuroinflammatory responses. Dexmedetomidine can improve sleep deprivation-induced anxiety by reducing response but the mechanism is unclear; (2) Methods: The model was established using an interference rod device. An open field test and elevated plus maze were used to detect emotional behavior mice. Mouse cortical tissues subjected RNA sequence (RNA-seq) analysis. Western blotting immunofluorescence expression p38/p-p38, MSK1/p-MSK1, NFκBp65/p- NFκBp65. Inflammatory cytokines detected enzyme-linked immunosorbent assay (ELISA); (3) Results: SD triggered anxiety-like behaviors in mice closely associated with inflammatory responses MAPK pathway (as demonstrated transcriptome analysis). led increased levels p-p38, p-MSK1, p-NFκB. P38 inhibitor SB203580 confirm important role p38/MSK1/NFκB SD-induced neuroinflammation. (Dex) effectively improves sleep-deprived attenuating oxidative stress cerebral cortex, mainly inhibiting activation pathway; (4) Conclusions: Dex inhibits pathway, thus cortex

Language: Английский

Citations

6
The Effects of Appropriate Perioperative Exercise on Perioperative Neurocognitive Disorders: a Narrative Review DOI Creative Commons
Hao Feng, Zheng Zhang,

Wenyuan Lyu

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(7), P. 4663 - 4676

Published: Dec. 19, 2023

Abstract Perioperative neurocognitive disorders (PNDs) are now considered the most common neurological complication in older adult patients undergoing surgical procedures. A significant increase exists incidence of post-operative disability and mortality with PNDs. However, no specific treatment is still available for Recent studies have shown that exercise may improve cognitive dysfunction-related disorders, including Neuroinflammation a key mechanism underlying exercise-induced neuroprotection PNDs; others include regulation gut microbiota mitochondrial synaptic function. Maintaining optimal skeletal muscle mass through preoperative important to prevent occurrence This review summarizes current clinical preclinical evidence proposes potential molecular mechanisms by which perioperative improves PNDs, providing new direction exploring exercise-mediated neuroprotective effects on In addition, it intends provide strategies prevention

Language: Английский

Citations

6