Exosomes in Reperfusion Injuries: Role in Pathophysiology and Perspectives as Treatment DOI Creative Commons
Maritza G. Verdugo-Molinares,

Marco Ku-Centurion,

Zesergio Melo

et al.

IntechOpen eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 23, 2023

This chapter focuses on the emerging field of exosomes in context reperfusion injuries. Exosomes, nano extracellular vesicles with diverse cargo, play a crucial role cell-to-cell communication. Exosome quantity and content changes have been implicated various pathologies, including kidney, brain, heart, liver ischemia-reperfusion injury. Particularly, derived from mesenchymal stem cells (MSCs) shown promising potential as treatment approach. aims to provide comprehensive understanding exosome biogenesis, organ-specific injury pathophysiology, advantages prospects exosome-based treatments. By exploring multifaceted aspects injuries, this will contribute advancement knowledge field.

Language: Английский

Human umbilical cord mesenchymal stem cell-derived exosomes provide neuroprotection in traumatic brain injury through the lncRNA TUBB6/Nrf2 pathway DOI
Li Zhang,

Wanshan Bai,

Yaonan Peng

et al.

Brain Research, Journal Year: 2023, Volume and Issue: 1824, P. 148689 - 148689

Published: Nov. 27, 2023

Language: Английский

Citations

13
Correlation Between Exosomes and Neuro-inflammation in Various Brain Disorders DOI
Prashant Kumar, Himanshu Sharma,

Abhishek Singh

et al.

Published: Jan. 1, 2024

One of the main causes death and disability worldwide is brain neurological disorder/disease. According to total DALYs (disability-adjusted life years), burden illnesses will continue rise. The prevalence condition rising with age as population ages grows, placing a significant financial strain on government agencies that provide assistance, treatment, rehabilitation. prevention diseases therapeutic approaches are therefore subject extensive research. In this book chapter, exosomes defined membrane-bound nanovesicles (30–100 nm) endosomal origins contain mRNAs, proteins, lipids. Within body, they take part in intricate intercellular communication system. They expelled from many cell types healthy or setting, by transporting active signals, influence activity receiving cells. addition serving potential drug delivery systems, also serve molecular payloads, novel messengers, coordinators complex regenerative processes, surface biomarkers for detection numerous chronic disorders. Exosomes have low immunogenicity, long biological half-life, ability pass blood–brain barrier. can be both beneficial detrimental treatment impact central nervous system, such traumatic encephalopathy, Alzheimer's disease, Parkinson's stroke, prion disease. Neuro-inflammation associated proinflammatory cytokines, T B lymphocytes, β-amyloid peptides 1–42, tau protein, well neuronal damage aberrant protein aggregation. There growing evidence peripheral system (PNS) (CNS) communicate. Extracellular vehicles (EVs), which regarded state-of-the-art information transport produced almost all Proteins, lipids, nucleic acids, range other bioactive regulators present transported EVs. Additionally, it has been established EVs mediating role between systems due their cross barrier (BBB). Along carrying molecules either sick state, exceptional promise targeted administration medications. mechanisms behind EV migration, connections contrasting immune interactions organs during CNS disorders neurodegenerative diseases, strokes, trauma explored chapter. Involvement function creation novel, minimally intrusive techniques, discussed.

Language: Английский

Citations

5
mTOR pathway – a potential therapeutic target in stroke DOI Creative Commons

Konstantinos Melanis,

Maria‐Ioanna Stefanou,

Konstantinos M. Themistoklis

et al.

Therapeutic Advances in Neurological Disorders, Journal Year: 2023, Volume and Issue: 16

Published: Jan. 1, 2023

Stroke is ranked as the second leading cause of death worldwide and a major long-term disability. A potential therapeutic target that could offer favorable outcomes in stroke mammalian rapamycin (mTOR) pathway. mTOR serine/threonine kinase composes two protein complexes, complex 1 (mTORC1) 2 (mTORC2), regulated by other proteins such tuberous sclerosis complex. Through significant number signaling pathways, pathway can modulate processes post-ischemic inflammation autophagy, both which play an integral part pathophysiological cascade stroke. Promoting or inhibiting under ischemic conditions lead to apoptosis instead sustained viability neurons. The purpose this review examine role acute stroke, while highlighting promising neuroprotective agents hamartin for modulation also discussed, with emphasis on implicated molecules steps warrant further elucidation order their properties be efficiently tested future clinical trials.

Language: Английский

Citations

12
Targeting Non-Coding RNA for CNS Injuries: Regulation of Blood-Brain Barrier Functions DOI
Li Zhang,

Wanshan Bai,

Lean Sun

et al.

Neurochemical Research, Journal Year: 2023, Volume and Issue: 48(7), P. 1997 - 2016

Published: Feb. 14, 2023

Language: Английский

Citations

11
Drug delivery based exosomes uptake pathways DOI
Moataz Dowaidar

Neurochemistry International, Journal Year: 2024, Volume and Issue: 179, P. 105835 - 105835

Published: Aug. 13, 2024

Language: Английский

Citations

4
Preserving Blood–Brain Barrier Integrity in Ischemic Stroke: a Review on MSCs-sEVs Content and Potential Molecular Targets DOI

David Arturo Lozano-López,

Luis Daniel Hernández‐Ortega, Lorenza González‐Mariscal

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Language: Английский

Citations

0
mir-330-5p from mesenchymal stem cell-derived exosomes targets SETD7 to reduce inflammation in rats with cerebral ischemia-reperfusion injury DOI
Wentao Liu, Yan Shen, Rongfang Pan

et al.

Journal of Molecular Histology, Journal Year: 2024, Volume and Issue: 56(1)

Published: Dec. 31, 2024

Language: Английский

Citations

0
Cerebral edema and cognitive dysfunction: pathophysiological interconnections in diabetic ketoacidosis in childhood DOI Open Access
Yuri V. Bykov

Pediatrician (St Petersburg), Journal Year: 2024, Volume and Issue: 15(4), P. 63 - 71

Published: Dec. 30, 2024

Diabetic ketoacidosis is one of the most common complications in children suffering from diabetes mellitus, a complication that may cause cerebral edema. After diabetic episode, some develop cognitive impairment, which could be linked to subclinical or clinical grade An analysis scientific literature has shown pathophysiological mechanisms development dysfunction with ketoacidosis-associated edema have not been fully elucidated. The key pathogenetic hypotheses under consideration include hypoxia, hypoperfusion and reperfusion, release vasoactive substances induction inflammation, acute hyperglycemia oxidative stress. Hypoxia leads hypoxic-ischaemic injury brain, affecting, among others, areas responsible for memory formation. Cerebral reperfusion trigger mitochondrial stress, worsens impairment patients Release inflammation impair functioning blood-brain barrier lead vasospasm. Acute hypoglycemia triggers brain tissue acidosis accumulation lactate glutamate, aggravating dysfunction. Oxidative stress causes neuronal damage, exacerbating manifestations described here setting either as individual collectively through synergistic effect. Further research needed expand knowledge interconnections between after episode.

Language: Английский

Citations

0
Exosomes in Reperfusion Injuries: Role in Pathophysiology and Perspectives as Treatment DOI Creative Commons
Maritza G. Verdugo-Molinares,

Marco Ku-Centurion,

Zesergio Melo

et al.

IntechOpen eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 23, 2023

This chapter focuses on the emerging field of exosomes in context reperfusion injuries. Exosomes, nano extracellular vesicles with diverse cargo, play a crucial role cell-to-cell communication. Exosome quantity and content changes have been implicated various pathologies, including kidney, brain, heart, liver ischemia-reperfusion injury. Particularly, derived from mesenchymal stem cells (MSCs) shown promising potential as treatment approach. aims to provide comprehensive understanding exosome biogenesis, organ-specific injury pathophysiology, advantages prospects exosome-based treatments. By exploring multifaceted aspects injuries, this will contribute advancement knowledge field.

Language: Английский

Citations

0