The Common Hallmarks of Aging, Circadian Rhythms and Cancer: Implications for Therapeutic Strategies

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.

Language: Английский

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Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy

The Annual Review of Pharmacology and Toxicology, Journal Year: 2023, Volume and Issue: 64(1), P. 89 - 114

Published: Sept. 19, 2023

Today's challenge for precision medicine involves the integration of impact molecular clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy. Meaningful improvements tolerability and/or medications through proper administration timing have been confirmed over past decade immunotherapy chemotherapy against cancer, as well commonly used pharmacological agents in cardiovascular, metabolic, inflammatory, neurological conditions. Experimental human studies recently revealed sexually dimorphic circadian responses. Dedicated randomized clinical trials should now aim to issue recommendations daily medical practice, integrating innovative technologies remote longitudinal monitoring metrics, statistical prediction clock function from single-timepoint biopsies, multiscale biorhythmic mathematical modelling. Importantly, chronofit patients with a robust function, who would benefit most chronotherapy, need be identified. Conversely, nonchronofit could emerging class chronobiotics targeting clock.

Language: Английский

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Physiological Rhythms and Biological Variation of Biomolecules: The Road to Personalized Laboratory Medicine

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6275 - 6275

Published: March 27, 2023

The concentration of biomolecules in living systems shows numerous systematic and random variations. Systematic variations can be classified based on the frequency as ultradian (<24 h), circadian (approximately 24 infradian (>24 which are partly predictable. Random biological known between-subject that among set points an analyte from different individuals within-subject variation, is variation around individuals' points. cannot predicted but estimated using appropriate measurement statistical procedures. Physiological rhythms analytes could considered essential elements predictive, preventive, particularly personalized laboratory medicine. This review aims to summarize research have been done about types physiological rhythms, variations, their effects tests. We searched PubMed Web Science databases for rhythm articles English without time restrictions with terms "Biological Within-subject Between-subject Ultradian Circadian rhythm, Infradian rhythms". It was concluded that, effective management predicting, preventing, personalizing medicine, safe valid interpretation patients' test results, both measurands should simultaneously.

Language: Английский

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Interactions of circadian clock genes with the hallmarks of cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(3), P. 188900 - 188900

Published: April 25, 2023

The molecular machinery of the circadian clock regulates expression many genes and processes in organism, allowing adaptation cellular activities to daily light-dark cycles. Disruption rhythm can lead various pathologies, including cancer. Thus, disturbance normal at both genetic environmental levels has been described as an independent risk factor for In addition, researchers have proposed that may a tissue-dependent and/or context-dependent role tumorigenesis function tumor suppressors oncogenes. Finally, core trigger or least be involved different hallmarks Hence, expanding knowledge basis would helpful identify new prognostic markers potential therapeutic targets.

Language: Английский

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Cellular senescence and metabolic reprogramming: Unraveling the intricate crosstalk in the immunosuppressive tumor microenvironment

Cancer Communications, Journal Year: 2024, Volume and Issue: 44(9), P. 929 - 966

Published: July 12, 2024

Abstract The intrinsic oncogenic mechanisms and properties of the tumor microenvironment (TME) have been extensively investigated. Primary features TME include metabolic reprogramming, hypoxia, chronic inflammation, immunosuppression. Previous studies suggest that senescence‐associated secretory phenotypes mediate intercellular information exchange play a role in dynamic evolution TME. Specifically, hypoxic adaptation, dysregulation, phenotypic shifts immune cells regulated by cellular senescence synergistically contribute to development an immunosuppressive thereby promoting progression events. This review provides comprehensive summary processes which regulates tumor‐adapted TME, with focus on complex underlying relationship between changes biological functions cells. available findings components collectively potential applications challenges targeted senescence‐based combination therapies clinical settings are further discussed within context advancing senescence‐related research.

Language: Английский

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The Relationship between Circadian Rhythm and Cancer Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5846 - 5846

Published: May 28, 2024

The circadian clock regulates biological cycles across species and is crucial for physiological activities biochemical reactions, including cancer onset development. interplay between the rhythm involves regulating cell division, DNA repair, immune function, hormonal balance, potential chronotherapy. This highlights importance of maintaining a healthy prevention treatment. article investigates complex relationship cancer, exploring how disruptions to internal may contribute tumorigenesis influence progression. Numerous databases are utilized conduct searches articles, such as NCBI, MEDLINE, Scopus. keywords used throughout academic archives “circadian rhythm”, ”cancer”, ”circadian clock”. Maintaining cycle prioritizing sleep habits minimizing disruptions, consistent schedules, reduced artificial light exposure, meal timing adjustments. Dysregulation gene can cause tumor growth, leading need regulate better treatment outcomes. components significantly impact cellular responses damage, influencing Understanding rhythm’s role in diseases their therapeutic targets essential treating preventing cancer. Disruptions promote abnormal development metastasis, potentially due system imbalances fluctuations.

Language: Английский

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Natural Compounds for Preventing Age-Related Diseases and Cancers

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7530 - 7530

Published: July 9, 2024

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.

Language: Английский

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Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock

npj Precision Oncology, Journal Year: 2024, Volume and Issue: 8(1)

Published: Feb. 20, 2024

Abstract Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major successes. This underlines necessity to understand glioblastoma biology on other levels and use these learnings for development new concepts. Mounting evidence in field circadian medicine points a tight interplay between disturbances system progression. The clock, an internal biological mechanism governing numerous physiological processes across 24-h cycle, also plays pivotal role regulationg key cellular functions, including DNA repair, cell cycle progression, apoptosis. These are integral tumour response therapy. Disruptions rhythms can influence growth, invasion, treatment patients. In this review, we explore robust association cancer hallmarks within context glioblastoma. We further discuss impact clock eight shown previously link molecular different cancers, summarize putative proteins rhythm chronotherapy By unravelling mechanisms behind intricate connections researchers pave way identification potential targets, innovative strategies personalized approaches. conclusion, review underscores significant advancement understanding future therapies glioblastoma, ultimately leading enhanced outcomes

Language: Английский

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Metabolic Reprogramming at the Edge of Redox: Connections Between Metabolic Reprogramming and Cancer Redox State

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 498 - 498

Published: Jan. 9, 2025

The importance of redox systems as fundamental elements in biology is now widely recognized across diverse fields, from ecology to cellular biology. Their connection metabolism particularly significant, it plays a critical role energy regulation and distribution within organisms. Over recent decades, has emerged relevant focus studies biological regulation, especially following its recognition hallmark cancer. This shift broadened cancer research beyond strictly genetic perspectives. interaction between carcinogenesis involves the essential metabolic pathways, such glycolysis Krebs cycle, well involvement redox-active components like specific amino acids cofactors. feedback mechanisms linking highlight development patterns that enhance flexibility adaptability tumor processes, influencing larger-scale phenomena circadian rhythms epigenetics.

Language: Английский

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Shaping the future of precision oncology: Integrating circadian medicine and mathematical models for personalized cancer treatment

Current Opinion in Systems Biology, Journal Year: 2024, Volume and Issue: 37, P. 100506 - 100506

Published: Feb. 29, 2024

The growing numbers of cancer cases represent a medical and societal burden worldwide. More than half all patients are treated with chemotherapy. Yet, chemotherapeutic drugs kill not only cells, but also healthy tissue, causing massive adverse side effects. Recent research on circadian medicine suggests that side-effects can be reduced, treatment efficacy increased, by considering the biological clock patients. Integrating profiles molecular markers in personalized mathematical models simulate individual dynamics drug uptake, action cellular response to This requires advanced computational tools balance prediction quality overfitting. Personalized will eventually lead an optimal alignment timing inner patient, reducing effects, increasing enhancing patient well-being.

Language: Английский

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