The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 374 - 403

Published: March 1, 2023

Language: Английский

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Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis

Cell Metabolism, Journal Year: 2018, Volume and Issue: 29(1), P. 141 - 155.e9

Published: Aug. 30, 2018

Language: Английский

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Exosomes in Angiogenesis and Anti-angiogenic Therapy in Cancers

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(16), P. 5840 - 5840

Published: Aug. 14, 2020

Angiogenesis is the process through which new blood vessels are formed from pre-existing ones. Exosomes involved in angiogenesis cancer progression by transporting numerous pro-angiogenic biomolecules like vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs), and microRNAs. promote suppressing expression of factor-inhibiting hypoxia-inducible 1 (HIF-1). Uptake tumor-derived exosomes (TEX) normal cells activates angiogenic signaling pathways stimulates vessel formation. TEX-driven cross-talk mesenchymal stem (MSCs) with immune blocks their anti-tumor activity. Effective inhibition tumor may arrest progression. Bevacizumab, a VEGF-specific antibody, was first antiangiogenic agent to enter clinic. The most important clinical problem associated therapy using VEGF- or VEFGR-targeting agents drug resistance. Combined strategies based on inhibitors immunotherapy effectively enhances therapies various cancers, but effective treatment requires further research.

Language: Английский

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Cancer associated-fibroblast-derived exosomes in cancer progression

Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)

Published: Dec. 1, 2021

To identify novel cancer therapies, the tumor microenvironment (TME) has received a lot of attention in recent years particular with advent clinical successes achieved by targeting immune checkpoint inhibitors (ICIs). The TME consists multiple cell types that are embedded extracellular matrix (ECM), including cells, endothelial cells and associated fibroblasts (CAFs), which communicate each other during progression. CAFs dominant heterogeneous type within pivotal role controlling invasion metastasis, evasion, angiogenesis chemotherapy resistance. mediate their effects part remodeling ECM secreting soluble factors vesicles. Exosomes subtype vesicles (EVs), contain various biomolecules such as nucleic acids, lipids, proteins. exosomes can be transmitted from one to another cell, thereby affect behavior receiving cell. As also present circulation, contents explored biomarkers for diagnosis prognosis patients. In this review, we concentrate on CAFs-derived communication between TME. First, introduce roles tumorigenesis. Thereafter, discuss ways interplay TME, focus exosomes. Then, elaborate mechanisms contribute progression, well impact We conclude discussing aspects deserve further investigation, emerging insights into making treatment inhibitor blockade more efficient.

Language: Английский

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Mechanisms driving the immunoregulatory function of cancer cells

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(4), P. 193 - 215

Published: Jan. 30, 2023

Language: Английский

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Colorectal Cancer Metastases in the Liver Establish Immunosuppressive Spatial Networking between Tumor-Associated SPP1+ Macrophages and Fibroblasts

Clinical Cancer Research, Journal Year: 2022, Volume and Issue: 29(1), P. 244 - 260

Published: Oct. 14, 2022

Abstract Purpose: The liver is the most frequent metastatic site for colorectal cancer. Its microenvironment modified to provide a niche that conducive cancer cell growth. This study focused on characterizing cellular changes in (mCRC) tumor (TME). Experimental Design: We analyzed series of microsatellite stable (MSS) mCRCs liver, paired normal tissue, and peripheral blood mononuclear cells using single-cell RNA sequencing (scRNA-seq). validated our findings multiplexed spatial imaging bulk gene expression with deconvolution. Results: identified TME-specific SPP1-expressing macrophages altered metabolism features, foam characteristics, increased activity extracellular matrix (ECM) organization. SPP1+ fibroblasts expressed complementary ligand–receptor pairs potential mutually influence their gene-expression programs. TME lacked dysfunctional CD8 T contained regulatory cells, indicative immunosuppression. Spatial these states TME. Moreover, had close proximity, which requirement intercellular communication networking. In an independent cohort we confirmed presence data. An proportion was associated worst prognosis patients. Conclusions: demonstrated mCRC characterized by transcriptional alterations Intercellular networking between supports growth immunosuppressed liver. These features can be used target immune-checkpoint–resistant MSS tumors.

Language: Английский

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Contribution of tumor microenvironment (TME) to tumor apoptosis, angiogenesis, metastasis, and drug resistance

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 14, 2025

Language: Английский

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Intercellular communication is crucial in the regulation of healthy aging via exosomes

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107591 - 107591

Published: Jan. 1, 2025

The hallmarks of aging encompass a variety molecular categories (genomic, telomeric, and epigenetic), organelles (proteostasis, autophagy, mitochondria), cellular components (including stem cells), systems (such as intercellular communication chronic inflammation), environmental factors (dysbiosis nutrient sensing). These play crucial role in the process. Despite their intricate interconnections, relationships among remain unclear. Although boundaries between these may be indistinct, they exhibit interdependence, with influence one hallmark extending to others. Building on this foundation, we investigated interrelations various provided systematic overview logical relationships, proposing that plays Exosomes function primary mode significantly impact Therefore, propose utilizing exosomes valuable tools for understanding mechanisms addressing age-related concerns. represent novel approach treatment diagnosis aging-related conditions animals. Furthermore, our research reveals exocytosis young nematodes slows process, while aged has opposite effect, accelerating aging. In conclusion, act messengers maintenance healthy process link indicators well-being.

Language: Английский

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Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: March 7, 2025

Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis development of tumor. The needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly correlated with improved survival outcomes many cancers. In recent years, increasing attention on the TLS tumor microenvironment, TLSs have emerged a novel target for anti-tumor therapy. Excitingly, studies shown contribution to immune responses. However, it unclear how form more effectively defense against through formation. Recent that inflammation plays role Interestingly, also found gut microbiota can regulate occurrence inflammation. Therefore, we here summarize potential effects microbiota- mediated or immunosuppression formation environments. Meanwhile, this review explores manipulate mature regulating microbiota/metabolites associated signal pathways potentially lead next-generation cancer immunotherapy.

Language: Английский

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The FGF/FGFR System in Breast Cancer: Oncogenic Features and Therapeutic Perspectives

Cancers, Journal Year: 2020, Volume and Issue: 12(10), P. 3029 - 3029

Published: Oct. 18, 2020

One of the major challenges in treatment breast cancer is heterogeneous nature disease. With multiple subtypes identified, there an unmet clinical need for development therapies particularly less tractable subtypes. Several transduction mechanisms are involved progression cancer, therefore making assessment molecular landscape that characterizes each patient intricate. Over last decade, numerous studies have focused on tyrosine kinase inhibitors (TKIs) to target main pathways dysregulated however their effectiveness often limited either by resistance treatments or appearance adverse effects. In this context, fibroblast growth factor/fibroblast factor receptor (FGF/FGFR) system represents emerging pathway and therapeutic be fully investigated among diverse anti-cancer settings cancer. Here, we recapitulated previous dealing with FGFR aberrations, such as gene amplification, point mutations, chromosomal translocations occur Furthermore, alterations FGF/FGFR signaling across different been described. Next, discussed functional interplay between axis important components tumor microenvironment. Lastly, pointed out usefulness inhibitors, revealed preclinical models

Language: Английский

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