Journal of Biosciences and Medicines,
Journal Year:
2023,
Volume and Issue:
11(08), P. 192 - 207
Published: Jan. 1, 2023
Glioblastoma
Multiforme
(GBM)
represents
one
of
the
most
aggressive
and
metastatic
brain
tumors,
with
a
dismal
success
rate
less
than
three
percent
after
five
years,
particularly
in
tumors
active
immune
checkpoints.
This
necessitates
development
targeted
endogenous
agents
for
precise
GBM
treatment.
Previous
experiments
utilizing
Chemovar
Specific
Cannabis
Extractions
(CSCEs),
fractionated
polar
solvents
quantified
using
Liquid
Gas
Column
Chromatography
combined
Mass
Spectrometry
(LC/GCMS),
have
shown
reduced
viability
motility
human
cell
lines.
However,
complexity
botanical
substance
has
hindered
personalization
standard
cannabis
medicines
due
to
unknown
synergistic
effects
multiple
compounds.
To
address
this
limitation,
our
study
focuses
on
exposing
AM251
cells
chemovar
fractions
extracted
non-polar
solvent,
thereby
isolating
broader
spectrum
constituents.
By
employing
LC/GCMS
conjunction
Nuclear
Magnetic
Resonance
(NMR),
we
identified
nine*
compounds
present
CSCE
that
exhibit
significant
efficacy
(0.1
μM)
inducing
cytotoxicity*
tumor
cells.
Conversely,
fraction
experiment
did
not
demonstrate
against
UM251
The
quantification
individual
within
extraction
selectively
induces
death
holds
promise
guiding
future
research
facilitating
standardized
therapy.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 29, 2024
The
nuclear-encoded
mitochondrial
protein
Tu
translation
elongation
factor,
(TUFM)
is
well-known
for
its
role
in
translation.
Originally
discovered
yeast,
TUFM
demonstrates
significant
evolutionary
conservation
from
prokaryotes
to
eukaryotes.
Dysregulation
of
has
been
associated
with
disorders.
Although
early
hypothesis
suggests
that
localized
within
mitochondria,
recent
studies
identify
presence
the
cytoplasm,
this
subcellular
distribution
being
linked
distinct
functions
TUFM.
Significantly,
addition
established
function
quality
control,
research
indicates
a
broader
involvement
regulation
programmed
cell
death
processes
(e.g.,
autophagy,
apoptosis,
necroptosis,
and
pyroptosis)
diverse
roles
viral
infection,
cancer,
other
disease
conditions.
This
review
seeks
offer
current
summary
TUFM’s
biological
complex
regulatory
mechanisms
human
health
disease.
Insight
into
these
intricate
pathways
controlled
by
may
lead
potential
development
targeted
therapies
range
diseases.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(22), P. 5471 - 5471
Published: Nov. 20, 2024
Cannabigerol
(CBG),
a
non-psychoactive
cannabinoid
found
in
cannabis,
has
emerged
as
promising
therapeutic
agent
with
diverse
range
of
potential
applications.
Unlike
its
well-known
counterpart
tetrahydrocannabinol
(THC),
CBG
does
not
induce
intoxication,
making
it
an
attractive
option
the
clinic.
Recent
research
shed
light
on
CBG's
intriguing
molecular
mechanisms,
highlighting
to
modulate
multiple
physiological
processes.
This
review
delves
into
current
understanding
interactions
and
explores
power
alleviate
various
conditions,
including
cancer,
metabolic,
pain,
inflammatory
disorders,
amongst
others.
We
discuss
how
interacts
endocannabinoid
system
other
key
signaling
pathways,
such
CB1,
CB2,
TPR
channels,
α2-adrenoceptor,
potentially
influencing
inflammation,
neurodegeneration,
ailments.
Additionally,
we
highlight
ongoing
efforts
aimed
at
elucidating
full
spectrum
safety
profile
clinical
settings.
Through
this
comprehensive
analysis,
aim
provide
deeper
role
promoting
human
health
pave
way
for
future
endeavors.
Journal of Pharmacology and Experimental Therapeutics,
Journal Year:
2023,
Volume and Issue:
387(2), P. 170 - 179
Published: Aug. 31, 2023
Excessive
daily
exposure
of
human
skin
to
natural
UVA
radiation
leads
impaired
redox
homeostasis
in
epidermal
keratinocytes,
resulting
changes
their
proteome.
Commonly
used
antioxidants
usually
exhibit
protection
a
narrowed
range,
which
makes
it
necessary
combine
effects.
Therefore,
the
aim
this
study
was
analyze
protective
effect
cannabigerol
(CBG)
and
3-O-ethyl
ascorbic
acid
(EAA),
separately
together,
on
proteomic
profile
irradiated
keratinocytes.
Proteomic
analysis
with
use
Q
Exactive
HF
mass
spectrometer,
combined
biostatistic
tests,
performed
UVA-irradiated
keratinocytes
indicated
enhanced
lowered
expression
186
160
proteins,
respectively.
CBG
treatment
after
irradiation
reduced
these
numbers
110
upregulated
49
downregulated
while
EAA
eliminated
all
changes.
completely
UV-induced
pro-inflammatory
proteins
significantly
increased
level
responsible
for
cellular
locomotion.
On
other
hand,
UVA-induced
4-hydroxynonenal
protein
adducts
fivefold,
whereas
had
no
modification.
At
same
time,
did
not
modify
expression/structure
relation
nonirradiated
control
case
an
unaccompanied
or
slightly
modified
when
mixture.
The
effects
structure
allowed
us
obtain
wider
cells
against
radiation,
compared
compounds
were
alone.
SIGNIFICANCE
STATEMENT:
allows
conclude
that
eliminates
keratinocyte
reduces
adducts.
radiation.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 11, 2024
Abstract
Glioma
is
the
most
common
malignant
tumor
in
central
nervous
system,
with
significant
health
burdens
to
patients.
Due
intrinsic
characteristics
of
glioma
and
lack
breakthroughs
treatment
modalities,
prognosis
for
patients
remains
poor.
This
results
a
heavy
psychological
financial
load
worldwide.
In
recent
years,
cannabidiol
(CBD)
has
garnered
widespread
attention
research
due
its
anti-tumoral,
anti-inflammatory,
neuroprotective
properties.
review
comprehensively
summarizes
preclinical
clinical
on
use
CBD
therapy,
as
well
current
status
nanomedicine
formulations
CBD,
discusses
potential
challenges
therapy
future.
Journal of Surgery,
Journal Year:
2023,
Volume and Issue:
8(13)
Published: Sept. 2, 2023
Abstract
Glioblastoma
Multiforme
(GBM)
is
the
most
common
malignant
brain
tumor
in
adults.
Today
it
considered
primary
treatment
with
Stupp
method,
which
combines
radiotherapy
and
chemotherapy
(temozolomide)
after
surgery,
has
a
moderate
success
rate
causes
recurrence.
Despite
improved
overall
survival
rates,
this
cancer
still
lacks
an
effective,
reliable,
less
toxic
option.
One
of
characteristics
that
cell
must
possess
order
to
survive
therapeutic
grow
ability
self-renew.
Therefore,
important
understand
molecular
mechanisms
regulate
process.
The
sex-determining
region
Y
(SRY)-Box
2
(SOX2)
transcription
factor
whose
activity
associated
maintaining
undifferentiated
state
stem
cells
various
tissues,
including
brain.
Several
studies
have
found
elevated
SOX2
levels
biopsies
from
GBM
patients,
higher
being
poor
outcomes.
silencing
could
represent
new
approach
combat
tumors
particular.
In
Review,
we
focus
on
role
tumorigenesis
discuss
recent
advances
inhibition
as
promising
strategy
for
GBM.
BioFactors,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Abstract
Stem
cells
play
a
critical
role
in
human
tissue
regeneration
and
repair.
In
addition,
cancer
stem
(CSCs),
subpopulations
of
sharing
similar
characteristics
as
normal
cells,
are
responsible
for
tumor
metastasis
resistance
to
chemo‐
radiotherapy
relapse.
Interestingly,
all
have
cannabinoid
receptors,
such
cannabidiol
(CBD),
that
perform
biological
functions.
The
aim
this
systematic
review
was
analyze
the
effect
CBD
on
both
somatic
(SSCs)
CSCs.
Of
276
articles
analyzed,
38
were
selected
according
inclusion
exclusion
criteria.
A
total
27
studied
SSCs,
finding
44%
focused
differentiation
56%
its
protective
activity.
On
other
hand,
11
looked
at
CSCs,
including
glioblastoma
(64%),
lung
(27%),
breast
(only
one
article).
Our
results
showed
exerted
differentiating
SCCs.
molecule
demonstrated
an
antiproliferative
some
although
most
analyses
performed
vitro.
Therefore,
vivo
studies
should
be
necessary
justify
clinical
use,
receptors
could
specific
target
act
SSCs
Current Protein and Peptide Science,
Journal Year:
2023,
Volume and Issue:
25(1), P. 27 - 43
Published: Aug. 31, 2023
Brain
tumors
have
high
morbidity
and
mortality
rates,
accounting
for
1.4%
of
all
cancers.
Gliomas
are
the
most
common
primary
brain
in
adults.
Currently,
several
therapeutic
approaches
used;
however,
they
associated
with
side
effects
that
affect
patients'quality
life.
Therefore,
further
studies
needed
to
develop
novel
protocols
a
more
favorable
effect
profile.
In
this
context,
cannabinoid
compounds
may
serve
as
potential
alternatives.
Journal of Biosciences and Medicines,
Journal Year:
2023,
Volume and Issue:
11(08), P. 192 - 207
Published: Jan. 1, 2023
Glioblastoma
Multiforme
(GBM)
represents
one
of
the
most
aggressive
and
metastatic
brain
tumors,
with
a
dismal
success
rate
less
than
three
percent
after
five
years,
particularly
in
tumors
active
immune
checkpoints.
This
necessitates
development
targeted
endogenous
agents
for
precise
GBM
treatment.
Previous
experiments
utilizing
Chemovar
Specific
Cannabis
Extractions
(CSCEs),
fractionated
polar
solvents
quantified
using
Liquid
Gas
Column
Chromatography
combined
Mass
Spectrometry
(LC/GCMS),
have
shown
reduced
viability
motility
human
cell
lines.
However,
complexity
botanical
substance
has
hindered
personalization
standard
cannabis
medicines
due
to
unknown
synergistic
effects
multiple
compounds.
To
address
this
limitation,
our
study
focuses
on
exposing
AM251
cells
chemovar
fractions
extracted
non-polar
solvent,
thereby
isolating
broader
spectrum
constituents.
By
employing
LC/GCMS
conjunction
Nuclear
Magnetic
Resonance
(NMR),
we
identified
nine*
compounds
present
CSCE
that
exhibit
significant
efficacy
(0.1
μM)
inducing
cytotoxicity*
tumor
cells.
Conversely,
fraction
experiment
did
not
demonstrate
against
UM251
The
quantification
individual
within
extraction
selectively
induces
death
holds
promise
guiding
future
research
facilitating
standardized
therapy.
