Methylphenidate, but not citalopram, decreases impulsive choice in rats performing a temporal discounting task DOI Creative Commons
Miranda Francoeur Koloski,

Alyssa Terry,

Nina Maxwell Lee

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: May 8, 2024

Drugs targeting monoamine systems remain the most common treatment for disorders with impulse control impairments. There is a body of literature suggesting that drugs affecting serotonin reuptake and dopamine can modulate distinct aspects impulsivity - though such tests are often performed using behavioral tasks prohibiting easy comparisons. Here, we directly compare pharmacologic agents affect (methylphenidate) vs (citalopram) manipulations on choice in temporal discounting task where rats could choose between small, immediate reward or large delayed at either 2 10s. In conditions, preferred small (2s) delay discounted long (10s) delay. Methylphenidate, transport inhibitor blocks dopamine, dose-dependently increased preference block. Citalopram, selective inhibitor, had no effect behavior. Impulsive behavior was least partially mediated by nucleus accumbens shell. Bilateral lesions to shell reduced during Following lesions, methylphenidate did not impact impulsivity. Our results suggest striatal dopaminergic via actions within shell, whereas may regulate different inhibition/impulsivity.

Language: Английский

Targeting Human Glucocorticoid Receptors in Fear Learning: A Multiscale Integrated Approach to Study Functional Connectivity DOI Open Access
Simone Battaglia, Chiara Di Fazio,

Matteo Mazzà

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 864 - 864

Published: Jan. 10, 2024

Fear extinction is a phenomenon that involves gradual reduction in conditioned fear responses through repeated exposure to fear-inducing cues. Functional brain connectivity assessments, such as functional magnetic resonance imaging (fMRI), provide valuable insights into how regions communicate during these processes. Stress, ubiquitous aspect of life, influences learning and by changing the activity amygdala, prefrontal cortex, hippocampus, leading enhanced and/or impaired extinction. Glucocorticoid receptors (GRs) are key stress response show dual function regulation: while they enhance consolidation memories, also facilitate Accordingly, GR dysregulation associated with anxiety mood disorders. Recent advancements cognitive neuroscience underscore need for comprehensive understanding integrates perspectives from molecular, cellular, systems levels. In particular, neuropharmacology provides neurotransmitter receptor systems, aiding investigation mechanisms underlying regulation potential therapeutic targets. A notable player this context cortisol, hormone, which significantly both memory reconsolidation Gaining thorough intricate interactions has implications terms addressing psychiatric disorders related stress. This review sheds light on complex between processes, emotions, their neural bases. endeavor, our aim reshape comprehension fear, stress, emotional well-being, ultimately development interventions.

Language: Английский

Citations

36
Neural Correlates and Molecular Mechanisms of Memory and Learning DOI Open Access
Simone Battaglia, Alessio Avenanti, László Vécsei

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2724 - 2724

Published: Feb. 27, 2024

Memory and learning are essential cognitive processes that enable us to obtain, retain, recall information [...].

Language: Английский

Citations

34
Error-related cardiac deceleration: Functional interplay between error-related brain activity and autonomic nervous system in performance monitoring DOI Creative Commons
Francesco Di Gregorio, Marco Steinhauser, Martin E. Maier

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 157, P. 105542 - 105542

Published: Jan. 11, 2024

Coordinated interactions between the central and autonomic nervous systems are crucial for survival due to inherent propensity human behavior make errors. In our ever-changing environment, when individuals mistakes, these errors can have life-threatening consequences. response errors, specific reactions occur in both brain activity heart rate detect correct Specifically, there two brain-related indicators of error detection awareness known as error-related negativity positivity. Conversely, cardiac deceleration denotes a momentary slowing following an error, signaling response. However, what is connection during processing? this review, we discuss functional neuroanatomical connections markers processing, exploring experimental conditions which they covary. Given current limitations available data, future research will continue investigate neurobiological factors governing brain-heart interaction, aiming utilize them combined assessing cognitive control healthy pathological conditions.

Language: Английский

Citations

24
The intricate brain–body interaction in psychiatric and neurological diseases DOI Creative Commons
Francesco Di Gregorio, Simone Battaglia

Advances in Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 33(4), P. 321 - 326

Published: March 21, 2024

A harmonic brain-body communication is fundamental to individual wellbeing and the basis of human cognition behavior.In last 2 decades, interaction between brain body functioning has become a central area study for neurologists neuroscientists in clinical non-clinical contexts.Indeed, axis dysfunctions occur many psychiatric, neurological neurodegenerative diseases.This editorial will focus on recent advances future therapeutic perspectives studying interactions health diseases.

Language: Английский

Citations

22
From Lab to Life: Exploring Cutting-Edge Models for Neurological and Psychiatric Disorders DOI Creative Commons
Masaru Tanaka, László Vécsei

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 613 - 613

Published: March 8, 2024

Neuroscience, neurology, and psychiatry are rapidly evolving fields that aim to understand the complex mechanisms underlying brain function dysfunction, as well develop effective interventions for various neurological psychiatric disorders [...]

Language: Английский

Citations

19
Innovation at the Intersection: Emerging Translational Research in Neurology and Psychiatry DOI Creative Commons
Masaru Tanaka, Simone Battaglia, Lydia Giménez‐Llort

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(10), P. 790 - 790

Published: May 7, 2024

Translational research in neurological and psychiatric diseases is a rapidly advancing field that promises to redefine our approach these complex conditions [...]

Language: Английский

Citations

19
Innovation at the Intersection: Emerging Translational Research in Neurology and Psychiatry DOI Open Access
Masaru Tanaka, Simone Battaglia, Lydia Giménez‐Llort

et al.

Published: April 17, 2024

The editorial explores the realm of emerging translational research in neurology and psychiatry, providing insights into various subjects, including neurodegenerative disorders innovative therapeutic methods. main objective is to study neurological psychiatric disorders, such as Alzheimer's disease, with a particular emphasis on techniques for neural regeneration repair. highlights importance taking comprehensive approach studying treating complex conditions. This involves thoroughly reviewing papers causes, development, biomarkers, treatment options these emphasizes necessity using multidisciplinary integrative methods gain deeper understanding improve development an animal model recurrent primary dysmenorrhea showcases employed investigation gynecological illustrating capacity connect fundamental scientific knowledge practical medical applications. cooperative endeavors researchers clinicians emphasized this lay foundation revolutionary advancements that hold potential enhance outcomes individuals afflicted globally.

Language: Английский

Citations

17
A Decade of Dedication: Pioneering Perspectives on Neurological Diseases and Mental Illnesses DOI Creative Commons
Masaru Tanaka, László Vécsei

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1083 - 1083

Published: May 13, 2024

Welcome to

Language: Английский

Citations

17
From Lab to Life: Exploring Cutting-Edge Models for Neurological and Psychiatric Disorders DOI Open Access
Masaru Tanaka, László Vécsei

Published: March 5, 2024

Delve into the dynamic realms of neuroscience, neurology, and psychiatry with this groundbreaking editorial, unveiling intricate mechanisms brain function dysfunction. Explore latest advancements in molecular biology, genetics, epigenetics, pharmacology, neuroimaging that are revolutionizing our understanding neurological psychiatric disorders. Uncover challenges gaps translating cutting-edge research practical clinical applications, aiming to enhance lives patients their families. Discover pivotal role neuroplasticity reshaping brain's adaptability throughout life, alongside promising potential non-invasive stimulation techniques like transcranial magnetic direct current stimulation. Embark on a journey innovation collaboration as researchers clinicians strive bridge gap between bench bedside, offering hope for improved diagnosis, prevention, treatment complex conditions. Join us exploration transformative ideas novel interventions hold key brighter future individuals society.

Language: Английский

Citations

16
Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress Disorder DOI Creative Commons
Ágnes Szabó, Zsolt Galla, Eleonóra Spekker

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 20, 2025

Backgrounds: Memory and emotion are especially vulnerable to psychiatric disorders such as post-traumatic stress disorder (PTSD), which is linked disruptions in serotonin (5-HT) metabolism. Over 90% of the 5-HT precursor tryptophan (Trp) metabolized via Trp-kynurenine (KYN) metabolic pathway, generates a variety bioactive molecules. Dysregulation KYN metabolism, particularly low levels kynurenic acid (KYNA), appears be neuropsychiatric disorders. The majority KYNA produced by aadat (kat2) gene-encoded mitochondrial kynurenine aminotransferase (KAT) isotype 2. Little known about consequences deleting enzyme gene. Methods: In CRISPR/Cas9-induced knockout (kat2-/-) mice, we examined effects on emotion, memory, motor function, Trp its metabolite levels, activities plasma urine 8-week-old males compared wild-type mice. Results: Transgenic mice showed more depressive-like behaviors forced swim test, but not tail suspension, anxiety, or memory tests. They also had fewer center field corner entries, shorter walking distances, jumping counts open test. Plasma generally consistent with those urine: antioxidant KYNs, 5-hydroxyindoleacetic acid, indole-3-acetic were lower; KATs, kynureninase, monoamine oxidase/aldehyde dehydrogenase lower, 3-monooxygenase was higher; oxidative excitotoxicity indices higher. displayed depression-like behavior learned helplessness model, emotional indifference, deficits, coupled decrease KYNA, shift metabolism toward KYN-3-hydroxykynurenine partial gut microbial Trp-indole pathway metabolite. Conclusions: This first evidence that gene induces uniquely experiences despair, appear associated excitatory neurotoxic stresses. may lead development double-hit preclinical model despair-based depression, better understanding these complex conditions, effective therapeutic strategies elucidating relationship between PTSD pathogenesis.

Language: Английский

Citations

2