Immune-related gene characterization and biological mechanisms in major depressive disorder revealed based on transcriptomics and network pharmacology DOI Creative Commons

Shasha Wu,

Qing Jiang,

Jinhui Wang

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 6, 2024

Major depressive disorder (MDD) is a severe psychiatric characterized by complex etiology, with genetic determinants that are not fully understood. The objective of this study was to investigate the pathogenesis MDD and explore its association immune system identifying hub biomarkers using bioinformatics analyses examining infiltrates in human autopsy samples.

Language: Английский

Increased atherogenicity in mood disorders: a systematic review, meta-analysis and meta-regression DOI
Ketsupar Jirakran, Abbas F. Almulla,

Thapanee Jaipinta

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 169, P. 106005 - 106005

Published: Jan. 8, 2025

Language: Английский

Citations

2
Simple dysmood disorder, a mild subtype of major depression, is not an inflammatory condition: Depletion of the compensatory immunoregulatory system DOI

Michael Maes,

Asara Vasupanrajit,

Ketsupar Jirakran

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 375, P. 75 - 85

Published: Jan. 21, 2025

Language: Английский

Citations

1
T cell activation and lowered T regulatory cell numbers are key processes in severe major depressive disorder: Effects of recurrence of illness and adverse childhood experiences DOI
Michaël Maes, Bo Zhou,

Muanpetch Rachayon

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 362, P. 62 - 74

Published: June 29, 2024

Language: Английский

Citations

8
Major depressive disorder, neuroticism, suicidal behaviors, and depression severity are all associated with neurotoxic immune networks and their intricate interactions with metabolic syndrome. DOI Creative Commons
Michaël Maes, Ketsupar Jirakran, Asara Vasupanrajit

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 5, 2024

Abstract Background Major depressive disorder (MDD) is considered to be a neuroimmune disorder. However, there are no data regarding the association between comprehensive immune profiles and their interactions with metabolic syndrome (MetS) in predicting neuroticism, suicidal behaviors, severity of outpatient MDD (OMDD). Methods We assayed 48 serum cytokines, chemokines, growth factors using multiplex assay 67 healthy controls 66 OMDD patients. Around 50% control participants had diagnosis MetS. Results Ten differentially expressed proteins (DEPs) were upregulated (i.e., CXCL12, TNFB, PDGF, CCL11, IL9, IL4, CCL5, CCL2, CCL4, IL1RN), indicating an immune, defense stress response. Six DEPs downregulated (VEGFA, IL12, CCL3, CSF1, IL1B, NGF), lowered neurogenesis regulation neuron death. Significant MetS caused a) substantial increases TNF signaling, upregulation IL17, TNF, IL1RN; b) downregulation VEGFA FGF. A large part variance neuroticism (26.6%), behaviors (23.6%), phenome (31.4%) was predicted by immunological TNFB or VEGFA. Discussion characterized immunoneurotoxic profile which partly explains phenome’s severity. Lowered IL-10 increased neurotoxicity characteristics other depression phenotypes, including severe first-episode inpatient MDD. The presence considerably exacerbates immunoneurotoxicity. Consequently, studies should always performed subjects without

Language: Английский

Citations

4
Psychosocial and neurobiological aspects of the worldwide refugee crisis: From vulnerability to resilience DOI Creative Commons

H. Anisman,

D Doubad,

Ajani Asokumar

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 165, P. 105859 - 105859

Published: Aug. 17, 2024

Anisman, H., Doubad, D., Asokumar, A. & Matheson, K. Psychosocial and neurobiological aspects of the worldwide refugee crisis: From vulnerability to resilience. NEUROSCI BIOBEHAV REV, XXXX. Immigration occurs between countries either obtain employment, for family reunification or escape violence other life-threatening conditions. Refugees asylum seekers are often obligated overcome a uniquely challenging set circumstances prior during migration. Settlement following immigration may pose yet another stressors related acculturation host country, as well financial insecurity, discrimination, language barriers, social isolation. Here we discuss multiple consequences experiences, focusing on health disturbances that frequently develop in adults children. Aside from psychosocial influences, immigration-related challenges cause hormonal, inflammatory immune, microbiota changes favor psychological physical illnesses. Some biological alterations subject modification by epigenetic changes, which have implications intergenerational trauma transmission, might disruptions parenting behaviors dysfunction. Despite hardships experienced, many immigrants their families exhibit positive adjustment after resettlement. We provide information diminish impacts associated with offer strength-based approaches foster

Language: Английский

Citations

3
Major depressive disorder, neuroticism, suicidal behaviors, and depression severity are all associated with neurotoxic immune networks and their intricate interactions with metabolic syndrome. DOI Creative Commons
Michaël Maes, Ketsupar Jirakran, Asara Vasupanrajit

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 21, 2024

Abstract Background Major depressive disorder (MDD) is considered to be a neuroimmune disorder. However, there are no data regarding the association between comprehensive immune profiles and their interactions with metabolic syndrome (MetS) in predicting neuroticism, suicidal behaviors, severity of outpatient MDD (OMDD). Methods We assayed 48 serum cytokines, chemokines, growth factors using multiplex assay 67 healthy controls 66 OMDD patients. Around 50% control participants had diagnosis MetS. Results Ten differentially expressed proteins (DEPs) were upregulated (i.e., CXCL12, TNFB, PDGF, CCL11, IL9, IL4, CCL5, CCL2, CCL4, IL1RN), indicating an immune, defense stress response. Six DEPs downregulated (VEGFA, IL12, CCL3, CSF1, IL1B, NGF), lowered neurogenesis regulation neuron death. Significant MetS caused a) substantial increases TNF signaling, upregulation IL17, TNF, IL1RN; b) downregulation VEGFA FGF. A large part variance neuroticism (26.6%), behaviors (23.6%), phenome (31.4%) was predicted by immunological TNFB or VEGFA. Discussion characterized immunoneurotoxic profile which partly explains phenome’s severity. Lowered IL-10 increased neurotoxicity characteristics other depression phenotypes, including severe first-episode inpatient MDD. The presence considerably exacerbates immunoneurotoxicity. Consequently, studies should always performed subjects without

Language: Английский

Citations

2
Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases DOI Creative Commons
Shaza S. Issa, Haidar Fayoud,

Alisa Shaimardanova

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1906 - 1906

Published: Aug. 20, 2024

Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer's, Parkinson's, Huntington's disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive motor abilities of patients. The underlying genetic component in hNDDs contributes to disease risk, creating a complex landscape. Considering fact that growth factors play crucial roles regulating cellular processes, proliferation, differentiation, survival, they could have therapeutic potential for hNDDs, provided appropriate dosing safe delivery approaches ensured. This article presents detailed overview factors, explores treating emphasizing neuronal growth, synaptic plasticity. However, challenges proper dosing, methods, patient variability can hinder clinical application.

Language: Английский

Citations

2
Complex Intersections Between Adverse Childhood Experiences and Negative Life Events Impact the Phenome of Major Depression DOI Creative Commons
Asara Vasupanrajit, Michaël Maes, Ketsupar Jirakran

et al.

Psychology Research and Behavior Management, Journal Year: 2024, Volume and Issue: Volume 17, P. 2161 - 2178

Published: May 1, 2024

There is evidence that adverse childhood experiences (ACEs) and negative life events (NLEs) are associated with major depression (MDD).

Language: Английский

Citations

1
A further examination of growth factors, T helper 1 polarization, and the gut microbiome in major depression: Associations with reoccurrence of illness, cognitive functions, suicidal behaviors, and quality of life DOI
Michaël Maes, Bo Zhou,

Asara Vasupanrajit

et al.

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 176, P. 430 - 441

Published: June 29, 2024

Language: Английский

Citations

1
The recurrence of illness (ROI) index is a key factor in major depression that indicates increasing immune-linked neurotoxicity and vulnerability to suicidal behaviors DOI Creative Commons

Michael Maes,

Ketsupar Jirakran, Asara Vasupanrajit

et al.

Psychiatry Research, Journal Year: 2024, Volume and Issue: 339, P. 116085 - 116085

Published: July 16, 2024

In this study, we aimed to investigate the associations between recurrence of illness (ROI) and biomarkers related an activated immune network, immune-linked neurotoxicity (INT), a combined INT atherogenicity index (METAMMUNE). The study involved 67 healthy controls 66 outpatient MDD (OMDD) participants. We utilized Multiplex method measure 48 cytokines examined METAMMUNE composite scores in association with different ROI indices. Our findings revealed that was successfully created by extracting validated principal component, from physician-rated or self-declared number depressive episodes, frequency lifetime suicidal ideation attempts. significantly associated indices, neuroticism, current behaviors, phenome. analysis also significant portion variance OMDD phenome, which includes anxiety, depression, can be accounted for regression on INT, ROI, emotional neglect abuse. A latent construct extracted three components, results indicate increasing indicates heightened immune-metabolic abnormalities, increased risk elevated severity phenome features.

Language: Английский

Citations

1