An Interpretable Deep Learning Optimized Wearable Daily Detection System for Parkinson’s Disease DOI Creative Commons
Min Chen,

Zhanfang Sun,

Xin Tao

et al.

IEEE Transactions on Neural Systems and Rehabilitation Engineering, Journal Year: 2023, Volume and Issue: 31, P. 3937 - 3946

Published: Jan. 1, 2023

Walking detection in the daily life of patients with Parkinson's disease (PD) is great significance for tracking progress disease. This study aims to implement an accurate, objective, and passive algorithm optimized based on interpretable deep learning architecture walking PD explore most representative spatiotemporal motor features. Five inertial measurement units attached wrist, ankle, waist are used collect motion data from 100 subjects during a 10-meter test. The raw each sensor subjected continuous wavelet transform train classification model constructed 6-channel convolutional neural network (CNN). results show that located at has best performance accuracy 98.01%±0.85% area under receiver operating characteristic curve (AUC) 0.9981±0.0017 ten-fold cross-validation. gradient-weighted class activation mapping shows feature points greater contribution were concentrated lower frequency band (0.5~3Hz) compared healthy controls. visual maps 3D CNN only three out six time series have contribution, which as basis further optimize input, greatly reducing processing costs (50%) while ensuring its (AUC=0.9929±0.0019). To our knowledge, this first consider interpretation-based optimization intelligent diagnosis PD.

Language: Английский

Emerging Potential of the Phosphodiesterase (PDE) Inhibitor Ibudilast for Neurodegenerative Diseases: An Update on Preclinical and Clinical Evidence DOI Creative Commons
Efthalia Angelopoulou, Efstratios‐Stylianos Pyrgelis, Christina Piperi

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(23), P. 8448 - 8448

Published: Dec. 2, 2022

Neurodegenerative diseases constitute a broad range of central nervous system disorders, characterized by neuronal degeneration. Alzheimer’s disease, Parkinson’s amyolotrophic lateral sclerosis (ALS), and progressive forms multiple (MS) are some the most frequent neurodegenerative diseases. Despite their diversity, these share common pathophysiological mechanisms: abnormal aggregation disease-related misfolded proteins, autophagosome–lysosome pathway dysregulation, impaired ubiquitin–proteasome system, oxidative damage, mitochondrial dysfunction excessive neuroinflammation. There is still no effective drug that could halt progression diseases, current treatments mainly symptomatic. In this regard, development novel multi-target pharmaceutical approaches presents an attractive therapeutic strategy. Ibudilast, anti-inflammatory firstly developed as asthma treatment, cyclic nucleotide phosphodiesterases (PDEs) inhibitor, which acts increasing amount adenosine monophosphate (cAMP) guanosine (cGMP), while downregulating pro-inflammatory factors, such tumor necrosis factor-α (TNF-α), macrophage migration inhibitory factor (MIF) Toll-like receptor 4 (TLR-4). The preclinical evidence shows ibudilast may act neuroprotectively in suppressing neuroinflammation, inhibiting apoptosis, regulating function affecting pathways, well attenuating stress. clinical trials ALS MS also show promising results. Herein, we aim to provide update on emerging potential discuss challenges suggest future directions.

Language: Английский

Citations

29
α-Synuclein and Mechanisms of Epigenetic Regulation DOI Creative Commons
Andrei Surguchov

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(1), P. 150 - 150

Published: Jan. 15, 2023

Synucleinopathies are a group of neurodegenerative diseases with common pathological lesions associated the excessive accumulation and abnormal intracellular deposition toxic species α-synuclein. The shared clinical features chronic progressive decline motor, cognitive, behavioral functions. These disorders include Parkinson's disease, dementia Lewy body, multiple system atrophy. Vigorous research in mechanisms pathology these illnesses is currently under way to find disease-modifying treatment molecular markers for early diagnosis. α-Synuclein prone-to-aggregate, small amyloidogenic protein roles synaptic vesicle trafficking, neurotransmitter release, signaling events. Its expression controlled by several mechanisms, one which epigenetic regulation. When transmitted nucleus, α-synuclein binds DNA histones participates regulatory functions controlling specific gene transcription. Here, we discuss various aspects involvement regulation health diseases.

Language: Английский

Citations

22
The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review DOI Open Access

Bombonica Gabriela Dogaru,

Constantin Munteanu

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12555 - 12555

Published: Aug. 8, 2023

This review explores the emerging role of hydrogen sulfide (H

Language: Английский

Citations

21
Effect Modification between Genes and Environment and Parkinson's Disease Risk DOI Creative Commons
María Teresa Periñán, Kajsa Brolin, Sara Bandrés‐Ciga

et al.

Annals of Neurology, Journal Year: 2022, Volume and Issue: 92(5), P. 715 - 724

Published: Aug. 1, 2022

Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and environmental factors interact to contribute its etiology. Remarkable progress has been made deciphering etiology through approaches, but there limited data about how modify penetrance, risk, severity. Here, we provide insights into modifiers of PD, discussing precedents from other neurological non‐neurological conditions. Based on these examples, outline contributing PD review potential penetrance clinical variability monogenic idiopathic PD. We also highlight the challenges propose future studies might tackle important questions. ANN NEUROL 2022;92:715–724

Language: Английский

Citations

26
The Role of miR-128 in Neurodegenerative Diseases DOI Open Access
Marika Lanza, Salvatore Cuzzocrea, Salvatore Oddo

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6024 - 6024

Published: March 23, 2023

Several neurodegenerative disorders are characterized by the accumulation of misfolded proteins and collectively known as proteinopathies. Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD) represent some most common whose steady increase in prevalence is having a major socio-economic impact on our society. Multiple laboratories have reported hundreds changes gene expression selective brain regions AD, PD, HD brains. While mechanisms underlying these remain an active area investigation, alterations noncoding RNAs, which HD, may account for In this review, we discuss role miR-128, highly expressed mammalian brains, HD. We highlight how miR-128 account, at least part, associated with Indeed, involved, among other things, regulation neuronal plasticity, cytoskeletal organization, death, events linked to various For example, reducing mouse model AD ameliorates cognitive deficits reduces neuropathology. Overall, data literature suggest that targeting might be beneficial mitigate behavioral phenotype diseases.

Language: Английский

Citations

13
Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease DOI Open Access
Érica Novaes Soares, Ana Carla dos Santos Costa,

Gabriel de Jesus Ferrolho

et al.

Published: Jan. 31, 2024

Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, postural instability, that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal losss and progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration, involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells specifically their pathology treatment.

Language: Английский

Citations

5
A Machine Learning Approach to Parkinson’s Disease Blood Transcriptomics DOI Open Access
Ester Pantaleo, A. Monaco, Nicola Amoroso

et al.

Genes, Journal Year: 2022, Volume and Issue: 13(5), P. 727 - 727

Published: April 21, 2022

The increased incidence and the significant health burden associated with Parkinson's disease (PD) have stimulated substantial research efforts towards identification of effective treatments diagnostic procedures. Despite technological advancements, a cure is still not available PD often diagnosed long time after onset when irreversible damage has already occurred. Blood transcriptomics represents potentially disruptive technology for early diagnosis PD. We used transcriptome data from PPMI study, large cohort study subjects age matched controls (HC), to perform classification vs. HC in around 550 samples. Using nested feature selection procedure based on Random Forests XGBoost we reached an AUC 72% found 493 candidate genes. further discussed importance selected genes through functional analysis GOs KEGG pathways.

Language: Английский

Citations

20
Uncovering the Molecular Link Between Lead Toxicity and Parkinson's Disease DOI
Liana Shvachiy, Vera Geraldes, Tiago F. Outeiro

et al.

Antioxidants and Redox Signaling, Journal Year: 2023, Volume and Issue: 39(4-6), P. 321 - 335

Published: Jan. 15, 2023

Significance: Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects millions around the world. The etiology of PD remains unknown, but environmental and occupational exposures to heavy metals are likely at play, may impact severity disease. Lead toxin known affect many organs in body throughout life, particularly central nervous system.

Language: Английский

Citations

11
Epigenome‐wide association study, meta‐analysis, and multiscore profiling of whole blood in Parkinson's disease DOI Creative Commons

Ingeborg Haugesag Lie,

Manuela Tan,

Maren Stolp Andersen

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility such changes are largely unexplored. We aimed to further elucidate role dysregulated disease evaluate biomarker potential methylation-based profiling. conducted an epigenome-wide association study (EWAS) whole blood, including 280 279 control participants from Oslo, Norway. Next, we took advantage data Progression Markers Initiative (PPMI) a previously published EWAS conduct blood meta-analysis incorporating results total 3068 participants. Finally, generated multiple scores for each Oslo PPMI participant tested their with status, individually joint multiscore model. In meta-analysis, confirm SLC7A11 hypermethylation nominate novel differentially methylated CpG near LPIN1. A model polygenic risk estimates epigenetic risk, smoking, leukocyte proportions differentiated patients area under receiver-operator curve 0.82 cohort 0.65 PPMI. Our highlight power profiling capture aspects indicating precision medicine neurodegenerative disorders. The specific CpGs across sets was limited but may improve if future studies designed account stage incorporate environmental exposure data.

Language: Английский

Citations

0
Mechanism of arsenic regulation of mitochondrial damage and autophagy induced synaptic damage through SIRT1 and protective effect of melatonin DOI
Xiaoli Zhang, Jing Wang, Mingjie Zhu

et al.

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111461 - 111461

Published: March 1, 2025

Language: Английский

Citations

0