Cell Reports, Journal Year: 2025, Volume and Issue: 44(3), P. 115432 - 115432
Published: March 1, 2025
Language: Английский
Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(7), P. 474 - 490
Published: May 31, 2023
Language: Английский
Citations
108
Cancer Letters, Journal Year: 2023, Volume and Issue: 556, P. 216074 - 216074
Published: Jan. 20, 2023
Pericytes are a type of mural cell located between the endothelial cells capillaries and basement membrane, which function to regulate capillary vasomotor maintain normal microcirculation local tissues organs have been identified as significant component in tumor microenvironment (TME). various interactions with different components TME, such constituting pre-metastatic niche, promoting growth cancer drug resistance through paracrine activity, inducing M2 macrophage polarization. While changes TME can affect number, phenotype, molecular markers pericytes. For example, pericyte detachment from facilitates situ invade circulating blood is beneficial membrane enzymatic hydrolysis proliferation budding, contribute angiogenesis metastasis. In this review, we discuss emerging role pericytes treatment related This review aimed provide more comprehensive understanding relationship tumors ideas for prevention malignant tumors.
Language: Английский
Citations
72
Nature Medicine, Journal Year: 2023, Volume and Issue: 30(1), P. 85 - 97
Published: Nov. 27, 2023
Language: Английский
Citations
42
Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(3), P. 1095 - 1116
Published: April 11, 2024
Abstract Tumor microenvironment (TME) has been demonstrated to play a significant role in tumor initiation, progression, and metastasis. Cancer-associated fibroblasts (CAFs) are the major component of TME exhibit heterogeneous properties their communication with cells. This heterogeneity CAFs can be attributed various origins, including quiescent fibroblasts, mesenchymal stem cells (MSCs), adipocytes, pericytes, endothelial cells, mesothelial Moreover, single-cell RNA sequencing identified diverse phenotypes CAFs, myofibroblastic (myCAFs) inflammatory (iCAFs) being most acknowledged, alongside newly discovered subtypes like antigen-presenting (apCAFs). Due these heterogeneities, exert multiple functions tumorigenesis, cancer stemness, angiogenesis, immunosuppression, metabolism, As result, targeted therapies aimed at TME, particularly focusing on rapidly developing, fueling promising future advanced tumor-targeted therapy.
Language: Английский
Citations
29
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 30, 2024
Hypoxia is a common feature of solid tumours affecting their biology and response to therapy. One the main transcription factors activated by hypoxia hypoxia-inducible factor (HIF), which regulates expression genes involved in various aspects tumourigenesis including proliferative capacity, angiogenesis, immune evasion, metabolic reprogramming, extracellular matrix (ECM) remodelling, cell migration. This can negatively impact patient outcomes inducing therapeutic resistance. The importance clearly demonstrated continued research into finding clinically relevant biomarkers, hypoxia-targeting therapies. problems lack applicable methods detection, standardisation. Additionally, lot detecting do not take consideration complexity hypoxic tumour microenvironment (TME). Therefore, this needs further elucidation as approximately 50% are hypoxic. ECM important component TME, developed both cancer associated fibroblasts (CAFs) cells. However, it distinguish different roles develop biomarkers novel compounds. Fibronectin (FN), collagen (COL) hyaluronic acid (HA) components that create fibres. These fibres crosslinked specific enzymes lysyl oxidase (LOX) stiffness induces fibrosis. partially regulated HIFs. review highlights understanding role current data shows contradictory results on also indicates needed identifying CAF subtypes exact roles; with some showing pro-tumorigenic capacity others having anti-tumorigenic roles. has made difficult fully elucidate CAFs within TME. clear an area requires unravelling strategies target have resulted worsened prognosis. cells discussed been modulating environment. Which led development immunotherapies PD-L1. hypoxia-induced changes confer resistance conventional therapies, such chemotherapy, radiotherapy, immunotherapy. summarizes knowledge TME its implications for therapy It discusses potential prognostic predictive indictors treatment response, well challenges opportunities targeting clinical trials.
Language: Английский
Citations
27
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: June 26, 2024
Abstract Head and neck squamous cell carcinomas (HNSCCs) are amongst the most aggressive, complex, heterogeneous malignancies. The standard of care treatments for HNC patients include surgery, radiotherapy, chemotherapy, or their combination. However, around 50% do not benefit while suffering severe toxic side effects, costing individuals society. Decades have been spent to improve HNSCC treatment outcomes with only limited success. Much research in has focused on understanding genetics malignant cells, but it become clear that tumour microenvironment (TME) plays an important role progression as well response HNSCC. Understanding crosstalk between cancer cells TME is crucial inhibiting resistance. Cancer-associated fibroblasts (CAFs), predominant component stroma HNSCC, serve primary source extra-cellular matrix (ECM) various pro-tumoral composites TME. activation CAFs primarily driven by cell-secreted molecules, which turn induce phenotypic changes, elevated secretive status, altered ECM production profile. Concurrently, play a pivotal modulating cycle, stemness, epithelial-mesenchymal transition (EMT), resistance targeted chemoradiotherapy cells. This modulation occurs through interactions secreted molecules direct contact CAF. Co-culture 3D models other types allows mimic milieu enable hypoxia reprograming stem (CSC). review aims provide update development comprising obtain better interaction providing preclinical testing platforms current combination emerging therapeutics.
Language: Английский
Citations
14
Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 24, 2024
Language: Английский
Citations
9
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 166, P. 115390 - 115390
Published: Sept. 4, 2023
The tumor microenvironment (TME) is crucial in cancer progression, and the extracellular matrix (ECM) an important TME component. Collagen a major ECM component that contributes to cell infiltration, expansion, distant metastasis during progression. Recent studies reported collagen deposited form wall along which cells can infiltrate prevent drugs from working on cells. Collagen-tumor interaction complex requires activation of multiple signaling pathways for biochemical mechanical interventions. In this review, we examine effect deposition progression discuss between This review aims illustrate functions mechanisms its role therapy. findings indicated appears be better target
Language: Английский
Citations
21
Small, Journal Year: 2023, Volume and Issue: 19(37)
Published: May 24, 2023
Canonical phototherapeutics have several limitations, including a lack of tumor selectivity, nondiscriminatory phototoxicity, and hypoxia aggravation. The microenvironment (TME) is characterized by hypoxia, acidic pH, high levels H2 O2 , GSH, proteases. To overcome the shortcomings canonical phototherapy achieve optimal theranostic effects with minimal side effects, unique TME characteristics are employed in development phototherapeutic nanomedicines. In this review, effectiveness three strategies for developing advanced based on various examined. first strategy involves targeted delivery to tumors assistance TME-induced nanoparticle disassembly or surface modification. second near-infrared absorption increase-induced activation triggered factors. third enhancing therapeutic efficacy ameliorating TME. functionalities, working principles, significance applications highlighted. Finally, possible challenges future perspectives further discussed.
Language: Английский
Citations
18
Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 97, P. 104 - 123
Published: Nov. 28, 2023
Language: Английский
Citations
18