In severe first episode major depressive disorder, psychosomatic, chronic fatigue syndrome, and fibromyalgia symptoms are driven by immune activation and increased immune-associated neurotoxicity DOI Creative Commons
Michaël Maes, Abbas F. Almulla, Bo Zhou

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 9, 2023

Abstract Background Major depressive disorder (MDD) is accompanied by activated neuro-immune pathways, increased physiosomatic and chronic fatigue-fibromyalgia (FF) symptoms. The most severe MDD phenotype, namely major dysmood (MDMD), associated with adverse childhood experiences (ACEs) negative life events (NLEs) which induce cytokines/chemokines/growth factors. Aims To delineate the impact of ACE+NLEs on FF symptoms in first episode (FE)-MDMD, examine whether these effects are mediated immune profiles. Methods ACEs, NLEs, symptoms, 48 factors were measured 64 FE-MDMD patients 32 normal controls. Results Physiosomatic, gastro-intestinal belong to same factor as depression, anxiety, melancholia, insomnia. extracted from seven domains labeled physio-affective phenome depression. A part (59.0%) variance explained independent interleukin (IL)-16 IL-8 (positively), CCL3 IL-1 receptor antagonist (inversely correlated). (46.5%) (IL)-16, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) (positively) combined activities immunoregulatory cytokines associated). Partial Least Squares analysis shows that exert a substantial influence partly an network composed IL-16, CCL27, TRAIL, macrophage-colony stimulating factor, stem cell growth factor. Conclusions caused immune-associated neurotoxicity due T helper (Th)-1 polarization, Th-1, M1 macrophage activation relative lowered compensatory protection.

Language: Английский

Immune activation and immune-associated neurotoxicity in Long-COVID: A systematic review and meta-analysis of 103 studies comprising 58 cytokines/chemokines/growth factors DOI
Abbas F. Almulla,

Yanin Thipakorn,

Bo Zhou

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 122, P. 75 - 94

Published: Aug. 9, 2024

Language: Английский

Citations

7
In major dysmood disorder, physiosomatic, chronic fatigue and fibromyalgia symptoms are driven by immune activation and increased immune-associated neurotoxicity DOI Creative Commons
Michaël Maes, Abbas F. Almulla, Bo Zhou

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 28, 2024

Abstract Major depressive disorder (MDD) is accompanied by activated neuro-immune pathways, increased physiosomatic and chronic fatigue-fibromyalgia (FF) symptoms. The most severe MDD phenotype, namely major dysmood (MDMD), associated with adverse childhood experiences (ACEs) negative life events (NLEs) which induce cytokines/chemokines/growth factors. To delineate the impact of ACE + NLEs on FF symptoms in first episode (FE)-MDMD, examine whether these effects are mediated immune profiles. ACEs, NLEs, symptoms, 48 factors were measured 64 FE-MDMD patients 32 normal controls. Physiosomatic, gastro-intestinal belong to same factor as depression, anxiety, melancholia, insomnia. extracted from seven domains labeled physio-affective phenome depression. A part (59.0%) variance explained independent interleukin (IL)-16 IL-8 (positively), CCL3 IL-1 receptor antagonist (inversely correlated). (46.5%) (IL)-16, TNF-related apoptosis-inducing ligand (TRAIL) (positively) combined activities immunoregulatory cytokines associated). Partial least squares analysis shows that exert a substantial influence partly an network composed interleukin-16, CCL27, TRAIL, macrophage-colony stimulating factor, stem cell growth factor. caused immune-associated neurotoxicity due T helper (Th)-1 polarization M1 macrophage activation relative lowered compensatory protection.

Language: Английский

Citations

5
Autoimmune responses to myelin-associated proteins as diagnostic and prognostic biomarkers of relapsing-remitting multiple sclerosis: Associations with human herpesvirus-6 and Epstein-Barr virus reactivation DOI Creative Commons
Aristo Vojdani, Abbas F. Almulla, Elroy Vojdani

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

The pathogenesis of relapsing-remitting multiple sclerosis (RRMS) is linked to autoimmune attacks against myelin proteins, and reactivation Epstein-Barr virus (EBV) human herpesvirus 6 (HHV-6). However, the connection between viral biomarkers has remained unclear. To investigate immunoglobulin (Ig)G/IgA/IgM responses targeting myelin-related proteins in association with EBV HHV-6 replication markers RRMS. We recruited 55 patients RRMS 63 healthy controls assessed IgG/IgA/IgM seven components, as well nuclear antigen 1 (EBNA-1) deoxyuridine-triphosphate nucleotidohydrolase (dUTPases). Disability was evaluated using Expanded Status Scale (EDSS) disease progression Multiple Sclerosis Severity Score (MSSS). levels were significantly higher than controls. IgG basic protein (MBP) (IgG-MBP), IgM-myelin-associated glycoprotein (IgM-MAG)-37-60, IgA-MBP, IgA-myelin-oligodendrocyte-glycoprotein (IgA-MOG-31-55) distinguished from a predictive accuracy 96.6 % (sensitivity = 95.7 %, specificity 95.2 %) an area under ROC curve 0.991. A large part variance EDSS (around 75 MSSS score (62.8 explained by IgG-MBP, IgM-MBP, IgA-MOG-31-55, IgM-MAG. Part (47.4 immune EBNA dUTPases HHV-6. Autoimmune reactivities are valuable severity Reactivation may trigger or maintain these thereby impacting progression.

Language: Английский

Citations

0
Reactivation of Human Herpesvirus 6 and Epstein-Barr Virus in relapsing remitting multiple sclerosis: association with disabilities, disease progression, and inflammatory processes. DOI Creative Commons
Abbas F. Almulla, Aristo Vojdani, Yingqian Zhang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract Background Multiple sclerosis (MS) is a chronic autoimmune disorder affecting the central nervous system (CNS). Reactivation of Human herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV) observed in MS. Objectives This study investigates immunoglobulins (Ig)G, IgM, IgA directed against EBV nuclear antigen EBNA-366-406, HHV-6 deoxyuridine-triphosphatase (dUTPase), different immune profiles 58 patients with relapsing remitting MS (RRMS) compared to 60 healthy controls. Methods We employed enzyme-linked immunosorbent assays (ELISA) measure viral antigens. Multiplex immunoassays were used cytokines, chemokines growth factor levels that compute profiles, including M1 macrophage, T helper (Th)-1, Th-17, overall activation. assessed disabilities using Expanded Disability Status Scale (EDSS) disease progression Sclerosis Severity Score (MSSS). Results IgG/IgA/IgM three antigens significantly higher RRMS than was discriminated from controls by IgG IgM dUTPase, yielding an accuracy 91.5% (sensitivity=87.3% specificity=95.2%). Neural network analysis showed EBV-dUTPase, yielded area under ROC curve 1 predictive 97.1%. There strong associations between IgG/IgM responses EBV-dUTPases EDSS/MSSS scores aberrations M1, Conclusions reactivation play key role these effects are mediated activation cytokine profiles.

Language: Английский

Citations

3
The Antidepressant- and Anxiolytic-Like Effects of the Phosphodiesterase Type-5 Inhibitor Tadalafil are Associated with the Modulation of the Gut-Brain Axis During CNS Autoimmunity DOI
Eduardo Duarte-Silva,

Alice Chevrollier Oriá,

Ingrid Prata Mendonça

et al.

Journal of Neuroimmune Pharmacology, Journal Year: 2024, Volume and Issue: 19(1)

Published: Aug. 19, 2024

Language: Английский

Citations

2
In severe first episode major depressive disorder, psychosomatic, chronic fatigue syndrome, and fibromyalgia symptoms are driven by immune activation and increased immune-associated neurotoxicity. DOI Creative Commons
Michaël Maes, Abbas F. Almulla, Bo Zhou

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 7, 2023

Abstract Background Major depressive disorder (MDD) is accompanied by activated neuro-immune pathways, increased physiosomatic and chronic fatigue-fibromyalgia (FF) symptoms. The most severe MDD phenotype, namely major dysmood (MDMD), associated with adverse childhood experiences (ACEs) negative life events (NLEs) which induce cytokines/chemokines/growth factors. Aims To delineate the impact of ACE + NLEs on FF symptoms in first episode (FE)-MDMD, examine whether these effects are mediated immune profiles. Methods ACEs, NLEs, symptoms, 48 factors were measured 64 FE-MDMD patients 32 normal controls. Results Physiosomatic, gastro-intestinal belong to same factor as depression, anxiety, melancholia, insomnia. extracted from seven domains labeled physio-affective phenome depression. A part (59.0%) variance explained independent interleukin (IL)-16 IL-8 (positively), CCL3 IL-1 receptor antagonist (inversely correlated). (46.5%) (IL)-16, TNF-related apoptosis-inducing ligand (TRAIL) (positively) combined activities immunoregulatory cytokines associated). Partial Least Squares analysis shows that exert a substantial influence partly an network composed interleukin-16, CCL27, TRAIL, macrophage-colony stimulating factor, stem cell growth factor. Conclusions caused immune-associated neurotoxicity due Th-1 polarization, T helper-1, M1 macrophage activation relative lowered compensatory protection.

Language: Английский

Citations

1
Factors Contributing to the Development of Neuropsychiatric Manifestations in Persons With Multiple Sclerosis: A Systematic Review DOI Open Access

Elizabeth Sangster,

Nidhi Lanka,

Prakash Acharya

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Multiple sclerosis (MS) is the most common chronic demyelinating disease affecting central nervous system (CNS) and distinguished by neuroinflammation neurodegeneration. It has four categories based on clinical course, with relapsing-remitting being type. MS predominantly manifests motor sensory dysfunctions. However, neuropsychiatric manifestations such as depression, anxiety, schizophrenia, bipolar disorder are not uncommon. Various factors may contribute to development of these manifestations; therefore, this study aimed unravel them. This systematic review implemented Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) 2020 guidelines. Five databases (PubMed, PubMed Central (PMC), ScienceDirect, Cochrane Library, Google Scholar) were used acquire articles published in past five years. After screening quality appraisal completed, eight deemed eligible inclusion study. The designs included cohort, cross-sectional, randomized-controlled trial (RCT), case report, case-control, narrative review. persons influenced various factors. These categorized into morphological changes brain, immunological mechanisms, socioeconomic factors, individual discussion. Each factor was found intermingle others, requiring further research understand features that each contributes. crucial improving life (QOL) prognosis living MS.

Language: Английский

Citations

0
In severe first episode major depressive disorder, psychosomatic, chronic fatigue syndrome, and fibromyalgia symptoms are driven by immune activation and increased immune-associated neurotoxicity DOI Creative Commons
Michaël Maes, Abbas F. Almulla, Bo Zhou

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 9, 2023

Abstract Background Major depressive disorder (MDD) is accompanied by activated neuro-immune pathways, increased physiosomatic and chronic fatigue-fibromyalgia (FF) symptoms. The most severe MDD phenotype, namely major dysmood (MDMD), associated with adverse childhood experiences (ACEs) negative life events (NLEs) which induce cytokines/chemokines/growth factors. Aims To delineate the impact of ACE+NLEs on FF symptoms in first episode (FE)-MDMD, examine whether these effects are mediated immune profiles. Methods ACEs, NLEs, symptoms, 48 factors were measured 64 FE-MDMD patients 32 normal controls. Results Physiosomatic, gastro-intestinal belong to same factor as depression, anxiety, melancholia, insomnia. extracted from seven domains labeled physio-affective phenome depression. A part (59.0%) variance explained independent interleukin (IL)-16 IL-8 (positively), CCL3 IL-1 receptor antagonist (inversely correlated). (46.5%) (IL)-16, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) (positively) combined activities immunoregulatory cytokines associated). Partial Least Squares analysis shows that exert a substantial influence partly an network composed IL-16, CCL27, TRAIL, macrophage-colony stimulating factor, stem cell growth factor. Conclusions caused immune-associated neurotoxicity due T helper (Th)-1 polarization, Th-1, M1 macrophage activation relative lowered compensatory protection.

Language: Английский

Citations

0