LncRNA-mir3471-limd1 regulatory network plays critical roles in HIBD DOI Creative Commons
Li Sun, Jun Wan, Bin Sun

et al.

Experimental Brain Research, Journal Year: 2023, Volume and Issue: 242(2), P. 443 - 449

Published: Dec. 26, 2023

Abstract The purpose of this study was to identify the target genes tcon_00044595, elucidate its activation site, and provide novel insights into pathogenesis treatment neonatal hypoxic–ischemic brain damage (HIBD). Through homologous blast analysis, we identified predicted sequences in neighboring regions long non-coding RNA (lncRNA) suggesting that limd1 is gene. Starbase utilized potential candidate microRNAs associated with lncRNA. interaction between investigated validated using various experimental methods including vitro cell culture, transfection, dual fluorescence reporter detection system, real-time PCR. Homology alignment analysis revealed lncRNA tcon_00044595 exhibited a 246 bp sequence at 3' end adjacent gene, conservation rate 68%. Analysis conducted on online three microRNA candidates: miR-3471, miR-883a-5p, miR-214-3p. Intracellular expression gene significantly down-regulated upon transfection while other two did not produce noticeable effects. Luciferase assays sites (UTR-1, UTR-2) miR-3471 3ʹUTR, UTR-1 exhibiting strong influence. Further CCK8 assay indicated protective role during low oxygen stroke HIBD. regulatory relationship (tcon_00044595), suggests their involvement occurrence development HIBD, providing new for investigating underlying mechanisms exploring targeted therapeutic approaches

Language: Английский

The Association of Redox Regulatory Drug Target Genes with Psychiatric Disorders: A Mendelian Randomization Study DOI Creative Commons
Zhe Lu, Yang Yang, Guorui Zhao

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 398 - 398

Published: March 27, 2024

Redox regulatory drug (RRD) targets may be considered potential novel of psychosis due to the fact that brain is highly susceptible oxidative stress imbalance. The aim present study identify associations between RRD targets’ perturbation and risk psychoses; achieve this, Mendelian randomization analyses were conducted. expression quantitative trait loci (eQTL) protein QTL data used derive genetic instrumental variables. We obtained latest summary genome-wide association studies on seven psychoses as outcomes, including schizophrenia (SCZ), bipolar disorder (BD), major depressive (MDD), attention-deficit/hyperactivity disorder, autism, obsessive–compulsive anorexia nervosa. In total, 95 unique included in eQTL panel, 48 pQTL one. Genetic variations vitamin C target (OGFOD2, OR = 0.784, p 2.14 × 10−7) melatonin (RORB, 1.263, 8.80 10−9) significantly related SCZ. variation E (PRKCB, 0.248, 1.24 10−5) was an increased BD. (P4HTM: cerebellum, 1.071, 4.64 10−7; cerebellar hemisphere, 1.092, 1.98 10−6) MDD. Cognitive function mediated effects causal associations. conclusion, this provides supportive evidence for a SCZ, BD or MDD, which partially by cognition.

Language: Английский

Citations

7
Sleep quality mediates the association between chronotype and mental health in young Indian adults DOI Creative Commons
Satyam Chauhan, Rakesh Pandey, Krupa Vakani

et al.

npj Mental Health Research, Journal Year: 2024, Volume and Issue: 3(1)

Published: June 24, 2024

Abstract There is increasing recognition of ‘higher preference for eveningness’ as a potential independent risk factor poor mental health. To examine the chronotype-mental health relationship while also quantifying roles sleep quality, relevant personality traits, and childhood trauma, we assessed 282 young adults (18–40 years; 195 females) residing in North India, between January March 2023 (to control seasonal variation), using self-report measures diurnal preference, patterns, (depression, anxiety, stress), traits (extraversion, neuroticism, schizotypy, impulsivity), trauma. The results showed significant association eveningness but this was fully mediated by quality. Neuroticism, emotional abuse cognitive disorganisation were correlated with well Neuroticism abuse, not disorganisation, had indirect effects on via Our findings highlight crucial role played quality relationship.

Language: Английский

Citations

3
The brain in chronic insomnia and anxiety disorder: a combined structural and functional fMRI study DOI Creative Commons

Minghe Xu,

Bo Li, Shuang Wang

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: June 4, 2024

Background Chronic insomnia disorder (CID) is usually associated with Generalized Anxiety Disorder (GAD), which may change brain structure and function. However, the possible markers, imaging characteristics, pathophysiology are unknown. Objective To look at probable pathogenesis of CID in combination GAD. Methods A total 57 patients concomitant GAD healthy controls (HC) were enrolled. Voxel-based morphometry (VBM) functional connectivity (FC) utilized to measure gray matter volume (GMV) changes. Correlation analysis was identify relationships between changes clinical characteristics. Results Patients had decreased GMV left cerebellum, right cerebellar peduncle, insula; increased FC cerebellum angular gyrus, as well insula anterior cingulate gyrus; several areas, including middle gyrus superior postcentral gyrus. These related data could be used relevant features, better understand etiology. Conclusion The intensity strongly severity anxiety. lower interpreted an characteristic CID. Reduced insula, aberrant function prefrontal lobe, contribute Abnormal patients’ complaints.

Language: Английский

Citations

2
Case report: A case of anti-recoverin antibody-positive encephalitis exhibiting Cotard and Capgras delusions that was successfully treated with electroconvulsive therapy DOI Creative Commons

Takaki Akahane,

N. Takahashi, Ryota Kobayashi

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 25, 2024

Recoverin is a neuron-specific calcium-binding protein that mainly located in the retina and pineal gland. Few reports have described patients with anti-recoverin antibody-positive encephalitis, no cases of psychosis associated this encephalitis been reported. We report patient Cotard Capgras delusions who was successfully treated electroconvulsive therapy (ECT). The 25-year-old woman. She exhibited disorientation, executive function deficits, tremors upper limbs, generalized athetoid-like involuntary movements, hallucinations, incontinence, fever, which led to her admission our hospital. Upon admission, she complained delusions. Various diagnostic tests, including cerebrospinal fluid analysis, antibody screening, brain imaging, were unremarkable, except for positivity serum antibodies, non-specific general slowing on electroencephalography decreased regional cerebral blood flow (rCBF) frontal occipital lobes, increased rCBF basal ganglia pons single-photon emission computed tomography. eventually diagnosed positive antibodies immunoglobulins steroids. Her neurological symptoms improved temporarily, but three months later, psychiatric symptoms, i.e., suicidal thoughts delusions, exaggerated. After ECT, condition significantly improved. In conclusion, present suggests gland dysfunction due or its cross-reactivity proteins may contribute neuropsychiatric observed ECT can be viable treatment option if immunotherapy proves ineffective. Additionally, prefrontal cortex clinical features

Language: Английский

Citations

1
Bases celulares y moleculares de la cronopatología en la enfermedad de Alzheimer DOI Creative Commons
Bettsy Bell Bosch Rodríguez, Marbelys Guevara Rodríguez

eNeurobiología, Journal Year: 2024, Volume and Issue: 15(37)

Published: April 19, 2024

Los relojes biológicos son osciladores anticipatorios autónomos que desempeñan un papel fundamental en la organización y procesamiento de información desde el genoma hasta desarrollo los organismos completos. Esta compleja jerárquica determina alteración crónica ritmos circadianos sea factor riesgo importante para una variedad enfermedades, incluyendo las patologías neurodegenerativas. La enfermedad Alzheimer (EA) representa trastorno neurodegenerativo más prevalente nuestra sociedad actual, durante mucho tiempo ha sido asociado con alteraciones (ciclos sueño/ vigilia, variaciones amplitud del ciclo liberación melatonina, cortisol, glucosa e insulina), así como perturbaciones ultradianos (diferentes fases sueño). El estudio cronopatología EA orientado busca relación bidireccional, puede comportarse bien causa o consecuencia, lo permitido revelar nuevas dianas terapéuticas capaces retrasar progresión esta enfermedad. objetivo este artículo consiste describir, a través revisión integral literatura médica, trastornos enfocada aportar bases fisiopatológicas ratificar correlación bidireccional existente.

Citations

1
Turn off that night light! Light-at-night as a stressor for adolescents DOI Creative Commons

Grace E. Guindon,

Cloey A. Murphy,

Maria E. Milano

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 31, 2024

Light-at-night is known to produce a wide variety of behavioral outcomes including promoting anxiety, depression, hyperactivity, abnormal sociability, and learning memory deficits. Unfortunately, we all live in 24-h society where people are exposed light-at-night or light pollution through night-shift work - the need for all-hours emergency services as well building street-lights, making exposure practically unavoidable. Additionally, increase screentime (tvs smart devices) during night also contributes poorer sleep impairments. Compounding these factors fact that adolescents tend be "night owls" prefer an evening chronotype compared younger children adults, so teenagers will have higher likelihood being light-at-night. Making matters worse prevalence high-school start times 8 am earlier combination too early school times, night, preference chronotypes recipe reduced sleep, which can contribute increased susceptibility issues this population. As such, mini-review show, using both human rodent model studies, how affects stress responses, connecting photic signaling circadian timing system hypothalamic-pituitary adrenal axis. review demonstrate more likely exhibit behavior response due changes development hormone regulation time period, discuss potential interventions help mitigate negative effects.

Language: Английский

Citations

1
Sleep Matters in Chronotype and Mental Health Association: Evidence from the UK and Germany DOI Creative Commons
Satyam Chauhan, Kaja Faßbender, Rakesh Pandey

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(10), P. 1020 - 1020

Published: Oct. 14, 2024

There is considerable evidence supporting the elevated risk of mental health problems in individuals with evening chronotype relative to those morning or intermediate chronotypes. Recent data, however, suggest that this may be explained, at least partially, by poor sleep quality.

Language: Английский

Citations

1
Pineal cyst in bipolar patient with normolithiaemia and positive fibromyalgic tender points DOI
Salvatore Marrone,

Antonio Alessandro Biancardino,

Evier Andrea Giovannini

et al.

Radiology Case Reports, Journal Year: 2024, Volume and Issue: 20(3), P. 1317 - 1322

Published: Dec. 12, 2024

Language: Английский

Citations

0
LncRNA-mir3471-limd1 regulatory network plays critical roles in HIBD DOI Creative Commons
Li Sun, Jun Wan, Bin Sun

et al.

Experimental Brain Research, Journal Year: 2023, Volume and Issue: 242(2), P. 443 - 449

Published: Dec. 26, 2023

Abstract The purpose of this study was to identify the target genes tcon_00044595, elucidate its activation site, and provide novel insights into pathogenesis treatment neonatal hypoxic–ischemic brain damage (HIBD). Through homologous blast analysis, we identified predicted sequences in neighboring regions long non-coding RNA (lncRNA) suggesting that limd1 is gene. Starbase utilized potential candidate microRNAs associated with lncRNA. interaction between investigated validated using various experimental methods including vitro cell culture, transfection, dual fluorescence reporter detection system, real-time PCR. Homology alignment analysis revealed lncRNA tcon_00044595 exhibited a 246 bp sequence at 3' end adjacent gene, conservation rate 68%. Analysis conducted on online three microRNA candidates: miR-3471, miR-883a-5p, miR-214-3p. Intracellular expression gene significantly down-regulated upon transfection while other two did not produce noticeable effects. Luciferase assays sites (UTR-1, UTR-2) miR-3471 3ʹUTR, UTR-1 exhibiting strong influence. Further CCK8 assay indicated protective role during low oxygen stroke HIBD. regulatory relationship (tcon_00044595), suggests their involvement occurrence development HIBD, providing new for investigating underlying mechanisms exploring targeted therapeutic approaches

Language: Английский

Citations

0