Interactions between gut microbiota and polyphenols: A mechanistic and metabolomic review

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 154979 - 154979

Published: July 18, 2023

Language: Английский

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Gut Microbiota and Breast Cancer: The Dual Role of Microbes

Cancers, Journal Year: 2023, Volume and Issue: 15(2), P. 443 - 443

Published: Jan. 10, 2023

Breast cancer is the most frequently diagnosed and also one of leading causes mortality among women. The genetic environmental factors known to date do not fully explain risk developing this disease. In recent years, numerous studies have highlighted dual role gut microbiota in preservation host health development different pathologies, them. Our capable producing metabolites that protect homeostasis but can produce molecules with deleterious effects, which, turn, may trigger inflammation carcinogenesis, even affect immunotherapy. purpose review describe mechanisms by which cause general, breast particular, compile clinical trials address alterations or changes women cancer.

Language: Английский

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Biotherapy Using Probiotics as Therapeutic Agents to Restore the Gut Microbiota to Relieve Gastrointestinal Tract Inflammation, IBD, IBS and Prevent Induction of Cancer

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5748 - 5748

Published: March 17, 2023

The gut microbiota is composed of several microbial strains with diverse and variable compositions in both healthy sick people. An undisturbed needs to be sustained order perform all physiological, metabolic, immune functions a normal way prevent the development diseases. This article has reviewed published information on issue disruption balance microbiota. could for many reasons, such as infection gastrointestinal tract, food poisoning, diarrhoea, chemotherapy, malnutrition, lifestyle, ageing. If this not restored normal, it might cause dysbiosis. Eventually, interrupted by dysbiosis initiate health issues, inflammation induction cancer, progression variety diseases irritable bowel syndrome inflammatory disease. review concluded that biotherapy natural using probiotic products, whether form food, beverages, or supplements, restore disrupted Metabolites secreted ingested probiotics help relieve tract can avoid cancer.

Language: Английский

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Irinotecan-gut microbiota interactions and the capability of probiotics to mitigate Irinotecan-associated toxicity

BMC Microbiology, Journal Year: 2023, Volume and Issue: 23(1)

Published: March 2, 2023

Abstract Background Irinotecan is a chemotherapeutic agent used to treat variety of tumors, including colorectal cancer (CRC). In the intestine, it transformed into SN-38 by gut microbial enzymes, which responsible for its toxicity during excretion. Objective Our study highlights impact on microbiota composition and role probiotics in limiting Irinotecan-associated diarrhea suppressing bacterial β-glucuronidase enzymes. Material methods To investigate effect composition, we applied 16S rRNA gene sequencing three groups stool samples from healthy individuals, colon cancer, treated patients ( n = 5/group). Furthermore, Lactobacillus spp.; Lactiplantibacillus plantarum (L. plantarum) , acidophilus acidophilus) Lacticaseibacillus rhamnosus L. rhamnosus) were single mixed form in-vitro explore expression E. coli . Also, introduced forms mice before administration Irinotecan, their protective effects explored assessing level reactive oxidative species (ROS) as well studying concomitant intestinal inflammation apoptosis. Results The was disturbed individuals with after treatment. group, Firmicutes more abundant than Bacteriodetes, opposite case colon-cancer or groups. Actinobacteria Verrucomicrobia markedly present within while Cyanobacteria noted Irinotecan-treated Enterobacteriaceae genus Dialister group other abundance Veillonella Clostridium Butryicicoccus, Prevotella increased compared Using spp. mixture models significantly relieved Irinotecan-induced through reduction both ROS, addition guarding epithelium against dysbiosis proliferative crypt injury. Conclusions Irinotecan-based chemotherapy altered microbiota. participates greatly determining efficacy chemotherapies, caused ß-glucuronidase can now be aimed modulated promote decrease chemotherapeutics. probiotic regimen this lowered mucositis, stress, cellular inflammation, apoptotic cascade induction Irinotecan.

Language: Английский

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Flavonoids: Antioxidant Powerhouses and Their Role in Nanomedicine

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 922 - 922

Published: July 29, 2024

This study emphasizes the critical role of antioxidants in protecting human health by counteracting detrimental effects oxidative stress induced free radicals. Antioxidants-found various forms such as vitamins, minerals, and phytochemicals abundant fruits vegetables-neutralize radicals stabilizing them through electron donation. Specifically, flavonoid compounds are highlighted robust defenders, addressing inflammation to avert chronic illnesses like cancer, cardiovascular diseases, neurodegenerative diseases. research explores bioactive potential flavonoids, shedding light on their not only safeguarding health, but also managing conditions diabetes, review highlights novel integration South African-origin flavonoids with nanotechnology, presenting a cutting-edge strategy improve drug delivery therapeutic outcomes. interdisciplinary approach, blending traditional wisdom contemporary techniques, propels exploration flavonoid-mediated nanoparticles toward groundbreaking pharmaceutical applications, promising revolutionary advancements healthcare. collaborative synergy between knowledge modern science contributes underscores significant step sustainable impactful biomedical innovations, aligning principles environmental conservation.

Language: Английский

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