WO3-ZnS Photocatalyzed Synthesis of Some Substituted Benzimidazoles as Effective Agents against Gastrointestinal Cancer DOI
Linlin Yue, Yifeng Hu,

Xiaohua He

et al.

Polycyclic aromatic compounds, Journal Year: 2023, Volume and Issue: 44(7), P. 4510 - 4530

Published: Sept. 9, 2023

Benzimidazoles, a class of nitrogen-containing heteroaromatic compounds, play crucial role in the development various important drugs. These compounds exhibit diverse biological functionalities. In this study, novel and environmentally friendly photocatalytic route is proposed for production benzimidazoles. This method involves oxidation alcohol to aldehyde using air as oxidant under visible-light conditions. Subsequently, fast condensation with o-phenylenediamine takes place, leading formation 2-substituted The key mediator process newly developed photocatalyst called WO3-ZnS, which activated by commercial green laser light wavelength 535 nm. To characterize nanocomposite, several techniques including FT-IR, XRD, EDS, FE-SEM were employed. analyses provided valuable insights into structure properties nanocomposite. Moreover, Tauc's was utilized estimate optical band gap photocatalyst. radical pathway reactive species such •O2- OH•, along h+. Stability reusability experiments confirmed reproducibility nano-photocatalyst reaction medium. Furthermore, primarily in-vitro cellular toxicity WO3-ZnS nanoparticles evaluated HCT-116 human cancer cell line through MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay. results demonstrated significant reduction viability, indicating cytotoxicity against these cancerous cells. finding highlights potential synthesized effective agents combating gastrointestinal cancer.

Language: Английский

Benzimidazole-Triazole Hybrids as Antimicrobial and Antiviral Agents: A Systematic Review DOI Creative Commons
Maria Marinescu

Antibiotics, Journal Year: 2023, Volume and Issue: 12(7), P. 1220 - 1220

Published: July 22, 2023

Bacterial infections have attracted the attention of researchers in recent decades, especially due to special problems they faced, such as their increasing diversity and resistance antibiotic treatment. The emergence development SARS-CoV-2 infection stimulated even more research find new structures with antimicrobial antiviral properties. Among heterocyclic compounds remarkable therapeutic properties, benzimidazoles, triazoles stand out, possessing antimicrobial, antiviral, antitumor, anti-Alzheimer, anti-inflammatory, analgesic, antidiabetic, or anti-ulcer activities. In addition, literature last decade reports benzimidazole-triazole hybrids improved biological properties compared simple mono-heterocyclic compounds. This review aims provide an update on synthesis methods these hybrids, along activities, well structure-activity relationship reported literature. It was found that presence certain groups grafted onto benzimidazole and/or triazole nuclei (-F, -Cl, -Br, -CF3, -NO2, -CN, -CHO, -OH, OCH3, COOCH3), some heterocycles (pyridine, pyrimidine, thiazole, indole, isoxazole, thiadiazole, coumarin) increases activity hybrids. Also, oxygen sulfur atom bridge connecting rings generally mentions only benzimidazole-1,2,3-triazole Both for additional ring activity, which is agreement three-dimensional binding mode summarizes advances derivatives potential agents covering articles published from 2000 2023.

Language: Английский

Citations

40
Recent advances of benzimidazole as anticancer agents DOI

Sneha Venugopal,

Balwinder Kaur, Anil Verma

et al.

Chemical Biology & Drug Design, Journal Year: 2023, Volume and Issue: 102(2), P. 357 - 376

Published: April 3, 2023

Cancer is the second leading cause of death globally, with 9.6 million deaths yearly. As a life-threatening disease, it necessitates emergence new therapies. Resistance to current chemotherapies drives scientists develop medications that will eventually be accessible. Because heterocycles are so common in biological substances, compounds play big part variety have been developed. The "Master Key" benzimidazole nucleus, which consists six-membered benzene ring fused five-membered imidazole/imidazoline ring, an azapyrrole. One aromatic nitrogen identified American therapies approved by Food and Drug Administration (FDA). Our results show benzimidazole's broad therapeutic spectrum due its structural isosteres purine, improves hydrogen bonding, electrostatic interactions topoisomerase complexes, intercalation DNA, other functions. It also enhances protein nucleic acid inhibition, tubulin microtubule degeneration, apoptosis, DNA fragmentation, Additionally, readers for designing more recent analogues as prospective cancer treatments.

Language: Английский

Citations

31
Recent advances in the application of heterogeneous catalysts for the synthesis of benzimidazole derivatives DOI
Mohammad Mavvaji, Senem Akkoç

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 505, P. 215714 - 215714

Published: Feb. 12, 2024

Language: Английский

Citations

13
A critical review of benzimidazole: Sky-high objectives towards the lead molecule to predict the future in medicinal chemistry DOI Creative Commons
Sabyasachi Banerjee, Sougata Mukherjee,

Priyobrata Nath

et al.

Results in Chemistry, Journal Year: 2023, Volume and Issue: 6, P. 101013 - 101013

Published: June 23, 2023

Out of several heterocyclic templates, the use a Benzimidazole (BZ) scaffold is immensely observed. This fused heterocycle comprises two ring nitrogen atoms placed at 1st and 3rd position, in which connected to hydrogen that gets released exhibit acidic property. The BZ for purpose making clinically useful compounds was started year 1944. derivatives have been consistently used as effective chemotherapeutic agents treat diverse range disorders. Apart from their clinical usefulness, BZ-based also confer high safety, bio-availability, stability. conditions, cancer, helminthiasis are few where this template has maximally utilized. present review emphasizes chronologically developments entire scope medicinal chemistry antibacterial, anticancer, antifungal, anti-inflammatory, anti-HIV (human immunodeficiency virus), anticonvulsant, antioxidant, antidiabetic, antitubercular, antileishmanial, antimalarial, anti-histaminic. covers patents on importance till 2020. primary objective develop comprehensive SAR (structure–activity relationship), turn assists chemist come up with novel ideas, while being implemented could produce enormous potential.

Language: Английский

Citations

19
Recent Advances in the Anticancer Applications of Benzimidazole Derivatives DOI
Mohammad Mavvaji, Senem Akkoç

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(35)

Published: Sept. 15, 2023

Abstract Cancer, one of the most deadly diseases worldwide, is still a crucial challenge to human well‐being. Hence, design and development modern protocols cure diverse kinds cancer seem highly necessary. On other hand, benzimidazole, as an essential pharmacophore, exhibits various biological therapeutic potency. This compound well‐known for its pharmaceutical features, including antifungal, antiviral, antibacterial, anticancer activities. Therefore, benzimidazole derivatives have played role due their outstanding capability, apoptotic effect, inhibitory potential. In recent decades, numerous drug types research been concentrated on finding new practical strategies employing benzimidazole‐based compounds. review focuses latest advancements methodologies exploiting benzimidazole‐bearing compounds treatment varied sorts cancer, considering mechanism function against cell lines.

Language: Английский

Citations

17
Synthesis, Anticancer Activity, and In Silico Modeling of Alkylsulfonyl Benzimidazole Derivatives: Unveiling Potent Bcl-2 Inhibitors for Breast Cancer DOI Creative Commons

Yemna Abbade,

Mehmet Murat Kışla, Mohammed Hassan

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(8), P. 9547 - 9563

Published: Feb. 14, 2024

A series of alkylsulfonyl 1H-benzo[d]imidazole derivatives were synthesized and evaluated for anticancer activity against human breast cancer cells, MCF-7 in vitro. The cytotoxic potential was determined using the xCELLigence real-time cell analysis, expression levels genes related to microtubule organization, tumor suppression, apoptosis, cycle, proliferation examined by quantitative polymerase chain reaction. Molecular docking Bcl-2 carried out AutoDock Vina, while ADME studies performed predict physicochemical drug-likeness properties compounds. results revealed that compounds 23 27 most potent cells. Gene analysis showed BCL-2 prominent gene studied. Treatment cells with resulted significant downregulation gene, fold changes 128 256, respectively. Docking predicted a strong interaction between target protein. Interestingly, all exhibit higher binding affinity toward than standard drug (compound vina score = −9.6 kcal/mol, vincristine −6.7 kcal/mol). dynamics simulations permanent stabilization site 200 ns. Based on Lipinski Veber's filters, displayed drug-like characteristics. These findings suggest promising downregulated gene. could be further explored as candidates treatment cancer.

Language: Английский

Citations

9
Magnetic nanomaterials as green and recoverable nanocatalysts: Research on synthesis of benzimidazole derivatives DOI
Khalid Mujasam Batoo, Mohammed Kadhem Abid, Abdul-hameed M. Hamoody

et al.

Synthetic Communications, Journal Year: 2024, Volume and Issue: 54(9), P. 709 - 734

Published: March 28, 2024

Research on benzimidazole derivatives is always an attractive challenge among synthetic chemists because are very key and important components in the structure of many drugs, biological active molecules, natural products. Benzimidazole interesting their valuable medicinal activities, such as anti-bacterial, anti-cancer, anti-tuberculosis, anti-fungal, pain killer, anti-HIV activities. During last decade, most reports field catalysts have been related to magnetic nanocatalysts, which shows high popularity remarkable efficiency this type catalyst performing chemical reactions. Magnetic nanocatalysts ideal both from point view green chemistry economically they easily separated reaction mixture significant catalytic activity. In review article, we summarized methods presented synthesis various based use nanomaterials recoverable catalysts.

Language: Английский

Citations

8
Bipyridine‐Fe (III)–Based Covalent Organic Frameworks for Efficient Photocatalytic Synthesis of Benzimidazoles DOI
Boai Li, Xiaohong Chen, Yuemin Zhu

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(6)

Published: May 2, 2025

ABSTRACT Covalent organic frameworks (COFs) with structural versatility, tunable photophysical properties, and excellent chemical stability recyclability have been widely used as heterogeneous photocatalysts. Developing metal‐based COFs for designability unprecedented properties is highly desirable. In this paper, a new COFs‐supported photocatalyst BD Fe ‐COF embedded metallic iron (III) was successfully synthesized by the metalation reaction of FeCl 3 ·6H 2 O bipyridine‐based BD‐COF, which prepared aldehyde‐amine condensation 2,2′‐bipyridine‐5,5′‐dicarboxaldehyde 4,4′,4″,4‴‐(pyrene‐1,3,6,8‐tetrayl) tetraaniline via solvothermal method. The as‐synthesized exhibited high crystalline, stability, good properties. Moreover, photoactive employed cost‐effective catalyst in cyclocondensation o ‐phenylenediamine aldehydes. advantages current photocatalytic system included to yields, easy work‐up process, short time, together recyclability.

Language: Английский

Citations

0
Rationale design, synthesis and antimicrobial activity of benzimidazole-pyridinecarbonitrile conjugates: Insights into ROS-induced oxidative damage and molecular dynamics simulations DOI

Hayam A. Abd El Salam,

Mostafa I. Abdelglil, Eman Sabry

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108627 - 108627

Published: May 1, 2025

Language: Английский

Citations

0
Mebendazole Treatment Disrupts the Transcriptional Activity of Hypoxia-Inducible Factors 1 and 2 in Breast Cancer Cells DOI Open Access
Natalie Joe, Yuanfeng Wang, Harsh Oza

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(4), P. 1330 - 1330

Published: Feb. 20, 2023

Breast cancer is the most diagnosed in women world. Mebendazole (MBZ) has been demonstrated to have preclinical efficacy across multiple cancers, including glioblastoma multiforme, medulloblastoma, colon, breast, pancreatic, and thyroid cancers. MBZ was also well tolerated a recent phase I clinical trial of adults with glioma. The mechanisms action reported so far for include tubulin disruption, inhibiting angiogenesis, promoting apoptosis, maintaining stemness. To elucidate additional mebendazole (MBZ), we performed RNA sequencing three different breast cell lines treated either or vehicle control. We compared top genes downregulated upon treatment expression profiles cells over 15,000 perturbagens using clue.io online analysis tool. In addition inhibitors, gene profile that correlated matched known hypoxia-inducible factor (HIF-1α -2α) inhibitors. HIF pathway main driver cellular response hypoxia, which occurs solid tumors. Preclinical data support inhibitors combination standard care treat Therefore, tested hypothesis could inhibit hypoxia response. Using HIF-reporter assays, demonstrate inhibits transcriptional activity HIFs mouse models by preventing induction HIF-1α, HIF-2α, HIF-1β protein under hypoxia. Taken together, our results suggest therapeutic setting warrants further consideration as therapy.

Language: Английский

Citations

9