Cancer Medicine,
Journal Year:
2023,
Volume and Issue:
12(24), P. 22109 - 22129
Published: Dec. 1, 2023
Abstract
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
common
malignant
tumors
in
world,
with
complex
etiology
and
mechanism,
a
high
mortality
rate.
Tumor‐associated
macrophages
(TAMs)
are
an
important
part
HCC
tumor
microenvironment.
Studies
recent
years
have
shown
that
TAMs
involved
multiple
stages
related
to
treatment
prognosis
HCC.
The
specific
mechanisms
between
gradually
being
revealed.
This
paper
reviews
advances
associated
HCC,
concentrating
on
overview
effects
drug
resistance
signaling
pathways
linked
providing
clues
for
determination
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: Aug. 30, 2021
Abstract
Wnt/β-catenin
signaling
has
been
broadly
implicated
in
human
cancers
and
experimental
cancer
models
of
animals.
Aberrant
activation
is
tightly
linked
with
the
increment
prevalence,
advancement
malignant
progression,
development
poor
prognostics,
even
ascendence
cancer-associated
mortality.
Early
investigations
have
proposed
theoretical
potential
that
efficient
repression
this
might
provide
promising
therapeutic
choices
managing
various
types
cancers.
Up
to
date,
many
therapies
targeting
developed,
which
assumed
endow
clinicians
new
opportunities
developing
more
satisfactory
precise
remedies
for
patients
aberrant
signaling.
However,
current
facts
indicate
clinical
translations
signaling-dependent
targeted
faced
un-neglectable
crises
challenges.
Therefore,
study,
we
systematically
reviewed
most
updated
knowledge
relatively
generate
a
clearer
accurate
awareness
both
developmental
stage
underlying
limitations
Wnt/β-catenin-targeted
Insights
study
will
help
readers
better
understand
roles
insights
acknowledge
challenges
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(23), P. 13135 - 13135
Published: Dec. 4, 2021
Liver
cancer
is
the
third
leading
cause
of
death
worldwide.
Representing
such
a
dramatic
impact
on
our
lives,
liver
significant
public
health
concern.
Sustainable
and
reliable
methods
for
preventing
treating
require
fundamental
research
its
molecular
mechanisms.
Cell
lines
are
treated
as
in
vitro
equivalents
tumor
tissues,
making
them
must-have
basic
nature
cancer.
According
to
recent
discoveries,
certified
cell
retain
most
genetic
properties
original
mimic
microenvironment.
On
other
hand,
modern
technologies
allowing
deepest
level
detail
omics
landscapes
have
shown
differences
even
between
samples
same
line
due
cross-
mycoplasma
infection.
This
observations
suggest
that,
some
cases,
cultures
not
suitable
models,
with
limited
predictive
value
effectiveness
new
treatments.
HepG2
popular
hepatic
line.
It
used
wide
range
studies,
from
oncogenesis
cytotoxicity
substances
liver.
In
this
regard,
we
set
out
collect
up-to-date
information
assess
whether
heterogeneity
allows
biomedical
studies
model
guaranteed
production
quality.
World Journal of Gastroenterology,
Journal Year:
2024,
Volume and Issue:
30(29), P. 3511 - 3533
Published: July 28, 2024
(CB),
used
in
traditional
Chinese
medicine,
exhibits
anti-tumor
effects
various
cancer
models.
It
also
constitutes
an
integral
component
of
a
compound
formulation
known
as
Pien
Tze
Huang,
which
is
indicated
for
the
treatment
liver
cancer.
However,
its
impact
on
tumor
microenvironment,
particularly
tumor-associated
macrophages
(TAMs),
not
well
understood.
Cancers,
Journal Year:
2019,
Volume and Issue:
11(8), P. 1085 - 1085
Published: July 31, 2019
The
increasing
set
of
liver-directed
therapies
(LDT)
have
become
an
integral
part
hepatocellular
carcinoma
(HCC)
treatment.
These
range
from
percutaneous
ablative
techniques
to
arterial
embolization,
and
varied
radiotherapy
strategies.
They
are
now
used
for
local
disease
control,
symptom
palliation,
bold
curative
big
challenge
in
the
face
these
innovative
sometimes
overlapping
technologies
is
identify
best
opportunity
use.
In
real
practice,
many
patients
may
take
benefit
LDT
as
a
bridge
treatment
such
resection
liver
transplantation.
Varying
trans-arterial
embolization
strategies
used,
comparison
between
established
developing
scarce.
Also,
radioembolization
utilizing
yttrium-90
(Y-90)
locally
advanced
or
intermediate-stage
HCC
needs
further
evidence
clinical
efficacy.
There
interest
on
LDT-led
changes
tumor
biology
that
could
implications
systemic
therapy
Foremost,
additional
its
apoptotic
necrotic
properties,
warrant
vascular
endothelial
growth
factor
(VEGF)
expression
release.
However,
chemoembolization
(TACE)
alongside
tyrosine-kinase
inhibitor
(TKI)
sorafenib
has
had
efficacy
contested.
Most
recently,
associating
Y-90
TKI
emerged.
Furthermore,
differences
immune
microenvironment
cell
infiltration
be
enhance
immunotherapy
patients.
Early
attempts
coordinate
being
made.
We
here
review
exposing
current
understand
extant
reach
future
applications
development
HCC.
Cancer Cell International,
Journal Year:
2021,
Volume and Issue:
21(1)
Published: April 13, 2021
Abstract
Hepatocellular
carcinoma
(HCC)
is
the
second
leading
cause
of
death
due
to
cancer.
Although
there
are
different
treatment
options,
these
strategies
not
efficient
in
terms
restricting
tumor
cell’s
proliferation
and
metastasis.
The
liver
microenvironment
contains
non-parenchymal
cells
with
supportive
or
inhibitory
effects
on
cancerous
phenotype
HCC.
Several
signaling
pathways
dis-regulated
HCC
uncontrolled
cell
propagation,
metastasis,
recurrence
cells.
Recent
studies
have
established
new
approaches
for
prevention
using
small
molecules.
Small
molecules
compounds
a
low
molecular
weight
that
usually
inhibit
specific
targets
signal
transduction
pathways.
These
components
can
induce
cycle
arrest,
apoptosis,
block
growth.
Devising
simultaneously
targeting
population
could
lead
more
relevant
research
outcomes.
may
open
avenues
minimal
cytotoxic
healthy
This
study
provides
latest
findings
critical
governing
behavior
control
both
vitro
vivo
models.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(1), P. 190 - 190
Published: Jan. 12, 2023
Lung
cancer
is
the
leading
cause
of
cancer-related
deaths
worldwide.
The
standard
care
for
advanced
non-small-cell
lung
(NSCLC)
without
driver-gene
mutations
a
combination
an
anti-PD-1/PD-L1
antibody
and
chemotherapy,
or
anti-CTLA-4
with
chemotherapy.
Although
there
were
fewer
cases
disease
progression
in
early
stages
treatment
than
antibodies
alone,
only
approximately
half
patients
had
long-term
response.
Therefore,
it
necessary
to
elucidate
mechanisms
resistance
immune
checkpoint
inhibitors.
Recent
reports
such
include
reduced
cancer-cell
immunogenicity,
loss
major
histocompatibility
complex,
dysfunctional
tumor-intrinsic
interferon-γ
signaling,
oncogenic
signaling
immunoediting.
Among
these,
Wnt/β-catenin
pathway
notable
potential
mechanism
escape
In
this
review,
we
will
summarize
findings
on
these
NSCLC
other
cancers,
focusing
signaling.
First,
review
molecular
biology
then
discuss
how
can
induce
immunoediting
We
also
describe
various
immune-checkpoint-inhibitor
resistance.
Finally,
propose
therapeutic
approaches
overcome
mechanisms.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: April 2, 2024
Hepatocellular
carcinoma
(HCC)
is
the
most
common
primary
malignant
liver
tumor
and
one
of
leading
causes
cancer-related
deaths
worldwide.
The
Wnt/β-Catenin
signaling
pathway
a
highly
conserved
involved
in
several
biological
processes,
including
improper
regulation
that
leads
to
tumorigenesis
progression
cancer.
New
studies
have
found
abnormal
activation
major
cause
HCC
tumorigenesis,
progression,
resistance
therapy.
perspectives
approaches
treating
will
arise
from
understanding
this
pathway.
This
article
offers
thorough
analysis
pathway’s
function
its
therapeutic
implications
HCC.
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Feb. 14, 2024
Long
noncoding
RNAs
(lncRNAs)
are
a
group
of
with
transcript
lengths
>200
nucleotides.
Mounting
evidence
suggests
that
lncRNAs
closely
associated
tumorigenesis.
LncRNA
H19
(H19)
was
the
first
lncRNA
to
function
as
an
oncogene
in
many
malignant
tumors.
Apart
from
established
role
promoting
cell
growth,
proliferation,
invasion,
migration,
epithelial-mesenchymal
transition
(EMT),
and
metastasis,
it
has
been
recently
discovered
also
inhibits
programmed
death
(PCD)
cancer
cells.
In
this
review,
we
summarize
mechanisms
by
which
regulates
PCD
cells
through
various
signaling
pathways,
molecular
mechanisms,
epigenetic
modifications.
Wnt/β-catenin
pathway
PI3K-Akt-mTOR
pathway.
It
acts
competitive
endogenous
RNA
(ceRNA)
regulation.
The
interaction
between
RNA-binding
proteins
(RBP)
apoptosis
cancer.
Moreover,
modifications,
including
DNA
methylation
histone
involved
H19-associated
conclusion,
via
chemoresistance,
highlighting
promising
research
significance
therapeutic
target.
We
hope
our
study
will
contribute
broader
understanding
development
treatment.
Cells,
Journal Year:
2024,
Volume and Issue:
13(13), P. 1102 - 1102
Published: June 26, 2024
This
review
describes
and
summarizes,
for
the
first
time,
molecular
mechanisms
of
cytotoxic
effect
selenium
nanoparticles
various
origins
on
hepatocellular
carcinoma
cells.
The
text
provides
information
from
recent
years
indicating
regulation
signaling
pathways
endoplasmic
reticulum
stress
by
nanoparticles;
cell
death
liver
cancer
cells
as
a
result
exposure
to
are
considered.
Particular
attention
is
paid
participation
selenoproteins
selenium-containing
thioredoxin
reductases
glutathione
peroxidases
in
these
processes.
Previously,
there
were
no
reviews
that
fully
reflected
effects
specifically
carcinoma,
despite
fact
many
experimental
articles
have
been
devoted
causes
this
disease
other
agents.
relevance
primarily
explained
development
drugs
approaches
treatment
prevention
still
fourth
leading
cause
world.
For
reason,
complete
understanding
latest
trends
oncology
etiologies,
especially
extremely
important.
International Journal of Biological Sciences,
Journal Year:
2020,
Volume and Issue:
17(1), P. 32 - 49
Published: Nov. 6, 2020
βII
spectrin,
the
most
common
isoform
of
non-erythrocyte
is
a
cytoskeleton
protein
present
in
all
nucleated
cells.
Interestingly,
spectrin
essential
for
development
various
organs
such
as
nerve,
epithelium,
inner
ear,
liver
and
heart.
The
functions
include
not
only
establishing
maintaining
cell
structure
but
also
regulating
variety
cellular
functions,
apoptosis,
adhesion,
spreading
cycle
regulation.
Notably,
dysfunction
associated
with
embryonic
lethality
DNA
damage
response.
More
recently,
detection
altered
expression
tumors
indicated
that
might
be
involved
progression
cancer.
Its
mutations
disorders
could
result
developmental
disabilities
diseases.
versatile
roles
disease
have
been
examined
an
increasing
number
studies;
nonetheless,
exact
mechanisms
are
still
poorly
understood.
Thus,
we
summarize
structural
features
biological
discuss
its
molecular
development,
homeostasis,
regeneration
differentiation.
This
review
highlight
potential
effects
cancer
other
diseases,
outstanding
questions
future
investigation
therapeutic
targets.
regulatory
mechanism
signal
inactivation
recovery
may
bring
hope
therapy
related