Cancers,
Journal Year:
2021,
Volume and Issue:
13(7), P. 1488 - 1488
Published: March 24, 2021
Pyruvate
is
a
key
molecule
in
the
metabolic
fate
of
mammalian
cells;
it
crossroads
from
where
metabolism
proceeds
either
oxidatively
or
ends
with
production
lactic
acid.
regulated
by
many
enzymes
that
together
control
carbon
flux.
Mitochondrial
pyruvate
carrier
(MPC)
responsible
for
importing
cytosol
to
mitochondrial
matrix,
phosphorylated
produce
adenosine
triphosphate
(ATP)
and
generate
intermediates
used
multiple
biosynthetic
pathways.
MPC
activity
has
an
important
role
glucose
homeostasis,
its
alteration
associated
diabetes,
heart
failure,
neurodegeneration.
In
cancer,
however,
controversy
surrounds
function.
some
cancers,
upregulation
appears
be
poor
prognosis.
However,
most
transformed
cells
undergo
switch
oxidative
glycolytic
metabolism,
so-called
Warburg
effect,
which,
amongst
other
possibilities,
induced
malfunction
downregulation.
Consequently,
impaired
function
might
induce
tumors
strong
proliferative,
migratory,
invasive
capabilities.
Moreover,
cancer
secrete
lactate,
acidifying
microenvironment,
which
turn
induces
angiogenesis,
immunosuppression,
expansion
stromal
cell
populations
supporting
tumor
growth.
This
review
examines
latest
findings
regarding
tumorigenic
processes
affected
MPC.
Analytical Chemistry,
Journal Year:
2021,
Volume and Issue:
93(34), P. 11826 - 11835
Published: Aug. 16, 2021
Cancer
ranks
as
a
leading
cause
of
death
in
every
country
the
world.
However,
if
they
are
discovered
early,
lot
cancers
can
be
prevented
or
cured.
Discovering
and
monitoring
cancer
markers
main
methods
for
early
diagnosis
cancer.
To
date,
many
fluorescent
probes
designed
used
only
react
with
single
marker,
which
always
causes
insufficient
accuracy
complex
systems.
Herein,
novel
near-infrared
(NIR)
probe
(CyO-DNP)
sequential
detection
H2S
H+
is
synthesized.
In
this
probe,
heptamethine
dye
selected
fluorophore
2,4-dinitrophenyl
(DNP)
ether
chosen
recognition
group.
presence
H2S,
CyO-DNP
transformed
into
CyO,
exhibits
an
intense
fluorescence
at
663
nm.
Then,
induces
protonation
CyO
to
obtain
CyOH,
final
emission
793
nm
significantly
enhances.
Owing
low
cytotoxicity
NIR
emission,
sequentially
monitor
endogenous
cells
image
exogenous
mice.
It
worth
mentioning
that
effectively
avoid
false
positive
signal
caused
by
liver
kidney
discriminate
normal
mice
tumor
accurately.
For
all
we
know,
first
accurate
detecting
H+.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(2), P. 764 - 764
Published: Jan. 14, 2021
Glucose
is
an
essential
nutrient
for
every
cell
but
its
metabolic
fate
depends
on
cellular
phenotype.
Normally,
the
product
of
cytosolic
glycolysis,
pyruvate,
transported
into
mitochondria
and
irreversibly
converted
to
acetyl
coenzyme
A
by
pyruvate
dehydrogenase
complex
(PDC).
In
some
pathological
cells,
however,
transport
blocked
due
inhibition
PDC
kinase.
This
altered
metabolism
referred
as
aerobic
glycolysis
(Warburg
effect)
common
in
solid
tumors
other
cells.
Switching
from
mitochondrial
oxidative
phosphorylation
provides
diseased
cells
with
advantages
because
rapid
production
ATP
activation
pentose
phosphate
pathway
(PPP)
which
nucleotides
required
elevated
metabolism.
Molecules,
called
glycolytics,
inhibit
convert
a
healthier
Glycolytics
often
function
inhibiting
hypoxia-inducible
factor-1α
leading
disinhibition
allowing
intramitochondrial
conversion
A.
Melatonin
glycolytic
converts
Herein
we
propose
that
melatonin's
explains
actions
variety
diseases.
Thus,
denominator
action
switching
phenotype
Cancers,
Journal Year:
2021,
Volume and Issue:
13(7), P. 1488 - 1488
Published: March 24, 2021
Pyruvate
is
a
key
molecule
in
the
metabolic
fate
of
mammalian
cells;
it
crossroads
from
where
metabolism
proceeds
either
oxidatively
or
ends
with
production
lactic
acid.
regulated
by
many
enzymes
that
together
control
carbon
flux.
Mitochondrial
pyruvate
carrier
(MPC)
responsible
for
importing
cytosol
to
mitochondrial
matrix,
phosphorylated
produce
adenosine
triphosphate
(ATP)
and
generate
intermediates
used
multiple
biosynthetic
pathways.
MPC
activity
has
an
important
role
glucose
homeostasis,
its
alteration
associated
diabetes,
heart
failure,
neurodegeneration.
In
cancer,
however,
controversy
surrounds
function.
some
cancers,
upregulation
appears
be
poor
prognosis.
However,
most
transformed
cells
undergo
switch
oxidative
glycolytic
metabolism,
so-called
Warburg
effect,
which,
amongst
other
possibilities,
induced
malfunction
downregulation.
Consequently,
impaired
function
might
induce
tumors
strong
proliferative,
migratory,
invasive
capabilities.
Moreover,
cancer
secrete
lactate,
acidifying
microenvironment,
which
turn
induces
angiogenesis,
immunosuppression,
expansion
stromal
cell
populations
supporting
tumor
growth.
This
review
examines
latest
findings
regarding
tumorigenic
processes
affected
MPC.
