Journal of Gastrointestinal Cancer, Journal Year: 2022, Volume and Issue: 54(3), P. 979 - 981
Published: Aug. 2, 2022
Language: Английский
Experimental Hematology and Oncology, Journal Year: 2024, Volume and Issue: 13(1)
Published: Aug. 1, 2024
Abstract Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy with high incidence, recurrence, and metastasis rates. The emergence of immunotherapy has improved the treatment advanced HCC, but problems such as drug resistance immune-related adverse events still exist in clinical practice. immunosuppressive tumor microenvironment (TME) HCC restricts efficacy essential for progression metastasis. Therefore, it necessary to elucidate mechanisms behind TME develop apply immunotherapy. This review systematically summarizes pathogenesis formation TME, by which accelerates We also status further discuss existing challenges potential therapeutic strategies targeting TME. hope inspire optimizing innovating immunotherapeutic comprehensively understanding structure function HCC.
Language: Английский
Citations
20
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.
Language: Английский
Citations
2
Cancers, Journal Year: 2023, Volume and Issue: 15(10), P. 2795 - 2795
Published: May 17, 2023
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and a leading cause cancer-related death worldwide. Immunotherapy has emerged as mainstay treatment option for unresectable HCC. Toll-like receptor 4 (TLR4) plays crucial role in innate immune response by recognizing responding primarily to bacterial lipopolysaccharides. In addition its system, TLR4 also been implicated adaptive immunity, including specific anti-tumor responses. particular, signaling pathway seems be involved regulation several hallmarks, such continuous activation cellular pathways that promote cell division growth, inhibition programmed death, promotion invasion metastatic mechanisms, epithelial-to-mesenchymal transition, angiogenesis, drug resistance, epigenetic modifications. Emerging evidence further suggests holds promise potential immunotherapeutic target The aim this review was explore multilayer aspects pathway, regarding diseases HCC, well utilization an immunotherapy
Language: Английский
Citations
19
Cancers, Journal Year: 2023, Volume and Issue: 15(12), P. 3161 - 3161
Published: June 13, 2023
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related deaths worldwide. There has been significant progress in understanding risk factors and epidemiology HCC during last few decades, resulting efficient preventative, diagnostic treatment strategies. Type 2 diabetes mellitus (T2DM) demonstrated to be a major factor for developing HCC. Metformin widely used hypoglycemic agent patients with T2DM shown play potentially beneficial role improving survival Experimental clinical studies evaluating outcomes metformin as an antineoplastic drug setting were reviewed. Pre-clinical evidence suggests that may enhance antitumor effects immune checkpoint inhibitors (ICIs) reverse effector T cells' exhaustion. However, there still limited regarding efficacy combination ICIs We appraised analyzed vitro animal aimed elucidate mechanisms action metformin, well assessed its impact on patients.
Language: Английский
Citations
19
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1381 - 1381
Published: Jan. 23, 2024
Hepatocellular carcinoma (HCC) remains a global health challenge with limited treatment options and poor prognosis for advanced-stage patients. Recent advancements in cancer immunotherapy have generated significant interest exploring novel approaches to combat HCC. One such approach involves the unique versatile subset of T cells known as γδ cells. represent distinct lymphocytes that differ from conventional αβ terms antigen recognition effector functions. They play crucial role immunosurveillance against various malignancies, including studies demonstrated can directly recognize target HCC cells, making them an attractive candidate immunotherapy. In this article, we aimed explore exerted by context We investigate strategies designed maximize therapeutic effectiveness these examine challenges opportunities inherent applying research findings clinical practice. The potential bring about revolutionary shift capitalizing on attributes offers considerable promise enhancing patient outcomes, warranting further investigation.
Language: Английский
Citations
7
Hepatoma Research, Journal Year: 2024, Volume and Issue: unknown
Published: April 26, 2024
Hepatocellular carcinoma (HCC) stands as a primary malignant liver tumor characterized by chronic inflammation and complex alterations within the microenvironment (TME). Lymphocyte activation gene 3 (LAG-3), also known CD223, has gained prominence potential next-generation immune checkpoint, maintaining continuous expression in response to persistent antigen exposure TME, warranting our attention. In patients with HCC, LAG-3 on T cells, regulatory cells (Tregs), natural killer (NK) contributes evasion, while high of leads increased angiogenesis poor prognosis. By interacting major histocompatibility class II molecules, promotes cell exhaustion suppresses antitumor responses, often collaboration other checkpoints like programmed death protein 1 (PD-1), Tregs NK modulates their suppressive functions, indirectly facilitating escape. may offer prognostic insights, correlating disease progression outcomes HCC patients, various preclinical studies highlight LAG-3-targeted therapies reinvigorating responses against few combination approaches targeting alongside demonstrating synergistic effects restoring function. Therefore, harnessing therapeutic target holds promise for enhancing immunity potentially improving treatment outcomes. Our narrative review aims delve into full spectrum signaling goal better understanding pathophysiological immunological basis its use arrest growth development.
Language: Английский
Citations
5
Cells, Journal Year: 2023, Volume and Issue: 12(16), P. 2036 - 2036
Published: Aug. 10, 2023
Hepatocellular carcinoma (HCC) is a primary liver cancer with high mortality rate and limited treatment options. Recent research has brought attention to the significant importance of intercellular communication in progression HCC, wherein exosomes have been identified as critical agents facilitating cell-to-cell signaling. In this article, we investigate impact macrophages both sources targets shedding light on intricate interplay between exosome-mediated macrophage involvement HCC pathogenesis. It investigates how derived from cells other cell types within tumor microenvironment (TME) can influence behavior, polarization, recruitment. Furthermore, section explores reciprocal interactions macrophage-derived cells, stromal immune elucidating their role growth, angiogenesis, metastasis, evasion. The findings presented here contribute better understanding offer new avenues for targeted interventions improved patient outcomes.
Language: Английский
Citations
13
Cancers, Journal Year: 2024, Volume and Issue: 16(14), P. 2549 - 2549
Published: July 15, 2024
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, posing a significant global health challenge with an increasing incidence. In recent years, multiple staging systems and scores have been proposed, emphasising necessity for development of precise prognostic tools. The well-documented etiological relationship between chronic inflammation carcinogenesis has prompted researchers to explore novel markers associated inflammatory status HCC patients. This review summarises current data about inflammation-based in context HCC. We discuss established like Glasgow Prognostic Score (GPS), modified GPS (mGPS) neutrophil-to-lymphocyte ratio (NLR) others not as extensively studied, examining their utility predicting survival outcomes treatment response Furthermore, we emerging scores, including nutritional index (PNI) other lymphocyte-based assessing potential refining risk stratification guiding therapeutic decisions era precision medicine. As research progresses these undergo further refinement integration into evolving landscape management, they carry improving patient outcomes.
Language: Английский
Citations
4
Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(1)
Published: Jan. 1, 2025
ABSTRACT Purpose Recent research (Li et al. 2021) suggests an upregulated expression and activation of H1 receptors on macrophages in the tumor microenvironment, concomitant H1‐antihistamine use is associated with improved overall survival patients lung skin cancers receiving immunotherapy. Therefore, we retrospectively evaluated impacts cancer during Methods All who had received at least one dose immune checkpoint inhibitors (ICIs) from July 1, 2014 to October 31, 2019 were identified Hong Kong's territory‐wide database, this date defined as baseline. A 1‐month landmark analysis was conducted follow–for up 6 months, including exposure period 1 month before after baseline date. Patients grouped according types primary percentages daily usage within period. The outcome survival. Results total 1740 (65.1% male, mean age 61.9 years) included analysis, which 529 (30.4%) 307 (17.6%) liver malignancies. multivariable Cox regression model estimated statistically significant improvement intermediate malignancies (adjusted hazard ratio [aHR] 0.223, 95% confidence interval [CI] 0.052–0.958, p = 0.044), but not maligancies. Similar frequency‐dependent effects Kaplan–Meier analysis. Conclusion benefits adjunctive H1‐antihistamines may be generation‐ tumor‐dependent. Further clinical mechanistic studies are required confirm findings.
Language: Английский
Citations
0
Cancers, Journal Year: 2023, Volume and Issue: 15(13), P. 3434 - 3434
Published: June 30, 2023
Liver cancer is a complex and challenging disease with limited treatment options dismal prognosis. Understanding the underlying molecular mechanisms driving liver progression metastasis crucial for developing effective therapeutic strategies. The EPH/ephrin system, which comprises family of cell surface receptors their corresponding ligands, has been implicated in pathogenesis HCC. This review paper aims to provide an overview current understanding role system Specifically, we discuss dysregulation signaling HCC its impact on various cellular processes, including proliferation, migration, invasion. Overall, emerges as compelling multifaceted player biology. Elucidating precise implications responses may pave way novel targeted therapies personalized approaches patients. Further research warranted unravel full potential clinical translation.
Language: Английский
Citations
9