Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(38)
Published: June 12, 2024
Abstract
Photoresponsive
drug
delivery
systems
(PDDSs)
have
emerged
as
a
promising
toolbox
for
delivery,
offering
precise
control
over
the
site,
duration,
and
dosage
of
light‐triggered
medication.
It
allows
controlled
release,
photo‐triggered
targeting,
diagnosis,
treatment,
improving
precision
efficacy
therapies
various
diseases.
Despite
progress
in
designing
different
PDDSs,
clinical
translation
has
been
limited
due
to
obstacles.
Herein,
this
review
article
focuses
on
three
critical
challenges
PDDSs:
1)
accumulation
at
diseased
lesions,
2)
light
irradiation,
3)
penetration
tissues.
Also,
summarizes
discusses
current
advancements
strategies
address
these
challenges.
Overall,
it
emphasizes
need
clarify
from
bench
bedside
develop
enhance
therapeutic
outcomes,
increase
compatibility
patient
compliance,
unlock
possibilities
therapies.
Cancers,
Journal Year:
2021,
Volume and Issue:
13(17), P. 4447 - 4447
Published: Sept. 3, 2021
Photodynamic
therapy
(PDT)
is
a
promising
against
cancer.
Even
though
it
has
been
investigated
for
more
than
100
years,
scientific
publications
have
grown
exponentially
in
the
last
two
decades.
For
this
reason,
we
present
brief
compendium
of
reviews
decades
classified
under
different
topics,
namely,
overviews,
about
specific
cancers,
and
meta-analyses
photosensitisers,
PDT
mechanisms,
dosimetry,
light
sources.
The
key
issues
main
conclusions
are
summarized,
including
ways
means
to
improve
outcomes.
Due
broad
scope
work
being
first
time
that
latest
performed
PDT,
may
be
interest
wide
audience.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(11), P. 4223 - 4242
Published: Jan. 1, 2022
Biological
environments
absorb
and
scatter
light,
which
complicates
the
controlled
illumination
of
internal
thermal
probes
distorts
emitted
light.
To
what
extent
is
this
a
problem
to
measure
temperature
how
can
it
be
faced?
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(13), P. 7361 - 7375
Published: March 24, 2023
An
advanced
photodynamic
molecular
beacon
(PMB)
was
designed
and
synthesized,
in
which
a
distyryl
boron
dipyrromethene
(DSBDP)-based
photosensitizer
Black
Hole
Quencher
3
moiety
were
connected
via
two
peptide
segments
containing
the
sequences
PLGVR
GFLG,
respectively,
of
cyclic
peptide.
These
short
are
well-known
substrates
matrix
metalloproteinase-2
(MMP-2)
cathepsin
B,
both
overexpressed
wide
range
cancer
cells
either
extracellularly
(for
MMP-2)
or
intracellularly
B).
Owing
to
efficient
Förster
resonance
energy
transfer
between
components,
this
PMB
fully
quenched
native
form.
Only
upon
interaction
with
MMP-2
buffer
solution
cells,
cleaved
specifically,
components
could
be
completely
separated,
thereby
restoring
activities
DSBDP
moiety.
This
also
activated
tumors,
it
effectively
suppressed
tumor
growth
A549
tumor-bearing
nude
mice
laser
irradiation
without
causing
notable
side
effects.
In
particular,
did
not
cause
skin
photosensitivity,
is
very
common
effect
therapy
(PDT)
using
conventional
"always-on"
photosensitizers.
The
overall
results
showed
that
"double-locked"
functioned
as
biological
AND
logic
gate
only
unlocked
by
coexistence
tumor-associated
enzymes,
greatly
enhance
specificity
PDT.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(13), P. 5092 - 5092
Published: June 29, 2023
Photodynamic
therapy,
an
alternative
that
has
gained
weight
and
popularity
compared
to
current
conventional
therapies
in
the
treatment
of
cancer,
is
a
minimally
invasive
therapeutic
strategy
generally
results
from
simultaneous
action
three
factors:
molecule
with
high
sensitivity
light,
photosensitizer,
molecular
oxygen
triplet
state,
light
energy.
There
much
be
said
about
each
these
elements;
however,
efficacy
photosensitizer
most
determining
factor
for
success
this
modality.
Porphyrins,
chlorins,
phthalocyanines,
boron-dipyrromethenes,
cyanines
are
some
N-heterocycle-bearing
dyes’
classes
biological
promise.
In
review,
concise
approach
taken
other
families
potential
photosensitizers
modifications
have
recently
appeared
literature
within
scope
their
photodynamic
application,
as
well
how
compounds
formulations
may
eventually
overcome
deficiencies
molecules
currently
clinically
used
revolutionize
eradicate
or
delay
growth
tumor
cells.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(8), P. 2075 - 2075
Published: Aug. 3, 2023
Photodynamic
therapy
(PDT)
is
an
increasingly
popular
dermatological
treatment
not
only
used
for
life-threatening
skin
conditions
and
other
tumors
but
also
cosmetic
purposes.
PDT
has
negligible
effects
on
underlying
functional
structures,
enabling
tissue
regeneration
feasibility.
uses
a
photosensitizer
(PS)
visible
light
to
create
cytotoxic
reactive
oxygen
species,
which
can
damage
cellular
organelles
trigger
cell
death.
The
foundations
of
modern
photodynamic
began
in
the
late
19th
early
20th
centuries,
recent
times,
it
gained
more
attention
due
development
new
sources
PSs.
This
review
focuses
latest
advancements
technology
treating
cancer
lesions.
It
discusses
research
developments
light-emitting
technologies,
their
potential
benefits
drawbacks,
implications
clinical
practice.
Finally,
this
summarizes
key
findings
use
treatment,
highlighting
limitations
current
approaches
providing
insights
into
future
directions
improve
both
efficacy
safety
PDT.
aims
provide
comprehensive
understanding
covering
various
aspects
ranging
from
mechanisms
technological
field.
