Mitochondrial-mediated apoptosis as a therapeutic target for FNC (2′-deoxy-2′-b-fluoro-4′-azidocytidine)-induced inhibition of Dalton’s lymphoma growth and proliferation DOI Creative Commons
Naveen Kumar, Sanjeev Kumar, Alok Shukla

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 22, 2024

Abstract Purpose T-cell lymphomas, refer to a diverse set of lymphomas that originate from T-cells, type white blood cell, with limited treatment options. This investigation aimed assess the efficacy and mechanism novel fluorinated nucleoside analogue (FNA), 2′-deoxy-2′-β-fluoro-4′-azidocytidine (FNC), against lymphoma using Dalton’s (DL)-bearing mice as model. Methods Balb/c transplanted DL tumor model received FNC study therapeutic lymphoma. Behavioral monitoring, physiological measurements, various analyses were conducted evaluate effects for mechanistic investigations. Results The results indicated prevented DL-altered behavior parameters, weight gain alteration in organ structure, hematological liver enzyme levels. Moreover, restored structures, attenuated angiogenesis, reduced cell viability proliferation through apoptosis. revealed diminished MMP levels, induced apoptosis ROS induction, activated mitochondrial-mediated pathways leading increase mean survival time mice. These findings suggest has potential mitigating DL-induced adverse effects. Conclusion represents an efficient targeted strategy FNC’s proficient ability induce generation reduction makes it promising candidate developing newer more effective anticancer therapies. Continued research could unveil role designing better approach NHL.

Language: Английский

Macrophage-Mimic Hollow Mesoporous Fe-Based Nanocatalysts for Self-Amplified Chemodynamic Therapy and Metastasis Inhibition via Tumor Microenvironment Remodeling DOI

Wenbao Zuo,

Weibin Chen,

Jinxue Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(4), P. 5053 - 5065

Published: Jan. 18, 2022

Fe-based nanomaterials with Fenton reaction activity are promising for tumor-specific chemodynamic therapy (CDT). However, most of the suffer from low catalytic efficiency due to its insufficient active site exposure and relatively high tumor intracellular pH, which greatly impede clinical application. Herein, macrophage membrane-camouflaged carbonic anhydrase IX inhibitor (CAI)-loaded hollow mesoporous ferric oxide (HMFe) nanocatalysts designed remodel microenvironment decreased pH self-amplified CDT. The HMFe not only serves as a agent active-atom enhance CDT but also provides cavity CAI loading. Meanwhile, membrane-camouflaging endows immune evading capability improves tumoritropic accumulation by recognizing endothelium cancer cells through α4/VCAM-1 interaction. Once internalized cells, could be specifically released, can inhibit CA induce H+ accelerating prevent metastasis because formation outside extracellular matrix degradation. In addition, employed highly efficient magnetic resonance imaging real-time monitor agents' bio-distribution treatment progress. Both in vitro vivo results well demonstrated that realize breast inhibition via remodeling, paradigm improving antimetastatic treatment.

Language: Английский

Citations

34
Development of Anticancer Peptides Using Artificial Intelligence and Combinational Therapy for Cancer Therapeutics DOI Creative Commons
Ji Su Hwang, Seok Gi Kim, Tae Hwan Shin

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(5), P. 997 - 997

Published: May 6, 2022

Cancer is a group of diseases causing abnormal cell growth, altering the genome, and invading or spreading to other parts body. Among therapeutic peptide drugs, anticancer peptides (ACPs) have been considered target kill cancer cells because unique characteristics such as high negative charge abundance microvilli in membrane when compared normal cell. ACPs several advantages, specificity, cost-effectiveness, low immunogenicity, minimal toxicity, tolerance under physiological conditions. However, development identification are time-consuming expensive traditional wet-lab-based approaches. Thus, application artificial intelligence on approaches can save time reduce cost identify candidate ACPs. Recently, machine learning (ML), deep (DL), hybrid (ML combined DL) emerged into without experimental analysis, owing advances computer power big data from system. Additionally, we suggest that combination therapy with classical might be one impactful increase efficiency therapy.

Language: Английский

Citations

33
Nanoconstructs for theranostic application in cancer: Challenges and strategies to enhance the delivery DOI Creative Commons
Shivani B. Mishra,

Tanvi Bhatt,

Hitesh Kumar

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 15, 2023

Nanoconstructs are made up of nanoparticles and ligands, which can deliver the loaded cargo at desired site action. Various nanoparticulate platforms have been utilized for preparation nanoconstructs, may serve both diagnostic as well therapeutic purposes. mostly used to overcome limitations cancer therapies, such toxicity, nonspecific distribution drug, uncontrolled release rate. The strategies employed during design nanoconstructs help improve efficiency specificity theranostic agents make them a successful approach therapy. designed with sole purpose targeting requisite site, overcoming barriers hinders its right placement benefit. Therefore, instead classifying modes delivery actively or passively targeted systems, they suitably classified autonomous nonautonomous types. At large, offer numerous benefits, however suffer from multiple challenges, too. Hence, challenges computational modelling methods artificial intelligence/machine learning processes being explored. current review provides an overview on attributes applications offered by agent in cancer.

Language: Английский

Citations

17
Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13C-labelled Z-OMPD DOI Creative Commons
Martin Grashei, Pascal Wodtke, Jason G. Skinner

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 21, 2023

pH alterations are a hallmark of many pathologies including cancer and kidney disease. Here, we introduce [1,5-13C2]Z-OMPD as hyperpolarized extracellular perfusion sensor for MRI which allows to generate multiparametric fingerprint renal disease status detect local tumor acidification. Exceptional long T1 two minutes at 1 T, high sensitivity up 1.9 ppm per unit suitability using the C1-label internal frequency reference enables imaging in vivo three compartments healthy rat kidneys. Spectrally selective targeting both 13C-resonances simultaneous filtration 3D 2D within one minute quantify blood flow, glomerular rates hydronephrotic kidneys with superior compared clinical routine methods. Imaging multiple biomarkers single session renders promising new agent oncology nephrology.

Language: Английский

Citations

17
Mitochondrial-mediated apoptosis as a therapeutic target for FNC (2′-deoxy-2′-b-fluoro-4′-azidocytidine)-induced inhibition of Dalton’s lymphoma growth and proliferation DOI Creative Commons
Naveen Kumar, Sanjeev Kumar, Alok Shukla

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 22, 2024

Abstract Purpose T-cell lymphomas, refer to a diverse set of lymphomas that originate from T-cells, type white blood cell, with limited treatment options. This investigation aimed assess the efficacy and mechanism novel fluorinated nucleoside analogue (FNA), 2′-deoxy-2′-β-fluoro-4′-azidocytidine (FNC), against lymphoma using Dalton’s (DL)-bearing mice as model. Methods Balb/c transplanted DL tumor model received FNC study therapeutic lymphoma. Behavioral monitoring, physiological measurements, various analyses were conducted evaluate effects for mechanistic investigations. Results The results indicated prevented DL-altered behavior parameters, weight gain alteration in organ structure, hematological liver enzyme levels. Moreover, restored structures, attenuated angiogenesis, reduced cell viability proliferation through apoptosis. revealed diminished MMP levels, induced apoptosis ROS induction, activated mitochondrial-mediated pathways leading increase mean survival time mice. These findings suggest has potential mitigating DL-induced adverse effects. Conclusion represents an efficient targeted strategy FNC’s proficient ability induce generation reduction makes it promising candidate developing newer more effective anticancer therapies. Continued research could unveil role designing better approach NHL.

Language: Английский

Citations

8