Clocks & Sleep,
Journal Year:
2024,
Volume and Issue:
6(4), P. 635 - 655
Published: Nov. 5, 2024
In
many
medical
settings,
medications
are
typically
administered
in
the
morning
or
evening,
aligning
with
patients'
daily
routines.
This
practice
does
not
stem
from
chronotherapy,
which
involves
scheduling
drug
administration
to
enhance
its
effectiveness,
but
rather
way
clinical
operations
structured.
The
timing
of
can
significantly
affect
a
medication's
effectiveness
and
side
effects,
impact
varying
by
up
ten
times
based
on
circadian
rhythms.
Disorders
such
as
major
depression,
bipolar
disorder,
schizophrenia
linked
disruptions
these
Recent
studies
have
found
that
dysfunctions,
including
genetic
neurohumoral
changes,
underlie
psychiatric
conditions.
Issues
an
altered
glucocorticoid
rhythm
due
impaired
HPA
axis
function,
disturbed
melatonin
balance,
sleep
disturbances
been
noted
psychotic
disorders.
Furthermore,
mood
disorders
associated
changes
expression
genes
The
intricate
relationship
between
cancer,
circadian
rhythms,
and
aging
is
increasingly
recognized
as
a
critical
factor
in
understanding
the
mechanisms
underlying
tumorigenesis
cancer
progression.
Aging
well-established
primary
risk
for
while
disruptions
rhythms
are
intricately
associated
with
progression
of
various
tumors.
Moreover,
itself
disrupts
leading
to
physiological
changes
that
may
accelerate
development.
Despite
these
connections,
specific
interplay
processes
their
collective
impact
on
remains
inadequately
explored
literature.
In
this
review,
we
systematically
explore
influence
We
discuss
how
core
genes
tumor
prognosis,
highlighting
shared
hallmarks
such
genomic
instability,
cellular
senescence,
chronic
inflammation.
Furthermore,
examine
aging,
focusing
crosstalk
contributes
tumorigenesis,
proliferation,
apoptosis,
well
metabolism
stability.
By
elucidating
common
pathways
linking
review
provides
new
insights
into
pathophysiology
identifies
potential
therapeutic
strategies.
propose
targeting
regulation
could
pave
way
novel
treatments,
including
chronotherapy
antiaging
interventions,
which
offer
important
benefits
clinical
management
cancer.
The Annual Review of Pharmacology and Toxicology,
Journal Year:
2023,
Volume and Issue:
64(1), P. 89 - 114
Published: Sept. 19, 2023
Today's
challenge
for
precision
medicine
involves
the
integration
of
impact
molecular
clocks
on
drug
pharmacokinetics,
toxicity,
and
efficacy
toward
personalized
chronotherapy.
Meaningful
improvements
tolerability
and/or
medications
through
proper
administration
timing
have
been
confirmed
over
past
decade
immunotherapy
chemotherapy
against
cancer,
as
well
commonly
used
pharmacological
agents
in
cardiovascular,
metabolic,
inflammatory,
neurological
conditions.
Experimental
human
studies
recently
revealed
sexually
dimorphic
circadian
responses.
Dedicated
randomized
clinical
trials
should
now
aim
to
issue
recommendations
daily
medical
practice,
integrating
innovative
technologies
remote
longitudinal
monitoring
metrics,
statistical
prediction
clock
function
from
single-timepoint
biopsies,
multiscale
biorhythmic
mathematical
modelling.
Importantly,
chronofit
patients
with
a
robust
function,
who
would
benefit
most
chronotherapy,
need
be
identified.
Conversely,
nonchronofit
could
emerging
class
chronobiotics
targeting
clock.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6275 - 6275
Published: March 27, 2023
The
concentration
of
biomolecules
in
living
systems
shows
numerous
systematic
and
random
variations.
Systematic
variations
can
be
classified
based
on
the
frequency
as
ultradian
(<24
h),
circadian
(approximately
24
infradian
(>24
which
are
partly
predictable.
Random
biological
known
between-subject
that
among
set
points
an
analyte
from
different
individuals
within-subject
variation,
is
variation
around
individuals'
points.
cannot
predicted
but
estimated
using
appropriate
measurement
statistical
procedures.
Physiological
rhythms
analytes
could
considered
essential
elements
predictive,
preventive,
particularly
personalized
laboratory
medicine.
This
review
aims
to
summarize
research
have
been
done
about
types
physiological
rhythms,
variations,
their
effects
tests.
We
searched
PubMed
Web
Science
databases
for
rhythm
articles
English
without
time
restrictions
with
terms
"Biological
Within-subject
Between-subject
Ultradian
Circadian
rhythm,
Infradian
rhythms".
It
was
concluded
that,
effective
management
predicting,
preventing,
personalizing
medicine,
safe
valid
interpretation
patients'
test
results,
both
measurands
should
simultaneously.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Journal Year:
2023,
Volume and Issue:
1878(3), P. 188900 - 188900
Published: April 25, 2023
The
molecular
machinery
of
the
circadian
clock
regulates
expression
many
genes
and
processes
in
organism,
allowing
adaptation
cellular
activities
to
daily
light-dark
cycles.
Disruption
rhythm
can
lead
various
pathologies,
including
cancer.
Thus,
disturbance
normal
at
both
genetic
environmental
levels
has
been
described
as
an
independent
risk
factor
for
In
addition,
researchers
have
proposed
that
may
a
tissue-dependent
and/or
context-dependent
role
tumorigenesis
function
tumor
suppressors
oncogenes.
Finally,
core
trigger
or
least
be
involved
different
hallmarks
Hence,
expanding
knowledge
basis
would
helpful
identify
new
prognostic
markers
potential
therapeutic
targets.
Cancer Communications,
Journal Year:
2024,
Volume and Issue:
44(9), P. 929 - 966
Published: July 12, 2024
Abstract
The
intrinsic
oncogenic
mechanisms
and
properties
of
the
tumor
microenvironment
(TME)
have
been
extensively
investigated.
Primary
features
TME
include
metabolic
reprogramming,
hypoxia,
chronic
inflammation,
immunosuppression.
Previous
studies
suggest
that
senescence‐associated
secretory
phenotypes
mediate
intercellular
information
exchange
play
a
role
in
dynamic
evolution
TME.
Specifically,
hypoxic
adaptation,
dysregulation,
phenotypic
shifts
immune
cells
regulated
by
cellular
senescence
synergistically
contribute
to
development
an
immunosuppressive
thereby
promoting
progression
events.
This
review
provides
comprehensive
summary
processes
which
regulates
tumor‐adapted
TME,
with
focus
on
complex
underlying
relationship
between
changes
biological
functions
cells.
available
findings
components
collectively
potential
applications
challenges
targeted
senescence‐based
combination
therapies
clinical
settings
are
further
discussed
within
context
advancing
senescence‐related
research.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5846 - 5846
Published: May 28, 2024
The
circadian
clock
regulates
biological
cycles
across
species
and
is
crucial
for
physiological
activities
biochemical
reactions,
including
cancer
onset
development.
interplay
between
the
rhythm
involves
regulating
cell
division,
DNA
repair,
immune
function,
hormonal
balance,
potential
chronotherapy.
This
highlights
importance
of
maintaining
a
healthy
prevention
treatment.
article
investigates
complex
relationship
cancer,
exploring
how
disruptions
to
internal
may
contribute
tumorigenesis
influence
progression.
Numerous
databases
are
utilized
conduct
searches
articles,
such
as
NCBI,
MEDLINE,
Scopus.
keywords
used
throughout
academic
archives
“circadian
rhythm”,
”cancer”,
”circadian
clock”.
Maintaining
cycle
prioritizing
sleep
habits
minimizing
disruptions,
consistent
schedules,
reduced
artificial
light
exposure,
meal
timing
adjustments.
Dysregulation
gene
can
cause
tumor
growth,
leading
need
regulate
better
treatment
outcomes.
components
significantly
impact
cellular
responses
damage,
influencing
Understanding
rhythm’s
role
in
diseases
their
therapeutic
targets
essential
treating
preventing
cancer.
Disruptions
promote
abnormal
development
metastasis,
potentially
due
system
imbalances
fluctuations.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7530 - 7530
Published: July 9, 2024
Aging
is
a
multifaceted
process
influenced
by
hereditary
factors,
lifestyle,
and
environmental
elements.
As
time
progresses,
the
human
body
experiences
degenerative
changes
in
major
functions.
The
external
internal
signs
of
aging
manifest
various
ways,
including
skin
dryness,
wrinkles,
musculoskeletal
disorders,
cardiovascular
diseases,
diabetes,
neurodegenerative
cancer.
Additionally,
cancer,
like
aging,
complex
disease
that
arises
from
accumulation
genetic
epigenetic
alterations.
Circadian
clock
dysregulation
has
recently
been
identified
as
an
important
risk
factor
for
cancer
development.
Natural
compounds
herbal
medicines
have
gained
significant
attention
their
potential
preventing
age-related
diseases
inhibiting
progression.
These
demonstrate
antioxidant,
anti-inflammatory,
anti-proliferative,
pro-apoptotic,
anti-metastatic,
anti-angiogenic
effects
well
circadian
regulation.
This
review
explores
cancers,
specific
natural
targeting
key
features
these
conditions.
npj Precision Oncology,
Journal Year:
2024,
Volume and Issue:
8(1)
Published: Feb. 20, 2024
Abstract
Glioblastoma
is
one
of
the
most
lethal
cancers
with
current
therapeutic
options
lacking
major
successes.
This
underlines
necessity
to
understand
glioblastoma
biology
on
other
levels
and
use
these
learnings
for
development
new
concepts.
Mounting
evidence
in
field
circadian
medicine
points
a
tight
interplay
between
disturbances
system
progression.
The
clock,
an
internal
biological
mechanism
governing
numerous
physiological
processes
across
24-h
cycle,
also
plays
pivotal
role
regulationg
key
cellular
functions,
including
DNA
repair,
cell
cycle
progression,
apoptosis.
These
are
integral
tumour
response
therapy.
Disruptions
rhythms
can
influence
growth,
invasion,
treatment
patients.
In
this
review,
we
explore
robust
association
cancer
hallmarks
within
context
glioblastoma.
We
further
discuss
impact
clock
eight
shown
previously
link
molecular
different
cancers,
summarize
putative
proteins
rhythm
chronotherapy
By
unravelling
mechanisms
behind
intricate
connections
researchers
pave
way
identification
potential
targets,
innovative
strategies
personalized
approaches.
conclusion,
review
underscores
significant
advancement
understanding
future
therapies
glioblastoma,
ultimately
leading
enhanced
outcomes
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 498 - 498
Published: Jan. 9, 2025
The
importance
of
redox
systems
as
fundamental
elements
in
biology
is
now
widely
recognized
across
diverse
fields,
from
ecology
to
cellular
biology.
Their
connection
metabolism
particularly
significant,
it
plays
a
critical
role
energy
regulation
and
distribution
within
organisms.
Over
recent
decades,
has
emerged
relevant
focus
studies
biological
regulation,
especially
following
its
recognition
hallmark
cancer.
This
shift
broadened
cancer
research
beyond
strictly
genetic
perspectives.
interaction
between
carcinogenesis
involves
the
essential
metabolic
pathways,
such
glycolysis
Krebs
cycle,
well
involvement
redox-active
components
like
specific
amino
acids
cofactors.
feedback
mechanisms
linking
highlight
development
patterns
that
enhance
flexibility
adaptability
tumor
processes,
influencing
larger-scale
phenomena
circadian
rhythms
epigenetics.
Current Opinion in Systems Biology,
Journal Year:
2024,
Volume and Issue:
37, P. 100506 - 100506
Published: Feb. 29, 2024
The
growing
numbers
of
cancer
cases
represent
a
medical
and
societal
burden
worldwide.
More
than
half
all
patients
are
treated
with
chemotherapy.
Yet,
chemotherapeutic
drugs
kill
not
only
cells,
but
also
healthy
tissue,
causing
massive
adverse
side
effects.
Recent
research
on
circadian
medicine
suggests
that
side-effects
can
be
reduced,
treatment
efficacy
increased,
by
considering
the
biological
clock
patients.
Integrating
profiles
molecular
markers
in
personalized
mathematical
models
simulate
individual
dynamics
drug
uptake,
action
cellular
response
to
This
requires
advanced
computational
tools
balance
prediction
quality
overfitting.
Personalized
will
eventually
lead
an
optimal
alignment
timing
inner
patient,
reducing
effects,
increasing
enhancing
patient
well-being.