Challenges in the diagnosis and treatment of the malignant adnexal neoplasms of the head and neck

Current Opinion in Otolaryngology & Head & Neck Surgery, Journal Year: 2023, Volume and Issue: 31(2), P. 134 - 145

Published: Jan. 24, 2023

Purpose of review The current is to present the knowledge regarding epidemiology, diagnostics, and management malignant adnexal neoplasms (MANs). Recent findings Immunotherapy gene-related therapies are still being developed as methods salvage treatment in advanced disseminated cases: CACNA1S, ATP2A1, RYR1, MYLK3, well p53 or JAK/STAT pathways, may be therapeutic targets; efficiency talimogene laherparepvec nivolumab assessed. Summary MANs rare tumors, but due aging population their incidence increasing. Their clinical presentation unspecific, which makes diagnosis challenging. Histopathological assessment difficult even for experienced pathologists. Mohs micrographic surgery wide local excision recommended treat primary lesions. Adjuvant radiotherapy beneficial case insufficient positive surgical margins, nodal metastases, selected types like sebaceous, trichilemmal, pilomatrix carcinomas, induction large tumors located medically fragile cosmetically important regions. role chemotherapy not defined; however, it distant metastases. can improve prognosis stage disease.

Language: Английский

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Hidradenocarcinoma involving the male breast: Report of a case with emphasis on the differential diagnosis of invasive carcinoma with sweat gland differentiation

Human Pathology Reports, Journal Year: 2023, Volume and Issue: 31, P. 300698 - 300698

Published: Feb. 24, 2023

A 41-year-old male presented with a 2-month history of palpable peri-areolar nodule in the right breast. The patient underwent an excisional biopsy, which revealed solid and partially cystic mass breast parenchyma infiltrative border characterized by papillary proliferation cells clear or eosinophilic cytoplasm demonstrating cytologic atypia, numerous mitotic figures (>20/10 high-power fields), areas necrosis. Immunohistochemical analysis showed tumor were faintly positive for p63, negative SMMS, strongly diffusely estrogen, progesterone, androgen receptors. equivocal HER2 overexpression immunohistochemistry amplification fluorescence situ hybridization (FISH). Tumor also MAML2 rearrangements FISH. Diagnosis was consistent hidradenocarcinoma. Preoperative staging mammogram, axillary US, MRI did not reveal evidence residual metastases. subsequently wide local excision sentinel lymph node tumor. We report first case hidradenocarcinoma originating deep highlight challenges diagnosing this rare tumor, can mimic primary carcinoma.

Language: Английский

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Cuticular Poroma: A Rare Poroma Variant Simulating a Malignant Neoplasm That Often Harbors YAP1::NUTM1 Fusions Similar to Their Conventional Counterparts

American Journal of Dermatopathology, Journal Year: 2023, Volume and Issue: 45(8), P. 544 - 548

Published: June 15, 2023

Abstract: Cuticular poroma is a rare variant of composed exclusively or predominantly cuticular cells, namely large cells with ample eosinophilic cytoplasm. We report 7 cases this tumor identified among 426 neoplasms diagnosed as porocarcinoma. The patients were 4 males and 3 females, ranging in age from 18 to 88 years. All presented solitary asymptomatic nodule. location included knee (2 cases), shoulder, thigh, shin, lower arm, neck (each 1). lesions surgically removed. No evidence disease was observed 5 available follow-up (range 12–124 months). Microscopically, all variably sized, focally closed packed, interconnecting nodules constituted mostly cells. Small poroid focal feature tumors, whereas the remaining 2 cases, conspicuous but still minority. Five somewhat asymmetric, irregular outlines. Ductal differentiation intracytoplasmic vacuoles seen 6 tumors. Other features encountered intranuclear pseudoinclusions, cystic change, occasional multinucleated increased mitoses, stromal desmoplasia. Four tumors analyzed next-generation sequencing yielded YAP1::NUTM1 fusions. In addition, various mutations, unknown significance one neoplasm.

Language: Английский

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Lipomatous mixed tumor of the skin with cystic formation affecting the upper lip: A case report

Experimental and Therapeutic Medicine, Journal Year: 2022, Volume and Issue: 24(5)

Published: Sept. 7, 2022

Mixed tumor of the skin (MTS) is a rare neoplasm derived from sweat glands with reported frequency 0.01‑0.098% among all primary tumors. MTS often occurs in head and neck region characterized by mixture epithelial, myoepithelial stromal components. also shows various morphological patterns, thus presence variants components its rarity make clinical diagnosis even more difficult. A 47‑year‑old man was referred due to painless, slowly growing, exophytic swelling intracutaneous mass upper lip. Magnetic resonance imaging revealed that solid fatty component proximal portion, while distal portion cystic possibly contained highly viscous fluid. The located between orbicularis oris muscle Excisional biopsy performed lesion showed two intriguing features: extensive lipomatous stroma some large cysts. It histopathologically diagnosed as formation No evident signs recurrence were observed during follow‑up. present report describes this case includes brief literature review cases lip, since can be confused lesions settings rarity. Recognition clinicians different MTSs, including case, important for preventing erroneous treatment.

Language: Английский

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Cutaneous Adenoid Cystic Carcinoma

Mayo Clinic Proceedings, Journal Year: 2024, Volume and Issue: 99(6), P. 1017 - 1018

Published: June 1, 2024

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