Diabetes mellitus and glymphatic dysfunction: Roles for oxidative stress, mitochondria, circadian rhythm, artificial intelligence, and imaging DOI Open Access
Kenneth Maiese

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 29, 2024

Diabetes mellitus (DM) is a debilitating disorder that impacts all systems of the body and has been increasing in prevalence throughout globe. DM represents significant clinical challenge to care for individuals prevent onset chronic disability ultimately death. Underlying cellular mechanisms development are multi-factorial origin involve pathways associated with production reactive oxygen species generation oxidative stress as well dysfunction mitochondrial organelles, programmed cell death, circadian rhythm impairments. These can failure glymphatic pathway brain linked rhythms disorders during loss metabolic homeostasis. New studies incorporate number promising techniques examine patients include machine learning artificial intelligence potentially predict dysfunction.

Language: Английский

Indole-3 Carbinol and Diindolylmethane Mitigated β-Amyloid-Induced Neurotoxicity and Acetylcholinesterase Enzyme Activity: In Silico, In Vitro, and Network Pharmacology Study DOI Creative Commons
Kakarla Ramakrishna,

Praditha Karuturi,

Queen Siakabinga

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(8), P. 184 - 184

Published: Aug. 16, 2024

Background: Alzheimer’s disease (AD) is a neurodegenerative characterized by beta-amyloid (Aβ) deposition and increased acetylcholinesterase (AchE) enzyme activities. Indole 3 carbinol (I3C) diindolylmethane (DIM) are reported to have neuroprotective activities against various neurological diseases, including ischemic stroke, Parkinson’s disease, neonatal asphyxia, depression, stress, neuroinflammation, excitotoxicity, except for AD. In the present study, we investigated anti-AD effects of I3C DIM. Methods: Docking molecular dynamic studies AchE network pharmacological were conducted DIM’s self AchE-induced Aβ aggregation investigated. The DIM Aβ-induced neurotoxicity assessed in SH-S5Y5 cells observing cell viability ROS. Results: with show binding efficiency −7.0 −10.3, respectively, dynamics revealed better interaction stability between AchE. Network indicated that interacted several proteins involved pathophysiology Further, significantly inhibited (IC50: (18.98 µM) (11.84 µM)) self-induced aggregation. Both compounds enhanced exposed reduced equipotential neuroprotection when compared donepezil. Conclusions: Our findings indicate both inhibiting induced

Language: Английский

Citations

28
Indole 3 carbinol attenuated memory impairment, oxidative stress, inflammation, and apoptosis in bilateral common carotid artery occlusion induced brain damage in rats DOI
Srikanth Yalabaka,

T. Julius,

Miriyala Sai Siva Gayathri

et al.

3 Biotech, Journal Year: 2025, Volume and Issue: 15(2)

Published: Jan. 29, 2025

Language: Английский

Citations

2
The Role of Brain-Derived Neurotrophic Factor as an Essential Mediator in Neuronal Functions and the Therapeutic Potential of Its Mimetics for Neuroprotection in Neurologic and Psychiatric Disorders DOI Creative Commons

Tadahiro Numakawa,

Ryutaro Kajihara

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 848 - 848

Published: Feb. 12, 2025

Among neurotrophins, including nerve growth factor (NGF), brain-derived neurotrophic (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4/5), BDNF has been extensively studied for its physiological role in cell survival synaptic regulation the central nervous system's (CNS's) neurons. binds to TrkB (a tyrosine kinase) with high affinity, resulting downstream intracellular signaling cascades play crucial roles determining fate, neuronal differentiation maturation of CNS It well demonstrated that downregulation/dysregulation BDNF/TrkB system is implicated pathogenesis neurologic psychiatric disorders, such as Alzheimer's disease (AD) depression. Interestingly, effects mimetic compounds flavonoids, small molecules which can activate TrkB-mediated signaling, have investigated potential therapeutic strategies brain diseases, given p75NTR, a common neurotrophin receptor, also contributes death under variety pathological conditions neurodegeneration. Since downregulation associated pathophysiology neurodegenerative diseases understanding how alterations contribute progression could provide valuable insight prevention these diseases. The present review shows recent advances molecular mechanisms underlying plasticity, providing critical insights into impact mimetics

Language: Английский

Citations

2
Epigallocatechin -3- gallate mitigates diazinon neurotoxicity via suppression of pro-inflammatory genes and upregulation of antioxidant pathways DOI Creative Commons

Charles Etang Onukak,

Omowumi Femi‐Akinlosotu, Adedunsola A. Obasa

et al.

BMC Neuroscience, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 10, 2025

Diazinon is a commonly used organophosphate (OP) insecticide especially in developing countries for the control of insect pests, however, exposure to its toxic impact humans and other non-target species remains an important public health concern. The study aimed investigate effect epigallocatechin -3- gallate (EGCG), abundant green tea plants on neurobehavioural, biochemical, pathological changes brain male Wistar rats following diazinon toxicity. Sixty adult were acclimatized seven days subsequently randomly assigned into six treatment groups as follows: Group I: Control group (0.2 mL distilled water); II: at 3 mg/kg (1% LD50); III: (3 mg/kg) + EGCG (50 mg/kg, ~ 2% IV: (100 5% V: VI: mg/kg). All treatments administered orally once daily 14 days. Neurobehavioural studies, biomarkers oxidative stress, histology, immunohistochemistry, quantitative polymerase chain reaction (RT qPCR) performed. alone impaired recognition memory, increased stress markers altered antioxidant defense brain. It upregulated TNF-α IL-6 genes repressed GPx 4 gene expressions. was also associated with GFAP, Tau, α-SN immunoreactivity. Microscopic examination revealed loss Purkinje hippocampal cells Co-treatment however improved cognition, lowered markers, status suppressed IL-6. In conclusion, findings from this demonstrated that offered protection against diazinon-induced neurotoxicity. Hence, natural sources such fruits vegetables could offer immense benefits by protecting inflammation neurodegenerative disease conditions. Clinical trial number Not applicable.

Language: Английский

Citations

0
The role of gut microbiota‐derived metabolites in neuroinflammation DOI Creative Commons

Lingjie Mu,

Yijie Wang

Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Abstract Neuroinflammation, a key defense mechanism of the nervous system, is associated with changes in inflammatory markers and stimulation neuroimmune cells such as microglia astrocytes. Growing evidence indicates that gut microbiota its metabolites directly or indirectly regulate host health. According to recent studies, bacterial dysbiosis closely linked several central system disorders cause neuroinflammation, including multiple sclerosis, Alzheimer's disease, Parkinson's sepsis‐associated encephalopathy, ischemic stroke. Recent findings indicate bidirectional communication network between influences neuroinflammation cognitive function. Dysregulation this can affect generation cytotoxic metabolites, promote impair cognition. This review explores lesser‐studied microbiota‐derived involved neuroinflammation—bile acids, trimethylamine‐N‐oxide, indole derivatives—as targets for creating new treatment tools neuroinflammatory illnesses, well possible biomarkers early diagnosis prognosis.

Language: Английский

Citations

0
Recent advances in catalytic approaches for the synthesis of 3-substituted indoles: mechanisms and strategies DOI Creative Commons
Ebraheem Abdu Musad Saleh,

Kakul Hussin Firoz,

Subasini Uthirapathy

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(16), P. 12255 - 12290

Published: Jan. 1, 2025

This review highlights recent advancements in the catalytic synthesis of 3-substituted indoles, focusing on improved efficiency, selectivity, and sustainability attained through use various systems green chemistry approaches.

Language: Английский

Citations

0
Unveiling the role of astrogliosis in Alzheimer’s disease Pathology: Insights into mechanisms and therapeutic approaches DOI

Mohit Paidlewar,

Sneha Kumari,

Rishika Dhapola

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112940 - 112940

Published: Aug. 17, 2024

Language: Английский

Citations

3
Diabetes mellitus and glymphatic dysfunction: Roles for oxidative stress, mitochondria, circadian rhythm, artificial intelligence, and imaging DOI Open Access
Kenneth Maiese

World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 29, 2024

Diabetes mellitus (DM) is a debilitating disorder that impacts all systems of the body and has been increasing in prevalence throughout globe. DM represents significant clinical challenge to care for individuals prevent onset chronic disability ultimately death. Underlying cellular mechanisms development are multi-factorial origin involve pathways associated with production reactive oxygen species generation oxidative stress as well dysfunction mitochondrial organelles, programmed cell death, circadian rhythm impairments. These can failure glymphatic pathway brain linked rhythms disorders during loss metabolic homeostasis. New studies incorporate number promising techniques examine patients include machine learning artificial intelligence potentially predict dysfunction.

Language: Английский

Citations

0