Computational and Theoretical Chemistry, Journal Year: 2024, Volume and Issue: 1232, P. 114461 - 114461
Published: Jan. 6, 2024
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 115973 - 115973
Published: Dec. 7, 2023
The resistance of cancer cells to chemotherapy, also known as chemo-resistance, poses a significant obstacle treatment and can ultimately result in patient mortality. Epithelial-mesenchymal transition (EMT) is one the many factors processes responsible for chemo-resistance. Studies have shown that targeting EMT help overcome nanotechnology nanomedicine emerged promising approaches achieve this goal. This article discusses potential inhibiting proposes viable strategy combat chemo-resistance various solid tumors, including breast cancer, lung pancreatic glioblastoma, ovarian gastric hepatocellular carcinoma. While has results EMT, further research necessary explore its full overcoming discovering more effective methods future.
Language: Английский
Citations
27
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2441 - 2467
Published: March 1, 2024
Abstract: New nanotechnology strategies for enhancing drug delivery in brain disorders have recently received increasing attention from designers. The treatment of neurological conditions, including tumors, stroke, Parkinson's Disease (PD), and Alzheimer's disease (AD), may be greatly influenced by nanotechnology. Numerous studies on neurodegeneration demonstrated the effective application nanomaterials illnesses. Nanocarriers (NCs) made it easier to deliver drugs precisely where they are needed. Thus, most use is various diseases, as this amplifies overall impact medication emphasizes significance nanotherapeutics through gene therapy, enzyme replacement blood-barrier mechanisms. Recent advances led development multifunctional nanotherapeutic agents, a promising disorders. This novel method reduces side effects improves outcomes. review critically assesses efficient nano-based systems light obstacles outstanding achievements. that transfer medications across blood-brain barrier nano-assisted therapies, nano-immunotherapy, nano-gene nano scaffolds, 3D 6D printing, been widely explored study aimed evaluate existing literature regarding can penetrate (BBB) therapeutic agents treat Keywords: delivery, nanomedicine, nano-therapeutics, nanocarriers,
Language: Английский
Citations
13
Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(7), P. 4233 - 4245
Published: June 5, 2024
In the area of drug delivery aided by stimuli-responsive polymers, biodegradability nanocarriers is one major challenges that needs to be addressed with utmost sincerity. Herein, a hydrogen sulfide (H2S) responsive hydrophobic dansyl-based trigger molecule custom designed and successfully incorporated into water-soluble polyurethane backbone, which made esterase enzyme susceptible urethane bonds. The amphiphilic polyurethanes, PUx (x = 2 3) biotin chain end, formed self-assembled nanoaggregates. A hemolysis cytotoxicity profile doxorubicin (DOX)-loaded biotinylated PU3 revealed it nonhemolytic has excellent selectivity toward HeLa cells (biotin receptor-positive cell lines) causing ∼60% death while maintaining almost 100% viability for HEK 293T receptor-negative lines). Furthermore, better cellular internalization DOX-loaded fluorescent in than confirmed receptor-mediated endocytosis. Thus, this work ensures synthesized polymers serve as biodegradable anticancer therapeutics.
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6219 - 6219
Published: June 5, 2024
According to data from the World Health Organization (WHO), cancer is considered be one of leading causes death worldwide, and new therapeutic approaches, especially improved novel treatment regimens, are in high demand. Considering that many chemotherapeutic drugs tend have poor pharmacokinetic profiles, including rapid clearance limited on-site accumulation, a combined approach with tumor-homing peptide (THP)-functionalized magnetic nanoparticles could lead remarkable improvements. This confirmed by an increasing number papers this field, showing on-target functionalization improves their penetration properties ensures tumor-specific binding, which results increased clinical response. review aims highlight potential applications THPs combination carriers across various fields, pharmacoeconomic perspective.
Language: Английский
Citations
9
Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(10), P. 1719 - 1719
Published: Oct. 18, 2021
Metal-based nanoparticles are widely used to deliver bioactive molecules and drugs improve cancer therapy. Several research works have highlighted the synthesis of gold silver by green chemistry, using biological entities minimize use solvents control their physicochemical properties. Recent advances in evaluating anticancer effect biogenic Au Ag mainly focused on conventional 2D cell culture vivo murine models that allow determination half-maximal inhibitory concentration, a critical parameter move forward clinical trials. However, interaction between tumor microenvironment is not yet fully understood. Therefore, it necessary develop more human-like evaluation or existing ones for better understanding molecular bases cancer. This review provides recent biosynthesized seven most common relevant cancers assessment. In addition, general idea silico, vitro, ex vivo, metal-based nanoparticles.
Language: Английский
Citations
50
Antioxidants, Journal Year: 2021, Volume and Issue: 10(5), P. 685 - 685
Published: April 27, 2021
The disadvantages of conventional anticancer drugs, such as their low bioavailability, poor targeting efficacy, and serious side effects, have led to the discovery new therapeutic agents potential drug delivery systems. In particular, introduction nano-sized systems (NDDSs) has opened horizons for effective cancer treatment. These are considered that provide deep tissue penetration specific targeting. On other hand, nuclear factor erythroid 2-related 2 (NRF2)-based treatment approaches attracted tremendous attention produced encouraging results. However, lack formulation strategies is one factors hinder clinical application NRF2 modulators. this review, we initially focus on critical role in cells NRF2-based Subsequently, review preparation characterization NDDSs encapsulating modulators discuss therapy.
Language: Английский
Citations
44
International Journal of Nanomedicine, Journal Year: 2022, Volume and Issue: Volume 17, P. 3751 - 3775
Published: Aug. 1, 2022
Abstract: Glioma is characterized by high mortality and low postoperative survival. Despite the availability of various therapeutic approaches molecular typing, treatment failure rate recurrence glioma remain high. Given limitations existing tools, nanotechnology has emerged as an alternative option. Nanoparticles, such polydopamine (PDA)-based nanoparticles, are embodied with reliable biodegradability, efficient drug loading rate, relatively toxicity, considerable biocompatibility, excellent adhesion properties, precisely targeted delivery, strong photothermal conversion properties. Therefore, they can further enhance effects in patients glioma. Moreover, contains pyrocatechol, amino carboxyl groups, active double bonds, catechol, other reactive groups that react biofunctional molecules containing amino, aldehyde, or sulfhydryl (main including, self-polymerization, non-covalent self-assembly, π-π stacking, electrostatic attraction interaction, chelation, coating covalent co-assembly), which form a reversible dynamic Schiff base bond extremely sensitive to pH values. Meanwhile, PDA capability be functionally modified. Consequently, aim this review summarize application PDA-based NPs acquire insight into effect drug-loaded nanocarriers (PDA NPs). A wealthy understanding argument these sides anticipated afford better approach develop more reasonable valid cancer nano-dru g delivery systems. Finally, we discuss expectation for prospective sphere some individual viewpoints. Keywords: glioma, polydopamine, polymeric therapy, chemotherapy, synergistic therapy
Language: Английский
Citations
35
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(7), P. 1377 - 1377
Published: June 29, 2022
Despite the noticeable evolution in wound treatment over centuries, a functional material that promotes correct and swift healing is important, considering relative weight of chronic wounds healthcare. Difficult to heal fashionable time, are more prone infections complications thereof. Nitric oxide (NO) has been explored for applications due its appealing properties, which context include vasodilation, angiogenesis promotion, cell proliferation, antimicrobial activity. NO delivery facilitated by molecules release when prompted, whose stability ensured using carriers. Hydrogels, popular materials dressings, have studied as scaffolds storage delivery, showing promising results such enhanced healing, controlled sustained release, bactericidal properties. Systems reported so far regarding hydrogels reviewed.
Language: Английский
Citations
29
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 229, P. 684 - 695
Published: Jan. 2, 2023
Language: Английский
Citations
19
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: March 15, 2023
Nanoconstructs are made up of nanoparticles and ligands, which can deliver the loaded cargo at desired site action. Various nanoparticulate platforms have been utilized for preparation nanoconstructs, may serve both diagnostic as well therapeutic purposes. mostly used to overcome limitations cancer therapies, such toxicity, nonspecific distribution drug, uncontrolled release rate. The strategies employed during design nanoconstructs help improve efficiency specificity theranostic agents make them a successful approach therapy. designed with sole purpose targeting requisite site, overcoming barriers hinders its right placement benefit. Therefore, instead classifying modes delivery actively or passively targeted systems, they suitably classified autonomous nonautonomous types. At large, offer numerous benefits, however suffer from multiple challenges, too. Hence, challenges computational modelling methods artificial intelligence/machine learning processes being explored. current review provides an overview on attributes applications offered by agent in cancer.
Language: Английский
Citations
17