Journal of Asian Multicultural Research for Medical and Health Science Study,
Journal Year:
2024,
Volume and Issue:
5(1), P. 1 - 6
Published: Feb. 10, 2024
Colorectal
cancer
is
the
third
most
common
type
of
in
world,
Indonesia
it
fourth
highest
position.
Nearly
1
million
deaths
a
year
were
due
to
colorectal
cancer.
Alcohol
increases
risk
developing
This
study
aims
analyze
differences
duration
alcohol
consumption
people
with
and
without
relationship
between
incidence
The
research
was
carried
out
at
Digestive
Surgery
Polyclinic,
H.
Adam
Malik
Hospital,
Medan.
Using
primary
secondary
data
involving
31
subjects.
Subjects
aged
30-80
years,
21
men,
10
women,
80.6%
suffered
from
28
(90.3%)
consumed
A
most.
mean
sufferers
those
14.76
±
3.33
years
11.00
3.688
years.
There
difference
cancer,
not
related
Cancer Immunology Immunotherapy,
Journal Year:
2024,
Volume and Issue:
74(1)
Published: Dec. 30, 2024
Despite
significant
advancements
in
cancer
immunotherapy,
many
patients
continue
to
respond
poorly.
Novel
therapeutic
strategies
and
drugs
are
urgently
needed.
Here,
we
found
that
CYP2E1
is
upregulated
M2
macrophages.
The
inhibitor,
Q11,
could
inhibit
macrophage
polarization,
while
overexpression
promote
it.
Increased
levels
of
macrophages
the
tumor
microenvironment
HCC
correlate
with
poor
prognosis.
Q11
cells
by
targeting
rather
than
directly
attacking
cells.
Both
Cyp2e1
knockout
effectively
suppress
growth.
reduces
production
metabolites
(
±)9(10)-DiHOME
±)12(13)-DiHOME,
thus
attenuating
PPARγ
activation
polarization.
In
summary,
our
findings
suggest
polarization
modulating
CYP2E1/(
or
±)12(13)-DiHOME/PPARγ
axis,
indicating
may
be
a
potential
target
for
HCC,
its
inhibitor
drug
treatment
HCC.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 2, 2024
Colorectal
cancer
(CRC)
is
a
leading
cause
of
morbidity
and
mortality
worldwide.
Detection
before
metastasis
efficient
treatment
disease
significantly
improve
patient
survival
quality
life.
However,
limitations
in
diagnosis
postoperative
surveillance
are
associated
with
low
CRC
detection
rates.
Thus,
this
project
aimed
to
evaluate
the
molecular
profile
patients
diagnosed
CRC,
as
biomarkers
constitute
new
frontier
for
diagnosis,
prognosis.
Methods
Results:
42
were
included
study,
predominantly
male
(59.5%),
median
age
63
years
(SD:
10.0;
min:
41;
max:
83).
The
majority
primary
tumors
located
rectum
(38.1%),
sigmoid
(33.3%)
ascending
(21.4%)
colon.
We
evaluated
genes
KRAS,
NRAS,
BRAF,
EGFR
TP53
using
Sanger
sequencing.
Somatic
germline
mutations
found
genes,
most
common
somatic
alteration
being
rs121913529
KRAS.
This
variant
was
also
strongly
alcoholism
(p
=
0.002).
Furthermore,
had
higher
compared
those
wild-type
alleles
(OR:
11.2;
95%
CI
1.25–2.45).
Conclusions:
Our
findings
support
relationship
between
alcohol
consumption
mutation,
which
classified
pathogenic
colorectal
cancer.
further
studies
investigating
link
consumption,
carcinogenesis
tumor
progression
ought
be
conducted.
Nutrition and Cancer,
Journal Year:
2023,
Volume and Issue:
75(4), P. 1211 - 1222
Published: March 12, 2023
Folate
is
hypothesized
to
accelerate
cell
proliferation
in
colorectal
cancer
(CRC)
by
supporting
DNA
synthesis,
while
alcohol
also
linked
gastrointestinal
epithelial
proliferation,
despite
biological
antagonism
of
folate.
We
report
associations
between
folate
and
consumption
with
the
marker
Ki67
CRC
tumors
from
Southern
Community
Cohort
Study.
Tumor
samples
were
obtained
formalin-fixed
paraffin-embedded
tissue
blocks.
The
percentage
cells
expressing
was
measured
immunohistochemically.
Exposures
assessed
via
questionnaire
pre-diagnosis.
Associations
linear
regression.
In
248
cases
(40–78
years),
neither
dietary
folate,
folic
acid
supplements,
nor
total
intake
associated
Ki67.
Folic
supplement
use
distal/rectal
(β
[95%
confidence
interval]:
7.5
[1.2-13.8],
p
=
.02)
but
not
proximal
(-1.4
[-7.1-4.3],
p=.62).
A
positive
trend
for
observed
(1.6
[0.0-3.3]
per
200
μcg,
p-trend=.05).
Heavy
drinking
(women:
≥1
drink/day,
men:
≥2
drinks/day)
higher
(6.4
[1.0-11.9],
vs.
nondrinkers,
p=.02),
especially
(10.4
[1.6-19.1],
p=.02).
Negative
interaction
alcohol,
(p-interaction=.06).
Modest
tumor
expression
suggest
accelerated
consistent
folate's
role
synthesis.
Journal of Asian Multicultural Research for Medical and Health Science Study,
Journal Year:
2024,
Volume and Issue:
5(1), P. 1 - 6
Published: Feb. 10, 2024
Colorectal
cancer
is
the
third
most
common
type
of
in
world,
Indonesia
it
fourth
highest
position.
Nearly
1
million
deaths
a
year
were
due
to
colorectal
cancer.
Alcohol
increases
risk
developing
This
study
aims
analyze
differences
duration
alcohol
consumption
people
with
and
without
relationship
between
incidence
The
research
was
carried
out
at
Digestive
Surgery
Polyclinic,
H.
Adam
Malik
Hospital,
Medan.
Using
primary
secondary
data
involving
31
subjects.
Subjects
aged
30-80
years,
21
men,
10
women,
80.6%
suffered
from
28
(90.3%)
consumed
A
most.
mean
sufferers
those
14.76
±
3.33
years
11.00
3.688
years.
There
difference
cancer,
not
related
