Diagnostic Pathology,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Nov. 25, 2024
The
main
difficulty
in
the
diagnosis
of
atypical
situ
adenocarcinoma
lies
distinction
between
true
and
false
stromal
invasion.
Moreover,
how
to
identify
local
alveolar
wall
collapse
lung
whether
trapped
adenoid
structure
around
scar
is
an
invasion
component
have
become
key
points
for
accurate
adenocarcinoma.
In
present
study,
we
detected
40
cases
invasive
by
using
immunohistochemical
techniques.
We
found
FAP-α
had
not
immunreactivity
stroma
situ.
However,
it
stained
areas
staining
pattern
could
represent
hyperplastic
myofibroblast
demonstrated
stroma.
This
study
provides
strong
evidence
that
effective
tool
evaluate
presence
or
absence
Our
findings
will
contribute
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9463 - 9463
Published: Aug. 30, 2024
Colorectal
cancer
(CRC)
represents
a
significant
global
health
burden,
with
high
incidence
and
mortality
rates
worldwide.
Recent
progress
in
research
highlights
the
distinct
clinical
molecular
characteristics
of
colon
versus
rectal
cancers,
underscoring
tumor
location's
importance
treatment
approaches.
This
article
provides
comprehensive
review
our
current
understanding
CRC
epidemiology,
risk
factors,
pathogenesis,
management
strategies.
We
also
present
intricate
cellular
architecture
colonic
crypts
their
roles
intestinal
homeostasis.
carcinogenesis
multistep
processes
are
described,
covering
conventional
adenoma-carcinoma
sequence,
alternative
serrated
pathways,
influential
Vogelstein
model,
which
proposes
sequential
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(2), P. 577 - 577
Published: Jan. 11, 2023
FAPI
PET/CT
is
a
novel
imaging
tool
targeting
fibroblast
activation
protein
(FAP),
with
high
tumor
uptake
rate
and
low
background
noise.
Therefore,
the
appearance
of
provides
good
tumor-to-background
ratio
between
non-tumor
tissues,
which
beneficial
to
staging,
description
detection.
Colorectal
cancer
has
biological
characteristics
expression
FAP,
foundation
for
targeted
FAP
imaging.
may
have
potential
role
in
changing
staging
re-staging
colorectal
cancer,
monitoring
recurrence
treatment
management,
improving
prognosis
patients.
This
review
will
summarize
application
status
provide
directions
further
research.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(24), P. 15576 - 15576
Published: Dec. 8, 2022
Tumours
are
complex
systems
with
dynamic
interactions
between
tumour
cells,
non-tumour
and
extracellular
components
that
comprise
the
microenvironment
(TME).
The
majority
of
TME's
cells
cancer-associated
fibroblasts
(CAFs),
which
crucial
in
matrix
(ECM)
construction,
metabolism,
immunology,
adaptive
chemoresistance,
cell
motility.
CAF
subtypes
have
been
identified
based
on
expression
protein
markers.
CAFs
may
act
as
promoters
or
suppressors
depending
a
variety
factors,
including
cancer
stage.
Indeed,
shown
to
promote
growth,
survival
spread,
secretome
changes,
but
they
can
also
slow
tumourigenesis
at
an
early
stage
through
mechanisms
still
poorly
understood.
Stromal-cancer
governed
by
soluble
factors
determine
outcome
tumourigenic
process.
Cancer
release
enhance
ability
secrete
multiple
tumour-promoting
chemokines,
acting
malignant
proliferation,
migration,
invasion.
This
crosstalk
has
given
new
prominence
stromal
from
being
considered
mere
physical
support
becoming
key
players
Here,
we
focus
concept
non-healing
wound
relevance
chronic
inflammation
initiation.
In
addition,
review
heterogeneous
origins
markers
together
potential
therapeutic
implications
"re-education"
and/or
targeting
progression
inhibition.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 1988 - 1988
Published: Feb. 25, 2025
Colorectal
cancer
(CRC)
is
a
major
cause
of
cancer-related
mortality
worldwide,
with
significant
impact
on
public
health.
Current
treatment
options
include
surgery,
chemotherapy,
radiotherapy,
molecular-targeted
therapy,
and
immunotherapy.
Despite
advancements
in
these
therapeutic
modalities,
resistance
remains
challenge,
often
leading
to
failure,
poor
progression-free
survival,
recurrence.
Mechanisms
CRC
are
multifaceted,
involving
genetic
mutations,
epigenetic
alterations,
tumor
heterogeneity,
the
microenvironment.
Understanding
mechanisms
at
molecular
level
crucial
for
identifying
novel
targets
developing
strategies
overcome
resistance.
This
review
provides
an
overview
diverse
driving
drug
sporadic
discusses
currently
under
investigation
counteract
this
Several
promising
being
explored,
including
targeting
transport,
key
signaling
pathways,
DNA
damage
response,
cell
death
modifications,
stem
cells,
The
integration
emerging
approaches
that
target
aims
enhance
efficacy
current
treatments
improve
patient
outcomes.
Non-coding RNA Research,
Journal Year:
2023,
Volume and Issue:
8(4), P. 615 - 632
Published: Sept. 11, 2023
Colorectal
cancer
(CRC)
is
ranked
as
the
world's
third-most
prevalent
cancer,
and
metastatic
CRC
considerably
increases
cancer-related
fatalities
globally.
A
number
of
complex
mechanisms
that
are
strictly
controlled
at
molecular
level
involved
in
metastasis,
which
primary
reason
for
death
people
with
CRC.
Recently,
it
has
become
clear
exosomes,
small
extracellular
vesicles
released
by
non-tumorous
tumorigenic
cells,
play
a
critical
role
communication
mediators
among
tumor
microenvironment
(TME).
To
facilitate
between
TME
non-coding
RNAs
(ncRNAs)
crucial
recognized
potent
regulators
gene
expression
cellular
processes,
such
metastasis
drug
resistance.
NcRNAs
now
many
hallmarks
including
metastasis.
Exosomal
ncRNAs,
like
miRNAs,
circRNAs,
lncRNAs,
have
been
demonstrated
to
influence
contribute
However,
link
exosomal
ncRNAs
not
well
understood.
This
review
highlights
essential
roles
progression
disease
explores
therapeutic
choices
open
patients
who
metastases.
ncRNA
treatment
strategy
development
still
its
early
phases;
consequently,
additional
investigation
required
improve
delivery
methods
find
novel
targets
confirm
effectiveness
safety
these
therapies
preclinical
clinical
contexts.
