Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Aug. 14, 2024
Abstract
Receptor
tyrosine
kinases
(RTKs),
a
category
of
transmembrane
receptors,
have
gained
significant
clinical
attention
in
oncology
due
to
their
central
role
cancer
pathogenesis.
Genetic
alterations,
including
mutations,
amplifications,
and
overexpression
certain
RTKs,
are
critical
creating
environments
conducive
tumor
development.
Following
discovery,
extensive
research
has
revealed
how
RTK
dysregulation
contributes
oncogenesis,
with
many
subtypes
showing
dependency
on
aberrant
signaling
for
proliferation,
survival
progression.
These
findings
paved
the
way
targeted
therapies
that
aim
inhibit
crucial
biological
pathways
cancer.
As
result,
RTKs
emerged
as
primary
targets
anticancer
therapeutic
Over
past
two
decades,
this
led
synthesis
validation
numerous
small
molecule
kinase
inhibitors
(TKIs),
now
effectively
utilized
treating
various
types.
In
manuscript
we
provide
comprehensive
understanding
context
We
explored
alterations
specific
receptors
across
different
malignancies,
special
dedicated
examination
current
inhibitors,
highlighting
potential
therapies.
By
integrating
latest
evidence,
seek
elucidate
pivotal
biology
efficacy
inhibition
promising
treatment
outcomes.
Journal of Inflammation Research,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 3563 - 3580
Published: Aug. 1, 2023
Abstract:
Bone
homeostasis
is
a
dynamic
equilibrium
state
of
bone
formation
and
absorption,
ensuring
skeletal
development
repair.
immunity
encompasses
all
aspects
the
intersection
between
immune
systems,
including
various
signaling
pathways,
cytokines,
crosstalk
cells
under
both
homeostatic
pathological
conditions.
Therefore,
as
key
cell
types
in
immunity,
macrophages
can
polarize
into
classical
pro-inflammatory
M1
alternative
anti-inflammatory
M2
influence
body
environment,
participating
regulation
metabolism
playing
roles
homeostasis.
not
only
act
precursors
osteoclasts
(OCs),
differentiate
mature
OCs,
but
also
secrete
cytokines
to
promote
resorption;
while
osteogenic
factors,
stimulating
differentiation
mineralization
osteoblast
mesenchymal
stem
(MSCs),
subsequently
increase
formation.
Once
polarization
imbalanced,
resulting
dysregulation
will
cause
inflammatory
stimulation,
release
large
amount
factors
affecting
metabolism,
leading
conditions
such
osteoporosis
(OP),
rheumatoid
arthritis
(RA),
steroid-induced
femoral
head
necrosis
(SANFH).
In
this
review,
we
introduce
pathways
related
macrophage
polarization,
well
their
relationships
with
OB,
OC,
MSC.
We
discuss
diseases
imbalance,
regulating
them,
which
may
help
develop
new
methods
for
treating
metabolic
disorders.
Keywords:
macrophage,
Frontiers in Genetics,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 29, 2023
Colorectal
cancer
(CRC)
is
one
of
the
main
fatal
cancers.
Cell
signaling
such
as
Janus
kinase/signal
transducer
and
activator
transcription
(JAK/STAT)
substantially
influences
process
gene
expression
cell
growth.
Long
non-coding
RNAs
(lncRNAs)
play
regulatory
roles
in
signaling,
proliferation,
fate.
Hence,
lncRNAs
can
be
considered
biomarkers
The
inhibitory
or
activating
effects
different
on
JAK/STAT
pathway
regulate
proliferation
tumor
suppression.
Additionally,
immune
responses
which
a
role
immunotherapy.
Mechanisms
CRC
via
regulation
mainly
include
invasion,
metastasis,
apoptosis,
adhesion,
control
inflammation.
More
profound
findings
are
warranted
to
specifically
target
terms
activation
suppression
hindering
proliferation.
Here,
understand
lncRNA
cross-talk
through
pathway,
we
collected
related
vitro
vivo
data.
Future
insights
may
pave
way
for
development
novel
diagnostic
tools,
therapeutic
interventions,
personalized
treatment
strategies
patients.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Aug. 14, 2024
Abstract
Receptor
tyrosine
kinases
(RTKs),
a
category
of
transmembrane
receptors,
have
gained
significant
clinical
attention
in
oncology
due
to
their
central
role
cancer
pathogenesis.
Genetic
alterations,
including
mutations,
amplifications,
and
overexpression
certain
RTKs,
are
critical
creating
environments
conducive
tumor
development.
Following
discovery,
extensive
research
has
revealed
how
RTK
dysregulation
contributes
oncogenesis,
with
many
subtypes
showing
dependency
on
aberrant
signaling
for
proliferation,
survival
progression.
These
findings
paved
the
way
targeted
therapies
that
aim
inhibit
crucial
biological
pathways
cancer.
As
result,
RTKs
emerged
as
primary
targets
anticancer
therapeutic
Over
past
two
decades,
this
led
synthesis
validation
numerous
small
molecule
kinase
inhibitors
(TKIs),
now
effectively
utilized
treating
various
types.
In
manuscript
we
provide
comprehensive
understanding
context
We
explored
alterations
specific
receptors
across
different
malignancies,
special
dedicated
examination
current
inhibitors,
highlighting
potential
therapies.
By
integrating
latest
evidence,
seek
elucidate
pivotal
biology
efficacy
inhibition
promising
treatment
outcomes.
