Applied Materials Today, Journal Year: 2024, Volume and Issue: 38, P. 102193 - 102193
Published: April 17, 2024
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 203, P. 115130 - 115130
Published: Oct. 31, 2023
Language: Английский
Citations
45
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 1, 2024
Malignant bone tumors, which are difficult to treat with current clinical strategies, originate from tissues and can be classified into primary secondary types. Due the specificity of microenvironment, results traditional means treating tumors often unsatisfactory, so there is an urgent need develop new treatments for malignant tumors. Recently, nanoparticle-based approaches have shown great potential in diagnosis treatment. Nanoparticles (NPs) gained significant attention due their versatility, making them highly suitable applications tissue engineering, advanced imaging techniques, targeted drug delivery. For diagnosis, NPs enhance contrast sensitivity by integrating targeting ligands, significantly improve specific recognition localization tumor cells early detection. treatment, enable delivery, increasing accumulation at sites while reducing systemic toxicity. In conclusion, understanding microenvironment using unique properties holds promise improving disease management, enhancing treatment outcomes, ultimately quality life patients Further research development will undoubtedly contribute advancement personalized medicine field oncology.
Language: Английский
Citations
18
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(3), P. 303 - 303
Published: Feb. 1, 2024
Recently, drug delivery strategies based on nanomaterials have attracted a lot of interest in different kinds therapies because their superior properties. Polydopamine (PDA), one the most interesting materials nanomedicine its versatility and biocompatibility, has been widely investigated field. It can be easily functionalized to favor processes like cellular uptake blood circulation, it also induce release through two stimuli: NIR light irradiation pH. In this review, we describe PDA nanomaterials’ performance delivery, size, morphology, surface charge. Indeed, these characteristics strongly influence main mechanisms involved system: uptake, loading, release. The understanding connections between nanosystems’ properties phenomena is pivotal obtain controlled design new nanocarriers specific applications.
Language: Английский
Citations
17
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 457, P. 141315 - 141315
Published: Jan. 5, 2023
Language: Английский
Citations
26
Small, Journal Year: 2024, Volume and Issue: unknown
Published: May 10, 2024
Abstract Due to the presence of spatial barriers, persistent bacteria, and excessive inflammation in bacteria biofilm‐infected wounds, current nanoplatforms cannot effectively address these issues simultaneously during therapeutic process. Herein, a novel biomimetic photothermal nanoplatform integrating silver polydopamine nanoparticles (Ag/PDAs) that can damage biofilms, kill bacterial persisters, reduce for wound treatment is presented. These findings reveal Ag/PDAs exhibit broad‐spectrum antimicrobial activity through direct membrane structure. Additionally, demonstrate potent conversion efficiency. When combined with near‐infrared (NIR) irradiation, disrupt structure biofilms synergistically eradicate resident bacteria. Furthermore, show remarkable anti‐inflammatory properties counteracting bacterium‐induced macrophage polarization. The vivo results confirm topical application significantly suppress Staphylococcus aureus wounds murine models, concurrently facilitating healing. This research provides promising avenue eradication wounds.
Language: Английский
Citations
13
Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26616 - e26616
Published: Feb. 18, 2024
A multitude of sight-threatening retinal diseases, affecting hundreds millions around the globe, lack effective pharmacological treatments due to ocular barriers and common drug delivery limitations. Polymeric nanoparticles (PNPs) are versatile carriers with sustained release profiles tunable physicochemical properties which have been explored for both anterior posterior tissues. PNPs can incorporate a wide range drugs overcome challenges conventional delivery. Moreover, be engineered respond specific stimuli such as ultraviolet, visible, or near-infrared light, allow precise spatiotemporal control release, enabling tailored treatment regimens reducing number required administrations. The objective this study is emphasize therapeutic potential light-triggered drug-loaded polymeric treat diseases through an exploration pathologies, in delivery, current production methodologies recent applications. Despite challenges, light-responsive hold promise substantially enhancing landscape aiming improved quality life patients.
Language: Английский
Citations
10
Surfaces and Interfaces, Journal Year: 2024, Volume and Issue: 48, P. 104344 - 104344
Published: April 11, 2024
As a material-independent adhesive coating agent with excellent functionality on interfaces of materials, polydopamine (PDA) has been widely applicable in bioengineering, environment, and energy fields. Conventional methods using dopamine (DA) solutions suffer from slow deposition rates, hindering the attainment adequate thickness durability. This work introduces technique involving rapid capillary-induced solution infusion in-air polymerization to overcome these limitations. By immersing nanostructured surfaces for just 10 seconds into solution, DA is uniformly infused onto surface, distributed evenly over surfaces. Polymerization facilitated by oxygen diffusion air, resulting formation conformal up micrometer thick. These PDA coatings exhibit persistent superhydrophilicity water contact angles below 10° maintain resistance abrasion, sonication, oil fouling. Additionally, when applied microfiber textiles, leads underwater repellency. Our method holds promise compatibility various wet-based techniques such as drop casting, spraying, spin coating, or ink-jet printing, opening avenues versatile applications diverse
Language: Английский
Citations
9
Small, Journal Year: 2023, Volume and Issue: 20(11)
Published: Dec. 15, 2023
The optimal treatment for tracheal tumors necessitates sequential tumor elimination and cartilage reconstruction. This study introduces an innovative inorganic nanosheet, MnO
Language: Английский
Citations
17
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1205 - 1224
Published: Feb. 1, 2024
Introduction: Enhancing the efficacy of berberine (BBR) in treatment ulcerative colitis (UC) through development dopamine-coated nanoparticles (PDA@BBR NPs) with ROS-responsive and adhesive properties. Methods: Berberine (BBR were synthesized using nonsolvent precipitation method, their surfaces coated polydopamine (PDA) oxidative polymerization. The PDA@BBR NPs characterized by transmission electron microscopy (TEM), size analysis, zeta potential analysis. Drug loading encapsulation efficiency analyzed fluorescence spectroscopy. responsiveness these to reactive oxygen species (ROS) was assessed vitro, while properties therapeutic on UC evaluated vivo. Results: Physicochemical property studies showed that PDA BBR have good dispersion stability. In vitro results could prolong retention time drug at colonic site realize gradual release under ROS environment. addition, animal exhibited significant anti-inflammatory effects DSS-induced effectively reduced intestinal mucosal damage. Conclusion: are adhere well a high capacity. They shown mice UC, indicating this formulation may be promising option. Keywords: berberine, polydopamine, ROS-responsive, adhesion retention,
Language: Английский
Citations
7
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216043 - 216043
Published: July 3, 2024
Language: Английский
Citations
7