Cancer Immunotherapy: The Checkpoint between Chronic Colitis and Colorectal Cancer DOI Open Access
Ramya Ephraim, Jack Feehan,

Sarah Fraser

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(24), P. 6131 - 6131

Published: Dec. 12, 2022

Inflammatory Bowel Disease (IBD) is a group of diseases that cause intestinal inflammation and lesions because an abnormal immune response to host gut microflora. Corticosteroids, anti-inflammatories, antibiotics are often used reduce non-specific relapse rates; however, such treatments ineffective over time. Patients with chronic colitis more susceptible developing colorectal cancer, especially those longer duration colitis. There limit in using chemotherapy due side effects, leading reduced efficacy, leaving urgent need improve identify new therapeutic targets. Cancer immunotherapy has made significant advances recent years mainly categorized as cancer vaccines, adoptive cellular immunotherapy, or checkpoint blockade therapies. Checkpoint markers expressed on cells evade the system, result inhibitors have transformed treatment last 5–10 years. Immune produced long-lasting clinical responses both single combination Winnie mice viable model spontaneous like human IBD. Determining expression levels tissues from these will provide insights into disease initiation, progression, cancer. Such information lead identification novel development without vaccines slow stop progression.

Language: Английский

Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons DOI Creative Commons
Adel Naimi, Rebar N. Mohammed, Ahmed Raji

et al.

Cell Communication and Signaling, Journal Year: 2022, Volume and Issue: 20(1)

Published: April 7, 2022

Abstract The main breakthrough in tumor immunotherapy was the discovery of immune checkpoint (IC) proteins, which act as a potent suppressor system by myriad mechanisms. After that, scientists focused on molecules mainly. Thereby, much effort spent to progress novel strategies for suppressing these inhibitory axes, resulting evolution inhibitors (ICIs). Then, ICIs have become promising approach and shaped paradigm shift immunotherapies. CTLA-4 plays an influential role attenuation induction naïve memory T cells engagement with its responding ligands like B7-1 (CD80) B7-2 (CD86). Besides, PD-1 is predominantly implicated adjusting cell function peripheral tissues through interaction programmed death-ligand 1 (PD-L1) PD-L2. Given their suppressive effects anti-tumor immunity, it has firmly been documented that based therapies can be practical rational therapeutic approaches treat cancer patients. Nonetheless, inherent or acquired resistance ICI some treatment-related toxicities restrict application clinic. current review will deliver comprehensive overview human tumors alone combination other modalities support more desired outcomes lower

Language: Английский

Citations

286
The Crosstalk Between Tumor Cells and the Immune Microenvironment in Breast Cancer: Implications for Immunotherapy DOI Creative Commons
Vincenzo Salemme, Giorgia Centonze, Federica Cavallo

et al.

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: March 11, 2021

Breast cancer progression is a complex process controlled by genetic and epigenetic factors that coordinate the crosstalk between tumor cells components of microenvironment (TME). Among those, immune play dual role during onset progression, as they can protect from killing immunogenic neoplastic cells, but in meanwhile also shape immunogenicity, contributing to escape. The interplay TME influences outcome immunotherapy many other anti-cancer therapies. Herein, we present an updated view pro- anti-tumor activities main cell populations breast TME, such T NK myeloid innate lymphoid mast eosinophils, underlying cytokine-, cell-cell contact- microvesicle-based mechanisms. Moreover, current novel therapeutic options revert immunosuppressive activity will be discussed. To this end, clinical trials assessing efficacy CAR-T CAR-NK vaccination, death-inducing chemotherapy, DNA methyl transferase histone deacetylase inhibitors, cytokines or their inhibitors immunotherapies patients reviewed. knowledge elapses experimental therapies targeting it, would help develop new combination treatments able overcome evasion mechanisms optimize benefit immunotherapies.

Language: Английский

Citations

188
The Effects of Obesity on Anti-Cancer Immunity and Cancer Immunotherapy DOI Open Access
Matthew J. Woodall, Silke Neumann, Katrin Campbell

et al.

Cancers, Journal Year: 2020, Volume and Issue: 12(5), P. 1230 - 1230

Published: May 14, 2020

Cancer is one of the leading causes morbidity and mortality worldwide. Traditional treatments include surgery, chemotherapy radiation therapy, more recently targeted therapies including immunotherapy are becoming routine care for some cancers. Immunotherapy aims to upregulate patient’s own immune system, enabling it destroy cancerous cells. Obesity a metabolic disorder characterized by significant weight that an important contributor many different diseases, impacts system causes, among other things, state chronic low-grade inflammation. This hypothesized impact efficacy immunotherapies. review discusses effects obesity on cancer immunotherapy, current evidence effect checkpoint blockade, something which currently published reviews this topic have not delved into. Data from several studies show even though inflammation with reductions in effector populations, has beneficial patient survival following anti-PD-1/PD-L1 anti-CTLA-4 treatment. However, research field just emerging further work needed expand our understanding patients likely benefit immunotherapy.

Language: Английский

Citations

93
Signaling pathways governing breast cancer stem cells behavior DOI Creative Commons
Kai Song,

Maryam Farzaneh

Stem Cell Research & Therapy, Journal Year: 2021, Volume and Issue: 12(1)

Published: April 16, 2021

Abstract Breast cancer is the second common and leading cause of malignancy among females overall. stem cells (BCSCs) are a small population breast that play critical role in metastasis to other organs body. BCSCs have both self-renewal differentiation capacities, which thought contribute aggressiveness metastatic lesions. Therefore, targeting can be suitable approach for treatment cancer. Growing evidence has indicated Wnt, NFκB, Notch, BMP2, STAT3, hedgehog (Hh) signaling pathways govern epithelial-to-mesenchymal transition (EMT) activation, growth, tumorigenesis primary regions. miRNAs as central regulatory molecules also roles BCSC self-renewal, metastasis, drug resistance. Hence, these might novel therapeutic diagnosis therapy. This review discusses known mechanisms involved stimulation or prevention tumorigenesis.

Language: Английский

Citations

92
Computational Oncology in the Multi-Omics Era: State of the Art DOI Creative Commons
Guillermo de Anda‐Jáuregui, Enrique Hernández-Lemus

Frontiers in Oncology, Journal Year: 2020, Volume and Issue: 10

Published: April 7, 2020

Cancer is the quintessential complex disease. As technologies evolve faster each day, we are able to quantify different layers of biological elements that contribute emergence and development malignancies. In this multi-omics context, use integrative approaches mandatory in order gain further insights on oncological phenomena, move forward toward precision medicine paradigm. review, will focus computational oncology as an discipline incorporates knowledge from mathematical, physical, fields biomedical understanding cancer. We discuss current roles computation context multi-omic technologies, which include: data acquisition processing; management clinical research settings; classification, diagnosis, prognosis; models setting, including their for therapeutic target identification. machine learning network two most promising emerging paradigms, oncology. These provide a foundation how integrate description into coherent frameworks allow advances both basic settings.

Language: Английский

Citations

82
Peptide-Drug Conjugates: A New Hope for Cancer Management DOI Creative Commons
Vivek P. Chavda,

Hetvi K. Solanki,

Majid Davidson

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(21), P. 7232 - 7232

Published: Oct. 25, 2022

Cancer remains the leading cause of death worldwide despite advances in treatment options for patients. As such, safe and effective therapeutics are required. Short peptides provide advantages to be used cancer management due their unique properties, amazing versatility, progress biotechnology overcome peptide limitations. Several appealing peptide-based therapeutic strategies have been developed. Here, we an overview conjugates, better equivalents antibody-drug as next generation drugs required precise targeting, enhanced cellular permeability, improved drug selectivity, reduced toxicity efficient cancers. We discuss basic components conjugates release action, including cytotoxins from linker. also present peptide-drug under different stages clinical development well regulatory other challenges.

Language: Английский

Citations

59
The Role of TAMs in Tumor Microenvironment and New Research Progress DOI Creative Commons

Yawei Feng,

Zhiqiang Ye,

Furong Song

et al.

Stem Cells International, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 11

Published: Aug. 15, 2022

Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment (TME) and play a key role in TME, participating the process occurrence, growth, invasion, metastasis. Among them, metastasis to tissue is step malignant development tumor. In this paper, latest progress TAMs formation summarized. It particularly noteworthy that cell animal experiments show can provide favorable for occurrence tumors. At same time, clinical pathological accumulation related poor efficacy. Finally, paper discusses feasibility TAMs-targeted therapy as new indirect cancer therapy. This provides theoretical basis finding potentially effective macrophage-targeted

Language: Английский

Citations

45
Self-Amplifying RNA Approach for Protein Replacement Therapy DOI Open Access
Dimitri Papukashvili, Nino Rcheulishvili, Cong Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(21), P. 12884 - 12884

Published: Oct. 25, 2022

Messenger RNA (mRNA) technology has already been successfully tested preclinically and there are ongoing clinical trials for protein replacement purposes; however, more effort put into the development of prevention strategies against infectious diseases. Apparently, mRNA vaccine approval coronavirus disease 2019 (COVID-19) is a landmark opening new opportunities managing diverse health disorders based on this approach. Indeed, apart from diseases, it also widely in numerous directions including cancer treatment inherited disorders. Interestingly, self-amplifying (saRNA)-based believed to display developed therapy compared with conventional technique terms its lower dosage requirements, relatively fewer side effects, possessing long-lasting effects. Nevertheless, some challenges still exist that need be overcome order achieve saRNA-based drug clinics. Hence, current review discusses feasibility saRNA utility various rare hereditary diseases provides detailed overview advantages, molecular structure, mechanism action, relevant delivery platforms.

Language: Английский

Citations

39
Lipid- and Polymer-Based Nanocarrier Platforms for Cancer Vaccine Delivery DOI
Suhair Sunoqrot, Sara A. Abdel Gaber, Razan Abujaber

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 4998 - 5019

Published: Jan. 18, 2024

Cancer immunotherapy has gained popularity in recent years the search for effective treatment modalities various malignancies, particularly those that are resistant to conventional chemo- and radiation therapy. vaccines target cancer-immunity cycle by boosting patient's own immune system recognize kill cancer cells, thus serving as both preventative curative therapeutic tools. Among different types of vaccines, based on nanotechnology have shown great promise advancing field immunotherapy. Lipid-based nanoparticles (NPs) become most advanced platforms vaccine delivery, but polymer-based NPs also received considerable interest. This Review aims provide an overview nanotechnology-enabled landscape, focusing advances lipid- nanovaccines their hybrid structures discussing challenges against clinical translation these important nanomedicines.

Language: Английский

Citations

13
Berberine: Potential preventive and therapeutic strategies for human colorectal cancer DOI
Yuqian Feng, Jiamin Lu, Jin Jiang

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(4)

Published: May 14, 2024

Colorectal cancer (CRC) is a common digestive tract tumor, with incidences continuing to rise. Although modern medicine has extended the survival time of CRC patients, its adverse effects and financial burden cannot be ignored. multi-step process can caused by disturbance gut microbiome chronic inflammation's stimulation. Additionally, presence precancerous lesions also risk factor for CRC. Consequently, scientists are increasingly interested in identifying multi-target, safe, economical herbal natural products. This paper summarizes berberine's (BBR) regulatory mechanisms occurrence development The findings indicate that BBR regulates homeostasis controls mucosal inflammation prevent In stage, inhibits cell proliferation, invasion, metastasis, blocks cycle, induces apoptosis, metabolism, angiogenesis, enhances chemosensitivity. plays role overall management Therefore, using as an adjunct prevention treatment could become future trend oncology.

Language: Английский

Citations

9