Molecular Biotechnology, Journal Year: 2023, Volume and Issue: unknown
Published: Dec. 25, 2023
Language: Английский
Melanoma Research, Journal Year: 2023, Volume and Issue: unknown
Published: Dec. 4, 2023
The intricate pathways of the sympathetic nervous system hold an inherently protective role in setting acute stress. This is achieved through dynamic immunomodulatory and neurobiological networks. However, excessive chronic exposure to these stress-induced stimuli appears cause physiologic dysfunction several mechanisms that may impair psychosocial, neurologic, immunologic health. Numerous preclinical observations have identified beta-2 adrenergic receptor (β2-AR) subtype possess strongest impact on immune stressful stimuli. prolonged expression β2-ARs suppress surveillance promote tumorigenesis within multiple cancer types. occurs pathways, including (1) decreasing frequency function CD8 + T-cells infiltrating tumor microenvironment (TME) via inhibition metabolic reprogramming during T cell activation, (2) establishing immunosuppressive profile TME promotion exhausted phenotype while simultaneously enhancing local paracrine metastatic potential. use nonselective β-AR antagonists reverse many tumorigenic also provide additive therapeutic benefit for various checkpoint modulating agents commonly utilized inhibitors. Here we review translational clinical highlighting foundational hypotheses signaling promotes a pro-tumoral immunophenotype blockade augment response scope melanoma.
Language: Английский
Citations
7
Developmental Cell, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Citations
2
Cancers, Journal Year: 2022, Volume and Issue: 14(24), P. 6132 - 6132
Published: Dec. 12, 2022
Small-cell lung cancer (SCLC), representing 15–20% of all cancers, is an aggressive malignancy with a distinct natural history, poor prognosis, and limited treatment options. We have previously identified Schwann cells (SCs), the main glial peripheral nervous system, in tumor tissues demonstrated that they may support spreading metastasis formation vitro vivo models. However, role SCs progression SCLC has not been investigated. To clarify this issue, cell proliferation assay, annexin V apoptosis transwell migration invasion assay were conducted to elucidate roles tumor-associated (TA-SCs) proliferation, apoptosis, migration, vitro, compared control group. In addition, animal models assess SC action’s effects on also developed. The result confirmed TA-SCs well-established significant facilitating we observed promotes growth exhibited advantage show repair-like phenotype, which allowed defining them as repair (TAR-SCs). Potential molecular mechanisms pro-tumorigenic activity TAR-SCs investigated by screening differentially expressed genes constructing networks messenger-, micro-, long- non-coding RNA (mRNA-miRNA-lncRNA) using DMS114 cells, human SCLC, stimulated media from DMS114-activated SCs, non-stimulated appropriate controls. This study improves our understanding how especially tumor-activated promote progression. Our results highlight new functional phenotype bring insights into characterization system-tumor crosstalk.
Language: Английский
Citations
10
Translational research, Journal Year: 2023, Volume and Issue: 265, P. 1 - 16
Published: Nov. 8, 2023
Epstein-Barr virus (EBV) related- nasopharyngeal carcinoma (NPC) is a squamous of the mucosal lining. Endemic areas (EA) are east and Southeast Asia, were NPC was recorded with higher incidence longer estimated survival than in non-endemic area (NEA) such as Europe, We analyzed gene expression microenvironment properties both to identify molecular subtypes assess biological clinical correlates that might explain differences outcome between EA- NEA-NPCs.Six EA-NPC transcriptomic datasets, including tumor normal samples, integrated meta-analysis using ConsensusClusterPlus bioinformatic approach. Based on biological/functional characterization four identified clusters identified: Cl1, Immune-active; Cl2, defense-response; Cl3, proliferation; Cl4, perineural-interaction/EBV-exhaustion. Kaplan–Meier analysis, applied single dataset available disease-free indicated Cl3 cluster worst prognosis (P = 0.0476), confirmed when applying previously published prognostic signatures. A classifier signature generated its performance 0.0368) validation dataset. Prediction treatment response suggested better responses to: radiotherapy immune checkpoint inhibitors immune-active defense-response clusters; chemotherapy proliferation cluster; cisplatin perineural-interaction/EBV-exhaustion cluster. RNA sequencing for profiling performed 50 NEA-NPC Italian samples.In NEA cohort, Cl2 represented, while almost absent. The immune/biological treatment-response prediction analyses partially replicated results.Well characterized retrospective prospective cohorts needed validate obtained results can help designing future studies.
Language: Английский
Citations
4
Neuroscience Bulletin, Journal Year: 2024, Volume and Issue: unknown
Published: June 16, 2024
Language: Английский
Citations
1
EBioMedicine, Journal Year: 2024, Volume and Issue: 108, P. 105325 - 105325
Published: Sept. 4, 2024
Language: Английский
Citations
1
Biomedicines, Journal Year: 2022, Volume and Issue: 10(10), P. 2531 - 2531
Published: Oct. 10, 2022
Neurotrophins (NTs) represent a group of growth factors with pleiotropic activities at the central nervous system level. The prototype these molecules is represented by nerve factor (NGF), but other similar functions have been identified, including brain derived-growth (BDNF), neurotrophin 3 (NT-3), and NT-4/5. These act binding specific low (p75) high-affinity tyrosine kinase (TrkA, TrkB, TrkC) receptors. More recently, shown effects outside in different organs, particularly lungs. are involved natural development lungs, their homeostasis. However, they also important pathological conditions, lung cancer. involvement neurotrophins cancer has detailed most for non-small cell (NSCLC), particular adenocarcinoma. This review aimed to extensively analyze current knowledge NTs clarify novel molecular mechanisms diagnostic therapeutic purposes. Several clinical trials on humans ongoing using NT receptor antagonists types further applications. pharmacological intervention against signaling may be essential directly counteract biology, indirectly modulate it an inhibitory way affecting neurogenesis and/or angiogenesis potential impacts tumor progression.
Language: Английский
Citations
7
Cancer and Metastasis Reviews, Journal Year: 2023, Volume and Issue: 42(1), P. 255 - 276
Published: Jan. 5, 2023
Language: Английский
Citations
3
Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11
Published: Sept. 20, 2023
Perineural invasion (PNI) is a pathological feature of many cancers associated with poor outcomes, metastases, and recurrence. In relation to ovarian cancer (OC), there no information about PNI's role mechanisms. Our study found that patients PNI-positive symptoms had significantly shorter overall survival (OS) time than PNI-negative symptoms. Multivariate analyses demonstrated PNI represented substantial independent prognostic factor in OC patients. At the transcriptome level, it noteworthy positivity was negatively correlated degree infiltration immune killer cells tumor tissues, including macrophage, central memory CD4 T-cell, natural cells, monocyte, T-cell. The results this revealed TAS2Rs proteins were markedly upregulated tissues predicted prognoses. Moreover, Immunohistochemical analysis TAS2R10 protein prognoses OC. Consequently, we for first powerful predictor prognosis analyzed its expression pattern some preliminary biochemical characterization, providing new clues guiding clinical prevention treatment
Language: Английский
Citations
2
Advanced Biology, Journal Year: 2022, Volume and Issue: 6(9)
Published: Aug. 4, 2022
Abstract Head and neck cancer (HNC) is the seventh most common worldwide, majority being oral squamous cell carcinoma. Despite advances in diagnosis treatment, survival rate of patients with HNC remains stagnant. The cancer‐nerve interaction has been recognized as an important driver progression. Schwann cells, a type peripheral glia, have implicated promoting growth, migration, dispersion, invasion into nerve many cancers. Here, it demonstrated that presence cells makes more aggressive by their proliferation, extracellular matrix breakdown, altering metabolism. Furthermore, became larger, circular, projections nuclei following co‐culturing cells. RNA‐sequencing analysis exposure to shows corresponding changes genes involved hallmarks metabolism; enriched KEGG pathways are spliceosome, RNA transport, cycle, axon guidance, signaling regulating pluripotency stem cAMP signaling, WNT proteoglycans PI3K‐Akt signaling. Taken together, these results suggest significant role for facilitating progression, highlighting potential target treat
Language: Английский
Citations
4