Recent advances in the delivery and applications of nonviral CRISPR/Cas9 gene editing

Drug Delivery and Translational Research, Journal Year: 2023, Volume and Issue: 13(5), P. 1500 - 1519

Published: March 29, 2023

Language: Английский

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Tumor-targeted delivery of SNHG15 siRNA using a ZIF-8 nanoplatform: Towards a more effective prostate cancer therapy

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129233 - 129233

Published: Jan. 4, 2024

Language: Английский

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ZIF-8 modified with 2-undecylimidazolate as filler for mixed matrix membranes for CO₂ separation

Journal of Materials Chemistry A, Journal Year: 2024, Volume and Issue: 12(17), P. 10316 - 10328

Published: Jan. 1, 2024

A novel modification of zeolitic imidazolate framework-8 with 2-undecylimidazolate was explored to enhance its hydrophobicity and improve compatibility polymer PIM-1 when incorporated as a filler in mixed matrix membranes.

Language: Английский

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Current status and prospect of ZIF-based materials for breast cancer treatment

Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 232, P. 113612 - 113612

Published: Oct. 26, 2023

Language: Английский

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Biomaterials Elicit Pyroptosis Enhancing Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(7)

Published: Nov. 5, 2023

Abstract Cancer immunotherapy has the potential to revolutionize treatment of malignant tumors, but its effectiveness is limited by low immune response rate and immune‐related adverse events. Pyroptosis, as an inflammatory programmed cell death type, triggers strong acute antitumor immunity, converting “cold” tumors “hot”. Particularly, biomaterials loading pyroptosis inducers targeting tumor microenvironment engineer pyroptosis, have achieved great progress in recent years. Herein, design strategy, mechanism pathway, role induce cancer are comprehensively reviewed. The present review focuses on application biomaterials‐induced immunotherapy, including nanogel, polymer prodrug, nanovesicle, mesoporous material. Additionally, synthesis a series stimuli‐responsive nanoplatforms, glutathione‐responsive, pH‐responsive, reactive oxygen species‐responsive, enzyme‐mimicking catalytic performance, described. Meanwhile, it augments multiple processes uptake, antigen presentation, T‐cell activation, expansion. Finally, perspectives pyroptosis‐mediated inflammation break through vascular basement membrane barrier achieving efficient volcanic penetration discussed. Artificial intelligence, multi‐omics analysis, anthropogenic animal models organoids presented, aiming provide guidance assistance for constructing effective controllable pyroptosis‐engineered improving immunotherapy.

Language: Английский

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Drug carrier wonders: Synthetic strategies of zeolitic imidazolates frameworks (ZIFs) and their applications in drug delivery and anti-cancer activity

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 329, P. 103184 - 103184

Published: May 17, 2024

Language: Английский

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Recent advances in natural polysaccharides-based controlled release nanosystems for anti-cancer phototherapy

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 301, P. 120311 - 120311

Published: Nov. 8, 2022

Language: Английский

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A new era in cancer treatment: harnessing ZIF-8 nanoparticles for PD-1 inhibitor delivery

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 12(4), P. 872 - 894

Published: Dec. 11, 2023

This review delves into the potential of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles in augmenting efficacy cancer immunotherapy, with a special focus on delivery programmed cell death receptor 1 (PD-1) inhibitors. The multifunctional nature ZIF-8 as drug carriers is emphasized, their ability to encapsulate range therapeutic agents, including PD-1 inhibitors, and facilitate targeted tumor locations. By manipulating pore size surface characteristics nanoparticles, controlled release can be realized. strategic use deliver inhibitors presents precise modality for treatment, reducing off-target impacts enhancing effectiveness. combined strategy addresses existing challenges constraints current immunotherapy techniques, ultimate goal patient outcomes therapy.

Language: Английский

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Synergistic cerium oxide nanozymes: targeting DNA damage and alleviating tumor hypoxia for improved NSCLC radiotherapy efficiency

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 10, 2024

Abstract Radiotherapy (RT) is one of the important treatment modalities for non-small cell lung cancer (NSCLC). However, maximum radiation dose that NSCLC patient can receive varies little. Therefore, exploitation novel RT sensitization approaches a critical need clinical treatment. resistance in linked to tumor microenvironment (TME) hypoxia, cycle arrest and associated genetic alterations. Here, we designed method targeted delivery quercetin (QT) CeO 2 enhance sensitivity. We loaded QT into @ZIF-8-HA nanoparticles prevent its degradation circulatory system successfully delivered tumors. Under protection Zeolitic Imidazolate Framework-8 (ZIF-8), nanocomplexes exhibited excellent catalytic mimetic activity decomposing H O , thus significantly reversing hypoxia TME, while radiosensitizer caused DNA damage directly after RT. In subcutaneous model, overcame enhanced therapeutic efficacy. This multiple strategy combining nanozymes opens promising approach NSCLC.

Language: Английский

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Recent advances and synergistic effect of bioactive zeolite imidazolate frameworks (ZIFs) for biosensing applications

Talanta, Journal Year: 2024, Volume and Issue: 275, P. 126097 - 126097

Published: April 17, 2024

Language: Английский

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