Development and Application of Polyphenols in Food: A Comprehensive Review DOI Creative Commons
Yanpei Huang, Haiming Chen, Weijun Chen

et al.

Food Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

ABSTRACT This review provides an in‐depth analysis of functional mechanisms and research trends in the application polyphenol food. The polyphenols are to maintain homeostasis organism through direct or synergistic effects, such as activating Kelch‐like ECH‐associated protein‐1 (Keap1)–nuclear factor erythroid 2‐related 2 (Nrf2) pathway for antioxidative inhibiting nuclear kappa‐B (NF‐κB) anti‐inflammatory inducing modifying p53 proteins anticancer DNA replication antibacterial effects. However, have limited bioavailability due their low water solubility, chemical instability, rapid metabolism. physicochemical properties can be improved by regional modifications nanoembedding systems, which has led intensive direction improving intestinal environment polyphenols. Further unveiling molecular enhancing will result better exploiting potential health benefit

Language: Английский

The interplay between diet and the gut microbiome: implications for health and disease DOI
Fiona C. Ross, Dhrati Patangia, Ghjuvan Micaelu Grimaud

et al.

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(11), P. 671 - 686

Published: July 15, 2024

Language: Английский

Citations

100
Diet strategies for promoting healthy aging and longevity: An epidemiological perspective DOI Creative Commons
Frank B. Hu

Journal of Internal Medicine, Journal Year: 2023, Volume and Issue: 295(4), P. 508 - 531

Published: Oct. 23, 2023

Abstract In recent decades, global life expectancies have risen significantly, accompanied by a marked increase in chronic diseases and population aging. This narrative review aims to summarize findings on the dietary factors influencing longevity, primarily from large cohort studies. First, maintaining healthy weight throughout is pivotal for aging mirroring benefits of lifelong, moderate calorie restriction today's obesogenic food environment. Second, specific types or sources fat, protein, carbohydrates are more important disease risk mortality than their quantity. Third, some traditional diets (e.g., Mediterranean, Nordic, Okinawa) contemporary patterns, such as plant‐based diet index, DASH (dietary approaches stop hypertension) diet, alternate eating been associated with lower longevity. These patterns share many common components predominance nutrient‐rich plant foods; limited red processed meats; culinary herbs spices prevalent cuisines) while embracing distinct elements different cultures. Fourth, combining other lifestyle could extend disease‐free 8–10 years. While adhering core principles diets, it crucial adapt recommendations individual preferences cultures well nutritional needs populations. Public health strategies should aim create healthier environment where nutritious options readily accessible, especially public institutions care facilities elderly. Although further mechanistic studies human trials needed better understand molecular effects aging, there pressing need establish maintain long‐term cohorts studying culturally diverse

Language: Английский

Citations

45
Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders DOI Creative Commons
Maria Scuto,

Francesco Rampulla,

Giuseppe Maria Reali

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 484 - 484

Published: April 18, 2024

The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest preventing therapeutically impacting neuropathologies gastrointestinal diseases. Polyphenols polyphenol-combined nanoparticles in synergy with probiotics shown to improve gut bioavailability blood-brain barrier (BBB) permeability, thus inhibiting oxidative stress, metabolic dysfunction inflammation linked dysbiosis ultimately onset progression central nervous system (CNS) disorders. In accordance hormesis, polyphenols display biphasic dose-response by activating at a low dose Nrf2 pathway resulting upregulation

Language: Английский

Citations

27
Promotion of healthy aging through the nexus of gut microbiota and dietary phytochemicals DOI Creative Commons
Laura M. Beaver, Paige Jamieson, Carmen P. Wong

et al.

Advances in Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 100376 - 100376

Published: Jan. 1, 2025

Aging is associated with the decline of tissue and cellular functions, which can promote development age-related diseases like cancer, cardiovascular disease, neurodegeneration, disorders musculoskeletal immune systems. Healthspan length time an individual in good health free from chronic disabilities aging. Two modifiable factors that influence healthspan, healthy aging, prevent diseases, are diet microbiota gastrointestinal tract (gut microbiota). This review will discuss how dietary phytochemicals gut work concert to a First overview provided influences aging through its impact on barrier integrity, function, mitochondria function oxidative stress. Next, mechanisms by effect health, inflammation, nurture diverse microbial composition discussed. Lastly, directly producing bioactive metabolites food urolithin A, equol, hesperetin sulforaphane. These other phytochemical derived may healthspan Importantly, individual's capacity produce promoting cruciferous vegetables, berries, nuts, citrus soy products be dependent specific bacteria present gut.

Language: Английский

Citations

2
Advances in dietary polyphenols: Regulation of inflammatory bowel disease (IBD) via bile acid metabolism and the gut-brain axis DOI
Kexin Jiang,

Yun-Qing Bai,

Ruyan Hou

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 472, P. 142932 - 142932

Published: Jan. 21, 2025

Language: Английский

Citations

2
Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management DOI Creative Commons

Yueyue Guan,

Guo-hua Tang,

Lei Li

et al.

Archives of Pharmacal Research, Journal Year: 2024, Volume and Issue: 47(2), P. 146 - 164

Published: Jan. 15, 2024

Abstract The gut microbiota that exists in the human gastrointestinal tract is incredibly important for maintenance of general health as it contributes to multiple aspects host physiology. Recent research has revealed a dynamic connection between and central nervous system, can influence neurodegenerative diseases (NDs). Indeed, imbalances microbiota, or dysbiosis, play vital role pathogenesis progression diseases, particularly NDs. Herbal medicine been used centuries treat including These compounds help relieve symptoms delay NDs by improving intestinal barrier function, reducing neuroinflammation, modulating neurotransmitter production. Notably, herbal mitigate regulating microbiota. Therefore, an in-depth understanding potential mechanisms which regulates treatment explain from novel perspective propose therapeutic strategies In this review, we investigate neuroprotective effects medicine, focusing on its ability regulate restore homeostasis. We also highlight challenges future priorities integration modern medicine. As global population ages, access information becoming increasingly developing effective treatments these diseases.

Language: Английский

Citations

14
Dietary Phenolic Compounds—Wellbeing and Perspective Applications DOI Open Access
Dasha Mihaylova, Maria Dimitrova-Dimova, Aneta Popova

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4769 - 4769

Published: April 27, 2024

Contemporary living is continuously leading to poor everyday choices resulting in the manifestation of various diseases. The benefits plant-based nutrition are undeniable and research on topic rising. Modern man now aware possibilities that plant can provide seeking ways benefit from it. Dietary phenolic compounds among easily accessible beneficial substances exhibit antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, antifungal, antiparasitic, analgesic, anti-diabetic, anti-atherogenic, antiproliferative, as well cardio-and neuroprotective activities. Several industries exploring incorporate biologically active their produce. This review concentrated presenting current information about dietary contribution maintaining good health. Additionally, this content will demonstrate importance prosperity natural for fields, i.e., food industry, cosmetology, biotechnology, others.

Language: Английский

Citations

13
Berberine regulates intestinal microbiome and metabolism homeostasis to treat ulcerative colitis DOI
Tao Yang,

Niping Qin,

Fahui Liu

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 338, P. 122385 - 122385

Published: Jan. 4, 2024

Language: Английский

Citations

11
Relationships between Habitual Polyphenol Consumption and Gut Microbiota in the INCLD Health Cohort DOI Open Access
Alexandra Adorno Vita, Kristen M. Roberts,

A. Erik Gundersen

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 773 - 773

Published: March 8, 2024

While polyphenol consumption is often associated with an increased abundance of beneficial microbes and decreased opportunistic pathogens, these relationships are not completely described for polyphenols consumed via habitual diet, including culinary herb spice consumption. This analysis the International Cohort on Lifestyle Determinants Health (INCLD Health) cohort uses a dietary questionnaire 16s microbiome data to examine between gut microbiota in healthy adults (n = 96). In this exploratory analysis, microbial taxa, but diversity measures, differed by levels Taxa identified as biomarkers daily (mg/day) included Lactobacillus, Bacteroides, Enterococcus, Eubacterium ventriosum group, Ruminococcus torques Sutterella. frequency polyphenol-weighted use Lachnospiraceae UCG-001, UCG-004, Methanobrevibacter, Lachnoclostridium, Lachnotalea. Several differentiating taxa carry out activities important human health, although those previously pro-inflammatory qualities certain contexts displayed inverse Our results suggest that higher quantities may support intestinal environment where bacteria represented lower relative compared less potentially virulent qualities.

Language: Английский

Citations

9
The Gut Microbial Regulation of Epigenetic Modification from a Metabolic Perspective DOI Open Access

Xingtong Lin,

Hui Han, Nan Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7175 - 7175

Published: June 29, 2024

Obesity is a global health challenge that has received increasing attention in contemporary research. The gut microbiota been implicated the development of obesity, primarily through its involvement regulating various host metabolic processes. Recent research suggests epigenetic modifications may serve as crucial pathways which and metabolites contribute to pathogenesis obesity other disorders. Hence, understanding interplay between mechanisms for elucidating impact on host. This review focuses relationship with several obesity-related pathogenic mechanisms, including energy dysregulation, inflammation, maternal inheritance. These findings could novel therapeutic targets probiotics, prebiotics, fecal transplantation tools treating disruptions. It also aid developing strategies modulate microbiota, thereby characteristics obesity.

Language: Английский

Citations

8