The Role of the Gut Microbiome in Neuroinflammation and Chemotherapy-Induced Peripheral Neuropathy DOI Creative Commons
Svetlana Shatunova, Rubina Aktar, Madusha Peiris

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 979, P. 176818 - 176818

Published: July 18, 2024

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most debilitating adverse effects caused by chemotherapy drugs such as paclitaxel, oxaliplatin and vincristine. It untreatable often leads to discontinuation cancer therapy a decrease in quality life patients. well-established that neuroinflammation activation immune glial cells are among major drivers CIPN. However, these processes still poorly understood, while many alone can drive consequent neuroinflammation, it remains elusive what extent gut microbiome influences processes. In this review, we focus on mechanisms driving CIPN, address bidirectional pathways which communicates with nervous systems. Additionally, critically evaluate literature addressing how chemotherapy-induced dysbiosis imbalance bacterial products may contribute cells, both possibly CIPN development, could use knowledge for development effective treatment strategies.

Language: Английский

Fecal microbiome transfer an investigative tool and treatment strategy in cancer DOI
Margaret S. Bohm, A. Ramesh, Joseph F. Pierre

et al.

AJP Gastrointestinal and Liver Physiology, Journal Year: 2024, Volume and Issue: 327(5), P. G711 - G726

Published: Oct. 8, 2024

The microbiome impacts the onset, progression, and therapy response of certain types cancer. Fecal microbial transplants (FMTs) are an increasingly prevalent tool to test these mechanisms that require standardization by field.

Language: Английский

Citations

3
Visceral adiposity in postmenopausal women is associated with a pro-inflammatory gut microbiome and immunogenic metabolic endotoxemia DOI Creative Commons
Mohamed Gaber,

Adam S. Wilson,

Amy E. Millen

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Oct. 4, 2024

Abstract Background Obesity, and in particular abdominal obesity, is associated with an increased risk of developing a variety chronic diseases. aging, menopause are each differential shifts the gut microbiome. Obesity causes low-grade inflammation due to lipopolysaccharide (LPS) levels which termed “metabolic endotoxemia.” We examined association visceral adiposity tissue (VAT) area, circulating endotoxemia markers, bacterial microbiome cohort aged postmenopausal women. Methods Fifty women (mean age 78.8 ± 5.3 years) who had existing adipose measurements via dual x-ray absorptiometry (DXA) were selected from extremes VAT: n = 25 low VAT area (45.6 12.5 cm 2 ) high (177.5 31.3 ). Dietary intake used estimate Healthy Eating Index (HEI) score was assessed food frequency questionnaire. Plasma LPS, LPS-binding protein (LBP), anti-LPS antibodies, anti-flagellin anti-lipoteichoic acid (LTA) antibodies measured by ELISA. Metagenomic sequencing performed on fecal DNA. Female C57BL/6 mice consuming high-fat or low-fat diet treated 0.4 mg/kg diet-derived isolated LPS modeling metabolic endotoxemia, outcomes after 6 weeks. Results Women group showed Proteobacteria abundance lower Firmicutes/Bacteroidetes ratio. LBP concentration positively area. anti-LPS, anti-LTA, IgA significantly correlated measurements. elevated LPS-expressing bacteria compared Gut species that significant associations both (anti-LPS LBP) ( Escherichia coli , Shigella spp., Klebsiella spp.) Veillonella atypica . eating index scores negatively % body fat levels. Preclinical murine model diet-fed administered fecal-derived displayed reduced weight, decreased fat, improved glucose tolerance test parameters when saline-injected LPS-treated groups diet. Conclusions Increased immunogenic markers. Low-fat fecal-isolated giving mechanistic insights into potential pro-health signaling mediated under-acylated isoforms.

Language: Английский

Citations

3
Quantification of 10 B vitamins in mouse colon by LC-MS/MS: Application on breast cancer mice treated with doxorubicin DOI
Jing Wu, Yan Xu, Jiahong Yang

et al.

Journal of Chromatography B, Journal Year: 2023, Volume and Issue: 1222, P. 123714 - 123714

Published: April 8, 2023

Language: Английский

Citations

8
NIR diagnostic imaging of triple-negative breast cancer and its lymph node metastasis for high-efficiency hypoxia-activated multimodal therapy DOI Creative Commons
Yi Pan,

Longcai Liu,

Yichen He

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 2, 2023

Triple-negative breast cancer (TNBC) possesses special biological behavior and clinicopathological characteristics, which is highly invasive propensity to metastasize lymph nodes, leading a worse prognosis than other types of cancer. Thus, the development an effective therapeutic method significant improve survival rate TNBC patients.In this work, liposome-based theranostic nanosystem (ILA@Lip) was successfully prepared by simultaneously encapsulating IR 780 as photosensitizer lenvatinib anti-angiogenic agent, together with banoxantrone (AQ4N) molecule hypoxia-activated prodrug. The ILA@Lip can be applied for near-infrared (NIR) fluorescence diagnostic imaging its node metastasis multimodal therapy. Lenvatinib in inhibit angiogenesis cutting oxygen supply, thereby enhanced hypoxia levels. Meanwhile, large amounts reactive species (ROS) were produced while irradiated 808 nm laser, also rapidly exhausted tumor cells worsen hypoxia. Through creating extremely hypoxic TNBC, conversion non-toxic AQ4N toxic AQ4 much more efficiency chemotherapy. Cytotoxicity assay indicated excellent biocompatibility normal tissues, but showed high toxicity cells. Also, vivo tumors treated laser irradiation admirably suppressed both subcutaneous model orthotopic models.Utilizing profound strategy create microenvironment higher efficacy chemotherapy, realized collective suppression growth has promising potential clinical translation.

Language: Английский

Citations

8
The Role of the Gut Microbiome in Neuroinflammation and Chemotherapy-Induced Peripheral Neuropathy DOI Creative Commons
Svetlana Shatunova, Rubina Aktar, Madusha Peiris

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 979, P. 176818 - 176818

Published: July 18, 2024

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most debilitating adverse effects caused by chemotherapy drugs such as paclitaxel, oxaliplatin and vincristine. It untreatable often leads to discontinuation cancer therapy a decrease in quality life patients. well-established that neuroinflammation activation immune glial cells are among major drivers CIPN. However, these processes still poorly understood, while many alone can drive consequent neuroinflammation, it remains elusive what extent gut microbiome influences processes. In this review, we focus on mechanisms driving CIPN, address bidirectional pathways which communicates with nervous systems. Additionally, critically evaluate literature addressing how chemotherapy-induced dysbiosis imbalance bacterial products may contribute cells, both possibly CIPN development, could use knowledge for development effective treatment strategies.

Language: Английский

Citations

2