Advances in immunotherapy for triple-negative breast cancer

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Sept. 2, 2023

Immunotherapy has recently emerged as a treatment strategy which stimulates the human immune system to kill tumor cells. Tumor immunotherapy is based on editing, enhances antigenicity of cells and increases tumoricidal effect It also suppresses immunosuppressive molecules, activates or restores function, anti-tumor responses, inhibits growth f cell. This offers possibility reducing mortality in triple-negative breast cancer (TNBC).Immunotherapy approaches for TNBC have been diversified recent years, with breakthroughs this entity. Research checkpoint inhibitors (ICIs) made it possible identify different molecular subtypes formulate individualized schedules. review highlights unique microenvironment integrates analyzes advances ICI therapy. discusses strategies combination ICIs chemotherapy, radiation therapy, targeted emerging methods such nanotechnology, ribonucleic acid vaccines, gene Currently, numerous ongoing completed clinical trials are exploring utilization conjunction existing modalities TNBC. The objective these investigations assess effectiveness various combined determine most effective regimens patients TNBC.This provides insights into used overcome drug resistance immunotherapy, explores directions development

Language: Английский

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Tissue mechanics in stem cell fate, development, and cancer

Developmental Cell, Journal Year: 2021, Volume and Issue: 56(13), P. 1833 - 1847

Published: June 8, 2021

Language: Английский

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Nanoparticle drug delivery systems and their applications as targeted therapies for triple negative breast cancer

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 134, P. 101070 - 101070

Published: Jan. 16, 2023

Language: Английский

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Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells

Theranostics, Journal Year: 2020, Volume and Issue: 10(16), P. 7053 - 7069

Published: Jan. 1, 2020

Lipids, the basic components of cell membrane, execute fundamental roles in almost all activities including cell-cell recognition, signalling transduction and energy supplies.Lipid metabolism is elementary for life sustentation that balances activity between synthesis degradation.An accumulating amount data has indicated abnormal lipid cancer stem cells (CSCs), alteration exerts a great impact on CSCs' properties such as capability self-renewal, differentiation, invasion, metastasis, drug sensitivity resistance.CSCs' formation maintenance cannot do without regulation fatty acids cholesterol.In normal embryonic development, cholesterol are regulated by some important pathways (such Hedgehog, Notch, Wnt pathways); these also play crucial initiating and/or maintaining properties, shown to be commonly modulated CSCs; other hand, altered turn modifies generates additional impacts CSCs.Metabolic rewiring considered an ideal hallmark CSCs, metabolic alterations would promising therapeutic targets CSCs aggressive tumors.In this review, we summarize most updated findings abnormalities prospect potential applications targeting anticancer treatment.

Language: Английский

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Breast Cancer Stem Cells: Biomarkers, Identification and Isolation Methods, Regulating Mechanisms, Cellular Origin, and Beyond

Cancers, Journal Year: 2020, Volume and Issue: 12(12), P. 3765 - 3765

Published: Dec. 14, 2020

Despite recent advances in diagnosis and treatment, breast cancer (BC) is still a major cause of cancer-related mortality women. Breast stem cells (BCSCs) are small but significant subpopulation heterogeneous demonstrating strong self-renewal proliferation properties. Accumulating evidence has proved that BCSCs the driving force behind BC tumor initiation, progression, metastasis, drug resistance, recurrence. As disease, contains full spectrum different subtypes, subtypes further exhibit distinct proportions BCSCs, which correspond to treatment responses disease-specific outcomes. This review summarized current knowledge BCSC biomarkers their clinical relevance, methods for identification isolation mechanisms regulating BCSCs. We also discussed cellular origin single-cell lineage tracing transcriptomics potential identifying development

Language: Английский

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Biomarkers in Triple-Negative Breast Cancer: State-of-the-Art and Future Perspectives

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(13), P. 4579 - 4579

Published: June 27, 2020

Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors characterized by aggressive behavior, high risk distant recurrence, and poor survival. Chemotherapy still the main therapeutic approach for this subgroup patients, therefore, progress in treatment TNBC remains an important challenge. Data derived from molecular technologies have identified TNBCs with different gene expression mutation profiles that may help developing targeted therapies. So far, however, only few these shown to improve prognosis outcomes patients. Robust predictive biomarkers accelerate clinical are needed. Herein, we review prognostic TNBC, discuss current evidence supporting their use, look at future research field.

Language: Английский

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Signaling pathways governing breast cancer stem cells behavior

Stem Cell Research & Therapy, Journal Year: 2021, Volume and Issue: 12(1)

Published: April 16, 2021

Abstract Breast cancer is the second common and leading cause of malignancy among females overall. stem cells (BCSCs) are a small population breast that play critical role in metastasis to other organs body. BCSCs have both self-renewal differentiation capacities, which thought contribute aggressiveness metastatic lesions. Therefore, targeting can be suitable approach for treatment cancer. Growing evidence has indicated Wnt, NFκB, Notch, BMP2, STAT3, hedgehog (Hh) signaling pathways govern epithelial-to-mesenchymal transition (EMT) activation, growth, tumorigenesis primary regions. miRNAs as central regulatory molecules also roles BCSC self-renewal, metastasis, drug resistance. Hence, these might novel therapeutic diagnosis therapy. This review discusses known mechanisms involved stimulation or prevention tumorigenesis.

Language: Английский

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Pentadecanoic Acid, an Odd-Chain Fatty Acid, Suppresses the Stemness of MCF-7/SC Human Breast Cancer Stem-Like Cells through JAK2/STAT3 Signaling

Nutrients, Journal Year: 2020, Volume and Issue: 12(6), P. 1663 - 1663

Published: June 3, 2020

Saturated fatty acids possess few health benefits compared to unsaturated acids. However, increasing experimental evidence demonstrates the nutritionally beneficial role of odd-chain saturated in human health. In this study, anti-cancer effects pentadecanoic acid were evaluated breast carcinoma MCF-7/stem-like cells (SC), a cell line with greater mobility, invasiveness, and cancer stem properties parental MCF-7 cells. Pentadecanoic exerted selective cytotoxic MCF-7/SC Moreover, reduced stemness suppressed migratory invasive ability as evidenced by results flow cytometry, mammosphere formation assay, an aldehyde dehydrogenase activity Western blot experiments conducted analyze expression markers—CD44, β-catenin, MDR1, MRP1—and epithelial–mesenchymal transition (EMT) markers—snail, slug, MMP9, MMP2. addition, interleukin-6 (IL-6)-induced JAK2/STAT3 signaling, induced cycle arrest at sub-G1 phase, promoted caspase-dependent apoptosis MCF-7/SC. These findings indicate that can serve novel signaling inhibitor suggest acid-rich food intake during treatments.

Language: Английский

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An Insight Into the Cancer Stem Cell Survival Pathways Involved in Chemoresistance in Triple-Negative Breast Cancer

Future Oncology, Journal Year: 2021, Volume and Issue: 17(31), P. 4185 - 4206

Published: Aug. 3, 2021

Triple-negative breast cancer (TNBC) is the most complex, aggressive and fatal subtype of cancer. Owing to lack targeted therapy heterogenic nature TNBC, chemotherapy remains sole treatment option for with taxanes anthracyclines representing general chemotherapeutic regimen in TNBC therapy. But unfortunately, patients develop resistance existing regimen, resulting approximately 90% failure. Breast stem cells (BCSCs) are one major causes development chemoresistance patients. After surviving damage, presence BCSCs results relapse recurrence TNBC. Several pathways known regulate BCSCs’ survival, such as Wnt/β-catenin, Hedgehog, JAK/STAT HIPPO pathways. Therefore it imperative target these context eliminating chemoresistance. In this review we will discuss novel strategies various preclinical clinical studies give an insight into overcoming We present a detailed account recent carried out that open exciting perspective relation mechanisms

Language: Английский

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Targeting Autophagy in Breast Cancer

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(21), P. 7836 - 7836

Published: Oct. 22, 2020

Breast cancer is a heterogeneous disease consisting of different biological subtypes, with differences in terms incidence, response to diverse treatments, risk progression, and sites metastases. In the last years, several molecular targets have emerged new drugs, targeting PI3K/Akt/mTOR cyclinD/CDK/pRb pathways tumor microenvironment been integrated into clinical practice. However, it clear now that breast able develop resistance these drugs identification underlying mechanisms paramount drive further drug development. Autophagy highly conserved homeostatic process can be activated antineoplastic agents as cytoprotective mechanism. Inhibition autophagy could enhance cell death by anti-cancer therapies, representing an attractive approach control resistance. this manuscript, we present review focusing on its interplay targeted used for treatment.

Language: Английский

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