Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5978 - 5978
Published: March 22, 2023
The genetic and metabolomic abundance of the microbiome exemplifies that comprises a more extensive set genes than entire human genome, which justifies numerous metabolic immunological interactions between gut microbiota, macroorganisms immune processes. These have local systemic impacts can influence pathological process carcinogenesis. latter be promoted, enhanced or inhibited by microbiota host. This review aimed to present evidence host might significant exogenic factor for cancer predisposition. It is beyond doubt cross-talk cells in terms epigenetic modifications regulate gene expression patterns cell fate both beneficial adverse directions host’s health. Furthermore, bacterial metabolites could shift pro- anti-tumor processes one direction another. However, exact mechanisms behind these are elusive require large-scale omics studies better understand possibly discover new therapeutic approaches cancer.
Language: Английский
Citations
18
Macromolecular Research, Journal Year: 2023, Volume and Issue: 31(8), P. 739 - 752
Published: May 4, 2023
Language: Английский
Citations
17
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102515 - 102515
Published: Sept. 1, 2024
Language: Английский
Citations
8
Haematologica, Journal Year: 2024, Volume and Issue: 109(10), P. 3237 - 3250
Published: May 9, 2024
The gut microbiota plays a critical role in maintaining healthy human body and its dysregulation is associated with various diseases. In this study, we investigated the influence of microbiome diversity on development chronic lymphocytic leukemia (CLL). Analysis stool samples from 59 CLL patients revealed individual heterogeneous compositions, but allowed for grouping according to their diversity. Interestingly, lower an enrichment bacteria linked poor health suffered more advanced or aggressive form CLL. Eµ-TCL1 mouse model CLL, observed faster course disease when mice were housed high hygiene conditions. Shotgun DNA sequencing fecal showed that was which dominated by Mucispirillum Parabacteroides genera comparison kept under conclusion, applied taxonomic analyses demonstrate link between clinical humans, as well mice. Our novel data serve basis further investigations decipher pathological mechanistic intestinal development.
Language: Английский
Citations
5
Aggregate, Journal Year: 2023, Volume and Issue: 5(1)
Published: Sept. 18, 2023
Abstract Increasing evidence suggests that intratumoral microbiota plays a pivotal role in tumor progression, immunosurveillance, metastasis, and chemosensitivity. Particularly, pancreatic ductal adenocarcinoma, tumor‐resident Gammaproteobacteria could transform the chemotherapeutic drug gemcitabine (Gem) into its inactive form, thus rendering chemotherapy ineffective. Herein, strategy for selectively eradicating bacteria was described overcoming Gem resistance cancer animal model. An antimicrobial peptide linked with photosensitizer through poly (ethylene glycol) chain, which can self‐assemble micelles diameter of ∼20 nm. The efficiently kill under light irradiation by inducing membrane depolarization, thereby inhibiting metabolism. In bacteria‐resident model, selective photodynamic eradication demonstrated to reverse resistance. This research highlights antibacterial therapy as promising adjuvant modulating microbiota.
Language: Английский
Citations
11
Journal of bone oncology, Journal Year: 2024, Volume and Issue: 44, P. 100523 - 100523
Published: Jan. 5, 2024
The importance of the gut microbiota in human health has become increasingly apparent recent years, especially when relationship between and host is no longer symbiotic. It long been appreciated that dysbiosis can be detrimental to associated with numerous disease states. Only within last decade, however, was implicated bone biology. Dubbed osteomicrobiology, this emerging field aims understand microbiome microenvironment both disease. Importantly, key one major clinical challenges facing cancer biologists: metastasis, may lie osteomicrobiology; however link bacteria metastasis only beginning explored. This review will discuss (i) osteomicrobiology as an field, (ii) current understanding context bone.
Language: Английский
Citations
4
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 172, P. 116218 - 116218
Published: Feb. 2, 2024
Microbial metabolites have been indicated to communicate with the host's endocrine system, regulating hormone production, immune-endocrine communications, and interactions along gut-brain axis, eventually affecting occurrence of cancer. Furthermore, microbiota such as short-chain fatty acids (SCFAs) found affect tumor microenvironment boost immunity against tumors. SCFAs, including butyrate acetate, demonstrated exert anti-proliferative anti-protective activity on pancreatic cancer cells. The employing microbial metabolic products in conjunction radiation chemotherapy has shown promising outcomes terms reducing treatment side effects boosting effectiveness. Certain metabolites, valerate butyrate, made known improve efficiency CAR T-cell treatment, whilst others, indole-derived tryptophan inhibit immunity. This review explores intricate interplay between tumorigenesis, spanning mechanistic insights discovery potential therapeutic biomarkers.
Language: Английский
Citations
4
Immunological Reviews, Journal Year: 2024, Volume and Issue: 325(1), P. 9 - 22
Published: May 28, 2024
Stem-like T cells are characterized by their ability to self-renew, survive long-term, and give rise a heterogeneous pool of effector memory cells. Recent advances in single-cell RNA-sequencing (scRNA-seq) lineage tracing technologies revealed an important role for stem-like both autoimmunity cancer. In cancer, constitute arm the anti-tumor immune response giving that mediate tumor control. contrast, perform unfavorable forming reservoir long-lived autoreactive replenish pathogenic, T-cell thereby driving disease pathology. This review provides background on discovery function cancer autoimmunity. Moreover, influence microbiota metabolism is summarized. Lastly, implications our knowledge about clinical treatment strategies will be discussed.
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 15302 - 15302
Published: Dec. 4, 2022
Although cancer can be cured if detected early and treated effectively, it is still a leading cause of death worldwide. Tumor development limited by an appropiate immune response, but promoted chronic extensive inflammation through metabolic dysregulation angiogenesis. In the past decade, numerous efforts have been made in order to identify novel candidates with predictive values diagnostics. line this, researchers investigated involvement pentraxin-3 (PTX-3) cellular proliferation escape various types cancers, although has not clearly elucidated. PTX-3 member long pentraxin subfamily which plays important role regulating inflammation, innate immunity angiogenesis, tissue remodeling. Increased synthesis inflammatory biomarkers activation different mechanisms induce expression cells (neutrophils, monocytes, lymphocytes, myeloid dendritic cells, fibroblasts, epithelial cells). both pro- anti-tumor functions, thus dual functions oncogenesis. This review elucidates potential usefulness as serum biomarker cancer. While future investigations are needed, emerging promising tool for cancer’s diagnosis prognosis, also treatment monitoring.
Language: Английский
Citations
19
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 24, 2025
In recent years, tumor immunotherapy has made significant breakthroughs in the treatment of malignant tumors. However, individual differences efficacy have been observed clinical practice. There is increasing evidence that gut microbial metabolites influence distal via gut-liver axis, gut-brain axis and gut-breast a process may involve modulating expression immune cells cytokines microenvironment (TME). this review, we systematically explore relationship between immunotherapy, examine corresponding natural products their mechanisms action. The in-depth exploration research area will provide new ideas strategies to enhance mitigate adverse effects.
Language: Английский
Citations
0