Molecular patterns of neurodegeneration in coronavirus infection caused by SARS-CoV-2 DOI Open Access
А. О. Михайлов, Н. Г. Плехова, S. A. Sokotun

et al.

Epidemiology and Infectious Diseases, Journal Year: 2023, Volume and Issue: 28(3), P. 149 - 158

Published: June 15, 2023

BACKGROUND: The reports on the neurological and psychiatric consequences of coronavirus infection are particular relevance owing to their limited availability. molecular patterns nerve tissue damage an important task for understanding underlying mechanisms neurodegeneration. AIM: To study dynamics changes in content markers neurodegeneration neuroplasticity patients with acute long-term periods. MATERIALS AND METHODS: A total 200 aged 5183 years were assessed categorized into two age groups: 5165 6683 years. levels determined blood serum: neurofilament heavy chains (NEFH), S100 A6 protein, B -amyloid 1-42 (A1-42), microfilament associated tau protein (MAPt), serum amyloid P (SAP), neuroplasticity: neurotrophin 3 (NT3), 4 (NT4). was performed thrice period disease at time admission hospital 6 12 months after discharge. RESULTS: In first group patients, infection, women showed higher concentrations (3.20.2), (0.40.06), NT3 (1.10.1), MAPt (0.130.02), while values men NEFH (0.150.03), A1-42 (2.10.1), SAP (4.50.06). long-term, a general tendency long persistence high neuroprotection noted young compared women, indicating rehabilitation. After months, level calcium-binding proteins 1.50.2 pg/mL 0.30.04 ng/mL, which 1.10.1 0.20.04 respectively, women. during 4.30.1 versus 3.90.2 ng/mL significant difference. Analyses results second indicated B, NT3, SAP. CONCLUSION: both late periods active processes different groups, manifested as result increase concentration specific serum.

Language: Английский

UV 254 nm is more efficient than UV 222 nm in inactivating SARS-CoV-2 present in human saliva DOI
Renata Sesti‐Costa, Cyro von Zuben de Valega Negrão, Jacqueline Farinha Shimizu

et al.

Photodiagnosis and Photodynamic Therapy, Journal Year: 2022, Volume and Issue: 39, P. 103015 - 103015

Published: July 14, 2022

Language: Английский

Citations

21
COVID and nervous system: Mechanisms and consequences DOI
Federica Monaco, Marco Cascella

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 413 - 435

Published: Jan. 1, 2025

Language: Английский

Citations

0
Neuroimmunological Effect of Vitamin D on Neuropsychiatric Long COVID Syndrome: A Review DOI Open Access
Ting‐Bin Chen, Ching‐Mao Chang, Cheng‐Chia Yang

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3802 - 3802

Published: Aug. 30, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of disease 2019 (COVID-19). COVID-19 now recognized as a multiorgan with broad spectrum manifestations. A substantial proportion individuals who have recovered from are experiencing persistent, prolonged, and often incapacitating sequelae, collectively referred to long COVID. To date, definitive diagnostic criteria for COVID diagnosis remain elusive. An emerging public health threat neuropsychiatric COVID, encompassing range manifestations, such sleep disturbance, anxiety, depression, brain fog, fatigue. Although precise mechanisms underlying complications presently not fully elucidated, neural cytolytic effects, neuroinflammation, cerebral microvascular compromise, breakdown blood–brain barrier (BBB), thrombosis, hypoxia, neurotransmitter dysregulation, provoked neurodegeneration pathophysiologically linked long-term consequences, in addition systemic hyperinflammation maladaptation renin–angiotensin–aldosterone system. Vitamin D, fat-soluble secosteroid, potent immunomodulatory hormone potential beneficial effects on anti-inflammatory responses, neuroprotection, monoamine neurotransmission, BBB integrity, vasculometabolic functions, gut microbiota, telomere stability different phases SARS-CoV-2 infection, acting through both genomic nongenomic pathways. Here, we provide an up-to-date review pathophysiology plausible neurological contributions vitamin D mitigating

Language: Английский

Citations

10
Antidepressants with anti-inflammatory properties may be useful in long COVID depression DOI Open Access

Caroline Fenton,

Arnold Lee

Drugs & Therapy Perspectives, Journal Year: 2022, Volume and Issue: 39(2), P. 65 - 70

Published: Dec. 12, 2022

Language: Английский

Citations

15
Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases DOI Creative Commons
Walther Bild, Alexandru Vasincu, Răzvan-Nicolae Rusu

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(10), P. 1429 - 1429

Published: Oct. 6, 2022

Brain neurodegenerative diseases (BND) are debilitating conditions that especially characteristic of a certain period life and considered major threats to human health. Current treatments limited, meaning there is challenge in developing new options can efficiently tackle the different components pathophysiological processes these conditions. The renin-angiotensin-aldosterone system (RAS) an endocrine axis with important peripheral physiological functions such as blood pressure cardiovascular homeostasis, well water sodium balance systemic vascular resistance—functions which well-documented. However, recent work has highlighted paracrine autocrine RAS tissues, including central nervous (CNS). It known hyperactivation pro-inflammatory pro-oxidant effects, thus suggesting its pharmacological modulation could be used management present paper underlines involvement pathophysiology BNDs Parkinson’s disease (PD), Alzheimer’s (AD), multiple sclerosis (MS), Huntington’s (HD), motor neuron (MND), prion (PRD), identification drugs pharmacologically active substances act upon RAS, alleviate their symptomatology or evolution, thus, contribute novel therapeutic approaches.

Language: Английский

Citations

14
Shared miRNA landscapes of COVID-19 and neurodegeneration confirm neuroinflammation as an important overlapping feature DOI Creative Commons
Sara Redenšek, David Vogrinc, Katja Goričar

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: March 17, 2023

Introduction Development and worsening of most common neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s multiple sclerosis, have been associated with COVID-19 However, the mechanisms neurological symptoms in patients sequelae are not clear. The interplay between gene expression metabolite production CNS is driven by miRNAs. These small non-coding molecules dysregulated diseases COVID-19. Methods We performed a thorough literature screening database mining to search for shared miRNA landscapes SARS-CoV-2 infection neurodegeneration. Differentially expressed miRNAs were searched using PubMed, while differentially five (Alzheimer’s Huntington’s amyotrophic lateral sclerosis) Human microRNA Disease Database. Target genes overlapping miRNAs, identified miRTarBase, used pathway enrichment analysis Kyoto Encyclopedia Genes Genomes Reactome. Results In total, 98 found. Additionally, two them (hsa-miR-34a hsa-miR-132) highlighted promising biomarkers neurodegeneration, they all hsa-miR-155 was upregulated four studies found be neurodegeneration processes well. Screening targets 746 unique strong evidence interaction. significant KEGG Reactome pathways being involved signaling, cancer, transcription infection. more specific confirmed neuroinflammation important feature. Discussion Our based approach has that may valuable potential prediction patients. can further explored drug or agents modify signaling pathways. Graphical Abstract Shared among investigated identified. hsa-miR-34a has-miR-132, present after Furthermore, together A analyses on list target finally top 20 evaluated their identification new targets. feature neuroinflammation. AD, disease; ALS, sclerosis; COVID-19, coronavirus disease 2019; HD, KEGG, Genomes; MS, PD, disease.

Language: Английский

Citations

6
Oxidative stress and COVID-19-associated neuronal dysfunction: mechanisms and therapeutic implications DOI Creative Commons
Dylan Bowen, Suhrud Pathak,

Rishi Nadar

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2023, Volume and Issue: 55(8), P. 1153 - 1167

Published: April 28, 2023

Severe acute respiratory syndrome (SARS)-CoV-2 virus causes novel coronavirus disease 2019 (COVID-19), and there is a possible role for oxidative stress in the pathophysiology of neurological diseases associated with COVID-19. Excessive could be responsible thrombosis other neuronal dysfunctions observed This review discusses SARS-CoV-2 mechanisms involved. Furthermore, various therapeutics implicated treating COVID-19 that contributes to etiology pathogenesis COVID-19-induced dysfunction are discussed. Further mechanistic clinical research combat warranted understand exact mechanisms, its true effects need investigated minimize complications from

Language: Английский

Citations

6
Ebbing Strength, Fading Power: Unveiling the Impact of Persistent Fatigue on Muscle Performance in COVID-19 Survivors DOI Creative Commons
Mateusz Kowal, Ewa Morgiel, Sławomir Winiarski

et al.

Sensors, Journal Year: 2024, Volume and Issue: 24(4), P. 1250 - 1250

Published: Feb. 15, 2024

The total number of confirmed cases COVID-19 caused by SARS-CoV-2 virus infection is over 621 million. Post-COVID-19 syndrome, also known as long COVID or long-haul COVID, refers to a persistent condition where individuals experience symptoms and health issues after the acute phase COVID-19. aim this study was assess strength fatigue skeletal muscles in people recovered from A 94 took part cross-sectional study, with 45 participants (referred Post-COVID Cohort, PCC) 49 healthy age-matched volunteers (Healthy Control HCC). This research article uses direct dynamometry method provide detailed analysis post-COVID survivors’ power characteristics. Biodex System 4 Pro utilized evaluate muscle characteristics during test. work extensors flexors significantly higher PCC. PCC showed less both compared HCC. In conclusion, provides compelling evidence impact post-COVID-19 on performance, highlighting importance considering these effects rehabilitation care recovering virus. achieved lower values than

Language: Английский

Citations

0
Histomorphological Aspects of SARS-CoV-2-Induced Hippocampal Damage: A Case Series DOI Open Access
George S Stoyanov,

Lilyana Petkova,

Emran Lyutfi

et al.

Biomedical Reviews, Journal Year: 2023, Volume and Issue: 34(0), P. 81 - 81

Published: Dec. 31, 2023

The direct healthcare side effects of the coronavirus disease identified in 2019 (COVID-19) caused by severe acute respira-tory syndrome 2 (SARS-CoV-2) are immeasurable. Furthermore, chronic sequels yet to be adequately studied and evaluated context post-infectious specter, referred as a post-COVID syndrome. One most commonly reported such sequel is so-called "brain fog" – loss concentration, learning difficulties, confu-sion. Herein, we analyzed series 50 autopsies RT-PCR-proven COVID-19. Central nervous system (CNS) samples were obtained 49 cases, with dentate gyrus acquired 9 them. Histopathological spectrums hippocampal changes included vascular, degenerative, apoptotic, necrotic on H&E stains varying severity. diffuse nature vascular changes, together epitheliotropic especially endotheliotropic SARS-CoV-2, would suggest that CNS damage both hypoxic vasculotropic. Infected endothelial cells bulge desquamate (necrosis), disrupting blood-brain barrier secondary neurons permeating plasma substances.

Language: Английский

Citations

1
COVID-19-Associated Encephalopathy (COVEP): Basic Aspects of Neuropathology DOI Creative Commons
George S Stoyanov, Dimo Stoyanov, Martin Ivanov

et al.

Encyclopedia, Journal Year: 2022, Volume and Issue: 2(4), P. 1773 - 1789

Published: Oct. 27, 2022

SARS-CoV-2, a member of the betacoronavirus group and causative agent COVID-19, is virus affecting multiple systems, not only respiratory. One systems affected by central nervous system, with neuropathological studies reporting wide set morphological phenomena—neuroinflammation, vascular blood-brain barrier alterations, neurodegeneration, accelerated aging, while contradicting data present on direct neuroinvasive potential active viral replication within neurons. The depicted changes, other than an acute effect (which may contribute to death patient) also have chronic sequelae in context post-COVID syndrome cognitive impediments, sleep, mood disorders. following chapter describe basic aspects SARS-CoV-2 as based evidence scientific literature propose term COVEP—COVID-associated encephalopathy—to unite undisputed effects infection system morphology function.

Language: Английский

Citations

2