Wnt/β-catenin signaling in cancers and targeted therapies

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Aug. 30, 2021

Abstract Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals. Aberrant activation is tightly linked with the increment prevalence, advancement malignant progression, development poor prognostics, even ascendence cancer-associated mortality. Early investigations have proposed theoretical potential that efficient repression this might provide promising therapeutic choices managing various types cancers. Up to date, many therapies targeting developed, which assumed endow clinicians new opportunities developing more satisfactory precise remedies for patients aberrant signaling. However, current facts indicate clinical translations signaling-dependent targeted faced un-neglectable crises challenges. Therefore, study, we systematically reviewed most updated knowledge relatively generate a clearer accurate awareness both developmental stage underlying limitations Wnt/β-catenin-targeted Insights study will help readers better understand roles insights acknowledge challenges

Language: Английский

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The Curious Case of the HepG2 Cell Line: 40 Years of Expertise

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(23), P. 13135 - 13135

Published: Dec. 4, 2021

Liver cancer is the third leading cause of death worldwide. Representing such a dramatic impact on our lives, liver significant public health concern. Sustainable and reliable methods for preventing treating require fundamental research its molecular mechanisms. Cell lines are treated as in vitro equivalents tumor tissues, making them must-have basic nature cancer. According to recent discoveries, certified cell retain most genetic properties original mimic microenvironment. On other hand, modern technologies allowing deepest level detail omics landscapes have shown differences even between samples same line due cross- mycoplasma infection. This observations suggest that, some cases, cultures not suitable models, with limited predictive value effectiveness new treatments. HepG2 popular hepatic line. It used wide range studies, from oncogenesis cytotoxicity substances liver. In this regard, we set out collect up-to-date information assess whether heterogeneity allows biomedical studies model guaranteed production quality.

Language: Английский

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Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(29), P. 3511 - 3533

Published: July 28, 2024

(CB), used in traditional Chinese medicine, exhibits anti-tumor effects various cancer models. It also constitutes an integral component of a compound formulation known as Pien Tze Huang, which is indicated for the treatment liver cancer. However, its impact on tumor microenvironment, particularly tumor-associated macrophages (TAMs), not well understood.

Language: Английский

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Current State of Liver-Directed Therapies and Combinatory Approaches with Systemic Therapy in Hepatocellular Carcinoma (HCC)

Cancers, Journal Year: 2019, Volume and Issue: 11(8), P. 1085 - 1085

Published: July 31, 2019

The increasing set of liver-directed therapies (LDT) have become an integral part hepatocellular carcinoma (HCC) treatment. These range from percutaneous ablative techniques to arterial embolization, and varied radiotherapy strategies. They are now used for local disease control, symptom palliation, bold curative big challenge in the face these innovative sometimes overlapping technologies is identify best opportunity use. In real practice, many patients may take benefit LDT as a bridge treatment such resection liver transplantation. Varying trans-arterial embolization strategies used, comparison between established developing scarce. Also, radioembolization utilizing yttrium-90 (Y-90) locally advanced or intermediate-stage HCC needs further evidence clinical efficacy. There interest on LDT-led changes tumor biology that could implications systemic therapy Foremost, additional its apoptotic necrotic properties, warrant vascular endothelial growth factor (VEGF) expression release. However, chemoembolization (TACE) alongside tyrosine-kinase inhibitor (TKI) sorafenib has had efficacy contested. Most recently, associating Y-90 TKI emerged. Furthermore, differences immune microenvironment cell infiltration be enhance immunotherapy patients. Early attempts coordinate being made. We here review exposing current understand extant reach future applications development HCC.

Language: Английский

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Critical signaling pathways governing hepatocellular carcinoma behavior; small molecule-based approaches

Cancer Cell International, Journal Year: 2021, Volume and Issue: 21(1)

Published: April 13, 2021

Abstract Hepatocellular carcinoma (HCC) is the second leading cause of death due to cancer. Although there are different treatment options, these strategies not efficient in terms restricting tumor cell’s proliferation and metastasis. The liver microenvironment contains non-parenchymal cells with supportive or inhibitory effects on cancerous phenotype HCC. Several signaling pathways dis-regulated HCC uncontrolled cell propagation, metastasis, recurrence cells. Recent studies have established new approaches for prevention using small molecules. Small molecules compounds a low molecular weight that usually inhibit specific targets signal transduction pathways. These components can induce cycle arrest, apoptosis, block growth. Devising simultaneously targeting population could lead more relevant research outcomes. may open avenues minimal cytotoxic healthy This study provides latest findings critical governing behavior control both vitro vivo models.

Language: Английский

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Wnt/β-Catenin Signaling and Resistance to Immune Checkpoint Inhibitors: From Non-Small-Cell Lung Cancer to Other Cancers

Biomedicines, Journal Year: 2023, Volume and Issue: 11(1), P. 190 - 190

Published: Jan. 12, 2023

Lung cancer is the leading cause of cancer-related deaths worldwide. The standard care for advanced non-small-cell lung (NSCLC) without driver-gene mutations a combination an anti-PD-1/PD-L1 antibody and chemotherapy, or anti-CTLA-4 with chemotherapy. Although there were fewer cases disease progression in early stages treatment than antibodies alone, only approximately half patients had long-term response. Therefore, it necessary to elucidate mechanisms resistance immune checkpoint inhibitors. Recent reports such include reduced cancer-cell immunogenicity, loss major histocompatibility complex, dysfunctional tumor-intrinsic interferon-γ signaling, oncogenic signaling immunoediting. Among these, Wnt/β-catenin pathway notable potential mechanism escape In this review, we will summarize findings on these NSCLC other cancers, focusing signaling. First, review molecular biology then discuss how can induce immunoediting We also describe various immune-checkpoint-inhibitor resistance. Finally, propose therapeutic approaches overcome mechanisms.

Language: Английский

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Wnt/β-Catenin signaling pathway in hepatocellular carcinoma: pathogenic role and therapeutic target

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 2, 2024

Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor and one of leading causes cancer-related deaths worldwide. The Wnt/β-Catenin signaling pathway a highly conserved involved in several biological processes, including improper regulation that leads to tumorigenesis progression cancer. New studies have found abnormal activation major cause HCC tumorigenesis, progression, resistance therapy. perspectives approaches treating will arise from understanding this pathway. This article offers thorough analysis pathway’s function its therapeutic implications HCC.

Language: Английский

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Long noncoding RNA H19: functions and mechanisms in regulating programmed cell death in cancer

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Feb. 14, 2024

Long noncoding RNAs (lncRNAs) are a group of with transcript lengths >200 nucleotides. Mounting evidence suggests that lncRNAs closely associated tumorigenesis. LncRNA H19 (H19) was the first lncRNA to function as an oncogene in many malignant tumors. Apart from established role promoting cell growth, proliferation, invasion, migration, epithelial-mesenchymal transition (EMT), and metastasis, it has been recently discovered also inhibits programmed death (PCD) cancer cells. In this review, we summarize mechanisms by which regulates PCD cells through various signaling pathways, molecular mechanisms, epigenetic modifications. Wnt/β-catenin pathway PI3K-Akt-mTOR pathway. It acts competitive endogenous RNA (ceRNA) regulation. The interaction between RNA-binding proteins (RBP) apoptosis cancer. Moreover, modifications, including DNA methylation histone involved H19-associated conclusion, via chemoresistance, highlighting promising research significance therapeutic target. We hope our study will contribute broader understanding development treatment.

Language: Английский

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Molecular Mechanisms of the Therapeutic Effect of Selenium Nanoparticles in Hepatocellular Carcinoma

Cells, Journal Year: 2024, Volume and Issue: 13(13), P. 1102 - 1102

Published: June 26, 2024

This review describes and summarizes, for the first time, molecular mechanisms of cytotoxic effect selenium nanoparticles various origins on hepatocellular carcinoma cells. The text provides information from recent years indicating regulation signaling pathways endoplasmic reticulum stress by nanoparticles; cell death liver cancer cells as a result exposure to are considered. Particular attention is paid participation selenoproteins selenium-containing thioredoxin reductases glutathione peroxidases in these processes. Previously, there were no reviews that fully reflected effects specifically carcinoma, despite fact many experimental articles have been devoted causes this disease other agents. relevance primarily explained development drugs approaches treatment prevention still fourth leading cause world. For reason, complete understanding latest trends oncology etiologies, especially extremely important.

Language: Английский

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βII spectrin (SPTBN1): biological function and clinical potential in cancer and other diseases

International Journal of Biological Sciences, Journal Year: 2020, Volume and Issue: 17(1), P. 32 - 49

Published: Nov. 6, 2020

βII spectrin, the most common isoform of non-erythrocyte is a cytoskeleton protein present in all nucleated cells. Interestingly, spectrin essential for development various organs such as nerve, epithelium, inner ear, liver and heart. The functions include not only establishing maintaining cell structure but also regulating variety cellular functions, apoptosis, adhesion, spreading cycle regulation. Notably, dysfunction associated with embryonic lethality DNA damage response. More recently, detection altered expression tumors indicated that might be involved progression cancer. Its mutations disorders could result developmental disabilities diseases. versatile roles disease have been examined an increasing number studies; nonetheless, exact mechanisms are still poorly understood. Thus, we summarize structural features biological discuss its molecular development, homeostasis, regeneration differentiation. This review highlight potential effects cancer other diseases, outstanding questions future investigation therapeutic targets. regulatory mechanism signal inactivation recovery may bring hope therapy related

Language: Английский

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