Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 395, P. 123836 - 123836
Published: Dec. 20, 2023
Language: Английский
Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 510 - 510
Published: March 14, 2024
Chemoresistance is a challenge in cancer treatment, limiting the effectiveness of chemotherapy. Mushroom extracts have shown potential as treatments for therapies, offering possible solution to overcome chemoresistance. This systematic review aimed explore role mushroom enhancing chemotherapy and reversing chemoresistance cells. We searched PubMed, Web Science Scopus databases, following PRISMA guidelines, registered on PROSPERO. The acted by inhibiting proliferation cells, well effect mechanisms which they included regulating anti-apoptotic proteins, JAK2/STAT3 pathway, ERK1/2 modulating microRNAs p-glycoprotein. These results highlight modulate multiple order improve efficacy work sheds light use an aid combat Although studies are limited, diversity mushrooms their bioactive compounds show promising innovative strategies treat more effectively. It crucial carry out further better understand therapeutic
Language: Английский
Citations
4
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 212 - 212
Published: Jan. 31, 2024
The potential benefits of drug repurposing have gained attention as an alternative to developing de novo drugs. using central nervous system (CNS) drugs anticancer has been explored in several types human cancers, such breast and colon cancer, among others. Here, we examine the effect CNS sertraline, paroxetine, chlorpromazine on squamous carcinoma cells bladder (UM-UC-5). After exposing UM-UC-5 increased concentrations each for 48 h, assessed their metabolic activity MTT assay. Based those results, calculated cell viability half-maximal inhibitory concentration (IC50) values. results suggest that were effective against order potency sertraline > paroxetine. Interestingly, was more potent than 5-fluorouracil (5-FU), a widely used drug. This study demonstrated, first time, promising cancer vitro supports improve treatment. Nevertheless, further studies are necessary understand mechanism action vivo activity.
Language: Английский
Citations
3
Cancers, Journal Year: 2022, Volume and Issue: 15(1), P. 128 - 128
Published: Dec. 25, 2022
Liquid biopsy has dramatically changed cancer management in the last decade; however, despite huge number of miRNA signatures available for diagnostic or prognostic purposes, it is still unclear if dysregulated miRNAs bloodstream could be used to develop miRNA-based therapeutic approaches. In one author's previous work, nine were found early-stage colon (CRC) patients by NGS analysis followed RT-dd-PCR validation. present study, biological effects targeting most relevant with anti-miRNA peptide nucleic acids (PNAs) verified, and their anticancer activity terms apoptosis induction was evaluated. Our data demonstrate that up-regulated using PNAs leads down-regulation target associated inhibition activation pro-apoptotic pathway CRC cellular models. Moreover, very high percentages apoptotic cells when other agents, such as sulforaphane (SFN). The presented sustain idea a known role tumor pathology might tool design protocols anti-tumor therapy based on miRNA-targeting molecules.
Language: Английский
Citations
11
Biomedicines, Journal Year: 2023, Volume and Issue: 11(3), P. 903 - 903
Published: March 15, 2023
Chemotherapy still plays a central role in the treatment of cancer. However, it is often accompanied by off-target effects that result severe side-effects and development drug resistance. The aim this work was to study efficacy different repurposed drugs on viability MCF-7 SH-SY5Y breast cancer neuroblastoma cells, respectively. In addition, combinations these with classical chemotherapeutic (doxorubicin) were also carried out. cytotoxic evaluated individually combination both cell lines, assessed MTT assays morphological evaluation cells. results demonstrated atorvastatin reduced lines. nitrofurantoin able induce but not doxorubicin induced higher inhibition than individually. two they potentiate each other. Synergism studies revealed more effective compared Taken together, our preliminary highlights potential use context neuroblastoma.
Language: Английский
Citations
5
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 97 - 97
Published: Dec. 21, 2022
The combination of Carboplatin with Paclitaxel is the mainstay treatment for high-grade serous carcinoma; however, many patients advanced disease undergo relapse due to chemoresistance. Drug repurposing coupled a two or more compounds independent mechanisms action has potential increase success rate antineoplastic treatment. purpose this study was explore whether repurposed drugs led therapeutic benefit. Hence, we assessed cytotoxic effects alone and in several (Pitavastatin, Metformin, Ivermectin, Itraconazole Alendronate) tumoral models, i.e., (OVCAR8) Carboplatin-Paclitaxel (OVCAR8 PTX R P) chemoresistant cell lines non-tumoral (HOSE6.3) line. Cellular viability measured using Presto Blue assay, synergistic interactions were evaluated Chou–Talalay, Bliss Independence Highest Single Agent reference models. Combining Pitavastatin Metformin displayed highest effect strongest synergism among all combinations OVCAR8 P cells, resulting chemotherapeutic superior as single agent. Concerning HOSE6.3 combining almost demonstrated safe pharmacological profile. Overall, propose that could act synergistically management carcinoma plus resistance
Language: Английский
Citations
8
Diseases, Journal Year: 2023, Volume and Issue: 11(1), P. 49 - 49
Published: March 14, 2023
We have previously shown that pitavastatin has the potential to be used treat ovarian cancer, although relatively high doses are likely necessary. One solution this problem is identify drugs synergistic with pitavastatin, thereby reducing dose necessary a therapeutic effect. Here, we tested combinations of anti-parasitic drug ivermectin in six cancer cell lines. When on its own, inhibited growth cells but only modest potency (IC50 = 10-20 µM). were combined and assessed assays, showed synergy 3 lines was most evident COV-318 (combination index ~ 0.6). Ivermectin potentiated reduction viability caused by 20-25% as well potentiating apoptosis induced activation caspase-3/7 (2-4 fold) annexin-labelling (3-5 fold). These data suggest may useful treatment when methods achieve an adequate concentration tumour tissue will
Language: Английский
Citations
4
Journal of Lab Animal Research, Journal Year: 2022, Volume and Issue: 1(1), P. 52 - 59
Published: Dec. 25, 2022
Ivermectin is a well-known antiparasitic drug in the macrolide class with 16-membered ring. It has been used for treating various parasitic diseases, including onchocerciasis, lymphatic filariasis, and strongyloidiasis. The present study aimed to review mechanisms of action therapeutic implications as an anticancer agent. over three decades, its safety well-established humans A growing body evidence suggests that ivermectin properties, making it attractive candidate types cancer. reason targets multiple signaling pathways, Wnt/β-catenin, PI3K/Akt/mTOR, STAT3 inhibit cancer cell proliferation induce apoptosis. Inhibition these pathways by leads suppression growth. Additionally, shown autophagy, which can lead programmed death cells. One significant advantages profile. Furthermore, easily available affordable, promising alternative conventional chemotherapy cancer, breast, lung, colon However, further research needed evaluate clinical effectiveness humans. Clinical trials are underway investigate ivermectin's efficacy treatment. In conclusion, profile low cost have turned into feasible chemotherapy, needs more investigation.
Language: Английский
Citations
4
Research in Veterinary Science, Journal Year: 2023, Volume and Issue: 156, P. 14 - 21
Published: Jan. 11, 2023
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11935 - 11935
Published: Nov. 6, 2024
Ovarian cancer (OC) remains one of the leading causes cancer-related mortality among women. Targeting insulin-like growth factor 1 (IGF-1) signaling pathway has emerged as a promising therapeutic strategy. Linsitinib, an IGF-1 receptor (IGF-1R) inhibitor, shown potential in disrupting this pathway. Additionally, metformin, commonly used treatment type 2 diabetes, been studied for its anti-cancer properties due to ability inhibit metabolic pathways that intersect with signaling, making it candidate combination therapy treatments. This study explores effects linsitinib and metformin on OVCAR3 cells by suppression siRNA-mediated
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 18(1), P. 14 - 14
Published: Dec. 25, 2024
Chemoresistance is a major obstacle in high-grade serous carcinoma (HGSC) treatment. Although many patients initially respond to chemotherapy, the majority of them relapse due Carboplatin and Paclitaxel resistance. Drug repurposing has surfaced as potentially effective strategy that works synergically with standard chemotherapy bypass chemoresistance. In prior study, using 2D cultures two HGSC chemoresistant cell lines, it was demonstrated combining or Pitavastatin Ivermectin resulted most notable synergy. Acknowledging culture systems are limited reflecting tumor architecture, 3D were generated provide insights on treatment efficacy tests more complex models. We aimed investigate whether offers therapeutic benefits Cultrex-based model. Here, cytotoxicity Paclitaxel, both alone combination Ivermectin, analyzed OVCAR8 PTX R C, cultures. Cellular viability assessed CellTiter-Glo® Luminescent assays. Also, explored synergistic interactions zero interaction potency, Loewe, Bliss independence, High-single agent reference Our research indicates chemotherapeutic drugs yields significantly cytotoxic effects than alone. For all combinations tested, at least one model indicated an additive effect; however, only consistently effect across lines cultured models, well four synergy models used assess drug interactions. Combining highest strongest for compared
Language: Английский
Citations
0